Mendelian Randomization Study of Metabolite Levels with Blood Traits and Complications in Sickle Cell Disease Patients

SOM SCD MR Results - L-Glutamine and SCD-related disease

Legend: The document presents the genetic associations for metabolites and SCD-related diseases and mendelian randomization analysis results. SNPs (effect alleles) are the lead variants in each gene region identified for their strong association (P < 5.0 × 10−5) with a given metabolite in GWASes of metabolite levels in Europe-ancestry individuals (Shin et al., Nature Genetics, 2014, n=7,824; Long et al., Nature Genetics, 2017, n=1,960). Association effect size with SCD-related diseases in the CSSCD are log odds ratios from logistic regression.

Abbreviations and symbols: *:Variants identified to be pleiotropic by Phenoscanner queries and were excluded from model 2 (Methods); EAF: Effect allele frequency; BETA: Regression effect size or log(odd ratio); P Value: Significance value; N:GWAS sample size; F = F-statistic; I2 = I square; Q=Cochrane Q; nSNP=number of SNPs; CI=confidence interval; Var_ex=variance explained; IVW(re)= Inverse variance weighted (multiplicative random effect).

L-Glutamine all individuals

Painful Crises

Instruments Associations with L-Glutamine & Painful Crises

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Painful Crises (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, 0.59, P = 0.24, N = 1101)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, -0.12, P = 0.31, N = 1101)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.12, P = 0.49, N = 1101)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, -0.021, P = 0.89, N = 1101)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, -0.052, P = 0.7, N = 1101)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, -0.018, P = 0.88, N = 1101)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.01, 0.16, P = 0.78, N = 1101)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.12, P = 0.5, N = 1101)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, 0.29, P = 0.074, N = 1101)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, -0.061, P = 0.71, N = 1101)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.035, 0.24, P = 0.45, N = 1101)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, -0.11, P = 0.42, N = 1101)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.045, 0.093, P = 0.74, N = 1101)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.026, P = 0.88, N = 1101)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.94, 0.25, P = 0.32, N = 1101)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, -0.32, P = 0.049, N = 1101)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.27, 0.013, P = 0.92, N = 1101)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.044, 0.25, P = 0.4, N = 1101)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.13, -0.0023, P = 0.99, N = 1101)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, 0.11, P = 0.36, N = 1101)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, 0.037, P = 0.77, N = 1101)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, -0.12, P = 0.43, N = 1101)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.77, -0.11, P = 0.43, N = 1101)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.042, 0.057, P = 0.85, N = 1101)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, -0.17, P = 0.17, N = 1101)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.19, 0.031, P = 0.84, N = 1101)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, -0.17, P = 0.33, N = 1101)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.025, 0.15, P = 0.69, N = 1101)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.15, P = 0.37, N = 1101)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.22, -0.11, P = 0.45, N = 1101)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, -0.0083, P = 0.94, N = 1101)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, -0.32, P = 0.023, N = 1101)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, -0.12, P = 0.31, N = 1101)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.75, 0.056, P = 0.67, N = 1101)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.079, -0.18, P = 0.42, N = 1101)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.082, P = 0.71, N = 1101)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.09, 0.24, P = 0.25, N = 1101)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.17, -0.031, P = 0.84, N = 1101)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, -0.064, P = 0.59, N = 1101)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, 0.052, P = 0.66, N = 1101)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.095, 0.42, P = 0.04, N = 1101)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.34, -0.091, P = 0.45, N = 1101)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.49, 0.092, P = 0.42, N = 1101)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.82, -0.16, P = 0.29, N = 1101)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.76, -0.14, P = 0.3, N = 1101)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.71, -0.18, P = 0.17, N = 1101)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, -0.0076, P = 0.96, N = 1101)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.037, P = 0.79, N = 1101)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, -0.073, P = 0.54, N = 1101)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.056, -0.11, P = 0.67, N = 1101)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.027, 0.68, P = 0.06, N = 1101)

Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.21 (-0.46- 0.03) P=0.086	12	30	0.000128 (0- 62.6)	NA	NA	0.016 P=0.56
MR-Egger	51	-0.27 (-0.61- 0.064) P=0.12	12	30	0.000128 (0- 62.6)	41	0.8	0.016 P=0.56
Weighted median	51	-0.26 (-0.63- 0.11) P=0.17	12	30	0.000128 (0- 62.6)	NA	NA	0.016 P=0.56

Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.21	0.12	-1.72	0.09
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.38 (-0.65- -0.12) P=0.0048	16	22	0 (0- 58.4)	NA	NA	-0.021 P=0.58
MR-Egger	27	-0.31 (-0.73- 0.11) P=0.16	16	22	0 (0- 58.4)	17	0.88	-0.021 P=0.58
Weighted median	27	-0.32 (-0.71- 0.084) P=0.12	16	22	0 (0- 58.4)	NA	NA	-0.021 P=0.58

Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.38	0.14	-2.82	0.01
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Cholecystectomy

Instruments Associations with L-Glutamine & Cholecystectomy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Cholecystectomy (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.66, P = 0.25, N = 1084)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, -0.08, P = 0.56, N = 1084)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.07, P = 0.74, N = 1084)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, 0.26, P = 0.15, N = 1084)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, -0.098, P = 0.53, N = 1084)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, 0.042, P = 0.76, N = 1084)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.01, 0.34, P = 0.63, N = 1084)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.52, P = 0.01, N = 1084)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.4, P = 0.033, N = 1084)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, -0.0037, P = 0.98, N = 1084)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.035, 0.2, P = 0.57, N = 1084)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.21, P = 0.2, N = 1084)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.044, -0.24, P = 0.48, N = 1084)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, 0.1, P = 0.61, N = 1084)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.94, -0.22, P = 0.46, N = 1084)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, 0.043, P = 0.82, N = 1084)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.27, -0.21, P = 0.18, N = 1084)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.044, -0.3, P = 0.37, N = 1084)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.13, 0.14, P = 0.5, N = 1084)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, 0.086, P = 0.55, N = 1084)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, 0.25, P = 0.086, N = 1084)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, -0.19, P = 0.27, N = 1084)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, 0.041, P = 0.79, N = 1084)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.042, -0.47, P = 0.16, N = 1084)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.73, -0.12, P = 0.4, N = 1084)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.19, -0.058, P = 0.75, N = 1084)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, -0.16, P = 0.42, N = 1084)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.025, 0.11, P = 0.8, N = 1084)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.12, P = 0.53, N = 1084)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.22, -0.12, P = 0.48, N = 1084)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, 0.12, P = 0.37, N = 1084)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, -0.16, P = 0.33, N = 1084)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, -0.14, P = 0.29, N = 1084)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.75, 0.23, P = 0.13, N = 1084)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.078, 0.12, P = 0.65, N = 1084)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.14, P = 0.59, N = 1084)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.09, -0.32, P = 0.2, N = 1084)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, 0.027, P = 0.88, N = 1084)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, 0.054, P = 0.69, N = 1084)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, -0.36, P = 0.0077, N = 1084)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.095, 0.46, P = 0.059, N = 1084)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.33, 0.092, P = 0.51, N = 1084)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.49, 0.0036, P = 0.98, N = 1084)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.82, -0.1, P = 0.54, N = 1084)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.76, -0.13, P = 0.39, N = 1084)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.71, 0.03, P = 0.84, N = 1084)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.22, P = 0.19, N = 1084)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.23, P = 0.16, N = 1084)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, -0.075, P = 0.58, N = 1084)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.056, -0.23, P = 0.44, N = 1084)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.026, -0.083, P = 0.85, N = 1084)

Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.06 (-0.39- 0.27) P=0.72	12	30	0 (0- 98)	NA	NA	-0.051 P=0.13
MR-Egger	51	0.13 (-0.27- 0.54) P=0.52	12	30	0 (0- 98)	53	0.33	-0.051 P=0.13
Weighted median	51	-0.097 (-0.54- 0.35) P=0.67	12	30	0 (0- 98)	NA	NA	-0.051 P=0.13

Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.06	0.17	-0.36	0.72
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.17 (-0.56- 0.22) P=0.39	16	22	0 (0- 96.8)	NA	NA	-0.041 P=0.38
MR-Egger	27	-0.027 (-0.53- 0.48) P=0.92	16	22	0 (0- 96.8)	27	0.36	-0.041 P=0.38
Weighted median	27	-0.25 (-0.78- 0.28) P=0.36	16	22	0 (0- 96.8)	NA	NA	-0.041 P=0.38

Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.17	0.2	-0.87	0.39
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Retinopathy

Instruments Associations with L-Glutamine & Retinopathy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Retinopathy (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.98, 0.8, P = 0.1, N = 566)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.48, 0.096, P = 0.47, N = 566)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, 0.094, P = 0.63, N = 566)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.18, -0.17, P = 0.3, N = 566)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, -0.09, P = 0.54, N = 566)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, -0.13, P = 0.31, N = 566)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.011, 0.31, P = 0.63, N = 566)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.11, 0.41, P = 0.046, N = 566)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.17, 0.23, P = 0.19, N = 566)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.16, -0.24, P = 0.16, N = 566)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.037, -0.36, P = 0.28, N = 566)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.8, 0.081, P = 0.6, N = 566)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.039, 0.16, P = 0.63, N = 566)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, 0.16, P = 0.41, N = 566)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, 0.2, P = 0.48, N = 566)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, 0.088, P = 0.63, N = 566)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.27, -0.4, P = 0.0062, N = 566)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.042, -0.33, P = 0.31, N = 566)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.13, 0.36, P = 0.065, N = 566)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, 0.06, P = 0.66, N = 566)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, -0.2, P = 0.15, N = 566)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.19, 0.026, P = 0.87, N = 566)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.77, -0.2, P = 0.17, N = 566)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.04, -0.068, P = 0.84, N = 566)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, 0.028, P = 0.84, N = 566)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, 0.019, P = 0.91, N = 566)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.9, -0.11, P = 0.58, N = 566)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.027, 0.51, P = 0.2, N = 566)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.12, P = 0.54, N = 566)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, -0.033, P = 0.83, N = 566)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.48, -0.076, P = 0.55, N = 566)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.24, 0.078, P = 0.6, N = 566)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.55, -0.049, P = 0.69, N = 566)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, -0.36, P = 0.012, N = 566)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.073, -0.12, P = 0.62, N = 566)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.28, P = 0.24, N = 566)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.087, -0.38, P = 0.09, N = 566)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.17, 0.29, P = 0.081, N = 566)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.53, 0.074, P = 0.57, N = 566)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.5, -0.076, P = 0.54, N = 566)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.092, -0.36, P = 0.11, N = 566)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.33, -0.09, P = 0.51, N = 566)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.49, 0.14, P = 0.29, N = 566)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.81, -0.16, P = 0.34, N = 566)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.74, -0.035, P = 0.81, N = 566)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.72, 0.089, P = 0.53, N = 566)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, -0.096, P = 0.54, N = 566)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.21, P = 0.16, N = 566)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.44, 0.15, P = 0.25, N = 566)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.057, -0.067, P = 0.8, N = 566)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.033, 0.43, P = 0.24, N = 566)

Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.073 (-0.4- 0.25) P=0.66	12	30	4.6 (0- 97.4)	NA	NA	0.022 P=0.5
MR-Egger	51	-0.16 (-0.57- 0.25) P=0.45	12	30	4.6 (0- 97.4)	61	0.12	0.022 P=0.5
Weighted median	51	-0.2 (-0.66- 0.26) P=0.4	12	30	4.6 (0- 97.4)	NA	NA	0.022 P=0.5

Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.07	0.17	-0.44	0.66
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	0.15 (-0.25- 0.54) P=0.46	16	22	5.05 (0- 97.5)	NA	NA	0.014 P=0.77
MR-Egger	27	0.1 (-0.42- 0.62) P=0.71	16	22	5.05 (0- 97.5)	32	0.16	0.014 P=0.77
Weighted median	27	0.21 (-0.31- 0.72) P=0.43	16	22	5.05 (0- 97.5)	NA	NA	0.014 P=0.77

Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.15	0.2	0.74	0.46
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Priapism

Instruments Associations with L-Glutamine & Priapism

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Priapism (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.11, P = 0.88, N = 556)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.48, 0.13, P = 0.45, N = 556)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.89, 0.21, P = 0.44, N = 556)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, -0.014, P = 0.95, N = 556)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.77, -0.069, P = 0.72, N = 556)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, 0.098, P = 0.56, N = 556)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.013, 0.073, P = 0.93, N = 556)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.11, 0.031, P = 0.9, N = 556)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.15, -0.17, P = 0.46, N = 556)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, -0.19, P = 0.43, N = 556)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.031, -0.19, P = 0.68, N = 556)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.065, P = 0.76, N = 556)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.044, 0.17, P = 0.69, N = 556)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.27, P = 0.3, N = 556)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, 0.71, P = 0.072, N = 556)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.15, -0.052, P = 0.83, N = 556)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.0017, P = 0.99, N = 556)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.042, -0.39, P = 0.35, N = 556)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, -0.18, P = 0.48, N = 556)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, 0.029, P = 0.87, N = 556)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, 0.035, P = 0.85, N = 556)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, 0.24, P = 0.27, N = 556)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.78, 0.034, P = 0.86, N = 556)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.048, -0.15, P = 0.7, N = 556)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, -0.12, P = 0.51, N = 556)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.2, 0.21, P = 0.33, N = 556)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, -0.19, P = 0.47, N = 556)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.018, 0.3, P = 0.63, N = 556)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.3, P = 0.22, N = 556)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, 0.23, P = 0.24, N = 556)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, 0.1, P = 0.53, N = 556)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.21, P = 0.32, N = 556)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, 0.031, P = 0.85, N = 556)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.74, -0.18, P = 0.34, N = 556)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.08, 0.13, P = 0.68, N = 556)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.24, P = 0.45, N = 556)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.095, -0.08, P = 0.79, N = 556)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, -0.014, P = 0.95, N = 556)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, -0.13, P = 0.47, N = 556)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, 0.12, P = 0.46, N = 556)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.1, -0.18, P = 0.53, N = 556)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.33, -0.13, P = 0.47, N = 556)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.48, -0.17, P = 0.33, N = 556)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.81, -0.3, P = 0.16, N = 556)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, -0.12, P = 0.53, N = 556)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.71, -0.0019, P = 0.99, N = 556)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.056, P = 0.79, N = 556)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.25, -0.19, P = 0.35, N = 556)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, 0.054, P = 0.75, N = 556)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.058, -0.11, P = 0.76, N = 556)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.029, 0.079, P = 0.87, N = 556)

Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	0.034 (-0.24- 0.31) P=0.81	12	30	0 (0- 0)	NA	NA	-0.014 P=0.73
MR-Egger	51	0.087 (-0.41- 0.58) P=0.73	12	30	0 (0- 0)	25	1	-0.014 P=0.73
Weighted median	51	0.13 (-0.42- 0.67) P=0.65	12	30	0 (0- 0)	NA	NA	-0.014 P=0.73

Results from Univariable MRPRESSO of L-Glutamine & Priapism - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.03	0.14	0.24	0.81
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	0.091 (-0.25- 0.43) P=0.6	16	22	0 (0- 0)	NA	NA	-0.029 P=0.6
MR-Egger	27	0.19 (-0.41- 0.8) P=0.54	16	22	0 (0- 0)	13	0.97	-0.029 P=0.6
Weighted median	27	0.21 (-0.45- 0.87) P=0.53	16	22	0 (0- 0)	NA	NA	-0.029 P=0.6

Results from Univariable MRPRESSO of L-Glutamine & Priapism - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.09	0.17	0.52	0.61
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Leg Ulcers

Instruments Associations with L-Glutamine & Leg Ulcers

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Leg Ulcer (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.91, P = 0.11, N = 1155)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, 0.095, P = 0.47, N = 1155)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.088, P = 0.66, N = 1155)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, -0.36, P = 0.034, N = 1155)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, -0.22, P = 0.14, N = 1155)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, 0.098, P = 0.47, N = 1155)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.011, -0.62, P = 0.42, N = 1155)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.02, P = 0.92, N = 1155)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.16, P = 0.39, N = 1155)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, 0.019, P = 0.92, N = 1155)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.035, 0.33, P = 0.31, N = 1155)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, -0.0017, P = 0.99, N = 1155)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.044, 0.58, P = 0.071, N = 1155)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, 0.29, P = 0.13, N = 1155)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.94, -0.12, P = 0.69, N = 1155)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, -0.014, P = 0.94, N = 1155)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.28, -0.15, P = 0.31, N = 1155)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.045, 0.03, P = 0.93, N = 1155)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.13, 0.06, P = 0.77, N = 1155)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, -0.16, P = 0.24, N = 1155)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, -0.089, P = 0.53, N = 1155)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, 0.069, P = 0.68, N = 1155)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.77, -0.26, P = 0.075, N = 1155)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.042, -0.39, P = 0.23, N = 1155)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, 0.0027, P = 0.98, N = 1155)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.19, -0.024, P = 0.89, N = 1155)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, 0.17, P = 0.39, N = 1155)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.026, -0.53, P = 0.23, N = 1155)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.23, P = 0.23, N = 1155)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.22, -0.091, P = 0.56, N = 1155)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, 0.18, P = 0.16, N = 1155)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.0032, P = 0.98, N = 1155)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, 0.07, P = 0.58, N = 1155)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.75, 0.11, P = 0.46, N = 1155)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.077, 0.16, P = 0.53, N = 1155)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.032, P = 0.9, N = 1155)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.089, -0.057, P = 0.81, N = 1155)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.17, -0.14, P = 0.4, N = 1155)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, 0.025, P = 0.85, N = 1155)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, 0.067, P = 0.61, N = 1155)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.098, 0.14, P = 0.56, N = 1155)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.34, 0.051, P = 0.7, N = 1155)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.49, -0.14, P = 0.28, N = 1155)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.82, -0.075, P = 0.64, N = 1155)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.76, -0.063, P = 0.66, N = 1155)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.72, 0.24, P = 0.1, N = 1155)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.059, P = 0.71, N = 1155)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.13, P = 0.4, N = 1155)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, -0.15, P = 0.25, N = 1155)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.056, 0.54, P = 0.064, N = 1155)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.026, 0.26, P = 0.53, N = 1155)

Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	0.091 (-0.19- 0.38) P=0.53	12	30	0.332 (0- 49.2)	NA	NA	0.0017 P=0.96
MR-Egger	51	0.084 (-0.29- 0.46) P=0.66	12	30	0.332 (0- 49.2)	45	0.64	0.0017 P=0.96
Weighted median	51	-0.034 (-0.47- 0.41) P=0.88	12	30	0.332 (0- 49.2)	NA	NA	0.0017 P=0.96

Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.09	0.15	0.62	0.54
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	0.17 (-0.13- 0.48) P=0.26	16	22	0 (0- 28.3)	NA	NA	-0.0013 P=0.98
MR-Egger	27	0.18 (-0.29- 0.65) P=0.46	16	22	0 (0- 28.3)	18	0.83	-0.0013 P=0.98
Weighted median	27	0.091 (-0.41- 0.59) P=0.72	16	22	0 (0- 28.3)	NA	NA	-0.0013 P=0.98

Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.17	0.16	1.12	0.27
beta.exposure	Outlier-corrected	NA	NA	NA	NA

eGFR

Instruments Associations with L-Glutamine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	eGFR (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.12, P = 0.56, N = 859)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, -0.0057, P = 0.91, N = 859)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.022, P = 0.77, N = 859)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, 0.093, P = 0.14, N = 859)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, 0.04, P = 0.47, N = 859)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, -0.021, P = 0.67, N = 859)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.011, -0.093, P = 0.69, N = 859)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.13, P = 0.078, N = 859)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.075, P = 0.25, N = 859)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, -0.057, P = 0.37, N = 859)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.037, -0.18, P = 0.15, N = 859)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.093, P = 0.12, N = 859)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.042, 0.063, P = 0.6, N = 859)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.075, P = 0.3, N = 859)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, 0.089, P = 0.4, N = 859)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, -0.0097, P = 0.89, N = 859)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.28, 0.021, P = 0.7, N = 859)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.041, -0.011, P = 0.93, N = 859)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, -0.014, P = 0.85, N = 859)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, -0.0076, P = 0.88, N = 859)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, -0.036, P = 0.5, N = 859)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, 0.15, P = 0.015, N = 859)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, 0.041, P = 0.46, N = 859)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.039, -0.056, P = 0.66, N = 859)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, -0.12, P = 0.019, N = 859)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, 0.034, P = 0.58, N = 859)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, -0.064, P = 0.37, N = 859)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.025, -0.1, P = 0.51, N = 859)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, -0.071, P = 0.3, N = 859)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.22, -0.027, P = 0.64, N = 859)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, 0.081, P = 0.085, N = 859)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.0063, P = 0.91, N = 859)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, -0.0017, P = 0.97, N = 859)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.76, 0.09, P = 0.11, N = 859)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.075, 0.14, P = 0.12, N = 859)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.031, P = 0.74, N = 859)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.088, 0.061, P = 0.48, N = 859)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.17, -0.065, P = 0.3, N = 859)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, 0.13, P = 0.012, N = 859)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, -0.035, P = 0.46, N = 859)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.095, 0.067, P = 0.42, N = 859)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.34, 0.021, P = 0.67, N = 859)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, -0.025, P = 0.6, N = 859)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.81, -0.02, P = 0.74, N = 859)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, -0.017, P = 0.76, N = 859)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.72, 0.016, P = 0.77, N = 859)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.21, -0.014, P = 0.82, N = 859)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.0071, P = 0.9, N = 859)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, -0.065, P = 0.18, N = 859)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.053, 0.065, P = 0.54, N = 859)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.027, 0.057, P = 0.7, N = 859)

Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	0.027 (-0.085- 0.14) P=0.64	12	30	5.42 (0- 57.8)	NA	NA	-0.0089 P=0.44
MR-Egger	51	0.061 (-0.08- 0.2) P=0.4	12	30	5.42 (0- 57.8)	50	0.43	-0.0089 P=0.44
Weighted median	51	0.015 (-0.15- 0.18) P=0.85	12	30	5.42 (0- 57.8)	NA	NA	-0.0089 P=0.44

Results from Univariable MRPRESSO of L-Glutamine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.03	0.06	0.47	0.64
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.026 (-0.18- 0.13) P=0.74	16	22	17 (0- 95.4)	NA	NA	-0.011 P=0.56
MR-Egger	27	0.012 (-0.19- 0.21) P=0.91	16	22	17 (0- 95.4)	33	0.12	-0.011 P=0.56
Weighted median	27	-0.0049 (-0.2- 0.19) P=0.96	16	22	17 (0- 95.4)	NA	NA	-0.011 P=0.56

Results from Univariable MRPRESSO of L-Glutamine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.08	-0.34	0.74
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Aseptic Necrosis

Instruments Associations with L-Glutamine & Aseptic Necrosis

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Aseptic Necrosis (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, 0.37, P = 0.5, N = 1155)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, -0.098, P = 0.45, N = 1155)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, 0.17, P = 0.39, N = 1155)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, -0.19, P = 0.27, N = 1155)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, 0.096, P = 0.52, N = 1155)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.4, 0.053, P = 0.69, N = 1155)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.011, -0.51, P = 0.4, N = 1155)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.011, P = 0.96, N = 1155)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.12, P = 0.5, N = 1155)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.15, -0.057, P = 0.75, N = 1155)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.035, -0.29, P = 0.39, N = 1155)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, -0.011, P = 0.94, N = 1155)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.044, 0.14, P = 0.65, N = 1155)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.28, P = 0.15, N = 1155)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.94, 0.12, P = 0.67, N = 1155)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.14, -0.3, P = 0.092, N = 1155)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.28, -0.41, P = 0.0053, N = 1155)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.045, -0.2, P = 0.53, N = 1155)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.13, 0.14, P = 0.49, N = 1155)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, -0.13, P = 0.32, N = 1155)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.3, -0.063, P = 0.65, N = 1155)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.18, -0.2, P = 0.23, N = 1155)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.77, -0.022, P = 0.88, N = 1155)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.042, -0.33, P = 0.31, N = 1155)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.72, -0.36, P = 0.0085, N = 1155)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.19, -0.077, P = 0.64, N = 1155)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.87, 0.049, P = 0.8, N = 1155)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.026, -0.65, P = 0.13, N = 1155)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.06, P = 0.74, N = 1155)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.22, -0.067, P = 0.66, N = 1155)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.47, -0.14, P = 0.27, N = 1155)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, -0.21, P = 0.16, N = 1155)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.56, -0.074, P = 0.56, N = 1155)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.75, 0.15, P = 0.31, N = 1155)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.077, -0.12, P = 0.62, N = 1155)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.23, P = 0.34, N = 1155)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.089, 0.19, P = 0.42, N = 1155)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.17, -0.25, P = 0.14, N = 1155)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.54, 0.0018, P = 0.99, N = 1155)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, -0.15, P = 0.23, N = 1155)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.098, 0.17, P = 0.47, N = 1155)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.34, -0.094, P = 0.48, N = 1155)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.49, 0.066, P = 0.6, N = 1155)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.82, -0.38, P = 0.023, N = 1155)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.76, 0.0033, P = 0.98, N = 1155)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.72, -0.042, P = 0.77, N = 1155)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.16, P = 0.32, N = 1155)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.11, P = 0.46, N = 1155)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.43, -0.099, P = 0.45, N = 1155)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.056, -0.098, P = 0.73, N = 1155)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.026, 0.91, P = 0.026, N = 1155)

Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.12 (-0.44- 0.19) P=0.44	12	30	2.53 (0- 98.6)	NA	NA	-0.024 P=0.45
MR-Egger	51	-0.031 (-0.43- 0.37) P=0.88	12	30	2.53 (0- 98.6)	55	0.25	-0.024 P=0.45
Weighted median	51	-0.095 (-0.52- 0.33) P=0.67	12	30	2.53 (0- 98.6)	NA	NA	-0.024 P=0.45

Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.12	0.16	-0.77	0.45
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.16 (-0.5- 0.19) P=0.37	16	22	3.47 (0- 65.3)	NA	NA	-0.048 P=0.26
MR-Egger	27	0.012 (-0.45- 0.47) P=0.96	16	22	3.47 (0- 65.3)	22	0.61	-0.048 P=0.26
Weighted median	27	-0.24 (-0.78- 0.29) P=0.37	16	22	3.47 (0- 65.3)	NA	NA	-0.048 P=0.26

Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.16	0.18	-0.9	0.38
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Glutamine individuals age 18 and older

Painful Crises

Instruments Associations with L-Glutamine & Painful Crises

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Painful Crises (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, 0.073, P = 0.92, N = 387)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.47, -0.32, P = 0.061, N = 387)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.89, 0.032, P = 0.9, N = 387)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.16, -0.025, P = 0.91, N = 387)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.75, 0.03, P = 0.88, N = 387)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.38, -0.14, P = 0.42, N = 387)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.01, -0.14, P = 0.87, N = 387)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.13, 0.31, P = 0.22, N = 387)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, 0.37, P = 0.13, N = 387)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.16, -0.34, P = 0.15, N = 387)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.047, 0.23, P = 0.55, N = 387)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, -0.24, P = 0.26, N = 387)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.041, 0.67, P = 0.12, N = 387)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.18, P = 0.49, N = 387)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, 0.27, P = 0.49, N = 387)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.16, -0.34, P = 0.14, N = 387)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.03, P = 0.88, N = 387)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.039, 0.82, P = 0.066, N = 387)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.11, -0.021, P = 0.94, N = 387)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, 0.066, P = 0.72, N = 387)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.32, 0.0033, P = 0.99, N = 387)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.17, -0.055, P = 0.8, N = 387)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, -0.11, P = 0.57, N = 387)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.039, -0.064, P = 0.89, N = 387)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.73, -0.36, P = 0.053, N = 387)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, 0.083, P = 0.71, N = 387)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.89, -0.17, P = 0.51, N = 387)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.018, 0.016, P = 0.98, N = 387)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, -0.12, P = 0.61, N = 387)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, 0.081, P = 0.7, N = 387)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.46, 0.0034, P = 0.98, N = 387)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.22, -0.34, P = 0.098, N = 387)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.52, -0.12, P = 0.47, N = 387)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, -0.16, P = 0.39, N = 387)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.074, -0.21, P = 0.52, N = 387)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.14, P = 0.65, N = 387)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.087, 0.47, P = 0.12, N = 387)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, 0.16, P = 0.46, N = 387)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, -0.24, P = 0.16, N = 387)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.51, 0.17, P = 0.32, N = 387)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.078, 0.5, P = 0.13, N = 387)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.32, 0.19, P = 0.27, N = 387)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, 0.18, P = 0.28, N = 387)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, -0.3, P = 0.15, N = 387)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, -0.0072, P = 0.97, N = 387)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.73, -0.3, P = 0.11, N = 387)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, -0.045, P = 0.83, N = 387)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.058, P = 0.77, N = 387)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, -0.19, P = 0.26, N = 387)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.049, 0.23, P = 0.55, N = 387)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.026, -0.35, P = 0.52, N = 387)

Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.26 (-0.64- 0.12) P=0.18	12	30	7.65 (0- 50.6)	NA	NA	0.017 P=0.68
MR-Egger	51	-0.33 (-0.83- 0.17) P=0.2	12	30	7.65 (0- 50.6)	46	0.6	0.017 P=0.68
Weighted median	51	-0.25 (-0.86- 0.35) P=0.42	12	30	7.65 (0- 50.6)	NA	NA	0.017 P=0.68

Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.26	0.19	-1.35	0.18
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Painful Crises - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.56 (-1- -0.082) P=0.022	16	22	0.000116 (0- 97.8)	NA	NA	-0.05 P=0.38
MR-Egger	27	-0.38 (-1- 0.24) P=0.24	16	22	0.000116 (0- 97.8)	25	0.47	-0.05 P=0.38
Weighted median	27	-0.71 (-1.4- -0.049) P=0.035	16	22	0.000116 (0- 97.8)	NA	NA	-0.05 P=0.38

Results from Univariable MRPRESSO of L-Glutamine & Painful Crises - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.56	0.24	-2.3	0.03
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Cholecystectomy

Instruments Associations with L-Glutamine & Cholecystectomy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Cholecystectomy (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.96, P = 0.17, N = 378)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.46, -0.24, P = 0.15, N = 378)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.16, P = 0.54, N = 378)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.16, 0.54, P = 0.017, N = 378)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.75, -0.17, P = 0.37, N = 378)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.38, 0.0079, P = 0.96, N = 378)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.13, -0.45, P = 0.069, N = 378)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.22, P = 0.34, N = 378)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.16, -0.14, P = 0.55, N = 378)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.046, -0.19, P = 0.62, N = 378)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.084, P = 0.68, N = 378)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.04, -0.076, P = 0.86, N = 378)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.041, P = 0.87, N = 378)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, -0.16, P = 0.67, N = 378)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.16, 0.18, P = 0.43, N = 378)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.19, P = 0.34, N = 378)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.04, 0.039, P = 0.93, N = 378)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, 0.34, P = 0.21, N = 378)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, 0.11, P = 0.54, N = 378)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, 0.18, P = 0.31, N = 378)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.17, -0.33, P = 0.12, N = 378)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, 0.14, P = 0.47, N = 378)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.04, -0.61, P = 0.15, N = 378)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.74, -0.0048, P = 0.98, N = 378)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, 0.18, P = 0.4, N = 378)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.88, -0.05, P = 0.85, N = 378)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.017, -0.083, P = 0.9, N = 378)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.15, 0.28, P = 0.25, N = 378)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, -0.19, P = 0.36, N = 378)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.46, 0.16, P = 0.32, N = 378)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.22, -0.25, P = 0.2, N = 378)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.52, -0.048, P = 0.77, N = 378)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, 0.24, P = 0.19, N = 378)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.074, -0.16, P = 0.61, N = 378)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.57, P = 0.07, N = 378)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.085, -0.51, P = 0.093, N = 378)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, -0.23, P = 0.29, N = 378)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, 0.14, P = 0.41, N = 378)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, -0.16, P = 0.33, N = 378)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.078, 0.79, P = 0.016, N = 378)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.31, 0.062, P = 0.72, N = 378)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, 0.14, P = 0.41, N = 378)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, -0.065, P = 0.75, N = 378)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, -0.18, P = 0.33, N = 378)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.73, 0.03, P = 0.87, N = 378)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.31, P = 0.13, N = 378)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.25, P = 0.23, N = 378)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, -0.0087, P = 0.96, N = 378)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.049, -0.17, P = 0.67, N = 378)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.025, -0.54, P = 0.34, N = 378)

Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	50	0.15 (-0.26- 0.56) P=0.47	12	30	5.78 (0- 71.1)	NA	NA	-0.06 P=0.14
MR-Egger	50	0.39 (-0.12- 0.9) P=0.14	12	30	5.78 (0- 71.1)	51	0.34	-0.06 P=0.14
Weighted median	50	-0.039 (-0.64- 0.57) P=0.9	12	30	5.78 (0- 71.1)	NA	NA	-0.06 P=0.14

Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.15	0.21	0.72	0.47
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Cholecystectomy - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.13 (-0.61- 0.36) P=0.61	16	22	0 (0- 77.1)	NA	NA	-0.037 P=0.53
MR-Egger	27	0.0062 (-0.63- 0.64) P=0.98	16	22	0 (0- 77.1)	27	0.36	-0.037 P=0.53
Weighted median	27	-0.12 (-0.81- 0.57) P=0.73	16	22	0 (0- 77.1)	NA	NA	-0.037 P=0.53

Results from Univariable MRPRESSO of L-Glutamine & Cholecystectomy - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.17	0.2	-0.87	0.39
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Retinopathy

Instruments Associations with L-Glutamine & Retinopathy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Retinopathy (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, 1.1, P = 0.14, N = 268)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.48, 0.29, P = 0.13, N = 268)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.89, -0.25, P = 0.42, N = 268)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.17, -0.53, P = 0.033, N = 268)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.75, -0.23, P = 0.29, N = 268)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.39, -0.076, P = 0.7, N = 268)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.013, 0.23, P = 0.8, N = 268)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.13, 0.64, P = 0.023, N = 268)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.011, P = 0.97, N = 268)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.17, 0.037, P = 0.88, N = 268)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.05, -0.53, P = 0.21, N = 268)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.033, P = 0.88, N = 268)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.037, 0.63, P = 0.21, N = 268)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.065, P = 0.82, N = 268)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, 0.24, P = 0.57, N = 268)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.15, -0.19, P = 0.46, N = 268)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.42, P = 0.06, N = 268)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.041, -0.19, P = 0.7, N = 268)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, 0.45, P = 0.14, N = 268)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.64, 0.011, P = 0.96, N = 268)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.34, -0.27, P = 0.16, N = 268)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.17, -0.21, P = 0.37, N = 268)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, -0.19, P = 0.37, N = 268)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.034, -0.32, P = 0.54, N = 268)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.75, 0.063, P = 0.77, N = 268)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.17, 0.27, P = 0.27, N = 268)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.9, 0.024, P = 0.94, N = 268)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.021, -0.027, P = 0.97, N = 268)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.4, P = 0.14, N = 268)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, -0.15, P = 0.52, N = 268)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.49, -0.2, P = 0.28, N = 268)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.06, P = 0.78, N = 268)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.54, -0.12, P = 0.49, N = 268)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.72, -0.35, P = 0.092, N = 268)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.073, -0.23, P = 0.52, N = 268)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.015, P = 0.97, N = 268)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.093, 0.037, P = 0.91, N = 268)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, 0.26, P = 0.29, N = 268)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, 0.12, P = 0.52, N = 268)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, -0.02, P = 0.91, N = 268)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.073, -0.46, P = 0.22, N = 268)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.33, 0.0037, P = 0.98, N = 268)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, 0.13, P = 0.47, N = 268)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.81, -0.26, P = 0.26, N = 268)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.73, -0.27, P = 0.18, N = 268)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.74, 0.16, P = 0.43, N = 268)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, -0.2, P = 0.39, N = 268)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.072, P = 0.75, N = 268)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, 0.11, P = 0.55, N = 268)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.06, -0.07, P = 0.86, N = 268)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.026, 0.96, P = 0.1, N = 268)

Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.39 (-0.81- 0.027) P=0.067	12	30	0.000154 (0- 74.8)	NA	NA	-0.015 P=0.73
MR-Egger	51	-0.33 (-0.88- 0.21) P=0.24	12	30	0.000154 (0- 74.8)	47	0.56	-0.015 P=0.73
Weighted median	51	-0.42 (-1- 0.19) P=0.18	12	30	0.000154 (0- 74.8)	NA	NA	-0.015 P=0.73

Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.39	0.21	-1.83	0.07
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Retinopathy - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.066 (-0.49- 0.36) P=0.76	16	22	0 (0- 29.4)	NA	NA	-0.052 P=0.41
MR-Egger	27	0.12 (-0.56- 0.8) P=0.73	16	22	0 (0- 29.4)	16	0.91	-0.052 P=0.41
Weighted median	27	-0.055 (-0.75- 0.64) P=0.88	16	22	0 (0- 29.4)	NA	NA	-0.052 P=0.41

Results from Univariable MRPRESSO of L-Glutamine & Retinopathy - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.15	0.2	0.74	0.46
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Priapism

Instruments Associations with L-Glutamine & Priapism

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Priapism (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.31, P = 0.76, N = 167)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.48, 0.2, P = 0.44, N = 167)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.89, 0.32, P = 0.44, N = 167)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.13, -0.91, P = 0.014, N = 167)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.76, -0.2, P = 0.49, N = 167)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.39, 0.42, P = 0.11, N = 167)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.13, 0.12, P = 0.77, N = 167)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.45, P = 0.22, N = 167)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.18, -0.11, P = 0.75, N = 167)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.048, -0.053, P = 0.93, N = 167)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.8, 0.095, P = 0.77, N = 167)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.045, 0.56, P = 0.4, N = 167)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.14, -0.66, P = 0.076, N = 167)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.94, 0.95, P = 0.1, N = 167)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.15, -0.18, P = 0.62, N = 167)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.21, -0.74, P = 0.043, N = 167)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.042, 0.11, P = 0.86, N = 167)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.11, 0.053, P = 0.91, N = 167)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.62, 0.095, P = 0.72, N = 167)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, 0.35, P = 0.23, N = 167)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.14, 0.12, P = 0.75, N = 167)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.77, 0.2, P = 0.48, N = 167)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.042, -0.5, P = 0.43, N = 167)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.73, -0.069, P = 0.8, N = 167)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.2, 0.21, P = 0.53, N = 167)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.91, -0.28, P = 0.53, N = 167)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.59, P = 0.11, N = 167)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.2, 0.51, P = 0.092, N = 167)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.45, 0.19, P = 0.41, N = 167)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.11, P = 0.74, N = 167)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.53, 0.015, P = 0.95, N = 167)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.7, -0.66, P = 0.013, N = 167)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.078, 0.16, P = 0.75, N = 167)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.19, P = 0.69, N = 167)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.11, -0.7, P = 0.093, N = 167)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.19, -0.076, P = 0.83, N = 167)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, -0.088, P = 0.74, N = 167)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, 0.54, P = 0.038, N = 167)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.075, -0.54, P = 0.31, N = 167)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.29, 0.1, P = 0.7, N = 167)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, -0.035, P = 0.9, N = 167)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, -0.65, P = 0.043, N = 167)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.73, -0.15, P = 0.57, N = 167)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.72, -0.1, P = 0.71, N = 167)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.21, 0.087, P = 0.79, N = 167)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.23, 0.071, P = 0.83, N = 167)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.46, 0.023, P = 0.93, N = 167)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.045, -0.54, P = 0.39, N = 167)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.027, 0.42, P = 0.58, N = 167)

Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	49	-0.29 (-0.93- 0.35) P=0.38	12	28	1.25e-05 (0- 95.1)	NA	NA	-0.062 P=0.33
MR-Egger	49	-0.047 (-0.85- 0.76) P=0.91	12	28	1.25e-05 (0- 95.1)	52	0.3	-0.062 P=0.33
Weighted median	49	-0.1 (-1- 0.82) P=0.83	12	28	1.25e-05 (0- 95.1)	NA	NA	-0.062 P=0.33

Results from Univariable MRPRESSO of L-Glutamine & Priapism - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.29	0.33	-0.89	0.38
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Priapism - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	26	-0.16 (-0.87- 0.56) P=0.67	15	20	0 (0- 84.1)	NA	NA	-0.19 P=0.036
MR-Egger	26	0.51 (-0.44- 1.5) P=0.3	15	20	0 (0- 84.1)	18	0.8	-0.19 P=0.036
Weighted median	26	0.012 (-1- 1) P=0.98	15	20	0 (0- 84.1)	NA	NA	-0.19 P=0.036

Results from Univariable MRPRESSO of L-Glutamine & Priapism - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.13	0.18	0.71	0.49
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Leg Ulcers

Instruments Associations with L-Glutamine & Leg Ulcers

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Leg Ulcer (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, -0.66, P = 0.33, N = 394)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.46, 0.13, P = 0.41, N = 394)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.18, P = 0.47, N = 394)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.16, -0.47, P = 0.031, N = 394)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.74, -0.26, P = 0.17, N = 394)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.38, 0.2, P = 0.22, N = 394)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.01, -0.94, P = 0.31, N = 394)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.25, P = 0.28, N = 394)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.19, P = 0.39, N = 394)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.16, 0.29, P = 0.21, N = 394)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.046, 0.26, P = 0.49, N = 394)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, -0.28, P = 0.15, N = 394)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.041, 0.058, P = 0.89, N = 394)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, 0.39, P = 0.1, N = 394)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, -0.15, P = 0.69, N = 394)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.16, 0.14, P = 0.51, N = 394)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, 0.059, P = 0.75, N = 394)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.039, 0.22, P = 0.59, N = 394)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, 0.23, P = 0.38, N = 394)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, -0.11, P = 0.53, N = 394)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, 0.073, P = 0.67, N = 394)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.17, -0.078, P = 0.7, N = 394)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, -0.11, P = 0.56, N = 394)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.038, -0.54, P = 0.2, N = 394)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.73, -0.12, P = 0.48, N = 394)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, -0.048, P = 0.82, N = 394)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.89, 0.076, P = 0.76, N = 394)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.019, -1, P = 0.085, N = 394)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, 0.25, P = 0.27, N = 394)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, -0.2, P = 0.3, N = 394)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.46, 0.16, P = 0.3, N = 394)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.22, 0.054, P = 0.77, N = 394)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.53, -0.073, P = 0.64, N = 394)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, 0.0054, P = 0.98, N = 394)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.074, 0.1, P = 0.74, N = 394)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, 0.082, P = 0.78, N = 394)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.088, 0.029, P = 0.92, N = 394)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, -0.49, P = 0.019, N = 394)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, 0.057, P = 0.72, N = 394)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, 0.085, P = 0.6, N = 394)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.077, 0.53, P = 0.091, N = 394)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.32, -0.08, P = 0.63, N = 394)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, -0.25, P = 0.13, N = 394)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, 0.012, P = 0.95, N = 394)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, -0.11, P = 0.53, N = 394)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.73, 0.34, P = 0.057, N = 394)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.062, P = 0.75, N = 394)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.21, P = 0.29, N = 394)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, -0.11, P = 0.49, N = 394)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.048, 0.47, P = 0.2, N = 394)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.025, 0.56, P = 0.29, N = 394)

Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.022 (-0.4- 0.36) P=0.91	12	30	0 (0- 70.1)	NA	NA	-0.045 P=0.24
MR-Egger	51	0.15 (-0.32- 0.63) P=0.53	12	30	0 (0- 70.1)	50	0.42	-0.045 P=0.24
Weighted median	51	-0.3 (-0.81- 0.2) P=0.24	12	30	0 (0- 70.1)	NA	NA	-0.045 P=0.24

Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.02	0.19	-0.12	0.91
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Leg Ulcers - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	0.054 (-0.4- 0.5) P=0.81	16	22	0.000147 (0- 94)	NA	NA	-0.053 P=0.32
MR-Egger	27	0.24 (-0.34- 0.83) P=0.42	16	22	0.000147 (0- 94)	25	0.48	-0.053 P=0.32
Weighted median	27	-0.29 (-0.93- 0.35) P=0.37	16	22	0.000147 (0- 94)	NA	NA	-0.053 P=0.32

Results from Univariable MRPRESSO of L-Glutamine & Leg Ulcers - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.17	0.16	1.12	0.27
beta.exposure	Outlier-corrected	NA	NA	NA	NA

eGFR

Instruments Associations with L-Glutamine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	eGFR (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.98, 0.37, P = 0.23, N = 365)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.46, -0.044, P = 0.54, N = 365)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, -0.092, P = 0.43, N = 365)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.16, 0.0081, P = 0.94, N = 365)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.74, 0.059, P = 0.5, N = 365)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.39, -0.087, P = 0.26, N = 365)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.011, -0.44, P = 0.22, N = 365)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, -0.025, P = 0.83, N = 365)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.039, P = 0.71, N = 365)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.17, 0.094, P = 0.32, N = 365)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.049, 0.023, P = 0.89, N = 365)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.1, P = 0.27, N = 365)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.041, 0.088, P = 0.63, N = 365)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.12, 0.08, P = 0.48, N = 365)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, -0.22, P = 0.18, N = 365)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.15, 0.0076, P = 0.94, N = 365)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.12, P = 0.15, N = 365)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.041, 0.15, P = 0.43, N = 365)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, -0.065, P = 0.58, N = 365)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, -0.17, P = 0.032, N = 365)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, 0.061, P = 0.44, N = 365)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.16, 0.18, P = 0.06, N = 365)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, -0.097, P = 0.24, N = 365)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.038, -0.15, P = 0.46, N = 365)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.74, -0.078, P = 0.34, N = 365)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, 0.29, P = 0.0023, N = 365)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.88, -0.011, P = 0.93, N = 365)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.021, -0.45, P = 0.086, N = 365)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.15, -0.022, P = 0.83, N = 365)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, -0.04, P = 0.65, N = 365)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.46, 0.12, P = 0.1, N = 365)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.23, 0.0076, P = 0.93, N = 365)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.54, -0.14, P = 0.061, N = 365)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, 0.023, P = 0.78, N = 365)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.071, 0.27, P = 0.064, N = 365)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.15, P = 0.28, N = 365)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.088, 0.086, P = 0.52, N = 365)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, -0.014, P = 0.89, N = 365)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, 0.048, P = 0.52, N = 365)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, -0.082, P = 0.25, N = 365)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.078, -0.0094, P = 0.95, N = 365)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.32, -0.02, P = 0.79, N = 365)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, -0.019, P = 0.8, N = 365)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, -0.036, P = 0.69, N = 365)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.74, -0.017, P = 0.84, N = 365)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.73, 0.071, P = 0.39, N = 365)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.21, -0.038, P = 0.67, N = 365)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, -0.035, P = 0.69, N = 365)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, 0.058, P = 0.45, N = 365)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.051, 0.11, P = 0.53, N = 365)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.025, 0.047, P = 0.85, N = 365)

Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	0.064 (-0.11- 0.24) P=0.48	12	30	3e-04 (0- 83.2)	NA	NA	-0.011 P=0.52
MR-Egger	51	0.11 (-0.11- 0.33) P=0.34	12	30	3e-04 (0- 83.2)	52	0.35	-0.011 P=0.52
Weighted median	51	0.11 (-0.14- 0.37) P=0.39	12	30	3e-04 (0- 83.2)	NA	NA	-0.011 P=0.52

Results from Univariable MRPRESSO of L-Glutamine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.06	0.09	0.71	0.48
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	0.046 (-0.18- 0.27) P=0.69	16	22	3.26 (0- 98.9)	NA	NA	-0.016 P=0.55
MR-Egger	27	0.1 (-0.19- 0.4) P=0.5	16	22	3.26 (0- 98.9)	31	0.2	-0.016 P=0.55
Weighted median	27	0.074 (-0.22- 0.37) P=0.62	16	22	3.26 (0- 98.9)	NA	NA	-0.016 P=0.55

Results from Univariable MRPRESSO of L-Glutamine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.08	-0.34	0.74
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Aseptic Necrosis

Instruments Associations with L-Glutamine & Aseptic Necrosis

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-glutamine (Shin et al/Long et al)	Aseptic Necrosis (CSSCD)
rs524219(G)/1:100821493	CDC14A	(0.93, -0.28, P = 4.7e-06, N = 1958)	(0.99, 0.95, P = 0.19, N = 394)
rs11166473(T)/1:101010015*	GPR88	(0.92, -0.36, P = 9.3e-08, N = 1958)	(0.46, -0.1, P = 0.53, N = 394)
rs2811981(A)/1:23950147*	MDS2	(0.89, -0.12, P = 3.8e-06, N = 1958)	(0.88, 0.27, P = 0.3, N = 394)
rs3127550(A)/1:49431909*	AGBL4	(0.49, 0.19, P = 5.7e-06, N = 1958)	(0.16, -0.19, P = 0.41, N = 394)
rs7394051(T)/10:122008026*	intergenic	(0.7, 0.0055, P = 2.2e-06, N = 7372)	(0.74, -0.083, P = 0.67, N = 394)
rs10762121(T)/10:68708291	CTNNA3	(0.18, -0.0094, P = 3.1e-05, N = 1768)	(0.38, 0.15, P = 0.39, N = 394)
rs11596604(A)/10:87141944*	intergenic	(0.024, 0.032, P = 2.5e-06, N = 1768)	(0.01, -0.31, P = 0.71, N = 394)
rs7078003(T)/10:99359412*	HOGA1	(0.17, 0.0087, P = 1.8e-06, N = 7372)	(0.12, 0.16, P = 0.52, N = 394)
rs7131407(T)/11:128431418	ETS1	(0.13, 0.0082, P = 3.2e-05, N = 7372)	(0.16, -0.072, P = 0.76, N = 394)
rs10431159(A)/11:70967219	SHANK2	(0.65, -0.0047, P = 4.8e-05, N = 7372)	(0.16, 0.27, P = 0.25, N = 394)
rs17666239(A)/12:47194757*	SLC38A4	(0.078, 0.0092, P = 1.7e-05, N = 7372)	(0.046, -0.1, P = 0.79, N = 394)
rs735246(A)/12:52547743	intergenic	(0.83, 0.0083, P = 4.8e-05, N = 7372)	(0.81, 0.2, P = 0.32, N = 394)
rs774044(T)/12:56837979*	TIMELESS	(0.055, -0.015, P = 5.6e-07, N = 7372)	(0.041, 0.16, P = 0.71, N = 394)
rs7313455(A)/12:56853231*	MIP	(0.44, 0.0062, P = 2.1e-08, N = 7372)	(0.13, -0.0075, P = 0.98, N = 394)
rs2657879(A)/12:56865338*	GLS2	(0.82, 0.015, P = 6.1e-18, N = 7372)	(0.95, -0.41, P = 0.28, N = 394)
rs12232026(A)/12:56960766*	RBMS2	(0.12, -0.0097, P = 4.4e-06, N = 7372)	(0.16, -0.16, P = 0.49, N = 394)
rs941893(T)/14:100542061*	EVL	(0.74, -0.0049, P = 4.1e-05, N = 7372)	(0.26, -0.4, P = 0.038, N = 394)
rs144325715(A)/14:95948631	intergenic	(0.021, -0.74, P = 5.3e-06, N = 1958)	(0.039, 0.12, P = 0.78, N = 394)
rs11636988(A)/15:26822814*	GABRB3	(0.57, -0.16, P = 6.5e-06, N = 1958)	(0.12, -0.021, P = 0.94, N = 394)
rs1910151(A)/15:38158699*	intergenic	(0.64, 0.0048, P = 2.2e-05, N = 7372)	(0.63, -0.045, P = 0.8, N = 394)
rs35150605(TAAC)/15:88047276	RP11-648K4.2	(0.25, -0.15, P = 6.3e-06, N = 1958)	(0.31, -0.3, P = 0.1, N = 394)
rs2560409(C)/16:24099496	PRKCB	(0.51, 0.26, P = 1.4e-06, N = 1958)	(0.17, -0.31, P = 0.14, N = 394)
rs16977047(T)/16:27924612*	GSG1L	(0.7, -0.0056, P = 1.1e-06, N = 7372)	(0.76, -0.14, P = 0.46, N = 394)
rs12447776(T)/16:84053027	SLC38A8	(0.019, 0.029, P = 4.1e-05, N = 1768)	(0.038, -0.049, P = 0.91, N = 394)
rs9912445(A)/17:37202603	LRRC37A11P	(0.79, 0.0052, P = 1.7e-05, N = 7372)	(0.73, -0.33, P = 0.071, N = 394)
rs8069305(A)/17:53638670	CTD-2033D24.2	(0.68, -0.0047, P = 4.9e-05, N = 7372)	(0.18, -0.08, P = 0.72, N = 394)
rs4798682(G)/18:8738265	SOGA2	(0.74, 0.15, P = 5e-06, N = 1958)	(0.89, 0.18, P = 0.5, N = 394)
rs73971292(C)/2:161821810	intergenic	(0.023, -0.65, P = 5.1e-06, N = 1958)	(0.019, -0.89, P = 0.13, N = 394)
rs780093(T)/2:27742603*	GCKR	(0.4, -0.0058, P = 1.9e-07, N = 7372)	(0.14, -0.24, P = 0.32, N = 394)
rs2199619(T)/2:28854958*	PLB1	(0.28, 0.0054, P = 5.2e-06, N = 7372)	(0.21, 0.12, P = 0.55, N = 394)
rs992580(C)/20:15246472*	MACROD2	(0.44, 0.15, P = 6.2e-06, N = 1958)	(0.46, -0.18, P = 0.28, N = 394)
rs6137021(A)/20:20375560*	RALGAPA2	(0.67, -0.0083, P = 4.5e-05, N = 1768)	(0.22, -0.28, P = 0.16, N = 394)
rs2425059(C)/20:33912371*	UQCC1	(0.38, 0.15, P = 5.6e-06, N = 1958)	(0.53, 0.0086, P = 0.96, N = 394)
rs2948828(A)/3:124811942	SLC12A8	(0.56, 0.0053, P = 2.2e-05, N = 7372)	(0.73, 0.023, P = 0.9, N = 394)
rs73168973(T)/3:151691599	intergenic	(0.21, -0.23, P = 4e-07, N = 1958)	(0.074, -0.17, P = 0.6, N = 394)
rs4699183(A)/4:106444435	AC004066.2	(0.9, -0.27, P = 6.2e-06, N = 1958)	(0.92, -0.36, P = 0.25, N = 394)
rs138354882(A)/4:171429817	intergenic	(0.028, -0.36, P = 4.5e-06, N = 1958)	(0.088, 0.05, P = 0.87, N = 394)
rs7667615(C)/4:182921992*	AC108142.1	(0.26, -0.17, P = 6.1e-06, N = 1958)	(0.18, -0.37, P = 0.093, N = 394)
rs542300(A)/6:12252237	intergenic	(0.51, -0.13, P = 7.2e-06, N = 1958)	(0.52, -0.022, P = 0.9, N = 394)
rs9478369(A)/6:153269698*	intergenic	(0.25, 0.0049, P = 4.1e-05, N = 7372)	(0.52, -0.17, P = 0.32, N = 394)
rs71569656(C)/6:22903627	RP1-209A6.1	(0.28, -0.14, P = 8.9e-06, N = 1958)	(0.077, 0.51, P = 0.13, N = 394)
rs2748991(T)/6:52596516	intergenic	(0.45, -0.007, P = 2.3e-06, N = 5604)	(0.32, -0.15, P = 0.38, N = 394)
rs1582256(C)/7:126634804	GRM8	(0.51, -0.18, P = 8.5e-06, N = 1958)	(0.5, -0.046, P = 0.79, N = 394)
rs767772939(CT)/7:128350744	FAM71F1	(0.096, 0.26, P = 4.1e-06, N = 1958)	(0.8, -0.31, P = 0.13, N = 394)
rs17837468(A)/7:138309274	SVOPL	(0.88, 0.0088, P = 3.8e-05, N = 7372)	(0.75, 0.06, P = 0.74, N = 394)
rs17152416(T)/7:25765238	AC003090.1	(0.76, 0.0049, P = 3.9e-05, N = 7372)	(0.73, -0.016, P = 0.93, N = 394)
rs4722699(T)/7:27456500*	intergenic	(0.27, -0.0048, P = 3.8e-05, N = 7372)	(0.2, 0.21, P = 0.31, N = 394)
rs1799211(T)/7:76240677	UPK3B	(0.41, -0.0082, P = 4.2e-06, N = 1768)	(0.24, 0.15, P = 0.45, N = 394)
rs9314463(A)/8:2525166	RP11-134O21.1	(0.19, 0.27, P = 9.1e-07, N = 1958)	(0.45, -0.29, P = 0.087, N = 394)
rs112508772(A)/9:140016354	snoU13	(0.025, 0.48, P = 7e-07, N = 1958)	(0.048, -0.17, P = 0.65, N = 394)
rs7848854(C)/9:7766733*	intergenic	(0.11, 0.0083, P = 2.4e-05, N = 7372)	(0.025, 0.097, P = 0.86, N = 394)

Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	51	-0.12 (-0.49- 0.26) P=0.53	12	30	3.44 (0- 41.6)	NA	NA	0.0033 P=0.93
MR-Egger	51	-0.13 (-0.62- 0.36) P=0.6	12	30	3.44 (0- 41.6)	45	0.62	0.0033 P=0.93
Weighted median	51	-0.14 (-0.73- 0.45) P=0.64	12	30	3.44 (0- 41.6)	NA	NA	0.0033 P=0.93

Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.12	0.19	-0.62	0.54
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Glutamine & Aseptic Necrosis - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.21 (-0.69- 0.26) P=0.38	16	22	8.21 (0- 64.5)	NA	NA	-0.029 P=0.61
MR-Egger	27	-0.11 (-0.73- 0.51) P=0.72	16	22	8.21 (0- 64.5)	26	0.42	-0.029 P=0.61
Weighted median	27	-0.19 (-0.91- 0.54) P=0.61	16	22	8.21 (0- 64.5)	NA	NA	-0.029 P=0.61

Results from Univariable MRPRESSO of L-Glutamine & Aseptic Necrosis - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.16	0.18	-0.9	0.38
beta.exposure	Outlier-corrected	NA	NA	NA	NA

SOM SCD MR Results - other metabolites and SCD-related disease

Painful Crises

Pyroglutamine

Instruments Associations with Pyroglutamine & Painful Crises

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Pyroglutamine (Shin et al/Long et al)	Painful Crises (CSSCD)
rs7512221(T)/1:220601623*	AC096644.1	(0.95, -0.04, P = 5e-06, N = 7354)	(0.58, 0.18, P = 0.13, N = 1101)
rs7556040(T)/1:220626220*	RP11-410C4.1	(0.95, -0.041, P = 3.4e-06, N = 7354)	(0.83, -0.37, P = 0.014, N = 1101)
rs9662967(T)/1:244957186	intergenic	(0.7, -0.019, P = 7.4e-07, N = 7354)	(0.38, -0.041, P = 0.74, N = 1101)
rs12098127(G)/1:48967002*	RP11-329A14.2	(0.18, 0.2, P = 2.6e-06, N = 1956)	(0.26, 0.035, P = 0.79, N = 1101)
rs56713017(C)/10:129008570	DOCK1	(0.11, 0.2, P = 5.4e-06, N = 1956)	(0.18, 0.053, P = 0.72, N = 1101)
rs11007183(A)/10:28939852*	RNU4ATAC6P	(0.11, -0.025, P = 9.8e-06, N = 7354)	(0.12, -0.056, P = 0.74, N = 1101)
rs2512652(C)/11:131259195	RNU6ATAC12P	(0.7, -0.052, P = 5.8e-06, N = 1764)	(0.88, -0.061, P = 0.72, N = 1101)
rs11223638(T)/11:133819222	IGSF9B	(0.14, -0.25, P = 3.7e-07, N = 1956)	(0.33, -0.052, P = 0.68, N = 1101)
rs11613331(A)/12:351467*	SLC6A13	(0.55, 0.037, P = 2.2e-25, N = 7354)	(0.28, 0.26, P = 0.044, N = 1101)
rs4140962(A)/12:475579*	KDM5A	(0.41, -0.033, P = 1.2e-19, N = 7354)	(0.64, -0.25, P = 0.042, N = 1101)
rs11116175(A)/12:84431621	intergenic	(0.16, 0.15, P = 7.1e-06, N = 1956)	(0.035, -0.13, P = 0.68, N = 1101)
rs9547116(C)/13:85845121	intergenic	(0.45, 0.16, P = 5.2e-06, N = 1956)	(0.11, -0.13, P = 0.49, N = 1101)
rs9547119(G)/13:85846010	intergenic	(0.45, 0.16, P = 4e-06, N = 1956)	(0.11, -0.14, P = 0.48, N = 1101)
rs1600760(A)/14:85104707*	intergenic	(0.66, -0.022, P = 5.1e-09, N = 7354)	(0.43, -0.1, P = 0.38, N = 1101)
rs12905776(T)/15:55170012	intergenic	(0.53, 0.11, P = 4e-06, N = 1956)	(0.27, 0.081, P = 0.53, N = 1101)
rs2551453(T)/18:53699500	CTD-2008L17.2	(0.26, -0.02, P = 7.3e-06, N = 7354)	(0.063, -0.15, P = 0.53, N = 1101)
rs6511763(C)/19:12186857*	ZNF844	(0.15, -0.15, P = 8.7e-06, N = 1956)	(0.67, -0.13, P = 0.3, N = 1101)
rs1132054(T)/19:49102399*	SULT2B1	(0.57, 0.02, P = 2.3e-06, N = 5590)	(0.25, -0.00082, P = 1, N = 1101)
rs715(T)/2:211543055*	CPS1	(0.71, 0.036, P = 2.5e-16, N = 7354)	(0.82, -0.11, P = 0.45, N = 1101)
rs2371015(T)/2:211549609*	intergenic	(0.34, 0.021, P = 2.2e-08, N = 7354)	(0.37, 0.1, P = 0.39, N = 1101)
rs11687290(A)/2:211647954*	intergenic	(0.73, -0.017, P = 7.4e-06, N = 7354)	(0.83, -0.082, P = 0.6, N = 1101)
rs79740025(T)/2:27677763*	IFT172	(0.19, 0.2, P = 2.9e-06, N = 1956)	(0.024, -0.15, P = 0.7, N = 1101)
rs239019(G)/21:17699639*	LINC00478	(0.97, 0.41, P = 9.1e-06, N = 1956)	(0.39, -0.08, P = 0.5, N = 1101)
rs80164931(G)/21:17705595	LINC00478	(0.032, 0.43, P = 1.8e-06, N = 1956)	(0.014, -0.4, P = 0.39, N = 1101)
rs139049(T)/22:44323597*	PNPLA3	(0.41, 0.11, P = 3.9e-06, N = 1956)	(0.36, -0.047, P = 0.7, N = 1101)
rs13057977(T)/22:49047339	FAM19A5	(0.15, 0.21, P = 9.9e-06, N = 1956)	(0.32, 0.2, P = 0.1, N = 1101)
rs77502708(C)/3:181192900	SOX2-OT	(0.026, 0.48, P = 2e-06, N = 1956)	(0.099, 0.2, P = 0.32, N = 1101)
rs2159892(T)/3:45383676*	intergenic	(0.64, -0.02, P = 3.6e-08, N = 7354)	(0.6, -0.043, P = 0.71, N = 1101)
rs17279437(A)/3:45814094*	SLC6A20	(0.095, 0.059, P = 1.3e-20, N = 7354)	(0.013, -0.0023, P = 1, N = 1101)
rs4071(C)/4:101319165*	EMCN	(0.76, -0.15, P = 8.9e-06, N = 1956)	(0.84, 0.091, P = 0.57, N = 1101)
rs17776892(A)/4:137356574	intergenic	(0.3, 0.035, P = 4e-06, N = 1764)	(0.16, -0.076, P = 0.63, N = 1101)
rs73863916(T)/4:169462085	PALLD	(0.021, 0.57, P = 4.5e-06, N = 1956)	(0.17, -0.029, P = 0.85, N = 1101)
rs11729049(A)/4:180719585	intergenic	(0.63, 0.017, P = 3.7e-06, N = 7354)	(0.87, -0.26, P = 0.13, N = 1101)
rs17250948(C)/4:182771958*	intergenic	(0.4, 0.14, P = 4.5e-06, N = 1956)	(0.28, -0.12, P = 0.34, N = 1101)
rs1203809(G)/4:2449545	RP11-503N18.3	(0.38, 0.09, P = 2.1e-06, N = 1956)	(0.2, 0.15, P = 0.3, N = 1101)
rs73221060(T)/4:31439776	intergenic	(0.051, -0.28, P = 1.8e-06, N = 1956)	(0.34, -0.017, P = 0.89, N = 1101)
rs12233879(A)/4:54263624*	FIP1L1	(0.14, -0.027, P = 4.5e-07, N = 7354)	(0.046, -0.22, P = 0.44, N = 1101)
rs77471043(G)/4:75060135	MTHFD2L	(0.01, 0.91, P = 2e-06, N = 1956)	(0.16, 0.15, P = 0.33, N = 1101)
rs11727631(T)/4:77576975	SHROOM3	(0.29, 0.017, P = 5.2e-06, N = 7354)	(0.47, -0.067, P = 0.57, N = 1101)
rs252984(T)/5:106752337	EFNA5	(0.19, -0.02, P = 7.6e-06, N = 7354)	(0.23, 0.17, P = 0.2, N = 1101)
rs1449167(T)/5:119998008*	PRR16	(0.64, 0.035, P = 5.4e-06, N = 1764)	(0.72, -0.1, P = 0.42, N = 1101)
rs199639973(A)/5:97107215	intergenic	(0.052, 0.28, P = 1.3e-06, N = 1956)	(0.057, 0.41, P = 0.11, N = 1101)
rs9346808(C)/6:160532652*	RP11-288H12.4	(0.23, -0.21, P = 7.5e-06, N = 1956)	(0.3, -0.083, P = 0.52, N = 1101)
rs12670725(A)/7:119577292*	intergenic	(0.81, 0.021, P = 6.2e-06, N = 7354)	(0.76, -0.049, P = 0.72, N = 1101)
rs5882739(GT)/7:20429461	ITGB8	(0.24, -0.06, P = 6.2e-06, N = 1956)	(0.68, 0.16, P = 0.21, N = 1101)
rs56142483(T)/8:41334474	intergenic	(0.088, -0.24, P = 8e-07, N = 1956)	(0.17, -0.059, P = 0.7, N = 1101)

Results from Univariable Mendelian Randomization of Pyroglutamine & Painful Crises - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	46	1.1 (0.94- 1.4) P=0.21	11	24	0 (0- 74.8)	NA	NA	0.014 P=0.62
MR-Egger	46	1.1 (0.84- 1.4) P=0.54	11	24	0 (0- 74.8)	40	0.64	0.014 P=0.62
Weighted median	46	1.1 (0.85- 1.5) P=0.37	11	24	0 (0- 74.8)	NA	NA	0.014 P=0.62

Results from Univariable MRPRESSO of Pyroglutamine & Painful Crises - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.12	0.1	1.26	0.21
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Pyroglutamine & Painful Crises - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	23	1.2 (0.97- 1.4) P=0.093	14	16	0 (0- 65.2)	NA	NA	-0.033 P=0.45
MR-Egger	23	1.3 (0.94- 1.7) P=0.13	14	16	0 (0- 65.2)	15	0.82	-0.033 P=0.45
Weighted median	23	1.2 (0.84- 1.6) P=0.35	14	16	0 (0- 65.2)	NA	NA	-0.033 P=0.45

Results from Univariable MRPRESSO of Pyroglutamine & Painful Crises - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.16	0.1	1.68	0.11
beta.exposure	Outlier-corrected	NA	NA	NA	NA

eGFR

cis-Aconitic acid

Instruments Associations with Cis-aconitate & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	cis-Aconitic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs35324600(T)/11:22530939	intergenic	(0.49, 0.15, P = 3.1e-06, N = 1947)	(0.28, 0.076, P = 0.16, N = 859)
rs6539223(G)/12:106007537	intergenic	(0.61, -0.1, P = 3.4e-06, N = 1947)	(0.89, -0.14, P = 0.065, N = 859)
rs138450783(CA)/14:63994788*	PPP2R5E	(0.061, -0.33, P = 3.1e-06, N = 1947)	(0.061, 0.042, P = 0.67, N = 859)
rs11648258(T)/16:82677875	CDH13	(0.11, 0.16, P = 4.4e-06, N = 1947)	(0.039, 0.27, P = 0.03, N = 859)
rs4798545(C)/18:7258907	intergenic	(0.63, 0.15, P = 8.2e-07, N = 1947)	(0.4, -0.00023, P = 1, N = 859)
rs2302891(T)/2:217064533	XRCC5	(0.24, 0.14, P = 2.3e-06, N = 1947)	(0.3, -0.063, P = 0.24, N = 859)
rs77430920(A)/3:1496695	intergenic	(0.097, -0.26, P = 6.5e-07, N = 1947)	(0.024, -0.37, P = 0.017, N = 859)
rs67411255(A)/3:162259082	intergenic	(0.29, 0.18, P = 2.3e-06, N = 1947)	(0.45, -0.042, P = 0.37, N = 859)
rs7662761(G)/4:182654376*	intergenic	(0.85, 0.19, P = 3.8e-06, N = 1947)	(0.81, -0.11, P = 0.066, N = 859)
rs7719640(A)/5:3752812*	intergenic	(0.58, 0.18, P = 4.8e-06, N = 1947)	(0.31, -0.023, P = 0.65, N = 859)
rs233947(A)/6:132324555*	RP11-69I8.3	(0.18, 0.13, P = 4.5e-06, N = 1947)	(0.62, -0.026, P = 0.61, N = 859)
rs55753187(C)/6:132717587	MOXD1	(0.29, 0.16, P = 8.2e-06, N = 1947)	(0.4, 0.027, P = 0.58, N = 859)
rs62572814(A)/9:83198655	intergenic	(0.072, 0.33, P = 9.4e-06, N = 1947)	(0.019, 0.02, P = 0.91, N = 859)

Results from Univariable Mendelian Randomization of Cis-aconitate & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	13	-0.013 (-0.28- 0.26) P=0.92	20	13	29.6 (0- 89.6)	NA	NA	0.043 P=0.67
MR-Egger	13	-0.26 (-1.4- 0.88) P=0.66	20	13	29.6 (0- 89.6)	22	0.025	0.043 P=0.67
Weighted median	13	-0.13 (-0.41- 0.15) P=0.37	20	13	29.6 (0- 89.6)	NA	NA	0.043 P=0.67

Results from Univariable MRPRESSO of Cis-aconitate & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.14	-0.09	0.93
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Cis-aconitate & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	9	0.15 (-0.22- 0.52) P=0.43	19	8.9	52.9 (0- 92.3)	NA	NA	0.018 P=0.92
MR-Egger	9	0.043 (-1.9- 2) P=0.97	19	8.9	52.9 (0- 92.3)	17	0.018	0.018 P=0.92
Weighted median	9	0.024 (-0.33- 0.38) P=0.89	19	8.9	52.9 (0- 92.3)	NA	NA	0.018 P=0.92

Results from Univariable MRPRESSO of Cis-aconitate & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.15	0.19	0.79	0.45
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Decanoylcarnitine

Instruments Associations with Decanoylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Decanoylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs2336566(T)/1:12085097*	MIIP	(0.81, -0.021, P = 3.5e-05, N = 7824)	(0.9, -0.049, P = 0.53, N = 859)
rs332765(T)/1:174655782*	RABGAP1L	(0.36, 0.13, P = 2.4e-06, N = 1950)	(0.9, -0.075, P = 0.34, N = 859)
rs1434889(A)/1:213511231*	intergenic	(0.69, -0.017, P = 5e-05, N = 7824)	(0.26, 0.089, P = 0.11, N = 859)
rs7552404(A)/1:76135946*	intergenic	(0.7, 0.056, P = 3.3e-43, N = 7824)	(0.83, -0.12, P = 0.061, N = 859)
rs699683(A)/1:76172512*	RP4-682C21.5	(0.068, 0.038, P = 1e-06, N = 7824)	(0.024, 0.036, P = 0.82, N = 859)
rs12130832(T)/1:76234294*	ACADM	(0.71, -0.037, P = 2.8e-19, N = 7824)	(0.79, 0.0095, P = 0.87, N = 859)
rs56352044(T)/1:76248706	RABGGTB	(0.23, -0.3, P = 9.1e-15, N = 1950)	(0.14, 0.15, P = 0.033, N = 859)
rs1144337(T)/1:76278877	MSH4	(0.1, 0.034, P = 1.5e-07, N = 7824)	(0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305	intergenic	(0.29, 0.034, P = 8.6e-17, N = 7824)	(0.32, -0.0091, P = 0.86, N = 859)
rs3762410(A)/1:97189288*	PTBP2	(0.3, -0.018, P = 2.8e-05, N = 7824)	(0.15, -0.042, P = 0.53, N = 859)
rs12255398(C)/10:122875878	intergenic	(0.21, -0.19, P = 3.6e-06, N = 1950)	(0.028, -0.04, P = 0.78, N = 859)
rs7894167(C)/10:47556919*	intergenic	(0.38, 0.17, P = 3.8e-06, N = 1950)	(0.52, 0.1, P = 0.037, N = 859)
rs11212307(A)/11:107506922*	ELMOD1	(0.95, -0.04, P = 3.7e-05, N = 7824)	(0.94, -0.019, P = 0.85, N = 859)
rs7116229(T)/11:113998407*	ZBTB16	(0.036, 0.048, P = 1.8e-05, N = 7824)	(0.22, -0.036, P = 0.53, N = 859)
rs12787276(T)/11:20313272*	intergenic	(0.25, 0.02, P = 3.3e-05, N = 7824)	(0.071, -0.16, P = 0.081, N = 859)
rs11828392(A)/11:21413243*	NELL1	(0.055, -0.045, P = 4.2e-05, N = 7824)	(0.012, -0.047, P = 0.83, N = 859)
rs10769307(T)/11:47923603*	RP11-793I11.1	(0.86, 0.024, P = 1.5e-05, N = 7824)	(0.74, 0.013, P = 0.8, N = 859)
rs7130402(A)/11:48115606*	PTPRJ	(0.93, 0.034, P = 2.4e-05, N = 7824)	(0.91, -0.013, P = 0.88, N = 859)
rs12289557(A)/11:8344945*	intergenic	(0.43, -0.18, P = 5.3e-06, N = 1950)	(0.028, 0.12, P = 0.42, N = 859)
rs11225932(T)/11:97160858	intergenic	(0.072, -0.35, P = 8.4e-06, N = 1950)	(0.013, 0.25, P = 0.24, N = 859)
rs7973509(A)/12:40354147*	SLC2A13	(0.27, -0.018, P = 2.2e-05, N = 7824)	(0.097, 0.042, P = 0.61, N = 859)
rs6538742(A)/12:97203085*	C12orf55	(0.72, -0.017, P = 4.4e-05, N = 7824)	(0.95, 0.044, P = 0.7, N = 859)
rs1557093(T)/13:108378235*	FAM155A	(0.89, -0.25, P = 2.6e-06, N = 1950)	(0.79, 0.096, P = 0.095, N = 859)
rs1220578(A)/13:24730147*	SPATA13	(0.078, -0.032, P = 6.9e-06, N = 7824)	(0.098, 0.098, P = 0.22, N = 859)
rs9546715(T)/13:85064464*	intergenic	(0.83, -0.021, P = 3.1e-05, N = 7824)	(0.88, -0.01, P = 0.89, N = 859)
rs8003176(T)/14:88760692*	KCNK10	(0.77, 0.036, P = 2e-05, N = 7824)	(0.9, 0.076, P = 0.34, N = 859)
rs11848217(G)/14:93048314*	RIN3	(0.24, -0.18, P = 7.1e-06, N = 1950)	(0.33, -0.029, P = 0.58, N = 859)
rs2062541(A)/16:16127235*	ABCC1	(0.61, 0.022, P = 2.9e-08, N = 7824)	(0.47, 0.048, P = 0.32, N = 859)
rs45512591(C)/16:16147264*	ABCC1	(0.28, -0.23, P = 4.7e-08, N = 1950)	(0.37, -0.056, P = 0.26, N = 859)
rs12932433(T)/16:7114043*	RBFOX1	(0.71, 0.019, P = 6.3e-06, N = 7824)	(0.59, 0.004, P = 0.94, N = 859)
rs11657401(A)/17:12762029*	ARHGAP44	(0.77, -0.022, P = 4.4e-05, N = 7824)	(0.91, -0.097, P = 0.24, N = 859)
rs4889820(A)/17:78089762*	GAA	(0.99, 0.091, P = 3.5e-05, N = 7824)	(0.86, -0.06, P = 0.4, N = 859)
rs8076629(A)/17:8024808*	HES7	(0.074, -0.033, P = 2.8e-05, N = 7824)	(0.2, -0.02, P = 0.75, N = 859)
rs948386(C)/18:19998810*	CTAGE1	(0.58, 0.017, P = 3.3e-05, N = 7824)	(0.5, -0.051, P = 0.29, N = 859)
rs3914856(C)/18:2413983	intergenic	(0.12, -0.025, P = 1.7e-05, N = 7824)	(0.041, 0.21, P = 0.08, N = 859)
rs2156436(T)/18:57457267*	intergenic	(0.031, 0.14, P = 1.7e-06, N = 7824)	(0.23, -0.027, P = 0.64, N = 859)
rs7257107(T)/19:35462829*	intergenic	(0.61, 0.018, P = 3.6e-05, N = 7824)	(0.77, -0.2, P = 0.00062, N = 859)
rs2239510(A)/19:36611284*	TBCB	(0.33, 0.018, P = 1.9e-05, N = 7824)	(0.23, 0.022, P = 0.7, N = 859)
rs2140779(T)/2:121302719*	AC073257.2	(0.15, -0.025, P = 9.9e-06, N = 7824)	(0.027, 0.11, P = 0.44, N = 859)
rs10191469(G)/2:149419648*	EPC2	(0.78, 0.17, P = 8.6e-06, N = 1950)	(0.36, -0.013, P = 0.79, N = 859)
rs10203979(C)/2:179022751*	intergenic	(0.23, 0.18, P = 3.4e-06, N = 1950)	(0.36, -0.074, P = 0.14, N = 859)
rs4675009(A)/2:226660503*	intergenic	(0.82, 0.21, P = 3.6e-06, N = 1950)	(0.82, -0.094, P = 0.14, N = 859)
rs2290101(C)/2:33952055*	MYADML	(0.34, 0.017, P = 4.4e-05, N = 7824)	(0.44, -0.11, P = 0.025, N = 859)
rs10495981(T)/2:49883809*	intergenic	(0.94, -0.034, P = 4.4e-05, N = 7824)	(0.99, -0.24, P = 0.25, N = 859)
rs1203869(T)/20:22533223*	LINC00261	(0.015, 0.099, P = 2.8e-05, N = 7824)	(0.15, -0.056, P = 0.39, N = 859)
rs2298450(T)/21:37623447*	DOPEY2	(0.37, -0.017, P = 2.2e-05, N = 7824)	(0.55, 0.0059, P = 0.9, N = 859)
rs5755595(T)/22:35518839*	CTA-714B7.5	(0.27, 0.24, P = 3.3e-06, N = 1950)	(0.055, 0.1, P = 0.35, N = 859)
rs331869(T)/3:255395	CHL1	(0.98, -0.13, P = 2.8e-06, N = 7824)	(0.81, -0.061, P = 0.32, N = 859)
rs2700436(T)/3:41573511*	ULK4	(0.76, -0.018, P = 4.4e-05, N = 7824)	(0.9, -0.0033, P = 0.97, N = 859)
rs6537038(A)/4:142166712*	RP11-586L23.1	(0.4, -0.019, P = 4.9e-06, N = 7824)	(0.32, -0.012, P = 0.81, N = 859)
rs35055965(T)/4:159193901*	RP11-597D13.7	(0.24, -0.23, P = 3.6e-09, N = 1950)	(0.16, -0.023, P = 0.72, N = 859)
rs8396(T)/4:159630817*	PPID	(0.7, 0.053, P = 8.7e-38, N = 7824)	(0.65, 0.014, P = 0.78, N = 859)
rs10857319(T)/4:159729794*	FNIP2	(0.35, 0.02, P = 1.1e-06, N = 7824)	(0.061, -0.071, P = 0.49, N = 859)
rs10003821(T)/4:159877388*	C4orf45	(0.36, -0.029, P = 1.6e-12, N = 7824)	(0.35, -0.0021, P = 0.97, N = 859)
rs595580(A)/4:24023919*	intergenic	(0.14, 0.022, P = 4.8e-05, N = 7824)	(0.13, 0.11, P = 0.13, N = 859)
rs9790569(T)/4:46734416*	COX7B2	(0.18, -0.2, P = 9.3e-06, N = 1950)	(0.14, -0.096, P = 0.17, N = 859)
rs6848595(A)/4:66601246*	intergenic	(0.8, 0.021, P = 2.4e-05, N = 7824)	(0.86, -0.015, P = 0.83, N = 859)
rs17157494(A)/5:104409021*	CTD-2374C24.1	(0.074, 0.035, P = 2.2e-06, N = 7824)	(0.03, -0.16, P = 0.25, N = 859)
rs10036208(T)/5:131571323*	P4HA2	(0.34, 0.02, P = 1.5e-06, N = 7824)	(0.22, 0.038, P = 0.51, N = 859)
rs1392171(A)/5:135631449*	TRPC7	(0.89, 0.024, P = 3.5e-05, N = 7824)	(0.87, -0.0074, P = 0.92, N = 859)
rs371846(T)/5:142188049*	ARHGAP26	(0.083, -0.03, P = 4.2e-05, N = 7824)	(0.25, -0.019, P = 0.73, N = 859)
rs447983(G)/5:155986075*	SGCD	(0.18, 0.22, P = 9.8e-06, N = 1950)	(0.42, -0.0042, P = 0.93, N = 859)
rs2042990(A)/5:66232373*	MAST4	(0.039, -0.04, P = 4.8e-05, N = 7824)	(0.019, -0.25, P = 0.17, N = 859)
rs13195853(T)/6:165808391*	PDE10A	(0.65, 0.018, P = 1.9e-05, N = 7824)	(0.85, 0.039, P = 0.57, N = 859)
rs4711830(T)/6:45810500*	intergenic	(0.13, 0.2, P = 6.1e-06, N = 1950)	(0.098, -0.058, P = 0.48, N = 859)
rs9352088(C)/6:74987577*	RP11-554D15.1	(0.75, -0.038, P = 3.1e-05, N = 7824)	(0.56, 0.036, P = 0.46, N = 859)
rs7795715(A)/7:154639804*	DPP6	(0.86, -0.025, P = 1.2e-05, N = 7824)	(0.82, -0.03, P = 0.64, N = 859)
rs7789113(A)/7:52525621*	intergenic	(0.37, 0.017, P = 3.1e-05, N = 7824)	(0.81, 0.081, P = 0.19, N = 859)
rs7800456(T)/7:81904348*	CACNA2D1	(0.29, 0.018, P = 2.5e-05, N = 7824)	(0.28, 0.063, P = 0.25, N = 859)
rs6958779(A)/7:92996871	intergenic	(0.59, -0.017, P = 4.1e-05, N = 7824)	(0.68, -0.016, P = 0.76, N = 859)
rs7819483(A)/8:144351394*	GLI4	(0.72, -0.019, P = 7.5e-06, N = 7824)	(0.46, -0.013, P = 0.79, N = 859)
rs7462737(T)/8:17615456*	MTUS1	(0.17, -0.021, P = 1.9e-05, N = 7824)	(0.26, -0.055, P = 0.31, N = 859)
rs3824142(A)/8:1947938*	KBTBD11	(0.12, -0.025, P = 4.7e-05, N = 7824)	(0.38, 0.006, P = 0.9, N = 859)
rs10504255(A)/8:59398461*	CYP7A1	(0.65, 0.017, P = 4.1e-05, N = 7824)	(0.93, -0.064, P = 0.49, N = 859)
rs7833895(A)/8:9989417*	MSRA	(0.93, 0.033, P = 1.5e-05, N = 7824)	(0.83, -0.021, P = 0.75, N = 859)
rs9556(T)/9:102732237*	STX17	(0.31, -0.019, P = 6.1e-06, N = 7824)	(0.27, 0.013, P = 0.81, N = 859)
rs6475272(T)/9:18949249*	FAM154A	(0.23, -0.024, P = 9.1e-07, N = 7824)	(0.067, 0.0017, P = 0.99, N = 859)
rs1556099(A)/9:7164502*	KDM4C	(0.75, 0.019, P = 1.8e-05, N = 7824)	(0.85, 0.1, P = 0.14, N = 859)

Results from Univariable Mendelian Randomization of Decanoylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	78	-0.08 (-0.22- 0.06) P=0.26	7.9	27	9.62 (0- 60.2)	NA	NA	-0.0027 P=0.79
MR-Egger	78	-0.062 (-0.25- 0.13) P=0.52	7.9	27	9.62 (0- 60.2)	80	0.35	-0.0027 P=0.79
Weighted median	78	-0.059 (-0.28- 0.17) P=0.61	7.9	27	9.62 (0- 60.2)	NA	NA	-0.0027 P=0.79

Results from Univariable MRPRESSO of Decanoylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.08	0.07	-1.12	0.27
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Decanoylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	8	-0.34 (-0.74- 0.052) P=0.089	17	6.2	14 (0- 97.6)	NA	NA	0.0023 P=0.95
MR-Egger	8	-0.35 (-0.92- 0.22) P=0.27	17	6.2	14 (0- 97.6)	7.9	0.25	0.0023 P=0.95
Weighted median	8	-0.45 (-0.92- 0.028) P=0.065	17	6.2	14 (0- 97.6)	NA	NA	0.0023 P=0.95

Results from Univariable MRPRESSO of Decanoylcarnitinee & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.34	0.2	-1.7	0.13
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Dodecanoylcarnitine

Instruments Associations with Dodecanoylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Dodecanoylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs2154184(T)/1:111432037*	CD53	(0.19, 0.22, P = 4.7e-06, N = 1955)	(0.056, -0.032, P = 0.75, N = 859)
rs332765(T)/1:174655782*	RABGAP1L	(0.36, 0.13, P = 2.4e-06, N = 1955)	(0.9, -0.075, P = 0.34, N = 859)
rs1408421(A)/1:17754767*	RCC2	(0.36, 0.034, P = 4.8e-05, N = 7824)	(0.24, -0.095, P = 0.091, N = 859)
rs736713(T)/1:19689279*	CAPZB	(0.047, -0.047, P = 2.4e-05, N = 7824)	(0.34, 0.015, P = 0.77, N = 859)
rs12087648(T)/1:198488490*	ATP6V1G3	(0.87, 0.029, P = 3.8e-05, N = 7824)	(0.72, -0.05, P = 0.36, N = 859)
rs12081432(T)/1:224413515	NVL	(0.33, -0.12, P = 1.8e-06, N = 1955)	(0.32, 0.069, P = 0.19, N = 859)
rs66713312(T)/1:236526499*	EDARADD	(0.24, 0.13, P = 4.3e-06, N = 1955)	(0.42, 0.036, P = 0.46, N = 859)
rs316841(T)/1:242322654*	PLD5	(0.38, 0.033, P = 4.9e-05, N = 7824)	(0.68, 0.0044, P = 0.93, N = 859)
rs7894167(C)/10:47556919*	intergenic	(0.38, 0.17, P = 3.8e-06, N = 1955)	(0.52, 0.1, P = 0.037, N = 859)
rs12218054(T)/10:49801239*	ARHGAP22	(0.22, -0.025, P = 1.4e-05, N = 7824)	(0.19, 0.042, P = 0.49, N = 859)
rs7902782(T)/10:8777109*	intergenic	(0.16, -0.028, P = 3.9e-05, N = 7824)	(0.22, -0.07, P = 0.22, N = 859)
rs4937603(T)/11:131022116*	intergenic	(0.43, 0.13, P = 1.6e-06, N = 1955)	(0.3, 0.017, P = 0.75, N = 859)
rs10766637(A)/11:20245859*	intergenic	(0.53, -0.034, P = 3e-05, N = 7824)	(0.21, 0.097, P = 0.11, N = 859)
rs9144(T)/11:87846757*	RAB38	(0.59, -0.02, P = 4.7e-05, N = 7824)	(0.84, -0.049, P = 0.46, N = 859)
rs10842869(A)/12:27335914*	intergenic	(0.44, -0.16, P = 2.8e-06, N = 1955)	(0.61, -0.036, P = 0.48, N = 859)
rs75605489(C)/12:4342877	intergenic	(0.061, -0.3, P = 9.7e-06, N = 1955)	(0.16, 0.085, P = 0.19, N = 859)
rs11180195(A)/12:75144208*	intergenic	(0.011, 0.17, P = 8.6e-06, N = 7824)	(0.04, -0.013, P = 0.92, N = 859)
rs2263942(A)/12:82420006*	intergenic	(0.97, 0.45, P = 1.1e-06, N = 1955)	(0.66, 0.035, P = 0.49, N = 859)
rs4900991(C)/14:50618737*	SOS2	(0.6, 0.021, P = 9.9e-06, N = 7824)	(0.89, 0.04, P = 0.61, N = 859)
rs7162018(A)/15:39365195*	RP11-624L4.1	(0.49, -0.022, P = 4.5e-06, N = 7824)	(0.21, 0.011, P = 0.85, N = 859)
rs12902624(C)/15:82533236*	EFTUD1	(0.88, 0.033, P = 4.3e-06, N = 7824)	(0.98, -0.53, P = 0.0052, N = 859)
rs193537(C)/16:16135043*	ABCC1	(0.3, -0.24, P = 1.8e-09, N = 1955)	(0.66, -0.019, P = 0.71, N = 859)
rs16966673(T)/16:63897984*	intergenic	(0.026, 0.12, P = 7.9e-06, N = 7824)	(0.11, 0.01, P = 0.9, N = 859)
rs10492879(T)/16:8432142*	intergenic	(0.94, -0.042, P = 1.8e-05, N = 7824)	(0.89, -0.071, P = 0.36, N = 859)
rs12928583(A)/16:84961276*	RP11-254F19.3	(0.54, 0.024, P = 9e-06, N = 7824)	(0.25, 0.02, P = 0.71, N = 859)
rs2546027(T)/19:35454215*	ZNF792	(0.54, 0.026, P = 4.1e-05, N = 7824)	(0.65, 0.019, P = 0.71, N = 859)
rs1003470(C)/19:36602729*	TBCB	(0.45, 0.023, P = 1.2e-06, N = 7824)	(0.3, 0.043, P = 0.41, N = 859)
rs346052(A)/19:44205082*	intergenic	(0.094, -0.16, P = 1.1e-06, N = 1955)	(0.16, -0.03, P = 0.64, N = 859)
rs1982669(T)/2:120539339*	PTPN4	(0.27, 0.02, P = 4.9e-05, N = 7824)	(0.28, -0.028, P = 0.6, N = 859)
rs843200(C)/2:156424356	intergenic	(0.54, -0.13, P = 8.9e-06, N = 1955)	(0.46, 0.056, P = 0.23, N = 859)
rs764741(A)/2:158089779	intergenic	(0.19, -0.27, P = 7.5e-06, N = 1955)	(0.092, -0.054, P = 0.51, N = 859)
rs10198528(A)/2:159358192*	PKP4	(0.58, 0.033, P = 3.1e-05, N = 7824)	(0.75, 0.086, P = 0.12, N = 859)
rs1465827(T)/2:212090820*	intergenic	(0.91, 0.033, P = 3.6e-05, N = 7824)	(0.95, -0.047, P = 0.67, N = 859)
rs2970899(T)/2:88421845*	FABP1	(0.77, 0.024, P = 2.3e-05, N = 7824)	(0.9, -0.073, P = 0.37, N = 859)
rs68088277(T)/20:16262002	KIF16B	(0.019, 0.61, P = 7.5e-06, N = 1955)	(0.1, 0.082, P = 0.31, N = 859)
rs73110340(G)/20:16262599	KIF16B	(0.019, 0.61, P = 6.4e-06, N = 1955)	(0.09, -0.0077, P = 0.93, N = 859)
rs4140469(A)/20:7152241	RP4-764O22.2	(0.76, -0.025, P = 9e-06, N = 7824)	(0.97, 0.046, P = 0.73, N = 859)
rs2298565(C)/21:45643396*	ICOSLG	(0.55, 0.02, P = 2.4e-05, N = 7824)	(0.68, 0.0037, P = 0.94, N = 859)
rs5755595(T)/22:35518839*	CTA-714B7.5	(0.27, 0.24, P = 3.3e-06, N = 1955)	(0.055, 0.1, P = 0.35, N = 859)
rs7631807(G)/3:104939338	intergenic	(0.76, -0.21, P = 8.8e-06, N = 1955)	(0.55, -0.098, P = 0.045, N = 859)
rs9880529(T)/3:176409064*	RP11-644C3.1	(0.87, 0.033, P = 3.8e-06, N = 7824)	(0.8, 0.035, P = 0.56, N = 859)
rs11927179(A)/3:68816377*	FAM19A4	(0.064, -0.042, P = 1e-05, N = 7824)	(0.15, -0.0077, P = 0.91, N = 859)
rs9852502(T)/3:88896473*	intergenic	(0.62, -0.26, P = 7.9e-06, N = 1955)	(0.5, 0.02, P = 0.68, N = 859)
rs4352478(A)/4:104212131	RP11-328K4.1	(0.22, 0.024, P = 1.9e-05, N = 7824)	(0.52, 0.0096, P = 0.84, N = 859)
rs2162399(T)/4:119822626	SYNPO2	(0.19, 0.044, P = 3.8e-05, N = 7824)	(0.36, -0.034, P = 0.5, N = 859)
rs1353305(A)/4:124326814*	SPRY1	(0.97, -0.1, P = 4.9e-05, N = 7824)	(0.82, 0.045, P = 0.47, N = 859)
rs10002155(A)/4:15916508	intergenic	(0.27, -0.18, P = 3.2e-06, N = 1955)	(0.32, -0.0014, P = 0.98, N = 859)
rs4690909(C)/4:159629151*	ETFDH	(0.69, 0.03, P = 1.1e-09, N = 7824)	(0.14, 0.012, P = 0.86, N = 859)
rs35189787(T)/4:159802267*	FNIP2	(0.21, -0.29, P = 5.3e-10, N = 1955)	(0.077, 0.091, P = 0.31, N = 859)
rs62306589(T)/4:56058510	intergenic	(0.29, 0.16, P = 4.5e-06, N = 1955)	(0.04, 0.093, P = 0.46, N = 859)
rs2535502(T)/4:58195220*	intergenic	(0.61, -0.021, P = 2.5e-05, N = 7824)	(0.66, 0.13, P = 0.009, N = 859)
rs6834160(A)/4:68030397*	intergenic	(0.98, 0.065, P = 4.6e-05, N = 7824)	(0.97, -0.22, P = 0.12, N = 859)
rs2119420(A)/4:80437117*	LINC00989	(0.24, 0.024, P = 2e-05, N = 7824)	(0.53, -0.068, P = 0.16, N = 859)
rs4836309(T)/5:126454090*	intergenic	(0.54, -0.022, P = 2.4e-06, N = 7824)	(0.5, -0.074, P = 0.13, N = 859)
rs274559(A)/5:131720070*	SLC22A5	(0.62, -0.023, P = 1.5e-06, N = 7824)	(0.62, 0.0015, P = 0.98, N = 859)
rs447983(G)/5:155986075*	SGCD	(0.18, 0.22, P = 9.8e-06, N = 1955)	(0.42, -0.0042, P = 0.93, N = 859)
rs7728965(T)/5:4231293*	intergenic	(0.23, 0.024, P = 3.9e-05, N = 7824)	(0.28, 0.025, P = 0.64, N = 859)
rs4711830(T)/6:45810500*	intergenic	(0.13, 0.2, P = 6.1e-06, N = 1955)	(0.098, -0.058, P = 0.48, N = 859)
rs1454715(A)/6:68827238*	intergenic	(0.22, 0.024, P = 2e-05, N = 7824)	(0.45, 0.067, P = 0.18, N = 859)
rs943087(T)/6:76754976*	IMPG1	(0.17, 0.031, P = 1.4e-06, N = 7824)	(0.2, -0.063, P = 0.29, N = 859)
rs3815553(T)/7:104535572*	LHFPL3	(0.47, -0.022, P = 4.1e-05, N = 7824)	(0.74, 0.045, P = 0.41, N = 859)
rs73231995(T)/7:123940656	RP5-921G16.1	(0.12, -0.22, P = 9.7e-06, N = 1955)	(0.012, 0.056, P = 0.8, N = 859)
rs1385234(A)/8:96681968*	KB-1047C11.2	(0.32, 0.022, P = 7e-06, N = 7824)	(0.39, 0.068, P = 0.18, N = 859)
rs10979297(A)/9:111024683*	intergenic	(0.67, -0.023, P = 6.9e-06, N = 7824)	(0.92, -0.1, P = 0.28, N = 859)
rs10819159(C)/9:129208748	MVB12B	(0.18, 0.2, P = 6.6e-06, N = 1955)	(0.1, 0.085, P = 0.28, N = 859)
rs3860894(A)/9:84007235*	intergenic	(0.47, 0.021, P = 4e-05, N = 7824)	(0.53, -0.032, P = 0.5, N = 859)

Results from Univariable Mendelian Randomization of Dodecanoylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	66	0.045 (-0.05- 0.14) P=0.35	12	36	0.00418 (0- 74.5)	NA	NA	-0.0066 P=0.5
MR-Egger	66	0.073 (-0.053- 0.2) P=0.26	12	36	0.00418 (0- 74.5)	65	0.43	-0.0066 P=0.5
Weighted median	66	0.067 (-0.072- 0.21) P=0.34	12	36	0.00418 (0- 74.5)	NA	NA	-0.0066 P=0.5

Results from Univariable MRPRESSO of Dodecanoylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.05	0.05	0.93	0.36
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Dodecanoylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	14	0.045 (-0.093- 0.18) P=0.52	20	14	9.75 (0- 64.5)	NA	NA	-0.021 P=0.45
MR-Egger	14	0.11 (-0.11- 0.33) P=0.34	20	14	9.75 (0- 64.5)	12	0.47	-0.021 P=0.45
Weighted median	14	0.022 (-0.18- 0.22) P=0.83	20	14	9.75 (0- 64.5)	NA	NA	-0.021 P=0.45

Results from Univariable MRPRESSO of Dodecanoylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.04	0.07	0.64	0.53
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Acetylcarnitine

Instruments Associations with L-Acetylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Acetylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs1281021(T)/1:11006668*	C1orf127	(0.04, 0.048, P = 4.7e-05, N = 7824)	(0.42, -0.091, P = 0.062, N = 859)
rs703116(A)/1:158644105*	SPTA1	(0.43, -0.019, P = 5e-05, N = 7824)	(0.12, -0.078, P = 0.29, N = 859)
rs16852535(A)/1:230881658*	CAPN9	(0.32, 0.011, P = 2e-05, N = 7824)	(0.54, -0.079, P = 0.11, N = 859)
rs2764907(C)/1:59356872*	RP4-794H19.1	(0.086, 0.019, P = 1e-05, N = 7824)	(0.015, -0.033, P = 0.87, N = 859)
rs1359850(A)/10:129785336*	PTPRE	(0.88, 0.015, P = 3e-05, N = 7824)	(0.98, 0.11, P = 0.52, N = 859)
rs12268890(T)/10:45803909*	OR13A1	(0.11, -0.015, P = 4.6e-05, N = 7824)	(0.39, 0.025, P = 0.61, N = 859)
rs2242206(T)/10:61414011*	SLC16A9	(0.26, 0.013, P = 1e-06, N = 7824)	(0.09, 0.076, P = 0.36, N = 859)
rs1171614(T)/10:61469538*	SLC16A9	(0.22, -0.028, P = 3.4e-23, N = 7824)	(0.24, -0.02, P = 0.73, N = 859)
rs624016(A)/10:6486611	PRKCQ	(0.34, -0.27, P = 8.2e-06, N = 1910)	(0.44, -0.021, P = 0.66, N = 859)
rs6583751(C)/10:92838776*	intergenic	(0.6, -0.012, P = 3.6e-06, N = 7824)	(0.49, 0.027, P = 0.58, N = 859)
rs2155639(T)/11:115492672*	intergenic	(0.34, -0.023, P = 1.3e-05, N = 7824)	(0.29, -0.083, P = 0.11, N = 859)
rs493384(A)/11:122114071	RP11-820L6.1	(0.012, -0.091, P = 4.9e-05, N = 7824)	(0.073, 0.033, P = 0.72, N = 859)
rs17831757(T)/11:61635200*	FADS2	(0.9, -0.015, P = 1.9e-05, N = 7824)	(0.95, -0.029, P = 0.78, N = 859)
rs10847395(A)/12:128007217*	intergenic	(0.48, -0.008, P = 2e-05, N = 7824)	(0.85, 0.013, P = 0.84, N = 859)
rs11052231(A)/12:32931618	intergenic	(0.046, -0.021, P = 4.4e-05, N = 7824)	(0.18, -0.074, P = 0.21, N = 859)
rs2263487(T)/12:47250827*	intergenic	(0.52, -0.0077, P = 2.8e-05, N = 7824)	(0.19, -0.01, P = 0.87, N = 859)
rs10735937(T)/12:67053882*	GRIP1	(0.16, -0.015, P = 8e-06, N = 7824)	(0.078, 0.2, P = 0.027, N = 859)
rs7332276(T)/13:107886865*	FAM155A	(0.47, -0.018, P = 3.1e-06, N = 7824)	(0.23, 0.097, P = 0.089, N = 859)
rs975508(A)/13:26565586*	ATP8A2	(0.55, -0.0081, P = 1.1e-05, N = 7824)	(0.59, -0.019, P = 0.7, N = 859)
rs2239265(T)/14:72513858	RGS6	(0.36, -0.79, P = 5.6e-06, N = 1910)	(0.48, -0.011, P = 0.82, N = 859)
rs10139470(T)/14:92150089*	CATSPERB	(0.25, -0.011, P = 3.9e-05, N = 7824)	(0.23, 0.012, P = 0.82, N = 859)
rs2121212(T)/15:102073092*	intergenic	(0.84, -0.013, P = 1.5e-05, N = 7824)	(0.63, 0.024, P = 0.64, N = 859)
rs2617228(T)/15:48991807	intergenic	(0.76, 0.17, P = 1.2e-06, N = 1910)	(0.71, -0.063, P = 0.22, N = 859)
rs8039391(A)/15:97234378*	intergenic	(0.16, -0.012, P = 1.4e-05, N = 7824)	(0.15, -0.0074, P = 0.91, N = 859)
rs197055(A)/16:1131175	SSTR5	(0.17, 0.32, P = 5.2e-06, N = 1910)	(0.024, 0.034, P = 0.83, N = 859)
rs9926669(A)/16:24318302	CACNG3	(0.2, 0.011, P = 2.6e-05, N = 7824)	(0.45, 0.052, P = 0.28, N = 859)
rs8072316(T)/17:2785024	RAP1GAP2	(0.56, -0.013, P = 1.4e-05, N = 7824)	(0.73, -0.0073, P = 0.89, N = 859)
rs60232438(A)/18:12003859	IMPA2	(0.15, 0.32, P = 9.2e-06, N = 1910)	(0.17, -0.017, P = 0.79, N = 859)
rs1367865(C)/18:49961055	DCC	(0.85, -0.25, P = 9.5e-06, N = 1910)	(0.94, -0.073, P = 0.49, N = 859)
rs17077300(A)/18:65087840*	intergenic	(0.91, -0.014, P = 4.8e-05, N = 7824)	(0.95, 0.17, P = 0.14, N = 859)
rs1401926(T)/19:21740932	RP11-678G14.2	(0.47, 0.0078, P = 2e-05, N = 7824)	(0.5, 0.061, P = 0.2, N = 859)
rs34810593(G)/19:21825360	RP11-420K14.1	(0.68, -0.58, P = 5.8e-06, N = 1910)	(0.33, 0.13, P = 0.011, N = 859)
rs2228070(T)/19:38956839*	RYR1	(0.23, 0.012, P = 8.2e-06, N = 7824)	(0.087, 0.16, P = 0.06, N = 859)
rs61003828(C)/19:4837150	PLIN3	(0.13, 0.23, P = 7.2e-06, N = 1910)	(0.1, -0.074, P = 0.35, N = 859)
rs12971535(C)/19:51069278	LRRC4B	(0.86, 0.25, P = 3.1e-06, N = 1910)	(0.65, -0.042, P = 0.41, N = 859)
rs12462064(T)/19:53628653*	ZNF415	(0.98, 0.064, P = 1.3e-05, N = 7824)	(0.95, -0.16, P = 0.14, N = 859)
rs922920(A)/2:111695479*	ACOXL	(0.52, -0.0078, P = 2.5e-05, N = 7824)	(0.32, -0.013, P = 0.8, N = 859)
rs2214270(T)/2:130336029	intergenic	(0.45, 0.008, P = 1.3e-05, N = 7824)	(0.36, -0.00081, P = 0.99, N = 859)
rs10194807(C)/2:171051041	MYO3B	(0.39, 0.16, P = 1.5e-06, N = 1910)	(0.62, 0.035, P = 0.48, N = 859)
rs34326128(T)/2:177202822*	MTX2	(0.076, -0.37, P = 2.8e-07, N = 1910)	(0.015, 0.19, P = 0.34, N = 859)
rs7579950(A)/2:200707606*	FTCDNL1	(0.046, -0.065, P = 4.6e-06, N = 7824)	(0.067, -0.036, P = 0.71, N = 859)
rs10164712(A)/2:218152840*	AC009492.1	(0.21, -0.011, P = 3.7e-05, N = 7824)	(0.23, 0.028, P = 0.63, N = 859)
rs11686145(T)/2:233121360*	DIS3L2	(0.023, -0.032, P = 2.5e-05, N = 7824)	(0.12, -0.062, P = 0.42, N = 859)
rs10210645(A)/2:237872402	intergenic	(0.095, 0.17, P = 4.4e-06, N = 1910)	(0.22, 0.035, P = 0.53, N = 859)
rs195592(T)/2:53488034*	intergenic	(0.82, -0.024, P = 4.8e-05, N = 7824)	(0.88, -0.053, P = 0.48, N = 859)
rs12615875(A)/2:73081791*	intergenic	(0.17, -0.012, P = 6.2e-06, N = 7824)	(0.53, 0.088, P = 0.061, N = 859)
rs6080491(T)/20:16900236*	intergenic	(0.17, -0.011, P = 1.8e-05, N = 7824)	(0.03, 0.11, P = 0.43, N = 859)
rs2205690(G)/20:38688310	intergenic	(0.95, -0.23, P = 2.4e-06, N = 1910)	(0.74, -0.083, P = 0.13, N = 859)
rs6126825(A)/20:51999923*	TSHZ2	(0.83, -0.011, P = 3.1e-05, N = 7824)	(0.76, 0.01, P = 0.86, N = 859)
rs11698080(T)/20:60899182*	LAMA5	(0.2, 0.011, P = 4e-05, N = 7824)	(0.26, -0.12, P = 0.038, N = 859)
rs4578928(T)/20:7210072	RP4-764O22.2	(0.49, 0.31, P = 5e-06, N = 1910)	(0.39, -0.099, P = 0.046, N = 859)
rs3773721(C)/3:122445778*	PARP14	(0.099, 0.3, P = 6.6e-06, N = 1910)	(0.049, 0.013, P = 0.91, N = 859)
rs1348656(T)/3:144933520*	intergenic	(0.8, -0.012, P = 6.5e-06, N = 7824)	(0.61, 0.03, P = 0.56, N = 859)
rs9289719(T)/3:145983688*	intergenic	(0.81, 0.012, P = 7.4e-06, N = 7824)	(0.41, 0.015, P = 0.76, N = 859)
rs9818568(G)/3:150300051	EIF2A	(0.49, -0.13, P = 9.6e-06, N = 1910)	(0.4, -0.032, P = 0.51, N = 859)
rs7665423(A)/4:10520600	CLNK	(0.014, 0.083, P = 4e-05, N = 7824)	(0.04, 0.013, P = 0.92, N = 859)
rs12506472(G)/4:124906097	intergenic	(0.22, 0.31, P = 8.7e-06, N = 1910)	(0.21, 8e-04, P = 0.99, N = 859)
rs3214037(A)/4:128688803*	SLC25A31	(0.014, -0.037, P = 4e-05, N = 7824)	(0.023, 0.16, P = 0.32, N = 859)
rs7688971(A)/4:145076356*	intergenic	(0.016, 0.073, P = 4.1e-05, N = 7824)	(0.092, -0.016, P = 0.85, N = 859)
rs12510399(T)/4:157216074*	AC108211.1	(0.13, -0.014, P = 3.8e-05, N = 7824)	(0.065, 0.081, P = 0.4, N = 859)
rs78509047(G)/4:181215706*	intergenic	(0.019, 0.87, P = 7.4e-06, N = 1910)	(0.14, 0.078, P = 0.27, N = 859)
rs6810706(A)/4:18750217*	intergenic	(0.55, 0.022, P = 5.4e-06, N = 7824)	(0.38, -0.021, P = 0.67, N = 859)
rs2920179(C)/4:4216951*	OTOP1	(0.21, 0.011, P = 3.8e-05, N = 7824)	(0.077, -0.091, P = 0.31, N = 859)
rs35379510(A)/4:86384715*	intergenic	(0.029, -0.058, P = 2.2e-05, N = 7824)	(0.21, 0.077, P = 0.19, N = 859)
rs17132827(T)/5:110489279*	AC010468.3	(0.91, 0.015, P = 2.1e-05, N = 7824)	(0.9, -0.058, P = 0.45, N = 859)
rs10037469(T)/5:130451873*	intergenic	(0.97, 0.03, P = 6e-07, N = 7824)	(0.73, 0.05, P = 0.37, N = 859)
rs7356708(C)/5:130593723	CDC42SE2	(0.038, -0.024, P = 4.2e-05, N = 7824)	(0.6, -0.031, P = 0.53, N = 859)
rs7716905(A)/5:131324377*	ACSL6	(0.97, 0.032, P = 1.5e-07, N = 7824)	(0.59, -0.046, P = 0.34, N = 859)
rs7705189(A)/5:131623358*	P4HA2	(0.51, 0.01, P = 3.9e-05, N = 7824)	(0.72, -0.13, P = 0.015, N = 859)
rs274567(T)/5:131714409*	SLC22A5	(0.37, 0.018, P = 2.8e-12, N = 7824)	(0.3, 0.049, P = 0.35, N = 859)
rs964922(A)/5:144943893*	PRELID2	(0.046, -0.12, P = 2.2e-06, N = 1910)	(0.078, 0.054, P = 0.56, N = 859)
rs17080396(A)/5:180005634*	CNOT6	(0.94, -0.018, P = 4.4e-05, N = 7824)	(0.9, -0.0076, P = 0.93, N = 859)
rs13184373(T)/5:30721169*	intergenic	(0.15, -0.012, P = 6.4e-06, N = 7824)	(0.17, -0.013, P = 0.84, N = 859)
rs7734716(T)/5:53707175*	LINC01033	(0.23, 0.023, P = 1.7e-05, N = 7824)	(0.2, -0.13, P = 0.026, N = 859)
rs10066016(G)/5:86197530	intergenic	(0.72, 0.32, P = 1.7e-06, N = 1910)	(0.55, 0.088, P = 0.065, N = 859)
rs9385645(A)/6:133694314*	EYA4	(0.84, 0.011, P = 3.3e-05, N = 7824)	(0.78, -0.013, P = 0.83, N = 859)
rs6570549(A)/6:143466564*	AIG1	(0.72, -0.011, P = 1.1e-05, N = 7824)	(0.95, 0.078, P = 0.49, N = 859)
rs662138(C)/6:160564476*	SLC22A1	(0.83, 0.014, P = 2.9e-07, N = 7824)	(0.95, 0.099, P = 0.35, N = 859)
rs9348257(A)/6:170442668*	intergenic	(0.26, 0.012, P = 2.7e-06, N = 7824)	(0.076, -0.049, P = 0.59, N = 859)
rs1655902(A)/6:29916855*	HLA-A	(0.82, -0.029, P = 1.3e-06, N = 7824)	(0.77, -0.013, P = 0.82, N = 859)
rs1885674(T)/6:71999404*	OGFRL1	(0.76, 0.011, P = 3.4e-05, N = 7824)	(0.8, 0.13, P = 0.024, N = 859)
rs9447587(T)/6:76720204*	IMPG1	(0.15, 0.015, P = 3.6e-05, N = 7824)	(0.17, -0.01, P = 0.87, N = 859)
rs12154346(A)/7:33543638*	BBS9	(0.9, 0.015, P = 2e-05, N = 7824)	(0.83, -0.039, P = 0.55, N = 859)
rs17461606(T)/8:101876369*	intergenic	(0.16, -0.14, P = 3.6e-06, N = 1910)	(0.021, -0.099, P = 0.56, N = 859)
rs17065805(T)/8:1150705*	CTD-2281E23.2	(0.94, -0.022, P = 8.2e-06, N = 7824)	(0.89, -0.027, P = 0.72, N = 859)
rs16904912(T)/8:134400251*	CTC-369M3.1	(0.2, 0.025, P = 1.5e-05, N = 7824)	(0.12, -0.0034, P = 0.96, N = 859)
rs4976950(A)/8:143297145*	TSNARE1	(0.03, -0.068, P = 3.7e-06, N = 7824)	(0.17, 0.013, P = 0.84, N = 859)
rs13257229(T)/8:21028044*	intergenic	(0.24, 0.021, P = 9.9e-06, N = 7824)	(0.064, -0.07, P = 0.47, N = 859)
rs1545087(A)/8:23622382*	RP11-175E9.1	(0.22, 0.011, P = 1.8e-05, N = 7824)	(0.33, -0.01, P = 0.84, N = 859)
rs16895268(T)/8:98169720*	intergenic	(0.18, -0.011, P = 2.8e-05, N = 7824)	(0.51, 0.0094, P = 0.84, N = 859)
rs10989419(T)/9:103934113*	LPPR1	(0.19, 0.013, P = 3.8e-06, N = 7824)	(0.1, -0.051, P = 0.54, N = 859)
rs7044502(A)/9:12481665	intergenic	(0.23, -0.19, P = 8e-06, N = 1910)	(0.27, 0.012, P = 0.82, N = 859)
rs11999015(C)/9:26942716	PLAA	(0.076, 0.24, P = 4.6e-07, N = 1910)	(0.17, 0.074, P = 0.26, N = 859)
rs1585956(T)/9:31371352*	RP11-271O3.1	(0.49, 0.17, P = 7.2e-06, N = 1910)	(0.66, 0.017, P = 0.73, N = 859)
rs2039787(T)/9:71875458*	intergenic	(0.18, 0.011, P = 4.5e-05, N = 7824)	(0.032, -0.029, P = 0.83, N = 859)
rs4087415(C)/9:73785818*	TRPM3	(0.98, 0.29, P = 8.7e-06, N = 1910)	(0.91, 0.072, P = 0.4, N = 859)

Results from Univariable Mendelian Randomization of L-Acetylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	96	-0.0073 (-0.074- 0.06) P=0.83	20	84	8.4 (0- 75.6)	NA	NA	-0.0095 P=0.21
MR-Egger	96	0.019 (-0.059- 0.096) P=0.64	20	84	8.4 (0- 75.6)	95	0.44	-0.0095 P=0.21
Weighted median	96	0.026 (-0.093- 0.15) P=0.67	20	84	8.4 (0- 75.6)	NA	NA	-0.0095 P=0.21

Results from Univariable MRPRESSO of L-Acetylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.03	-0.21	0.83
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Acetylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	26	-0.023 (-0.1- 0.056) P=0.57	66	75	26 (0- 54)	NA	NA	0.032 P=0.065
MR-Egger	26	-0.1 (-0.22- 0.0076) P=0.08	66	75	26 (0- 54)	24	0.49	0.032 P=0.065
Weighted median	26	0.012 (-0.11- 0.14) P=0.85	66	75	26 (0- 54)	NA	NA	0.032 P=0.065

Results from Univariable MRPRESSO of L-Acetylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.02	0.04	-0.56	0.58
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Butyrylcarnitine

Instruments Associations with Butyrylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Butyrylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs71628219(T)/1:176928724	ASTN1	(0.042, 1.1, P = 6.3e-06, N = 1909)	(0.013, 0.35, P = 0.086, N = 859)
rs1762470(T)/1:208423850*	RP11-2P2.1	(0.55, 0.018, P = 4.7e-07, N = 7824)	(0.81, 0.022, P = 0.72, N = 859)
rs7552486(C)/1:232645738	SIPA1L2	(0.94, 1, P = 5e-06, N = 1909)	(0.98, -0.043, P = 0.82, N = 859)
rs3120706(T)/1:246714022*	TFB2M	(0.99, 1.3, P = 1.9e-07, N = 1909)	(0.96, -0.008, P = 0.95, N = 859)
rs2201453(A)/1:80040353*	intergenic	(0.44, 0.015, P = 3.7e-05, N = 7824)	(0.67, 0.058, P = 0.26, N = 859)
rs2804412(A)/10:101522647*	intergenic	(0.12, 0.62, P = 6.9e-07, N = 1909)	(0.025, -0.081, P = 0.61, N = 859)
rs2242206(T)/10:61414011*	SLC16A9	(0.26, 0.018, P = 3.5e-05, N = 7824)	(0.09, 0.076, P = 0.36, N = 859)
rs1171615(T)/10:61469090*	SLC16A9	(0.78, 0.035, P = 6.8e-14, N = 7824)	(0.76, 0.02, P = 0.73, N = 859)
rs10997368(A)/10:68485405*	CTNNA3	(0.42, -0.015, P = 2.9e-05, N = 7824)	(0.32, 0.028, P = 0.58, N = 859)
rs2595414(A)/11:6918410	OR2D2	(0.83, -0.37, P = 4.6e-06, N = 1909)	(0.55, -0.011, P = 0.82, N = 859)
rs2996029(C)/12:120165182*	CIT	(0.48, -0.017, P = 4.2e-05, N = 7824)	(0.52, -0.1, P = 0.039, N = 859)
rs11611311(A)/12:120677587*	PXN	(0.86, 0.046, P = 1.6e-15, N = 7824)	(0.86, 0.035, P = 0.61, N = 859)
rs2076022(T)/12:120875790*	COX6A1	(0.39, -0.05, P = 4.2e-33, N = 7824)	(0.46, -0.022, P = 0.64, N = 859)
rs1168067(T)/12:121082469*	CABP1	(0.44, -0.081, P = 9.5e-87, N = 7824)	(0.21, -0.013, P = 0.83, N = 859)
rs503667(A)/12:121088750*	CABP1	(0.3, 0.054, P = 4.7e-36, N = 7824)	(0.29, 0.0067, P = 0.9, N = 859)
rs10849776(A)/12:121110235*	intergenic	(0.37, -0.34, P = 1.3e-41, N = 1909)	(0.68, 0.062, P = 0.23, N = 859)
rs10431384(A)/12:121127347*	MLEC	(0.68, -0.17, P = 1e-200, N = 7824)	(0.65, -0.0093, P = 0.85, N = 859)
rs525425(A)/12:121195625*	SPPL3	(0.52, -0.11, P = 1e-200, N = 7824)	(0.9, -0.0025, P = 0.97, N = 859)
rs73214896(T)/12:121296608*	SPPL3	(0.054, 0.21, P = 8.1e-07, N = 1909)	(0.022, 0.37, P = 0.022, N = 859)
rs10849820(A)/12:121375558*	intergenic	(0.91, 0.068, P = 5.1e-24, N = 7824)	(0.95, -0.025, P = 0.82, N = 859)
rs12368199(A)/12:121472167*	OASL	(0.15, 0.12, P = 1.7e-121, N = 7824)	(0.11, 0.0095, P = 0.91, N = 859)
rs4556628(T)/12:121477912*	OASL	(0.3, 0.068, P = 7e-58, N = 7824)	(0.35, 0.016, P = 0.76, N = 859)
rs10849843(A)/12:121544500*	RP11-216P16.6	(0.043, -0.047, P = 6.6e-07, N = 7824)	(0.055, -0.072, P = 0.5, N = 859)
rs7134248(T)/12:121897052*	KDM2B	(0.5, 0.031, P = 2.6e-05, N = 7824)	(0.38, 0.017, P = 0.74, N = 859)
rs2656823(G)/12:127815260*	RP11-955H22.3	(0.25, 1.2, P = 3.8e-06, N = 1909)	(0.58, -0.026, P = 0.6, N = 859)
rs34875552(G)/12:127931158	intergenic	(0.21, -0.51, P = 9.4e-07, N = 1909)	(0.074, 0.032, P = 0.72, N = 859)
rs17582686(C)/12:41961745	PDZRN4	(0.12, 0.16, P = 2.8e-06, N = 1909)	(0.022, -0.14, P = 0.37, N = 859)
rs1353147(A)/12:44815705*	intergenic	(0.91, 0.031, P = 4.2e-06, N = 7824)	(0.54, -0.053, P = 0.28, N = 859)
rs76038866(G)/12:70398710	RP11-611E13.2	(0.15, -0.15, P = 3.2e-06, N = 1909)	(0.019, 0.0063, P = 0.97, N = 859)
rs11843062(T)/13:105985355	intergenic	(0.85, 0.021, P = 4.1e-05, N = 7824)	(0.93, -0.18, P = 0.047, N = 859)
rs2323477(A)/13:37968251*	intergenic	(0.56, 0.92, P = 8.4e-06, N = 1909)	(0.47, -0.097, P = 0.041, N = 859)
rs2762180(C)/13:43749805	intergenic	(0.019, -0.42, P = 4e-06, N = 1909)	(0.077, -0.014, P = 0.88, N = 859)
rs12866255(A)/13:46303377	intergenic	(0.13, -0.32, P = 4.4e-06, N = 1909)	(0.063, -0.092, P = 0.34, N = 859)
rs4982433(T)/14:21703122	HNRNPC	(0.046, -0.43, P = 1e-05, N = 1909)	(0.016, -0.25, P = 0.2, N = 859)
rs181315(A)/14:48336387	intergenic	(0.93, 0.28, P = 6.4e-06, N = 1909)	(0.99, -0.27, P = 0.24, N = 859)
rs11620955(A)/14:65491255*	FNTB	(0.48, -0.016, P = 9.9e-06, N = 7824)	(0.29, -0.016, P = 0.76, N = 859)
rs77157541(C)/14:84364103	intergenic	(0.085, -0.45, P = 1.7e-06, N = 1909)	(0.011, 0.11, P = 0.63, N = 859)
rs58341578(A)/15:102065017	PCSK6	(0.035, 0.62, P = 2.6e-06, N = 1909)	(0.052, 0.12, P = 0.28, N = 859)
rs2066705(T)/15:25937004	ATP10A	(0.67, -0.38, P = 5.1e-06, N = 1909)	(0.2, -0.0033, P = 0.96, N = 859)
rs1827480(T)/15:32018249	OTUD7A	(0.69, 0.28, P = 1.1e-06, N = 1909)	(0.61, 0.1, P = 0.044, N = 859)
rs8036376(A)/15:39868627	THBS1	(0.87, -0.022, P = 2.6e-05, N = 7824)	(0.94, 0.16, P = 0.1, N = 859)
rs2956875(A)/15:76599041*	ETFA	(0.89, -0.034, P = 1.1e-08, N = 7824)	(0.78, -0.024, P = 0.68, N = 859)
rs12903671(G)/15:86784034	AGBL1	(0.61, 0.22, P = 5.8e-06, N = 1909)	(0.74, -0.062, P = 0.25, N = 859)
rs294546(A)/15:94847577	MCTP2	(0.55, -0.33, P = 4.6e-06, N = 1909)	(0.77, 0.13, P = 0.031, N = 859)
rs7191762(A)/16:23752777*	intergenic	(0.2, 1.3, P = 6e-06, N = 1909)	(0.17, 0.077, P = 0.23, N = 859)
rs2297514(C)/17:26093315	NOS2	(0.41, 0.77, P = 7.8e-06, N = 1909)	(0.55, -0.026, P = 0.6, N = 859)
rs2106336(T)/17:49800464*	CA10	(0.25, 0.69, P = 8.2e-06, N = 1909)	(0.096, 0.02, P = 0.8, N = 859)
rs12970487(G)/18:25809979	intergenic	(0.051, -0.41, P = 4.9e-07, N = 1909)	(0.083, -0.036, P = 0.68, N = 859)
rs11660811(A)/18:59870563	KIAA1468	(0.12, -0.32, P = 1.5e-06, N = 1909)	(0.026, -0.14, P = 0.35, N = 859)
rs12979749(G)/19:17463781*	PLVAP	(0.055, -0.35, P = 5.6e-06, N = 1909)	(0.13, 0.092, P = 0.2, N = 859)
rs3974831(G)/19:54306299*	NLRP12	(0.23, -0.4, P = 2.9e-06, N = 1909)	(0.12, -0.094, P = 0.2, N = 859)
rs10166038(A)/2:127442846	GYPC	(0.68, 0.018, P = 2.1e-05, N = 7824)	(0.82, -0.0078, P = 0.9, N = 859)
rs4575678(C)/2:160184773	BAZ2B	(0.73, -0.31, P = 3.2e-06, N = 1909)	(0.43, 0.044, P = 0.35, N = 859)
rs355896(A)/2:165635908*	COBLL1	(0.43, -0.014, P = 4.5e-05, N = 7824)	(0.8, -0.0099, P = 0.87, N = 859)
rs35467545(A)/2:228119461	COL4A3	(0.093, -0.42, P = 7.7e-06, N = 1909)	(0.038, 0.038, P = 0.77, N = 859)
rs4663190(T)/2:236174661	intergenic	(0.26, 0.29, P = 7.3e-06, N = 1909)	(0.7, -0.028, P = 0.61, N = 859)
rs150411636(T)/2:26280681	RAB10	(0.012, 0.67, P = 3.5e-06, N = 1909)	(0.038, -0.022, P = 0.86, N = 859)
rs2122033(C)/2:6366461*	intergenic	(0.72, -0.19, P = 8.7e-06, N = 1909)	(0.92, -0.094, P = 0.29, N = 859)
rs17697184(T)/2:70844368*	ADD2	(0.017, 0.12, P = 4.2e-05, N = 7824)	(0.03, -0.093, P = 0.5, N = 859)
rs17680254(C)/2:7405775*	RP11-557L19.1	(0.17, -0.34, P = 7.8e-06, N = 1909)	(0.033, 0.27, P = 0.043, N = 859)
rs6043520(C)/20:15738249	MACROD2	(0.38, 1, P = 7e-06, N = 1909)	(0.66, 0.036, P = 0.49, N = 859)
rs79183297(C)/20:25726841	intergenic	(0.05, 0.62, P = 9.9e-06, N = 1909)	(0.044, 0.09, P = 0.44, N = 859)
rs564621(A)/21:31541034	CLDN17	(0.9, -0.34, P = 9.7e-07, N = 1909)	(0.85, -0.063, P = 0.35, N = 859)
rs9613176(T)/22:26804801	intergenic	(0.26, 1.3, P = 6.2e-06, N = 1909)	(0.06, 0.03, P = 0.77, N = 859)
rs73479548(C)/22:48657745	intergenic	(0.025, 0.27, P = 8.5e-07, N = 1909)	(0.063, -0.094, P = 0.34, N = 859)
rs136770(G)/22:49800204*	intergenic	(0.53, -0.39, P = 1.4e-06, N = 1909)	(0.46, -0.021, P = 0.66, N = 859)
rs6808851(T)/3:20505047	intergenic	(0.88, 0.025, P = 2.3e-05, N = 7824)	(0.74, 0.029, P = 0.6, N = 859)
rs11915197(T)/3:20781663	intergenic	(0.59, -0.42, P = 6.6e-06, N = 1909)	(0.52, -0.0098, P = 0.84, N = 859)
rs1515458(G)/3:21913964	ZNF385D	(0.28, 0.44, P = 5.4e-06, N = 1909)	(0.21, -0.028, P = 0.63, N = 859)
rs11923037(C)/3:22487778	intergenic	(0.056, 0.73, P = 2.8e-06, N = 1909)	(0.025, 0.062, P = 0.69, N = 859)
rs10510534(A)/3:23048172*	intergenic	(0.062, 0.95, P = 8.8e-06, N = 1909)	(0.032, 0.034, P = 0.8, N = 859)
rs6445312(T)/3:63055960	LINC00698	(0.84, -0.5, P = 9.6e-06, N = 1909)	(0.76, -0.0016, P = 0.98, N = 859)
rs12646870(C)/4:146764120	ZNF827	(0.52, 0.65, P = 9.2e-06, N = 1909)	(0.59, -0.0069, P = 0.89, N = 859)
rs3103197(T)/4:42344469	RP11-63A11.1	(0.57, -0.017, P = 3.8e-05, N = 7824)	(0.77, -0.0059, P = 0.92, N = 859)
rs72862822(C)/4:73516604*	intergenic	(0.069, 0.62, P = 3.5e-07, N = 1909)	(0.22, -0.01, P = 0.86, N = 859)
rs71607390(G)/4:77775612	AC104687.1	(0.034, -0.37, P = 8.1e-06, N = 1909)	(0.015, -0.21, P = 0.3, N = 859)
rs76135410(A)/5:111566364	EPB41L4A	(0.097, -0.4, P = 9.5e-06, N = 1909)	(0.077, 0.041, P = 0.66, N = 859)
rs10477531(T)/5:114714807*	intergenic	(0.47, 0.24, P = 5e-06, N = 1909)	(0.34, -0.034, P = 0.51, N = 859)
rs12521097(A)/5:131575338*	P4HA2	(0.47, -0.018, P = 3.6e-07, N = 7824)	(0.43, 0.094, P = 0.054, N = 859)
rs7719428(C)/5:132180919*	RNA5SP192	(0.33, -0.018, P = 1.6e-05, N = 7824)	(0.47, -0.12, P = 0.017, N = 859)
rs1392378(T)/5:165821645*	intergenic	(0.77, 0.54, P = 8.2e-06, N = 1909)	(0.38, 0.017, P = 0.73, N = 859)
rs9313646(G)/5:173155866	AC008674.1	(0.32, -0.4, P = 4e-06, N = 1909)	(0.29, 0.034, P = 0.53, N = 859)
rs4458729(T)/6:104189269*	intergenic	(0.54, 0.78, P = 4.8e-06, N = 1909)	(0.35, 0.032, P = 0.53, N = 859)
rs58492300(G)/6:110684097	METTL24	(0.33, -0.41, P = 3.6e-07, N = 1909)	(0.34, -0.028, P = 0.58, N = 859)
rs1288153(A)/6:113293306	RNU6-1163P	(0.98, -0.18, P = 7.9e-06, N = 1909)	(0.85, 0.01, P = 0.88, N = 859)
rs10224061(C)/7:19852619*	AC004543.2	(0.15, -0.15, P = 9.5e-06, N = 1909)	(0.39, 0.018, P = 0.72, N = 859)
rs6462769(T)/7:37577324*	intergenic	(0.71, 0.019, P = 5.7e-06, N = 7824)	(0.64, -0.0053, P = 0.92, N = 859)
rs9638994(C)/7:45895291*	intergenic	(0.31, 0.18, P = 1.4e-06, N = 1909)	(0.56, -0.076, P = 0.13, N = 859)
rs2178045(A)/7:70231649	AUTS2	(0.099, -0.05, P = 3.7e-05, N = 7824)	(0.1, -0.17, P = 0.031, N = 859)
rs695195(A)/8:8633528	RP11-211C9.1	(0.16, -0.21, P = 4.4e-06, N = 1909)	(0.44, -0.032, P = 0.52, N = 859)
rs13289885(G)/9:108138947	SLC44A1	(0.029, 0.93, P = 9.5e-06, N = 1909)	(0.32, 0.055, P = 0.29, N = 859)
rs62566532(G)/9:6743110	KDM4C	(0.17, -0.19, P = 7.1e-07, N = 1909)	(0.1, 0.022, P = 0.78, N = 859)

Results from Univariable Mendelian Randomization of Butyrylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	92	0.003 (-0.025- 0.031) P=0.84	187	561	0.0128 (0- 48.5)	NA	NA	0.0042 P=0.65
MR-Egger	92	-0.0036 (-0.045- 0.037) P=0.86	187	561	0.0128 (0- 48.5)	85	0.63	0.0042 P=0.65
Weighted median	92	0.023 (-0.019- 0.066) P=0.28	187	561	0.0128 (0- 48.5)	NA	NA	0.0042 P=0.65

Results from Univariable MRPRESSO of Butyrylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.01	0.21	0.84
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Butyrylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	47	0.018 (-0.021- 0.057) P=0.37	190	298	0.00282 (0- 54.4)	NA	NA	-0.016 P=0.4
MR-Egger	47	0.045 (-0.03- 0.12) P=0.25	190	298	0.00282 (0- 54.4)	39	0.72	-0.016 P=0.4
Weighted median	47	0.025 (-0.038- 0.089) P=0.43	190	298	0.00282 (0- 54.4)	NA	NA	-0.016 P=0.4

Results from Univariable MRPRESSO of Butyrylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.02	0.02	0.89	0.38
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Tiglylcarnitine

Instruments Associations with Tiglylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Tiglylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs115886573(A)/1:182541031	RNASEL	(0.26, -0.15, P = 4.7e-06, N = 1956)	(0.17, 0.036, P = 0.57, N = 859)
rs149513885(A)/10:36506292	intergenic	(0.13, 0.17, P = 3.3e-06, N = 1956)	(0.015, -0.18, P = 0.38, N = 859)
rs10904923(G)/10:6807941*	intergenic	(0.092, -0.23, P = 1.9e-06, N = 1956)	(0.031, -0.075, P = 0.59, N = 859)
rs10998884(G)/10:71389673	C10orf35	(0.17, 0.27, P = 9.8e-06, N = 1956)	(0.066, 0.15, P = 0.1, N = 859)
rs12814936(A)/12:30164763	intergenic	(0.17, 0.17, P = 1.3e-06, N = 1956)	(0.031, 0.13, P = 0.35, N = 859)
rs11856930(G)/15:34028778*	RYR3	(0.46, -0.14, P = 9.2e-06, N = 1956)	(0.38, 0.085, P = 0.089, N = 859)
rs8041137(G)/15:89570030	intergenic	(0.63, 0.19, P = 1.9e-06, N = 1956)	(0.93, 0.039, P = 0.67, N = 859)
rs924135(T)/16:16123459*	ABCC1	(0.6, -0.15, P = 1.1e-06, N = 1956)	(0.47, 0.06, P = 0.21, N = 859)
rs62097702(A)/18:77148177	intergenic	(0.27, -0.2, P = 1.3e-06, N = 1956)	(0.099, -0.099, P = 0.22, N = 859)
rs139567843(A)/19:45019167	CEACAM20	(0.013, -0.77, P = 9.1e-06, N = 1956)	(0.012, 0.31, P = 0.17, N = 859)
rs56285383(T)/2:173602	intergenic	(0.3, 0.11, P = 9.2e-06, N = 1956)	(0.058, -0.11, P = 0.28, N = 859)
rs6717796(C)/2:18337669*	KCNS3	(0.35, 0.18, P = 1.3e-06, N = 1956)	(0.73, -0.091, P = 0.09, N = 859)
rs3092505(G)/20:44812412	CDH22	(0.27, 0.13, P = 1e-05, N = 1956)	(0.23, -0.012, P = 0.84, N = 859)
rs73049045(G)/3:30034421	RBMS3	(0.086, 0.38, P = 4.6e-07, N = 1956)	(0.016, -0.13, P = 0.52, N = 859)
rs62252141(C)/3:32514805	CMTM7	(0.093, 0.29, P = 2.7e-06, N = 1956)	(0.015, 0.35, P = 0.068, N = 859)
rs1372425(C)/3:77317940	ROBO2	(0.11, -0.28, P = 3.5e-06, N = 1956)	(0.14, 0.12, P = 0.093, N = 859)
rs372660405(AAAAC)/4:101436992	EMCN	(0.083, 0.29, P = 2.6e-06, N = 1956)	(0.024, 0.19, P = 0.24, N = 859)
rs28703837(C)/4:32085737	RP11-734I18.1	(0.11, -0.28, P = 4.1e-07, N = 1956)	(0.22, 0.018, P = 0.75, N = 859)
rs112580372(A)/4:89315397*	HERC6	(0.21, 0.21, P = 3.5e-06, N = 1956)	(0.12, -0.07, P = 0.35, N = 859)
rs10043226(C)/5:107243859	FBXL17	(0.076, -0.33, P = 5.1e-06, N = 1956)	(0.15, 0.035, P = 0.61, N = 859)
rs2338821(G)/5:141509433*	NDFIP1	(0.52, -0.13, P = 3.6e-06, N = 1956)	(0.78, -0.027, P = 0.65, N = 859)
rs115960372(T)/5:1518494	LPCAT1	(0.097, 0.29, P = 5.3e-06, N = 1956)	(0.017, -0.34, P = 0.066, N = 859)
rs1874167(T)/5:62424015	intergenic	(0.63, 0.21, P = 6.9e-06, N = 1956)	(0.35, 0.029, P = 0.56, N = 859)
rs9370853(A)/6:15991331*	RP11-401E14.2	(0.12, 0.23, P = 3.9e-06, N = 1956)	(0.085, -0.074, P = 0.39, N = 859)
rs4367541(C)/8:13041969	DLC1	(0.56, 0.12, P = 4.8e-06, N = 1956)	(0.51, -0.024, P = 0.61, N = 859)
rs1689897(A)/8:16847582	FGF20	(0.23, 0.18, P = 4.7e-06, N = 1956)	(0.3, 0.035, P = 0.5, N = 859)
rs4875308(A)/8:4060604*	CSMD1	(0.49, 0.17, P = 2.7e-06, N = 1956)	(0.18, -0.063, P = 0.31, N = 859)
rs3824419(C)/9:1056728*	DMRT2	(0.34, 0.16, P = 9.4e-07, N = 1956)	(0.16, -0.028, P = 0.66, N = 859)
rs7021791(A)/9:10928554*	intergenic	(0.6, -0.12, P = 1e-06, N = 1956)	(0.79, -0.022, P = 0.7, N = 859)

Results from Univariable Mendelian Randomization of Tiglylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	29	-0.11 (-0.25- 0.022) P=0.1	25	36	0.00319 (0- 58.6)	NA	NA	-0.0091 P=0.82
MR-Egger	29	-0.07 (-0.47- 0.33) P=0.73	25	36	0.00319 (0- 58.6)	30	0.31	-0.0091 P=0.82
Weighted median	29	-0.11 (-0.31- 0.088) P=0.28	25	36	0.00319 (0- 58.6)	NA	NA	-0.0091 P=0.82

Results from Univariable MRPRESSO of Tiglylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.11	0.07	-1.64	0.11
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Tiglylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	19	-0.033 (-0.21- 0.14) P=0.71	26	25	0.000966 (0- 76.4)	NA	NA	0.028 P=0.61
MR-Egger	19	-0.15 (-0.63- 0.33) P=0.55	26	25	0.000966 (0- 76.4)	22	0.2	0.028 P=0.61
Weighted median	19	-0.083 (-0.32- 0.15) P=0.49	26	25	0.000966 (0- 76.4)	NA	NA	0.028 P=0.61

Results from Univariable MRPRESSO of Tiglylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.09	-0.37	0.72
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Glutarylcarnitine

Instruments Associations with Glutarylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Glutarylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs7533102(T)/1:107828950	NTNG1	(0.38, 0.011, P = 1.6e-05, N = 7824)	(0.19, 0.077, P = 0.2, N = 859)
rs2798691(T)/1:113579103*	RP11-31F15.2	(0.32, 0.022, P = 2.4e-05, N = 7824)	(0.29, 0.0043, P = 0.93, N = 859)
rs7531982(A)/1:154596122*	ADAR	(0.51, 0.011, P = 9.1e-06, N = 7824)	(0.86, 0.11, P = 0.096, N = 859)
rs10918734(A)/1:167625495*	RCSD1	(0.95, 0.024, P = 6e-06, N = 7824)	(0.8, 0.0092, P = 0.88, N = 859)
rs17015767(C)/1:206951398	intergenic	(0.24, -0.011, P = 3.9e-05, N = 7824)	(0.13, -0.016, P = 0.83, N = 859)
rs13375749(T)/1:53695882*	MAGOH	(0.78, 0.03, P = 2.8e-28, N = 7824)	(0.79, 0.048, P = 0.42, N = 859)
rs12035926(A)/1:53752134	LRP8	(0.61, -0.011, P = 1.7e-05, N = 7824)	(0.91, -0.0038, P = 0.96, N = 859)
rs1193243(T)/1:7524776	CAMTA1	(0.4, 0.011, P = 4.3e-05, N = 7824)	(0.58, -0.011, P = 0.82, N = 859)
rs12745456(T)/1:76108055*	RP4-595K12.2	(0.73, 0.012, P = 7.3e-06, N = 7824)	(0.94, 0.018, P = 0.87, N = 859)
rs11189859(A)/10:100657705*	HPSE2	(0.89, 0.033, P = 1.5e-05, N = 7824)	(0.95, -0.017, P = 0.88, N = 859)
rs7923727(A)/10:11165615	CELF2	(0.53, -0.012, P = 2.1e-06, N = 7824)	(0.63, -0.071, P = 0.15, N = 859)
rs11017260(T)/10:129113943*	DOCK1	(0.94, -0.022, P = 1.8e-05, N = 7824)	(0.98, -0.13, P = 0.5, N = 859)
rs573812(T)/10:25631649	GPR158	(0.81, 0.012, P = 6.1e-06, N = 7824)	(0.52, 0.032, P = 0.51, N = 859)
rs7071006(A)/10:98382165*	PIK3AP1	(0.81, 0.014, P = 3.7e-05, N = 7824)	(0.47, 0.016, P = 0.75, N = 859)
rs10895511(T)/11:103552188*	RP11-563P16.1	(0.95, -0.053, P = 2.9e-06, N = 7824)	(0.53, -0.019, P = 0.7, N = 859)
rs7118414(C)/11:117811548	intergenic	(0.39, -0.011, P = 3.1e-05, N = 7824)	(0.33, -0.048, P = 0.36, N = 859)
rs4964150(T)/12:106017797*	intergenic	(0.22, -0.011, P = 3e-05, N = 7824)	(0.21, -0.038, P = 0.52, N = 859)
rs7970615(T)/12:130637090	FZD10-AS1	(0.23, 0.026, P = 1.9e-05, N = 7824)	(0.25, -0.073, P = 0.19, N = 859)
rs716955(A)/12:75593472*	KCNC2	(0.81, 0.013, P = 3.3e-05, N = 7824)	(0.91, 0.096, P = 0.25, N = 859)
rs3809197(T)/12:96883418*	C12orf55	(0.013, 0.11, P = 3.2e-07, N = 7824)	(0.13, -0.076, P = 0.29, N = 859)
rs9573172(A)/13:73953498	intergenic	(0.95, -0.023, P = 9.5e-06, N = 7824)	(0.99, 0.054, P = 0.79, N = 859)
rs11625658(A)/14:100723577*	YY1	(0.25, -0.013, P = 9e-07, N = 7824)	(0.23, 0.0019, P = 0.97, N = 859)
rs1059264(T)/14:100769163	SLC25A29	(0.33, -0.015, P = 5.6e-08, N = 7824)	(0.17, 0.042, P = 0.51, N = 859)
rs12050391(A)/14:32771346	intergenic	(0.22, -0.011, P = 1.9e-05, N = 7824)	(0.16, 0.013, P = 0.84, N = 859)
rs2291449(A)/15:76579234*	ETFA	(0.91, -0.028, P = 1.4e-10, N = 7824)	(0.99, 0.1, P = 0.62, N = 859)
rs4636879(T)/15:76630303*	ISL2	(0.19, 0.013, P = 5e-06, N = 7824)	(0.73, 0.036, P = 0.51, N = 859)
rs246234(C)/16:16128742*	ABCC1	(0.3, -0.02, P = 2.6e-14, N = 7824)	(0.5, -0.052, P = 0.28, N = 859)
rs8054670(T)/16:16132134*	ABCC1	(0.78, 0.015, P = 8e-09, N = 7824)	(0.63, 0.047, P = 0.33, N = 859)
rs8056893(A)/16:68304392*	SLC7A6	(0.73, -0.03, P = 2.2e-30, N = 7824)	(0.95, 0.11, P = 0.33, N = 859)
rs11644360(T)/16:68327089*	SLC7A6	(0.54, -0.018, P = 1.1e-12, N = 7824)	(0.11, 0.012, P = 0.88, N = 859)
rs933457(A)/17:36897107	PCGF2	(0.95, -0.025, P = 4.1e-05, N = 7824)	(0.71, 0.03, P = 0.57, N = 859)
rs766990(A)/18:6917171*	ARHGAP28	(0.2, 0.014, P = 2.8e-05, N = 7824)	(0.23, 0.033, P = 0.57, N = 859)
rs10411504(A)/19:12753644*	MAN2B1	(0.93, -0.023, P = 2.8e-05, N = 7824)	(0.93, 0.081, P = 0.4, N = 859)
rs4804736(A)/19:12936881	RTBDN	(0.16, -0.018, P = 6.8e-06, N = 7824)	(0.029, -0.12, P = 0.4, N = 859)
rs8012(A)/19:13010520	GCDH	(0.44, 0.037, P = 6.4e-45, N = 7824)	(0.19, 0.15, P = 0.014, N = 859)
rs11085835(T)/19:13332010	CACNA1A	(0.2, 0.015, P = 1e-08, N = 7824)	(0.13, 0.074, P = 0.29, N = 859)
rs7252894(T)/19:43719940	CEACAMP10	(0.032, -0.085, P = 2e-05, N = 7824)	(0.8, -0.0037, P = 0.95, N = 859)
rs7255066(T)/19:45146103	PVR	(0.74, -0.011, P = 4.3e-05, N = 7824)	(0.19, 0.031, P = 0.61, N = 859)
rs3770471(T)/2:15770775	DDX1	(0.15, -0.015, P = 1.5e-05, N = 7824)	(0.42, 0.034, P = 0.49, N = 859)
rs715(T)/2:211543055*	CPS1	(0.72, 0.021, P = 3.5e-16, N = 7824)	(0.81, -0.061, P = 0.33, N = 859)
rs4673545(A)/2:211565535*	intergenic	(0.73, 0.014, P = 4.5e-08, N = 7824)	(0.79, 0.0017, P = 0.98, N = 859)
rs11687290(A)/2:211647954*	intergenic	(0.73, -0.012, P = 7e-06, N = 7824)	(0.83, 0.02, P = 0.75, N = 859)
rs6745507(C)/2:213577416	AC079610.1	(0.62, -0.012, P = 3.7e-06, N = 7824)	(0.45, -0.044, P = 0.36, N = 859)
rs12621141(A)/2:99927112	C2orf15	(0.42, -0.013, P = 9.2e-07, N = 7824)	(0.24, 0.0089, P = 0.88, N = 859)
rs12625248(T)/20:55393483*	intergenic	(0.83, -0.03, P = 7.2e-06, N = 7824)	(0.89, -0.18, P = 0.021, N = 859)
rs8134964(A)/21:23291223*	intergenic	(0.32, 0.013, P = 4.3e-05, N = 7824)	(0.28, 0.028, P = 0.61, N = 859)
rs2838535(T)/21:45681579*	DNMT3L	(0.081, 0.037, P = 4.3e-05, N = 7824)	(0.16, -0.044, P = 0.5, N = 859)
rs7364173(T)/22:50681029*	TUBGCP6	(0.59, 0.011, P = 4.7e-05, N = 7824)	(0.6, -0.057, P = 0.26, N = 859)
rs12635778(A)/3:103451972	intergenic	(0.97, 0.033, P = 3.1e-05, N = 7824)	(0.9, 0.077, P = 0.34, N = 859)
rs9844004(C)/3:170958358	TNIK	(0.24, -0.016, P = 4.3e-05, N = 7824)	(0.41, -0.03, P = 0.54, N = 859)
rs1524307(T)/3:22673600	intergenic	(0.48, 0.025, P = 2e-06, N = 7824)	(0.54, 0.056, P = 0.25, N = 859)
rs7633111(T)/3:30840808	GADL1	(0.58, -0.013, P = 1.9e-06, N = 7824)	(0.2, -0.025, P = 0.68, N = 859)
rs9311834(A)/3:62030849*	PTPRG	(0.89, -0.015, P = 3.8e-05, N = 7824)	(0.76, -0.013, P = 0.82, N = 859)
rs6853898(A)/4:142171146	RP11-586L23.1	(0.96, -0.025, P = 4.3e-05, N = 7824)	(0.79, 0.034, P = 0.56, N = 859)
rs2070630(C)/4:159644494*	PPID	(0.29, -0.014, P = 1.4e-07, N = 7824)	(0.29, -0.047, P = 0.38, N = 859)
rs17223240(A)/4:159924295*	C4orf45	(0.091, -0.019, P = 2e-05, N = 7824)	(0.012, 0.1, P = 0.66, N = 859)
rs13112606(A)/4:17468047*	QDPR	(0.78, -0.011, P = 3.5e-05, N = 7824)	(0.82, 0.0036, P = 0.96, N = 859)
rs3911612(A)/4:180493646*	intergenic	(0.78, 0.011, P = 2.9e-05, N = 7824)	(0.35, -0.054, P = 0.28, N = 859)
rs17608635(A)/4:45079676*	intergenic	(0.23, -0.013, P = 5e-07, N = 7824)	(0.18, 0.017, P = 0.78, N = 859)
rs16837061(A)/4:5383127	STK32B	(0.8, 0.012, P = 9.8e-06, N = 7824)	(0.45, -0.09, P = 0.07, N = 859)
rs10003471(T)/4:92200866*	CCSER1	(0.11, 0.02, P = 5.7e-07, N = 7824)	(0.029, -0.091, P = 0.52, N = 859)
rs1981524(T)/5:131756506*	C5orf56	(0.2, 0.016, P = 3.1e-09, N = 7824)	(0.2, -0.13, P = 0.033, N = 859)
rs12521174(A)/5:156141605*	SGCD	(0.95, 0.027, P = 7.3e-06, N = 7824)	(0.89, 0.011, P = 0.88, N = 859)
rs1486945(T)/5:1943884*	RP11-259O2.1	(0.74, -0.012, P = 8.6e-06, N = 7824)	(0.68, -0.02, P = 0.7, N = 859)
rs2441949(A)/5:2627075*	intergenic	(0.091, 0.021, P = 1.1e-05, N = 7824)	(0.022, 0.032, P = 0.85, N = 859)
rs2561114(A)/5:38349215	EGFLAM	(0.69, -0.011, P = 3.1e-05, N = 7824)	(0.22, -0.051, P = 0.38, N = 859)
rs1697824(C)/5:73710929*	CTC-419K13.1	(0.41, -0.022, P = 1.4e-05, N = 7824)	(0.63, 0.0084, P = 0.87, N = 859)
rs1479045(T)/6:124963281*	NKAIN2	(0.21, 0.011, P = 4.6e-05, N = 7824)	(0.36, -0.055, P = 0.26, N = 859)
rs683369(C)/6:160551204*	SLC22A1	(0.77, -0.014, P = 1.1e-07, N = 7824)	(0.97, -0.17, P = 0.21, N = 859)
rs3798167(T)/6:160567928*	SLC22A1	(0.2, -0.013, P = 7.3e-07, N = 7824)	(0.16, -0.04, P = 0.55, N = 859)
rs3125055(A)/6:160736787*	intergenic	(0.12, 0.017, P = 2.1e-05, N = 7824)	(0.22, 0.045, P = 0.42, N = 859)
rs6941991(T)/6:18396689*	RNF144B	(0.42, 0.021, P = 4.1e-05, N = 7824)	(0.36, -0.038, P = 0.46, N = 859)
rs12202023(T)/6:19351564*	RPL5P20	(0.79, -0.014, P = 3.9e-07, N = 7824)	(0.92, 0.16, P = 0.077, N = 859)
rs807532(T)/6:24549668*	KIAA0319	(0.069, 0.02, P = 7.5e-06, N = 7824)	(0.15, 0.025, P = 0.71, N = 859)
rs12192135(A)/6:82001561*	intergenic	(0.26, -0.012, P = 4.7e-06, N = 7824)	(0.053, 0.088, P = 0.41, N = 859)
rs9353315(A)/6:86149938*	intergenic	(0.88, -0.015, P = 2.2e-05, N = 7824)	(0.73, -0.053, P = 0.34, N = 859)
rs10241456(A)/7:129712524	KLHDC10	(0.54, 0.012, P = 7.6e-06, N = 7824)	(0.82, 0.13, P = 0.037, N = 859)
rs2161873(T)/7:131974388*	PLXNA4	(0.71, 0.011, P = 3e-05, N = 7824)	(0.65, -0.088, P = 0.087, N = 859)
rs6967077(A)/7:51628033	intergenic	(0.21, 0.011, P = 4e-05, N = 7824)	(0.32, -0.11, P = 0.034, N = 859)
rs11780215(A)/8:118057538*	SLC30A8	(0.85, 0.016, P = 3.7e-06, N = 7824)	(0.97, 0.12, P = 0.44, N = 859)
rs4307325(A)/8:124421397	ATAD2	(0.7, 0.011, P = 1.5e-05, N = 7824)	(0.66, -0.11, P = 0.029, N = 859)
rs11784254(A)/8:40357901	intergenic	(0.23, 0.011, P = 2.5e-05, N = 7824)	(0.29, 0.078, P = 0.15, N = 859)
rs12680983(T)/8:42104338	RP11-231D20.2	(0.016, 0.11, P = 2.1e-05, N = 7824)	(0.046, 0.0082, P = 0.94, N = 859)
rs10097669(T)/8:4437465	CSMD1	(0.68, 0.011, P = 4.3e-05, N = 7824)	(0.95, 0.16, P = 0.16, N = 859)
rs10108023(A)/8:49717484	intergenic	(0.26, 0.012, P = 9.8e-06, N = 7824)	(0.77, 0.00052, P = 0.99, N = 859)
rs17641971(T)/8:49884817*	intergenic	(0.66, -0.025, P = 3.4e-22, N = 7824)	(0.77, -0.078, P = 0.17, N = 859)
rs11779189(C)/8:50030592*	intergenic	(0.61, 0.018, P = 6.8e-13, N = 7824)	(0.42, -0.0095, P = 0.84, N = 859)
rs12543837(A)/8:6413948	MCPH1	(0.88, 0.032, P = 1.7e-05, N = 7824)	(0.94, -0.033, P = 0.74, N = 859)
rs2033069(T)/8:81079607	TPD52	(0.32, 0.011, P = 4.7e-05, N = 7824)	(0.66, 0.033, P = 0.51, N = 859)
rs2987735(A)/9:103955515	LPPR1	(0.21, 0.011, P = 2.1e-05, N = 7824)	(0.41, -0.044, P = 0.38, N = 859)
rs1169752(A)/9:29329933*	intergenic	(0.77, -0.011, P = 4.5e-05, N = 7824)	(0.86, -0.06, P = 0.4, N = 859)
rs6559415(A)/9:81443855*	intergenic	(0.26, 0.011, P = 3e-05, N = 7824)	(0.74, -0.011, P = 0.84, N = 859)

Results from Univariable Mendelian Randomization of Glutarylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	92	0.18 (-0.34- 0.7) P=0.5	0.86	1	0 (0- 32.5)	NA	NA	0.0065 P=0.54
MR-Egger	92	-0.038 (-0.91- 0.83) P=0.93	0.86	1	0 (0- 32.5)	86	0.61	0.0065 P=0.54
Weighted median	92	0.044 (-0.85- 0.94) P=0.92	0.86	1	0 (0- 32.5)	NA	NA	0.0065 P=0.54

Results from Univariable MRPRESSO of Glutarylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.18	0.27	0.67	0.5
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Glutarylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	37	0.37 (-0.51- 1.3) P=0.41	0.88	0.42	2.54 (0- 66.8)	NA	NA	0.0047 P=0.77
MR-Egger	37	0.22 (-1.1- 1.6) P=0.75	0.88	0.42	2.54 (0- 66.8)	42	0.18	0.0047 P=0.77
Weighted median	37	0.044 (-1.3- 1.3) P=0.95	0.88	0.42	2.54 (0- 66.8)	NA	NA	0.0047 P=0.77

Results from Univariable MRPRESSO of Glutarylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.37	0.45	0.83	0.41
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Isovalerylcarnitine

Instruments Associations with Isovalerylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Isovalerylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs990034(A)/1:147251898*	RP11-433J22.3	(0.56, -0.012, P = 1.3e-05, N = 7824)	(0.44, 0.084, P = 0.088, N = 859)
rs10919117(A)/1:162267823*	NOS1AP	(0.51, -0.013, P = 4e-05, N = 7824)	(0.37, -0.07, P = 0.16, N = 859)
rs2501856(C)/1:212856985*	BATF3	(0.54, 0.012, P = 5.8e-06, N = 7824)	(0.75, 0.072, P = 0.19, N = 859)
rs10638035(TTG)/1:219889972	SLC30A10	(0.43, -0.13, P = 2.7e-06, N = 1959)	(0.68, -0.016, P = 0.75, N = 859)
rs35800687(G)/1:22731893	intergenic	(0.31, 0.22, P = 5e-06, N = 1959)	(0.17, -0.061, P = 0.35, N = 859)
rs771390(T)/1:34750936*	intergenic	(0.24, -0.016, P = 1.2e-05, N = 7824)	(0.19, -0.015, P = 0.8, N = 859)
rs10889028(A)/1:57625649*	DAB1	(0.42, -0.013, P = 7.1e-07, N = 7824)	(0.3, 0.089, P = 0.091, N = 859)
rs10157665(A)/1:97734344*	DPYD	(0.74, -0.017, P = 4.2e-05, N = 7824)	(0.96, 0.14, P = 0.28, N = 859)
rs4918121(A)/10:106392464	intergenic	(0.31, -0.23, P = 6.1e-06, N = 1959)	(0.13, 0.11, P = 0.13, N = 859)
rs884263(T)/10:36964639	intergenic	(0.53, 0.011, P = 4.4e-05, N = 7824)	(0.5, 0.0013, P = 0.98, N = 859)
rs7903712(C)/10:60516806*	BICC1	(0.21, 0.014, P = 4.9e-05, N = 7824)	(0.36, 0.00082, P = 0.99, N = 859)
rs12778367(A)/10:88116246	GRID1	(0.18, 0.2, P = 6.8e-06, N = 1959)	(0.026, -0.13, P = 0.38, N = 859)
rs2852371(A)/11:106408212*	intergenic	(0.58, 0.013, P = 4e-06, N = 7824)	(0.55, 0.051, P = 0.29, N = 859)
rs12294679(C)/11:11078054	intergenic	(0.23, -0.015, P = 3.8e-05, N = 7824)	(0.058, 0.0012, P = 0.99, N = 859)
rs4483623(T)/11:113352557	intergenic	(0.97, -0.038, P = 2.3e-05, N = 7824)	(0.97, -0.026, P = 0.86, N = 859)
rs7106005(T)/11:11598372	GALNT18	(0.82, 0.02, P = 7.7e-07, N = 7824)	(0.39, -0.061, P = 0.22, N = 859)
rs2198256(T)/11:80187596*	intergenic	(0.53, 0.011, P = 4.9e-05, N = 7824)	(0.19, 0.011, P = 0.86, N = 859)
rs80291290(T)/11:88372241	GRM5	(0.18, 0.23, P = 2.6e-06, N = 1959)	(0.034, 0.042, P = 0.75, N = 859)
rs12281336(T)/11:98040562*	intergenic	(0.032, -0.085, P = 5e-05, N = 7824)	(0.09, -0.016, P = 0.85, N = 859)
rs2682783(A)/12:119114569*	intergenic	(0.49, 0.012, P = 1.1e-05, N = 7824)	(0.51, -0.017, P = 0.71, N = 859)
rs4882733(C)/12:128796587	TMEM132C	(0.81, -0.019, P = 3.6e-05, N = 7824)	(0.6, -0.097, P = 0.045, N = 859)
rs56076700(A)/12:129163020	TMEM132C	(0.077, 0.35, P = 5e-06, N = 1959)	(0.069, 0.061, P = 0.52, N = 859)
rs4763908(T)/12:13100332	GPRC5D	(0.29, -0.015, P = 2.4e-05, N = 7824)	(0.78, -0.072, P = 0.21, N = 859)
rs11051552(A)/12:31890602*	intergenic	(0.52, -0.012, P = 8.5e-06, N = 7824)	(0.36, -0.11, P = 0.032, N = 859)
rs11177321(A)/12:69031913*	RAP1B	(0.12, 0.019, P = 1.6e-05, N = 7824)	(0.016, 0.011, P = 0.95, N = 859)
rs535554250(GA)/13:33192654	PDS5B	(0.29, 0.15, P = 7.8e-06, N = 1959)	(0.26, 0.064, P = 0.26, N = 859)
rs73178899(G)/13:37901134	intergenic	(0.14, 0.25, P = 4.1e-06, N = 1959)	(0.019, -0.12, P = 0.48, N = 859)
rs8003699(G)/14:21322586	intergenic	(0.85, -0.16, P = 4.9e-06, N = 1959)	(0.8, -0.039, P = 0.52, N = 859)
rs2354322(T)/14:62708880	intergenic	(0.67, 0.014, P = 3.2e-05, N = 7824)	(0.93, -0.32, P = 8e-04, N = 859)
rs8007846(A)/14:66262963*	intergenic	(0.55, 0.012, P = 8.4e-06, N = 7824)	(0.22, -0.012, P = 0.83, N = 859)
rs16970633(T)/15:40642877	PHGR1	(0.16, -0.019, P = 7.4e-06, N = 7824)	(0.33, 0.073, P = 0.15, N = 859)
rs9635324(A)/15:40703211*	IVD	(0.61, 0.034, P = 1.9e-35, N = 7824)	(0.79, 0.022, P = 0.71, N = 859)
rs17672041(T)/15:40722426*	IVD	(0.12, 0.03, P = 1.3e-11, N = 7824)	(0.019, 0.093, P = 0.6, N = 859)
rs2291449(A)/15:76579234*	ETFA	(0.91, -0.029, P = 2.4e-08, N = 7824)	(0.99, 0.1, P = 0.62, N = 859)
rs7170052(T)/15:93457650*	CHD2	(0.76, 0.015, P = 3.1e-05, N = 7824)	(0.92, -0.18, P = 0.041, N = 859)
rs13338173(A)/16:54227083	intergenic	(0.79, -0.014, P = 5e-05, N = 7824)	(0.81, -0.00038, P = 0.99, N = 859)
rs7212115(T)/17:10891477*	intergenic	(0.73, -0.016, P = 1.2e-05, N = 7824)	(0.57, 0.048, P = 0.28, N = 859)
rs8098563(A)/18:19930691*	RP11-535A5.1	(0.46, 0.013, P = 3e-05, N = 7824)	(0.37, 0.019, P = 0.71, N = 859)
rs16947039(T)/18:27211242*	intergenic	(0.074, 0.023, P = 1.9e-05, N = 7824)	(0.16, -0.012, P = 0.86, N = 859)
rs16977314(C)/18:40710349	intergenic	(0.89, 0.018, P = 4.7e-05, N = 7824)	(0.98, -0.13, P = 0.41, N = 859)
rs1878679(T)/18:40726416	intergenic	(0.11, -0.018, P = 4.4e-05, N = 7824)	(0.056, 0.088, P = 0.41, N = 859)
rs8099211(A)/18:43103958	RP11-749H17.1	(0.21, -0.015, P = 1.9e-05, N = 7824)	(0.39, -0.0087, P = 0.86, N = 859)
rs36035559(A)/19:7121597	INSR	(0.17, 0.17, P = 8.9e-06, N = 1959)	(0.015, 0.031, P = 0.88, N = 859)
rs2138480(A)/2:118142725*	intergenic	(0.12, -0.019, P = 1.8e-05, N = 7824)	(0.02, -0.13, P = 0.46, N = 859)
rs76530645(A)/2:175558061	AC018890.6	(0.11, -0.16, P = 4.6e-06, N = 1959)	(0.016, -0.043, P = 0.82, N = 859)
rs11680464(A)/2:1882824*	MYT1L	(0.066, 0.025, P = 2.9e-05, N = 7824)	(0.043, -0.14, P = 0.24, N = 859)
rs4505564(T)/2:240871018*	NDUFA10	(0.79, 0.016, P = 4.9e-06, N = 7824)	(0.94, -0.041, P = 0.69, N = 859)
rs17546912(C)/2:66225155	AC074391.1	(0.11, -0.31, P = 3.5e-06, N = 1959)	(0.015, -0.011, P = 0.96, N = 859)
rs2232575(C)/20:36974512	LBP	(0.16, -0.017, P = 3.3e-05, N = 7824)	(0.12, 0.006, P = 0.93, N = 859)
rs1201971(T)/20:59290436	intergenic	(0.47, 0.012, P = 1.4e-05, N = 7824)	(0.5, 0.02, P = 0.68, N = 859)
rs4616554(A)/21:32420859*	intergenic	(0.076, -0.026, P = 1.2e-05, N = 7824)	(0.2, 0.033, P = 0.59, N = 859)
rs9289761(T)/3:147443447	intergenic	(0.55, 0.023, P = 3.9e-05, N = 7824)	(0.32, 0.06, P = 0.24, N = 859)
rs12636822(C)/3:36329450	intergenic	(0.16, 0.21, P = 7.8e-06, N = 1959)	(0.032, 0.16, P = 0.24, N = 859)
rs383911(A)/3:41122345*	intergenic	(0.56, -0.013, P = 3e-06, N = 7824)	(0.33, -0.032, P = 0.54, N = 859)
rs13075137(T)/3:4765093*	ITPR1	(0.44, -0.024, P = 7.5e-06, N = 7824)	(0.23, 0.013, P = 0.82, N = 859)
rs12494255(A)/3:99003734	intergenic	(0.77, 0.031, P = 2.7e-06, N = 7824)	(0.8, -0.019, P = 0.74, N = 859)
rs6833958(T)/4:125848110	intergenic	(0.88, -0.27, P = 9.7e-07, N = 1959)	(0.84, -0.077, P = 0.24, N = 859)
rs7668227(A)/4:187061084	FAM149A	(0.9, 0.024, P = 7.9e-06, N = 7824)	(0.98, 0.16, P = 0.33, N = 859)
rs9327595(A)/5:130492613*	HINT1	(0.031, -0.042, P = 6.9e-07, N = 7824)	(0.23, -0.056, P = 0.34, N = 859)
rs7356708(C)/5:130593723	CDC42SE2	(0.039, -0.042, P = 4.4e-08, N = 7824)	(0.6, -0.031, P = 0.53, N = 859)
rs6596022(T)/5:130767121*	RAPGEF6	(0.96, 0.045, P = 6.8e-09, N = 7824)	(0.57, 0.036, P = 0.46, N = 859)
rs3805681(T)/5:131537860*	P4HA2	(0.54, 0.03, P = 1e-28, N = 7824)	(0.75, 0.01, P = 0.86, N = 859)
rs334902(C)/5:131586559*	P4HA2	(0.44, 0.029, P = 8e-27, N = 7824)	(0.38, -0.031, P = 0.52, N = 859)
rs11950562(A)/5:131652529*	SLC22A4	(0.52, 0.036, P = 2.3e-41, N = 7824)	(0.74, -0.034, P = 0.54, N = 859)
rs11385258(TA)/5:131748241	C5orf56	(0.35, 0.13, P = 4.9e-06, N = 1959)	(0.24, 0.12, P = 0.038, N = 859)
rs803222(A)/5:132208468*	LEAP2	(0.54, 0.011, P = 2.6e-05, N = 7824)	(0.31, 0.048, P = 0.35, N = 859)
rs10491300(T)/5:136354227*	SPOCK1	(0.083, 0.022, P = 4.5e-05, N = 7824)	(0.23, -0.06, P = 0.29, N = 859)
rs2963485(T)/5:148452043*	CTC-529P8.1	(0.19, -0.018, P = 1.1e-06, N = 7824)	(0.37, 0.013, P = 0.8, N = 859)
rs283429(C)/5:153904147*	intergenic	(0.088, 0.022, P = 4.2e-05, N = 7824)	(0.31, -0.038, P = 0.45, N = 859)
rs13355460(T)/5:157385133	intergenic	(0.65, 0.024, P = 4.9e-05, N = 7824)	(0.53, -0.0023, P = 0.96, N = 859)
rs10062095(A)/5:81900261*	intergenic	(0.77, 0.026, P = 4.3e-05, N = 7824)	(0.61, -0.021, P = 0.67, N = 859)
rs73435033(T)/6:11172620	RP3-510L9.1	(0.14, -0.24, P = 3.2e-06, N = 1959)	(0.17, -0.11, P = 0.076, N = 859)
rs4463295(A)/6:123016251	PKIB	(0.57, 0.013, P = 1.6e-06, N = 7824)	(0.36, 0.0094, P = 0.85, N = 859)
rs9464891(T)/6:16389631*	ATXN1	(0.12, -0.25, P = 5e-06, N = 1959)	(0.23, 0.096, P = 0.087, N = 859)
rs2213581(T)/6:32388546*	intergenic	(0.2, -0.026, P = 4e-05, N = 7824)	(0.22, 0.12, P = 0.033, N = 859)
rs10947808(T)/6:39323615*	KIF6	(0.81, -0.017, P = 1.2e-06, N = 7824)	(0.31, 0.00071, P = 0.99, N = 859)
rs972224(C)/6:41210049	TREML4	(0.092, 0.022, P = 3.3e-05, N = 7824)	(0.3, -0.088, P = 0.1, N = 859)
rs9504983(A)/6:6989041	RP11-556O15.1	(0.24, 0.15, P = 4.1e-06, N = 1959)	(0.052, -0.17, P = 0.13, N = 859)
rs444190(T)/7:101862777	CUX1	(0.94, -0.35, P = 8.5e-06, N = 1959)	(0.83, 0.054, P = 0.4, N = 859)
rs917402(T)/7:150969535	SMARCD3	(0.1, 0.23, P = 4.1e-06, N = 1959)	(0.013, -0.0089, P = 0.97, N = 859)
rs10259781(A)/7:152867025	intergenic	(0.046, 0.032, P = 3.5e-05, N = 7824)	(0.18, 0.019, P = 0.77, N = 859)
rs4716609(T)/7:155269627*	CNPY1	(0.21, 0.015, P = 1.2e-05, N = 7824)	(0.091, 0.1, P = 0.23, N = 859)
rs13242809(A)/7:22746564	intergenic	(0.27, -0.11, P = 6.7e-06, N = 1959)	(0.51, -0.05, P = 0.31, N = 859)
rs59591051(A)/7:29877857	WIPF3	(0.15, 0.23, P = 8.2e-06, N = 1959)	(0.21, -0.066, P = 0.27, N = 859)
rs11774655(T)/8:11271426	C8orf12	(0.075, 0.024, P = 4.3e-05, N = 7824)	(0.19, -0.016, P = 0.79, N = 859)
rs10096893(A)/8:2254703*	intergenic	(0.68, 0.034, P = 1e-05, N = 7824)	(0.56, 0.11, P = 0.034, N = 859)
rs17054370(T)/8:25669353*	intergenic	(0.92, 0.022, P = 2.5e-05, N = 7824)	(0.79, 0.0052, P = 0.93, N = 859)
rs891404(A)/8:40276391*	intergenic	(0.48, 0.012, P = 7.5e-06, N = 7824)	(0.6, -0.019, P = 0.7, N = 859)
rs13292819(A)/9:38227878	intergenic	(0.11, 0.022, P = 2.7e-05, N = 7824)	(0.059, 0.15, P = 0.14, N = 859)
rs10867534(T)/9:83054485	intergenic	(0.22, 0.18, P = 7.4e-06, N = 1959)	(0.44, -0.053, P = 0.28, N = 859)
rs2031970(T)/9:92204172	intergenic	(0.23, -0.24, P = 9.8e-06, N = 1959)	(0.084, -0.094, P = 0.27, N = 859)
rs9775485(T)/9:95611913	ZNF484	(0.59, -0.014, P = 2e-07, N = 7824)	(0.32, 0.037, P = 0.47, N = 859)

Results from Univariable Mendelian Randomization of Isovalerylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	92	-0.0013 (-0.14- 0.14) P=0.99	7.3	31	7.69 (0- 72.6)	NA	NA	-8.7e-05 P=0.99
MR-Egger	92	-0.00077 (-0.18- 0.17) P=0.99	7.3	31	7.69 (0- 72.6)	99	0.24	-8.7e-05 P=0.99
Weighted median	92	-0.11 (-0.35- 0.12) P=0.34	7.3	31	7.69 (0- 72.6)	NA	NA	-8.7e-05 P=0.99

Results from Univariable MRPRESSO of Isovalerylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.07	-0.02	0.99
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Isovalerylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	48	0.039 (-0.12- 0.2) P=0.62	12	29	9.84 (0- 83.7)	NA	NA	0.001 P=0.94
MR-Egger	48	0.034 (-0.18- 0.25) P=0.76	12	29	9.84 (0- 83.7)	55	0.17	0.001 P=0.94
Weighted median	48	0.064 (-0.16- 0.29) P=0.58	12	29	9.84 (0- 83.7)	NA	NA	0.001 P=0.94

Results from Univariable MRPRESSO of Isovalerylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.04	0.08	0.49	0.63
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Hexanoylcarnitine

Instruments Associations with Hexanoylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Hexanoylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs11184443(T)/1:105666096*	intergenic	(0.25, -0.015, P = 4e-05, N = 7824)	(0.32, 0.045, P = 0.38, N = 859)
rs16852535(A)/1:230881658*	CAPN9	(0.32, 0.016, P = 3.8e-06, N = 7824)	(0.54, -0.079, P = 0.11, N = 859)
rs4649225(A)/1:233544651*	intergenic	(0.35, -0.014, P = 4.1e-05, N = 7824)	(0.23, 0.033, P = 0.56, N = 859)
rs12060939(C)/1:74033051	intergenic	(0.27, -0.014, P = 4.2e-05, N = 7824)	(0.21, 0.0058, P = 0.92, N = 859)
rs10518500(T)/1:75808588*	SLC44A5	(0.79, 0.016, P = 3.3e-06, N = 7824)	(0.96, 0.018, P = 0.88, N = 859)
rs699683(A)/1:76172512*	RP4-682C21.5	(0.066, 0.034, P = 5.4e-09, N = 7824)	(0.024, 0.036, P = 0.82, N = 859)
rs11161521(T)/1:76216330*	ACADM	(0.7, 0.07, P = 6.4e-100, N = 7824)	(0.86, -0.13, P = 0.055, N = 859)
rs56352044(T)/1:76248706	RABGGTB	(0.23, -0.3, P = 9.1e-15, N = 1881)	(0.14, 0.15, P = 0.033, N = 859)
rs5745331(A)/1:76273313*	MSH4	(0.72, -0.048, P = 1.6e-45, N = 7824)	(0.89, 0.085, P = 0.27, N = 859)
rs1144337(T)/1:76278877	MSH4	(0.1, 0.03, P = 2.6e-09, N = 7824)	(0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305	intergenic	(0.29, 0.046, P = 5e-42, N = 7824)	(0.32, -0.0091, P = 0.86, N = 859)
rs572200(T)/1:76724652*	ST6GALNAC3	(0.21, -0.017, P = 4.9e-05, N = 7824)	(0.18, -0.024, P = 0.7, N = 859)
rs11162212(A)/1:77256966*	intergenic	(0.43, 0.014, P = 1.4e-05, N = 7824)	(0.53, -0.046, P = 0.34, N = 859)
rs228455(T)/1:79624739*	intergenic	(0.14, 0.036, P = 4.1e-05, N = 7824)	(0.31, 0.066, P = 0.21, N = 859)
rs3738572(A)/1:85391140*	MCOLN2	(0.46, 0.012, P = 1.4e-05, N = 7824)	(0.26, -0.028, P = 0.61, N = 859)
rs4463806(C)/10:115597993*	DCLRE1A	(0.77, -0.18, P = 6e-06, N = 1881)	(0.81, 0.1, P = 0.1, N = 859)
rs2242206(T)/10:61414011*	SLC16A9	(0.26, 0.015, P = 2.3e-05, N = 7824)	(0.09, 0.076, P = 0.36, N = 859)
rs1171615(T)/10:61469090*	SLC16A9	(0.78, 0.025, P = 4e-11, N = 7824)	(0.76, 0.02, P = 0.73, N = 859)
rs1998881(T)/10:8863208*	intergenic	(0.21, -0.017, P = 1.3e-06, N = 7824)	(0.2, -0.0023, P = 0.97, N = 859)
rs17503531(T)/10:91732224*	intergenic	(0.096, 0.021, P = 3.3e-05, N = 7824)	(0.17, 0.018, P = 0.78, N = 859)
rs12762813(A)/10:93461648*	intergenic	(0.12, -0.018, P = 3.7e-05, N = 7824)	(0.012, -0.21, P = 0.34, N = 859)
rs76988133(G)/11:103471636	intergenic	(0.061, -0.4, P = 1.2e-07, N = 1881)	(0.042, 0.084, P = 0.49, N = 859)
rs1613187(G)/11:122430156	intergenic	(0.8, 0.18, P = 8.7e-06, N = 1881)	(0.95, 0.0085, P = 0.94, N = 859)
rs11224138(T)/11:134842214*	intergenic	(0.13, -0.041, P = 5.3e-06, N = 7824)	(0.11, 0.17, P = 0.034, N = 859)
rs5806187(AAAT)/13:101608997	NALCN-AS1	(0.98, 0.38, P = 9.7e-06, N = 1881)	(0.85, -0.034, P = 0.62, N = 859)
rs7991563(A)/13:43688013*	DNAJC15	(0.8, -0.016, P = 2.7e-06, N = 7824)	(0.8, -0.024, P = 0.7, N = 859)
rs9671614(C)/14:33037956*	AKAP6	(0.44, 0.2, P = 6.7e-06, N = 1881)	(0.68, -0.0037, P = 0.94, N = 859)
rs8022497(C)/14:87533611*	intergenic	(0.068, 0.025, P = 4.9e-05, N = 7824)	(0.086, -0.031, P = 0.72, N = 859)
rs4779616(C)/15:33591069*	RP11-489D6.2	(0.053, 0.03, P = 3.4e-05, N = 7824)	(0.036, 0.072, P = 0.56, N = 859)
rs12915128(A)/15:68734922*	intergenic	(0.49, 0.027, P = 4.3e-05, N = 7824)	(0.81, 0.12, P = 0.048, N = 859)
rs1368843(A)/15:94908904*	MCTP2	(0.42, -0.014, P = 1.3e-05, N = 7824)	(0.34, 0.0079, P = 0.87, N = 859)
rs3743527(T)/16:16235681*	ABCC1	(0.22, 0.014, P = 4.7e-05, N = 7824)	(0.14, -0.032, P = 0.65, N = 859)
rs36021(A)/16:55711950	SLC6A2	(0.53, -0.17, P = 2.1e-06, N = 1881)	(0.64, -0.062, P = 0.21, N = 859)
rs8059932(A)/16:66155276*	intergenic	(0.08, -0.2, P = 9.8e-06, N = 1881)	(0.23, 0.039, P = 0.5, N = 859)
rs75887526(GCA)/16:78196411*	WWOX	(0.23, -0.24, P = 1.7e-06, N = 1881)	(0.23, -0.047, P = 0.42, N = 859)
rs12598663(T)/16:7846716*	intergenic	(0.93, 0.026, P = 3e-05, N = 7824)	(0.98, 0.052, P = 0.79, N = 859)
rs3764247(A)/16:810039*	MSLN	(0.76, -0.017, P = 2.1e-05, N = 7824)	(0.75, 0.00053, P = 0.99, N = 859)
rs8075029(G)/17:13395850*	HS3ST3A1	(0.87, -0.22, P = 7.7e-07, N = 1881)	(0.99, -0.5, P = 0.014, N = 859)
rs658591(T)/17:26610769	KRT18P55	(0.8, -0.019, P = 2e-06, N = 7824)	(0.63, -0.067, P = 0.18, N = 859)
rs76620359(C)/19:55725087	PTPRH	(0.054, 0.41, P = 2.7e-06, N = 1881)	(0.044, -0.15, P = 0.17, N = 859)
rs10170989(T)/2:107177168*	intergenic	(0.81, 0.017, P = 3.3e-05, N = 7824)	(0.86, -0.008, P = 0.91, N = 859)
rs10171649(C)/2:125399340*	CNTNAP5	(0.056, 0.028, P = 2.5e-05, N = 7824)	(0.15, 0.056, P = 0.41, N = 859)
rs10928415(A)/2:149553139	intergenic	(0.76, 0.22, P = 3e-06, N = 1881)	(0.35, -0.022, P = 0.66, N = 859)
rs3769423(A)/2:168872075*	STK39	(0.019, 0.051, P = 9.8e-06, N = 7824)	(0.36, -0.0088, P = 0.86, N = 859)
rs12987318(A)/2:19772919*	intergenic	(0.041, 0.034, P = 1.3e-05, N = 7824)	(0.084, -0.075, P = 0.4, N = 859)
rs6705260(T)/2:205039136	intergenic	(0.87, -0.25, P = 1.4e-06, N = 1881)	(0.97, -0.13, P = 0.34, N = 859)
rs7579973(A)/2:34933627	AC073218.2	(0.61, -0.025, P = 3.2e-05, N = 7824)	(0.61, 0.0033, P = 0.95, N = 859)
rs10164760(G)/2:62212279	COMMD1	(0.018, -0.61, P = 1.2e-06, N = 1881)	(0.36, 0.02, P = 0.69, N = 859)
rs4671179(G)/2:67586247	intergenic	(0.45, -0.15, P = 4.7e-06, N = 1881)	(0.37, 0.00051, P = 0.99, N = 859)
rs113107938(G)/2:7630499	intergenic	(0.018, 0.64, P = 1.3e-06, N = 1881)	(0.026, 0.17, P = 0.28, N = 859)
rs1666769(T)/2:79224687*	intergenic	(0.67, 0.015, P = 1.4e-05, N = 7824)	(0.57, 0.0097, P = 0.85, N = 859)
rs4669343(A)/2:8970482*	KIDINS220	(0.98, 0.085, P = 1.7e-05, N = 7824)	(0.93, -0.095, P = 0.3, N = 859)
rs143973511(T)/3:122452571*	PARP14	(0.1, -0.26, P = 3.7e-06, N = 1881)	(0.049, 0.013, P = 0.91, N = 859)
rs1348656(T)/3:144933520*	intergenic	(0.8, -0.015, P = 1.9e-05, N = 7824)	(0.61, 0.03, P = 0.56, N = 859)
rs17189202(A)/3:181986146*	intergenic	(0.13, 0.031, P = 1.6e-05, N = 7824)	(0.024, 0.014, P = 0.93, N = 859)
rs1682962(A)/3:3834752*	SUMF1	(0.58, 0.028, P = 2.2e-05, N = 7824)	(0.11, -0.18, P = 0.019, N = 859)
rs4074087(A)/3:4681908*	ITPR1	(0.07, 0.048, P = 2.1e-05, N = 7824)	(0.18, 0.05, P = 0.42, N = 859)
rs2070630(C)/4:159644494*	PPID	(0.29, -0.021, P = 6.8e-10, N = 7824)	(0.29, -0.047, P = 0.38, N = 859)
rs6536381(T)/4:159882193*	C4orf45	(0.3, 0.014, P = 2.2e-05, N = 7824)	(0.17, 0.029, P = 0.64, N = 859)
rs6553778(T)/4:168351130*	intergenic	(0.23, -0.017, P = 1.2e-06, N = 7824)	(0.28, 0.017, P = 0.75, N = 859)
rs4863170(C)/4:190333580*	intergenic	(0.37, -0.15, P = 5.6e-06, N = 1881)	(0.31, 0.028, P = 0.59, N = 859)
rs11728264(T)/4:29777582*	intergenic	(0.24, -0.015, P = 2.8e-05, N = 7824)	(0.74, -0.066, P = 0.23, N = 859)
rs1477626(A)/5:101329818	intergenic	(0.55, -0.026, P = 2.3e-05, N = 7824)	(0.33, -0.066, P = 0.21, N = 859)
rs3776418(A)/5:10708871*	DAP	(0.067, 0.024, P = 4.3e-05, N = 7824)	(0.047, 0.0086, P = 0.94, N = 859)
rs7716905(A)/5:131324377*	ACSL6	(0.96, 0.035, P = 2.2e-05, N = 7824)	(0.59, -0.046, P = 0.34, N = 859)
rs7705189(A)/5:131623358*	P4HA2	(0.51, 0.019, P = 1.6e-08, N = 7824)	(0.72, -0.13, P = 0.015, N = 859)
rs272869(A)/5:131677997*	SLC22A4	(0.37, 0.022, P = 1.4e-11, N = 7824)	(0.27, 0.11, P = 0.046, N = 859)
rs439787(T)/5:132882522*	FSTL4	(0.63, 0.025, P = 4.7e-05, N = 7824)	(0.51, 0.0037, P = 0.94, N = 859)
rs3798138(A)/5:136983954*	KLHL3	(0.023, -0.042, P = 4.1e-05, N = 7824)	(0.27, 0.11, P = 0.04, N = 859)
rs371846(T)/5:142188049*	ARHGAP26	(0.082, -0.025, P = 2.1e-05, N = 7824)	(0.25, -0.019, P = 0.73, N = 859)
rs11135316(A)/5:163939367*	CTC-340A15.2	(0.73, 0.028, P = 4e-05, N = 7824)	(0.6, -0.047, P = 0.33, N = 859)
rs1540603(A)/5:17220275*	BASP1	(0.012, -0.11, P = 1.2e-05, N = 7824)	(0.017, -0.39, P = 0.037, N = 859)
rs2002548(T)/5:173150415	CTB-43E15.3	(0.26, -0.14, P = 5.6e-06, N = 1881)	(0.28, 0.053, P = 0.33, N = 859)
rs13355979(A)/5:32984015*	CTD-2066L21.3	(0.57, -0.014, P = 3.7e-05, N = 7824)	(0.15, -0.047, P = 0.48, N = 859)
rs12521153(A)/5:52788201*	intergenic	(0.32, 0.16, P = 7.6e-06, N = 1881)	(0.27, 0.13, P = 0.015, N = 859)
rs6861760(T)/5:557551	intergenic	(0.025, 0.31, P = 4.4e-06, N = 1881)	(0.28, 0.084, P = 0.12, N = 859)
rs7734050(T)/5:57173905*	intergenic	(0.73, 0.014, P = 4.2e-05, N = 7824)	(0.65, -0.003, P = 0.95, N = 859)
rs1104684(G)/5:70968915	intergenic	(0.47, -0.14, P = 9.1e-06, N = 1881)	(0.83, -0.11, P = 0.084, N = 859)
rs4131193(A)/5:7583327*	ADCY2	(0.31, 0.014, P = 2.2e-05, N = 7824)	(0.56, -0.04, P = 0.42, N = 859)
rs10079045(A)/5:90266322	GPR98	(0.26, 0.17, P = 2.1e-06, N = 1881)	(0.66, -0.081, P = 0.12, N = 859)
rs170734(A)/5:98147041*	intergenic	(0.73, -0.015, P = 6.8e-06, N = 7824)	(0.69, -0.016, P = 0.76, N = 859)
rs10053087(C)/5:9920412*	intergenic	(0.033, 0.034, P = 4.2e-05, N = 7824)	(0.27, -0.066, P = 0.23, N = 859)
rs7745587(A)/6:108010940*	intergenic	(0.74, -0.016, P = 6.7e-06, N = 7824)	(0.87, -0.08, P = 0.25, N = 859)
rs11753995(A)/6:160575366*	SLC22A1	(0.16, -0.023, P = 7.2e-08, N = 7824)	(0.033, 0.013, P = 0.92, N = 859)
rs76002427(G)/6:164386971	intergenic	(0.078, -0.28, P = 7.5e-07, N = 1881)	(0.029, -0.26, P = 0.082, N = 859)
rs3846828(A)/6:24282117*	DCDC2	(0.1, 0.021, P = 3.2e-05, N = 7824)	(0.069, -0.038, P = 0.7, N = 859)
rs2071538(A)/6:32818678*	TAP1	(0.23, 0.015, P = 1.7e-05, N = 7824)	(0.026, -0.093, P = 0.53, N = 859)
rs9380734(C)/6:38293199	BTBD9	(0.02, -0.69, P = 7e-06, N = 1881)	(0.27, 0.055, P = 0.31, N = 859)
rs9352088(C)/6:74987577*	RP11-554D15.1	(0.75, -0.033, P = 3.1e-05, N = 7824)	(0.56, 0.036, P = 0.46, N = 859)
rs884760(T)/6:8363853*	intergenic	(0.28, 0.014, P = 3e-05, N = 7824)	(0.72, 0.00033, P = 1, N = 859)
rs4584058(A)/7:44132340*	intergenic	(0.35, -0.015, P = 1.1e-05, N = 7824)	(0.56, -0.051, P = 0.29, N = 859)
rs10280701(T)/7:83627847*	SEMA3A	(0.21, 0.015, P = 1.3e-05, N = 7824)	(0.076, 0.092, P = 0.3, N = 859)
rs10095671(T)/8:133378663*	KCNQ3	(0.91, -0.024, P = 4e-06, N = 7824)	(0.86, -0.00023, P = 1, N = 859)
rs145011241(GGAGT)/8:144238923	LY6H	(0.41, -0.21, P = 7.2e-06, N = 1881)	(0.47, 0.049, P = 0.31, N = 859)
rs11990475(A)/8:25954842*	intergenic	(0.9, -0.022, P = 1.9e-05, N = 7824)	(0.85, 0.059, P = 0.37, N = 859)
rs10096903(T)/8:85661097*	RALYL	(0.25, 0.015, P = 2e-05, N = 7824)	(0.4, -0.044, P = 0.38, N = 859)
rs11990096(A)/8:9195378*	RP11-115J16.1	(0.22, -0.029, P = 2.8e-05, N = 7824)	(0.42, 0.03, P = 0.55, N = 859)
rs2915420(T)/9:103955550*	LPPR1	(0.16, -0.02, P = 2.1e-06, N = 7824)	(0.17, 0.076, P = 0.25, N = 859)
rs3132311(A)/9:137430554*	RP11-473E2.4	(0.21, 0.014, P = 4.4e-05, N = 7824)	(0.037, -0.042, P = 0.74, N = 859)
rs79368155(T)/9:18097804*	intergenic	(0.047, 0.39, P = 6.2e-06, N = 1881)	(0.01, -0.00031, P = 1, N = 859)
rs12340115(A)/9:8281308*	intergenic	(0.99, 0.11, P = 3.6e-05, N = 7824)	(0.91, -0.088, P = 0.28, N = 859)
rs11141474(A)/9:89272127*	RP11-395D3.1	(0.28, -0.014, P = 4.6e-05, N = 7824)	(0.17, -0.073, P = 0.25, N = 859)

Results from Univariable Mendelian Randomization of Hexanoylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	102	-0.046 (-0.13- 0.038) P=0.28	8	38	0 (0- 70.4)	NA	NA	-0.0052 P=0.51
MR-Egger	102	-0.027 (-0.13- 0.072) P=0.59	8	38	0 (0- 70.4)	112	0.2	-0.0052 P=0.51
Weighted median	102	-0.06 (-0.17- 0.054) P=0.3	8	38	0 (0- 70.4)	NA	NA	-0.0052 P=0.51

Results from Univariable MRPRESSO of Hexanoylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.04	-1.07	0.28
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Hexanoylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	24	-0.046 (-0.14- 0.049) P=0.34	21	26	0 (0- 80.7)	NA	NA	0.012 P=0.55
MR-Egger	24	-0.078 (-0.22- 0.064) P=0.29	21	26	0 (0- 80.7)	28	0.18	0.012 P=0.55
Weighted median	24	-0.066 (-0.18- 0.052) P=0.27	21	26	0 (0- 80.7)	NA	NA	0.012 P=0.55

Results from Univariable MRPRESSO of Hexanoylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.05	-0.95	0.35
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Octanoylcarnitine

Instruments Associations with L-Octanoylcarnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Octanoylcarnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs11184443(T)/1:105666096*	intergenic	(0.25, -0.019, P = 1.4e-05, N = 7824)	(0.32, 0.045, P = 0.38, N = 859)
rs857703(A)/1:158687224*	OR6K3	(0.38, 0.014, P = 4.1e-05, N = 7824)	(0.13, 0.12, P = 0.11, N = 859)
rs332765(T)/1:174655782*	RABGAP1L	(0.36, 0.13, P = 2.4e-06, N = 1948)	(0.9, -0.075, P = 0.34, N = 859)
rs7552404(A)/1:76135946*	intergenic	(0.7, 0.075, P = 1.3e-77, N = 7824)	(0.83, -0.12, P = 0.061, N = 859)
rs699683(A)/1:76172512*	RP4-682C21.5	(0.067, 0.047, P = 5.4e-11, N = 7824)	(0.024, 0.036, P = 0.82, N = 859)
rs12130832(T)/1:76234294*	ACADM	(0.71, -0.049, P = 5.4e-33, N = 7824)	(0.79, 0.0095, P = 0.87, N = 859)
rs56352044(T)/1:76248706	RABGGTB	(0.23, -0.3, P = 9.1e-15, N = 1948)	(0.14, 0.15, P = 0.033, N = 859)
rs1144337(T)/1:76278877	MSH4	(0.1, 0.044, P = 3.3e-14, N = 7824)	(0.19, -0.061, P = 0.31, N = 859)
rs1796810(T)/1:76403305	intergenic	(0.29, 0.045, P = 6.1e-28, N = 7824)	(0.32, -0.0091, P = 0.86, N = 859)
rs185292654(T)/1:76465955	intergenic	(0.035, 0.55, P = 1.4e-06, N = 1948)	(0.026, 0.0014, P = 0.99, N = 859)
rs4463806(C)/10:115597993*	DCLRE1A	(0.77, -0.18, P = 6e-06, N = 1948)	(0.81, 0.1, P = 0.1, N = 859)
rs7894167(C)/10:47556919*	intergenic	(0.38, 0.17, P = 3.8e-06, N = 1948)	(0.52, 0.1, P = 0.037, N = 859)
rs1998881(T)/10:8863208*	intergenic	(0.21, -0.017, P = 5e-05, N = 7824)	(0.2, -0.0023, P = 0.97, N = 859)
rs17503531(T)/10:91732224*	intergenic	(0.096, 0.024, P = 4.2e-05, N = 7824)	(0.17, 0.018, P = 0.78, N = 859)
rs582119(T)/11:107443420	intergenic	(0.38, -0.015, P = 3.1e-05, N = 7824)	(0.48, 0.024, P = 0.62, N = 859)
rs4757051(A)/11:20333248*	intergenic	(0.72, -0.018, P = 1.9e-05, N = 7824)	(0.43, 0.11, P = 0.027, N = 859)
rs6485709(T)/11:46934309*	LRP4	(0.011, 0.13, P = 5.3e-06, N = 7824)	(0.041, 0.14, P = 0.25, N = 859)
rs7130402(A)/11:48115606*	PTPRJ	(0.93, 0.032, P = 9.9e-06, N = 7824)	(0.91, -0.013, P = 0.88, N = 859)
rs1480639(T)/12:29014476	intergenic	(0.57, -0.015, P = 3e-05, N = 7824)	(0.73, -0.031, P = 0.57, N = 859)
rs7973509(A)/12:40354147*	SLC2A13	(0.27, -0.018, P = 1.7e-05, N = 7824)	(0.097, 0.042, P = 0.61, N = 859)
rs7334793(T)/13:106512641	intergenic	(0.5, -0.015, P = 8e-06, N = 7824)	(0.39, 0.031, P = 0.53, N = 859)
rs1446791(A)/13:85194772*	intergenic	(0.17, -0.037, P = 2e-05, N = 7824)	(0.33, -0.061, P = 0.26, N = 859)
rs8012258(T)/14:104991128	TMEM179	(0.53, -0.014, P = 4.2e-05, N = 7824)	(0.33, -0.0044, P = 0.93, N = 859)
rs8003176(T)/14:88760692*	KCNK10	(0.77, 0.033, P = 4.5e-05, N = 7824)	(0.9, 0.076, P = 0.34, N = 859)
rs11848217(G)/14:93048314*	RIN3	(0.24, -0.18, P = 7.1e-06, N = 1948)	(0.33, -0.029, P = 0.58, N = 859)
rs1801591(A)/15:76578762*	ETFA	(0.09, 0.029, P = 3.4e-05, N = 7824)	(0.013, -0.1, P = 0.62, N = 859)
rs3816282(A)/15:79350840*	RASGRF1	(0.91, 0.041, P = 1.9e-05, N = 7824)	(0.94, 0.23, P = 0.025, N = 859)
rs2379991(T)/15:83445338*	FSD2	(0.28, 0.017, P = 4.6e-05, N = 7824)	(0.45, 0.0029, P = 0.95, N = 859)
rs924135(A)/16:16123459*	ABCC1	(0.38, -0.021, P = 1.1e-09, N = 7824)	(0.53, -0.06, P = 0.21, N = 859)
rs45512591(C)/16:16147264*	ABCC1	(0.28, -0.23, P = 4.7e-08, N = 1948)	(0.37, -0.056, P = 0.26, N = 859)
rs3743527(T)/16:16235681*	ABCC1	(0.22, 0.019, P = 4.7e-06, N = 7824)	(0.14, -0.032, P = 0.65, N = 859)
rs2239323(A)/16:16278695	ABCC6	(0.5, 0.015, P = 2.6e-05, N = 7824)	(0.65, 0.04, P = 0.44, N = 859)
rs79825592(T)/16:73692861	intergenic	(0.16, 0.28, P = 3.1e-06, N = 1948)	(0.026, -0.14, P = 0.36, N = 859)
rs2133336(A)/17:8313854*	NDEL1	(0.4, 0.015, P = 9.6e-06, N = 7824)	(0.17, -0.029, P = 0.65, N = 859)
rs2156436(T)/18:57457267*	intergenic	(0.031, 0.12, P = 2.5e-05, N = 7824)	(0.23, -0.027, P = 0.64, N = 859)
rs888860(A)/19:35465187*	intergenic	(0.35, -0.018, P = 9.4e-07, N = 7824)	(0.1, 0.19, P = 0.021, N = 859)
rs7246133(T)/19:53162102*	ZNF83	(0.66, 0.021, P = 9.5e-06, N = 7824)	(0.48, -0.0079, P = 0.87, N = 859)
rs7255657(A)/19:55902257*	RPL28	(0.93, 0.03, P = 3.7e-05, N = 7824)	(0.76, -0.073, P = 0.18, N = 859)
rs10170989(T)/2:107177168*	intergenic	(0.81, 0.02, P = 4.8e-05, N = 7824)	(0.86, -0.008, P = 0.91, N = 859)
rs1542341(T)/2:125383522*	CNTNAP5	(0.94, -0.034, P = 2.5e-05, N = 7824)	(0.8, -0.04, P = 0.51, N = 859)
rs10203979(C)/2:179022751*	intergenic	(0.23, 0.18, P = 3.4e-06, N = 1948)	(0.36, -0.074, P = 0.14, N = 859)
rs11885860(T)/2:180398739*	ZNF385B	(0.93, -0.036, P = 3.9e-05, N = 7824)	(0.95, 0.076, P = 0.49, N = 859)
rs6531077(A)/2:18237570*	KCNS3	(0.46, 0.015, P = 1.2e-05, N = 7824)	(0.8, -0.016, P = 0.79, N = 859)
rs4672596(T)/2:211648806*	intergenic	(0.4, 0.015, P = 9.6e-06, N = 7824)	(0.44, -0.026, P = 0.58, N = 859)
rs4675009(A)/2:226660503*	intergenic	(0.82, 0.21, P = 3.6e-06, N = 1948)	(0.82, -0.094, P = 0.14, N = 859)
rs17258702(A)/2:230764226*	TRIP12	(0.23, -0.017, P = 4.7e-05, N = 7824)	(0.036, 0.19, P = 0.15, N = 859)
rs2720162(T)/2:231629360*	CAB39	(0.61, -0.015, P = 7.3e-06, N = 7824)	(0.88, -0.12, P = 0.086, N = 859)
rs4241312(T)/2:3252636*	TSSC1	(0.48, 0.015, P = 1.6e-05, N = 7824)	(0.38, 0.0095, P = 0.85, N = 859)
rs2290101(C)/2:33952055*	MYADML	(0.34, 0.017, P = 2.7e-05, N = 7824)	(0.44, -0.11, P = 0.025, N = 859)
rs112844005(T)/2:44684630*	CAMKMT	(0.05, 0.31, P = 9.7e-06, N = 1948)	(0.043, -0.018, P = 0.87, N = 859)
rs6077844(A)/20:10579996*	SLX4IP	(0.42, 0.014, P = 2.5e-05, N = 7824)	(0.35, -0.08, P = 0.12, N = 859)
rs1203869(T)/20:22533223*	LINC00261	(0.015, 0.092, P = 4.9e-05, N = 7824)	(0.15, -0.056, P = 0.39, N = 859)
rs542126572(GT)/20:32973901	ITCH	(0.036, -0.23, P = 2e-06, N = 1948)	(0.015, -0.026, P = 0.9, N = 859)
rs9979265(T)/21:29692982	intergenic	(0.45, 0.014, P = 4.2e-05, N = 7824)	(0.56, -0.014, P = 0.78, N = 859)
rs2776278(A)/21:37342699*	RUNX1	(0.23, -0.017, P = 4.9e-05, N = 7824)	(0.26, -0.00052, P = 0.99, N = 859)
rs2835328(A)/21:37622915*	DOPEY2	(0.69, 0.018, P = 1.2e-05, N = 7824)	(0.83, -0.019, P = 0.77, N = 859)
rs4239866(T)/22:17788722*	intergenic	(0.39, -0.029, P = 2.9e-05, N = 7824)	(0.11, -0.047, P = 0.54, N = 859)
rs5755595(T)/22:35518839*	CTA-714B7.5	(0.27, 0.24, P = 3.3e-06, N = 1948)	(0.055, 0.1, P = 0.35, N = 859)
rs16855296(T)/3:144082862*	intergenic	(0.052, 0.038, P = 3.2e-05, N = 7824)	(0.016, -0.047, P = 0.8, N = 859)
rs17756228(T)/3:172371929*	NCEH1	(0.49, -0.014, P = 3.8e-05, N = 7824)	(0.39, 0.07, P = 0.17, N = 859)
rs6443446(G)/3:177049627*	intergenic	(0.66, 0.15, P = 3.1e-06, N = 1948)	(0.95, 0.042, P = 0.69, N = 859)
rs331869(T)/3:255395	CHL1	(0.98, -0.13, P = 7.8e-07, N = 7824)	(0.81, -0.061, P = 0.32, N = 859)
rs4402896(T)/3:29848896*	RBMS3	(0.56, 0.015, P = 1.8e-05, N = 7824)	(0.61, -0.096, P = 0.051, N = 859)
rs1682962(A)/3:3834752*	SUMF1	(0.58, 0.03, P = 3.7e-05, N = 7824)	(0.11, -0.18, P = 0.019, N = 859)
rs12503954(A)/4:113916575*	RP11-650J17.1	(0.29, -0.019, P = 2.1e-05, N = 7824)	(0.6, -0.083, P = 0.095, N = 859)
rs7663005(T)/4:142092124*	RNF150	(0.5, -0.014, P = 4.2e-05, N = 7824)	(0.093, 0.044, P = 0.61, N = 859)
rs4835221(T)/4:146248122*	intergenic	(0.7, -0.03, P = 2.6e-05, N = 7824)	(0.78, -0.00026, P = 1, N = 859)
rs956974(A)/4:156443527	RP13-487K5.1	(0.55, -0.014, P = 5e-05, N = 7824)	(0.8, 0.0081, P = 0.89, N = 859)
rs35055965(T)/4:159193901*	RP11-597D13.7	(0.24, -0.23, P = 3.6e-09, N = 1948)	(0.16, -0.023, P = 0.72, N = 859)
rs8396(T)/4:159630817*	PPID	(0.7, 0.048, P = 1.4e-31, N = 7824)	(0.65, 0.014, P = 0.78, N = 859)
rs10003821(T)/4:159877388*	C4orf45	(0.36, -0.025, P = 6.6e-10, N = 7824)	(0.35, -0.0021, P = 0.97, N = 859)
rs1347066(T)/4:159949116*	C4orf45	(0.54, 0.015, P = 2.1e-05, N = 7824)	(0.54, 0.031, P = 0.52, N = 859)
rs6857595(T)/4:187011126	TLR3	(0.28, 0.15, P = 9.6e-06, N = 1948)	(0.31, 0.022, P = 0.66, N = 859)
rs9790569(T)/4:46734416*	COX7B2	(0.18, -0.2, P = 9.3e-06, N = 1948)	(0.14, -0.096, P = 0.17, N = 859)
rs17157494(A)/5:104409021*	CTD-2374C24.1	(0.074, 0.029, P = 2.2e-05, N = 7824)	(0.03, -0.16, P = 0.25, N = 859)
rs274567(T)/5:131714409*	SLC22A5	(0.37, 0.016, P = 3.9e-06, N = 7824)	(0.3, 0.049, P = 0.35, N = 859)
rs419418(T)/5:142175364*	ARHGAP26	(0.92, 0.029, P = 4.7e-05, N = 7824)	(0.76, 0.028, P = 0.62, N = 859)
rs1995777(T)/5:32987956*	CTD-2066L21.3	(0.56, -0.014, P = 4.7e-05, N = 7824)	(0.22, -0.04, P = 0.49, N = 859)
rs10940072(A)/5:65916784	MAST4	(0.39, -0.015, P = 1.2e-05, N = 7824)	(0.31, 0.1, P = 0.052, N = 859)
rs1053657(T)/6:138734422*	HEBP2	(0.13, 0.023, P = 4.8e-05, N = 7824)	(0.54, 0.01, P = 0.83, N = 859)
rs13198822(T)/6:165806518*	PDE10A	(0.35, -0.014, P = 3.5e-05, N = 7824)	(0.15, -0.039, P = 0.57, N = 859)
rs2989521(G)/6:167804569	intergenic	(0.59, -0.16, P = 7.6e-06, N = 1948)	(0.82, 0.12, P = 0.061, N = 859)
rs6907864(T)/6:24293324*	DCDC2	(0.11, 0.026, P = 5.8e-06, N = 7824)	(0.14, 0.02, P = 0.78, N = 859)
rs212934(T)/6:25537934*	LRRC16A	(0.39, -0.014, P = 3.8e-05, N = 7824)	(0.34, 0.095, P = 0.065, N = 859)
rs9352088(C)/6:74987577*	RP11-554D15.1	(0.75, -0.036, P = 3.3e-05, N = 7824)	(0.56, 0.036, P = 0.46, N = 859)
rs884760(T)/6:8363853*	intergenic	(0.28, 0.019, P = 7.2e-06, N = 7824)	(0.72, 0.00033, P = 1, N = 859)
rs6968131(T)/7:138468569*	ATP6V0A4	(0.99, -0.19, P = 4.9e-05, N = 7824)	(0.87, -0.0073, P = 0.92, N = 859)
rs7795715(A)/7:154639804*	DPP6	(0.86, -0.024, P = 1.3e-05, N = 7824)	(0.82, -0.03, P = 0.64, N = 859)
rs10235922(C)/7:155247106*	EN2	(0.91, -0.03, P = 1.7e-05, N = 7824)	(0.93, -0.03, P = 0.75, N = 859)
rs10224131(A)/7:35200804*	DPY19L2P1	(0.42, -0.017, P = 3e-05, N = 7824)	(0.48, 0.082, P = 0.088, N = 859)
rs12718664(A)/7:52527761	intergenic	(0.59, -0.015, P = 2.4e-05, N = 7824)	(0.31, -0.055, P = 0.29, N = 859)
rs2072454(T)/7:55214348*	EGFR	(0.54, -0.014, P = 4.9e-05, N = 7824)	(0.5, 0.052, P = 0.28, N = 859)
rs7787623(T)/7:75404761*	CCL26	(0.25, -0.043, P = 3.1e-05, N = 7824)	(0.43, 0.017, P = 0.72, N = 859)
rs38558(T)/7:81884548*	CACNA2D1	(0.74, -0.018, P = 2e-05, N = 7824)	(0.93, -0.22, P = 0.015, N = 859)
rs7004977(T)/8:98483422*	intergenic	(0.82, 0.025, P = 4.9e-05, N = 7824)	(0.81, 0.058, P = 0.34, N = 859)
rs140294778(TC)/9:101327543*	GABBR2	(0.2, -0.18, P = 9.2e-06, N = 1948)	(0.022, -0.11, P = 0.53, N = 859)
rs76592182(C)/9:118487530	intergenic	(0.028, 0.58, P = 1.2e-06, N = 1948)	(0.06, 0.085, P = 0.4, N = 859)
rs6475272(T)/9:18949249*	FAM154A	(0.23, -0.018, P = 2.2e-05, N = 7824)	(0.067, 0.0017, P = 0.99, N = 859)
rs11143623(A)/9:76183000*	intergenic	(0.62, 0.014, P = 3.5e-05, N = 7824)	(0.25, 0.072, P = 0.22, N = 859)
rs10868458(A)/9:89277187*	RP11-395D3.1	(0.35, -0.017, P = 1.9e-06, N = 7824)	(0.15, -0.068, P = 0.3, N = 859)

Results from Univariable Mendelian Randomization of L-Octanoylcarnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	100	-0.029 (-0.17- 0.11) P=0.68	7.3	31	9.22 (0- 79.2)	NA	NA	-0.01 P=0.22
MR-Egger	100	0.034 (-0.14- 0.21) P=0.69	7.3	31	9.22 (0- 79.2)	115	0.11	-0.01 P=0.22
Weighted median	100	0.11 (-0.098- 0.33) P=0.29	7.3	31	9.22 (0- 79.2)	NA	NA	-0.01 P=0.22

Results from Univariable MRPRESSO of L-Octanoylcarnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.07	-0.41	0.68
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Octanoylcarnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	19	-0.092 (-0.3- 0.11) P=0.38	13	12	17.3 (0- 72.3)	NA	NA	-0.0099 P=0.55
MR-Egger	19	-0.051 (-0.3- 0.19) P=0.69	13	12	17.3 (0- 72.3)	17	0.44	-0.0099 P=0.55
Weighted median	19	0.12 (-0.18- 0.42) P=0.44	13	12	17.3 (0- 72.3)	NA	NA	-0.0099 P=0.55

Results from Univariable MRPRESSO of L-Octanoylcarnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.09	0.1	-0.88	0.39
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Ureidopropionic acid

Instruments Associations with Ureidopropionic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Ureidopropionic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs75277555(T)/1:92235001	TGFBR3	(0.072, 0.16, P = 4e-06, N = 1956)	(0.047, -0.008, P = 0.94, N = 859)
rs8013355(C)/14:52871418	intergenic	(0.32, 0.16, P = 1.7e-06, N = 1956)	(0.48, -0.013, P = 0.78, N = 859)
rs555045773(GA)/15:54319379	UNC13C	(0.15, -1.1, P = 6.2e-06, N = 1956)	(0.26, -0.069, P = 0.2, N = 859)
rs59930743(C)/17:3393604	ASPA	(0.22, 0.18, P = 2.8e-06, N = 1956)	(0.29, 0.013, P = 0.81, N = 859)
rs56104151(T)/18:61129481	intergenic	(0.17, 0.15, P = 8.1e-06, N = 1956)	(0.35, 0.031, P = 0.53, N = 859)
rs78734409(A)/2:12335302	AC096559.1	(0.038, 0.51, P = 3e-06, N = 1956)	(0.025, 0.14, P = 0.37, N = 859)
rs71394795(GTTTA)/2:12355843	AC096559.1	(0.034, 0.19, P = 4.9e-07, N = 1956)	(0.66, 0.016, P = 0.76, N = 859)
rs13427576(T)/2:56523619	CCDC85A	(0.12, 0.16, P = 9e-06, N = 1956)	(0.22, 0.0034, P = 0.95, N = 859)
rs11704820(G)/22:24912248	UPB1	(0.43, 0.16, P = 4.3e-07, N = 1956)	(0.32, 0.0044, P = 0.93, N = 859)
rs77020847(G)/3:150016629	intergenic	(0.013, 0.24, P = 2.1e-06, N = 1956)	(0.014, 0.074, P = 0.71, N = 859)
rs6788347(C)/3:37754694*	ITGA9	(0.5, 0.19, P = 4e-06, N = 1956)	(0.52, 0.081, P = 0.1, N = 859)
rs4698029(G)/4:10312798*	intergenic	(0.19, -0.39, P = 3.5e-17, N = 1956)	(0.21, -0.033, P = 0.56, N = 859)
rs13135526(A)/4:128932595*	C4orf29	(0.51, -0.08, P = 9.1e-06, N = 1956)	(0.61, 0.057, P = 0.25, N = 859)
rs2725772(T)/4:140438033*	SETD7	(0.84, 0.21, P = 8.9e-08, N = 1956)	(0.54, 0.08, P = 0.093, N = 859)
rs11735831(A)/4:9951591*	SLC2A9	(0.22, -0.43, P = 1.4e-23, N = 1956)	(0.45, -0.029, P = 0.54, N = 859)
rs33379(C)/5:171099634*	intergenic	(0.44, 0.16, P = 4e-06, N = 1956)	(0.77, -0.033, P = 0.58, N = 859)
rs76129636(G)/6:130978833	intergenic	(0.12, -0.41, P = 9.6e-06, N = 1956)	(0.26, -0.0077, P = 0.89, N = 859)
rs113133874(T)/6:33379903	PHF1	(0.11, -0.42, P = 7e-06, N = 1956)	(0.021, -0.051, P = 0.76, N = 859)
rs56286439(C)/7:14307105	DGKB	(0.2, -0.13, P = 4.8e-06, N = 1956)	(0.82, -0.0045, P = 0.94, N = 859)
rs2352451(G)/8:112781984	intergenic	(0.74, 0.18, P = 5.3e-06, N = 1956)	(0.78, -0.073, P = 0.21, N = 859)
rs7006208(A)/8:124157948	TBC1D31	(0.17, -0.96, P = 8e-06, N = 1956)	(0.26, -0.087, P = 0.11, N = 859)
rs74795659(A)/8:73633099	KCNB2	(0.068, 0.15, P = 9e-06, N = 1956)	(0.023, 0.24, P = 0.12, N = 859)

Results from Univariable Mendelian Randomization of Ureidopropionic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	22	0.078 (0.032- 0.12) P=0.00087	97	87	0 (0- 30.6)	NA	NA	-0.0057 P=0.77
MR-Egger	22	0.089 (-0.0047- 0.18) P=0.077	97	87	0 (0- 30.6)	11	0.93	-0.0057 P=0.77
Weighted median	22	0.068 (-0.02- 0.16) P=0.13	97	87	0 (0- 30.6)	NA	NA	-0.0057 P=0.77

Results from Univariable MRPRESSO of Ureidopropionic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.08	0.02	3.33	0
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Ureidopropionic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	16	0.07 (0.029- 0.11) P=0.00097	113	71	0 (0- 0)	NA	NA	-0.011 P=0.64
MR-Egger	16	0.088 (-0.011- 0.19) P=0.1	113	71	0 (0- 0)	5.4	0.98	-0.011 P=0.64
Weighted median	16	0.068 (-0.028- 0.17) P=0.16	113	71	0 (0- 0)	NA	NA	-0.011 P=0.64

Results from Univariable MRPRESSO of Ureidopropionic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.07	0.02	3.3	0
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Aminoadipic acid

Instruments Associations with Aminoadipic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Aminoadipic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs75602737(C)/1:112433228	KCND3	(0.09, -0.24, P = 3.5e-07, N = 1829)	(0.049, 0.17, P = 0.12, N = 859)
rs16860185(A)/1:162294070*	NOS1AP	(0.099, 0.26, P = 6.7e-06, N = 1829)	(0.012, 0.28, P = 0.22, N = 859)
rs6689907(T)/1:201701481	NAV1	(0.41, 0.2, P = 7.6e-06, N = 1829)	(0.37, 0.054, P = 0.28, N = 859)
rs78186327(A)/1:26304015	PAFAH2	(0.27, -0.24, P = 7.8e-06, N = 1829)	(0.034, 0.16, P = 0.21, N = 859)
rs61783628(T)/1:29209107	EPB41	(0.34, -0.18, P = 1.9e-06, N = 1829)	(0.1, -0.097, P = 0.22, N = 859)
rs12414405(T)/10:12160108	DHTKD1	(0.11, -0.26, P = 2.5e-07, N = 1829)	(0.021, -0.051, P = 0.76, N = 859)
rs12925619(C)/16:13529326	U91319.1	(0.9, -0.3, P = 7.3e-06, N = 1829)	(0.98, -0.32, P = 0.033, N = 859)
rs1484093(T)/18:35705672	intergenic	(0.71, 0.14, P = 8.4e-06, N = 1829)	(0.95, -0.22, P = 0.055, N = 859)
rs9964369(T)/18:3773106	DLGAP1	(0.33, 0.14, P = 1.4e-07, N = 1829)	(0.46, -0.0031, P = 0.95, N = 859)
rs1606889(G)/18:44214176*	LOXHD1	(0.33, -0.18, P = 8.3e-06, N = 1829)	(0.25, -0.079, P = 0.15, N = 859)
rs2161489(C)/19:17864452*	FCHO1	(0.91, 0.3, P = 8.8e-06, N = 1829)	(0.72, 0.064, P = 0.24, N = 859)
rs58855003(G)/2:150736508	intergenic	(0.1, 0.25, P = 5.9e-06, N = 1829)	(0.029, -0.19, P = 0.17, N = 859)
rs115962459(A)/2:216452525	AC012668.2	(0.017, -0.62, P = 7e-06, N = 1829)	(0.024, -0.11, P = 0.48, N = 859)
rs3821665(A)/3:151133816*	MED12L	(0.51, -0.14, P = 2.4e-07, N = 1829)	(0.3, -0.0077, P = 0.88, N = 859)
rs901212(A)/4:152913308	intergenic	(0.29, -0.16, P = 4.5e-06, N = 1829)	(0.38, 0.065, P = 0.18, N = 859)
rs2319481(T)/4:168502795	intergenic	(0.61, 0.13, P = 3.1e-06, N = 1829)	(0.3, 0.048, P = 0.36, N = 859)
rs793814(A)/4:185354974	IRF2	(0.63, -0.18, P = 5.5e-06, N = 1829)	(0.78, -0.067, P = 0.26, N = 859)
rs6837120(T)/4:42649123	ATP8A1	(0.48, -0.12, P = 2.1e-06, N = 1829)	(0.42, 0.099, P = 0.039, N = 859)
rs163450(T)/5:111868863	intergenic	(0.077, -0.24, P = 5.1e-06, N = 1829)	(0.2, -0.006, P = 0.92, N = 859)
rs4716060(A)/6:16310456	ATXN1	(0.27, -0.17, P = 2.4e-06, N = 1829)	(0.72, -0.039, P = 0.46, N = 859)
rs876607(A)/6:16382649	ATXN1	(0.24, 0.17, P = 5e-06, N = 1829)	(0.43, 0.081, P = 0.1, N = 859)
rs9464891(T)/6:16389631*	ATXN1	(0.12, -0.25, P = 5e-06, N = 1829)	(0.23, 0.096, P = 0.087, N = 859)
rs2490034(A)/6:3870889	intergenic	(0.84, -0.26, P = 1.1e-06, N = 1829)	(0.95, -0.047, P = 0.67, N = 859)
rs9361533(G)/6:80137259	intergenic	(0.3, 0.2, P = 3.8e-06, N = 1829)	(0.36, -0.052, P = 0.29, N = 859)
rs3800636(C)/7:137402718*	DGKI	(0.34, -0.19, P = 8.9e-06, N = 1829)	(0.75, 0.0054, P = 0.93, N = 859)
rs3936106(A)/7:36731349	AOAH	(0.18, 0.23, P = 6.4e-07, N = 1829)	(0.32, 0.062, P = 0.23, N = 859)
rs7831286(G)/8:1122672	CTD-2281E23.2	(0.14, -0.15, P = 9.9e-06, N = 1829)	(0.12, 0.02, P = 0.78, N = 859)
rs2125392(C)/9:76536127	intergenic	(0.72, -0.19, P = 5e-06, N = 1829)	(0.3, -0.02, P = 0.71, N = 859)
rs13295599(A)/9:87584025	NTRK2	(0.072, -0.41, P = 6.7e-06, N = 1829)	(0.019, 0.19, P = 0.29, N = 859)

Results from Univariable Mendelian Randomization of Aminoadipic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	29	0.05 (-0.09- 0.19) P=0.48	24	38	19.1 (0- 72.3)	NA	NA	-0.032 P=0.52
MR-Egger	29	0.21 (-0.28- 0.69) P=0.41	24	38	19.1 (0- 72.3)	39	0.059	-0.032 P=0.52
Weighted median	29	0.18 (0.0086- 0.35) P=0.04	24	38	19.1 (0- 72.3)	NA	NA	-0.032 P=0.52

Results from Univariable MRPRESSO of Aminoadipic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.05	0.07	0.7	0.49
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Aminoadipic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	23	0.045 (-0.12- 0.21) P=0.6	24	30	18.3 (0- 76.1)	NA	NA	-0.043 P=0.45
MR-Egger	23	0.26 (-0.32- 0.84) P=0.39	24	30	18.3 (0- 76.1)	31	0.066	-0.043 P=0.45
Weighted median	23	0.18 (-0.031- 0.39) P=0.095	24	30	18.3 (0- 76.1)	NA	NA	-0.043 P=0.45

Results from Univariable MRPRESSO of Aminoadipic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.05	0.09	0.53	0.6
beta.exposure	Outlier-corrected	NA	NA	NA	NA

2-Hydroxyglutarate

Instruments Associations with 2-Hydroxyglutarate & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	2-Hydroxyglutarate (Shin et al/Long et al)	eGFR (CSSCD)
rs6664149(T)/1:160600521	SLAMF1	(0.98, 0.081, P = 2.9e-05, N = 7824)	(0.91, 0.053, P = 0.54, N = 859)
rs6540821(A)/1:214495298	SMYD2	(0.91, -0.24, P = 9.6e-06, N = 1945)	(0.96, -0.0039, P = 0.98, N = 859)
rs11122423(A)/1:232257914	intergenic	(0.26, -0.14, P = 8.9e-06, N = 1945)	(0.59, 0.05, P = 0.3, N = 859)
rs1670157(T)/10:67667698	CTNNA3	(0.35, -0.022, P = 3e-05, N = 7824)	(0.084, 0.12, P = 0.18, N = 859)
rs6484669(T)/11:11120287	intergenic	(0.74, -0.02, P = 7.8e-06, N = 7824)	(0.85, 0.057, P = 0.39, N = 859)
rs1647967(A)/11:130943681	intergenic	(0.17, 0.018, P = 1.6e-05, N = 7824)	(0.045, 0.1, P = 0.36, N = 859)
rs2949855(T)/11:93722540*	HPRTP4	(0.19, -0.029, P = 1.1e-05, N = 7824)	(0.12, 0.048, P = 0.52, N = 859)
rs7972211(A)/12:14269986*	intergenic	(0.76, -0.026, P = 2.6e-05, N = 7824)	(0.74, -0.037, P = 0.49, N = 859)
rs4459375(T)/12:48356881	TMEM106C	(0.53, 0.15, P = 6.9e-06, N = 1945)	(0.54, -0.036, P = 0.47, N = 859)
rs36031950(TA)/12:49754105	DNAJC22	(0.064, 0.14, P = 1.6e-06, N = 1945)	(0.64, 0.09, P = 0.067, N = 859)
rs16963602(T)/13:104501480*	intergenic	(0.99, -0.064, P = 3.5e-05, N = 7824)	(0.89, -0.052, P = 0.5, N = 859)
rs7320880(A)/13:24350292	MIPEP	(0.17, 0.018, P = 2.1e-05, N = 7824)	(0.34, 0.063, P = 0.2, N = 859)
rs9544785(A)/13:78971070*	RNF219-AS1	(0.36, -0.015, P = 6.6e-06, N = 7824)	(0.31, 0.022, P = 0.67, N = 859)
rs1053019(A)/14:102808273	ZNF839	(0.061, 0.027, P = 3.7e-05, N = 7824)	(0.17, -0.094, P = 0.16, N = 859)
rs4900072(T)/14:91636532	C14orf159	(0.35, 0.18, P = 2.9e-06, N = 1945)	(0.14, -0.023, P = 0.75, N = 859)
rs12587020(T)/14:91678546	C14orf159	(0.57, -0.013, P = 4.2e-05, N = 7824)	(0.18, 0.013, P = 0.84, N = 859)
rs12886872(T)/14:91678812*	C14orf159	(0.44, 0.013, P = 4.8e-05, N = 7824)	(0.82, -0.013, P = 0.84, N = 859)
rs1043239(A)/15:63618110*	CA12	(0.42, 0.017, P = 1.4e-05, N = 7824)	(0.61, 0.053, P = 0.28, N = 859)
rs937098(T)/15:68894559*	CORO2B	(0.14, -0.023, P = 1.4e-05, N = 7824)	(0.53, -0.032, P = 0.5, N = 859)
rs2689255(C)/16:54222800*	intergenic	(0.56, 0.17, P = 6.9e-07, N = 1945)	(0.55, -0.022, P = 0.65, N = 859)
rs57029062(GC)/16:72712738	RP5-991G20.1	(0.98, 0.15, P = 9e-06, N = 1945)	(0.82, 0.023, P = 0.71, N = 859)
rs12716966(C)/16:83253620*	CDH13	(0.71, -0.015, P = 1.4e-05, N = 7824)	(0.53, -0.012, P = 0.8, N = 859)
rs16977497(A)/17:71021645*	SLC39A11	(0.045, 0.054, P = 9.9e-06, N = 7824)	(0.014, -0.055, P = 0.78, N = 859)
rs632953(A)/18:22000799	intergenic	(0.9, -0.022, P = 1.2e-05, N = 7824)	(0.77, -0.0061, P = 0.92, N = 859)
rs17654263(T)/18:28178839	intergenic	(0.017, 0.055, P = 4.6e-05, N = 7824)	(0.024, 0.12, P = 0.42, N = 859)
rs7566877(T)/2:139994754	intergenic	(0.97, -0.04, P = 1.9e-05, N = 7824)	(0.87, 0.026, P = 0.72, N = 859)
rs10196007(T)/2:145329033	AC010090.1	(0.82, -0.032, P = 7.6e-07, N = 7824)	(0.64, -0.017, P = 0.74, N = 859)
rs78147778(C)/2:242682029	D2HGDH	(0.24, 0.27, P = 3.7e-09, N = 1945)	(0.22, -0.027, P = 0.64, N = 859)
rs6707874(G)/2:242709363	D2HGDH	(0.36, 0.27, P = 2.1e-12, N = 1945)	(0.71, 0.0033, P = 0.95, N = 859)
rs2314702(C)/2:4402929	intergenic	(0.42, 0.022, P = 4.1e-05, N = 7824)	(0.38, 0.056, P = 0.25, N = 859)
rs2555453(A)/2:64528233*	intergenic	(0.29, 0.014, P = 4.8e-05, N = 7824)	(0.28, 0.079, P = 0.14, N = 859)
rs12106014(C)/20:10015761	ANKEF1	(0.55, 0.18, P = 6.4e-07, N = 1945)	(0.79, 0.036, P = 0.54, N = 859)
rs17690784(A)/20:16929912	intergenic	(0.89, -0.023, P = 2.2e-05, N = 7824)	(0.98, -0.13, P = 0.5, N = 859)
rs6064820(T)/20:58206004	PHACTR3	(0.72, 0.015, P = 4e-06, N = 7824)	(0.62, 0.064, P = 0.22, N = 859)
rs2426843(A)/20:58380845*	PHACTR3	(0.93, -0.027, P = 3.3e-05, N = 7824)	(0.28, 0.038, P = 0.48, N = 859)
rs670752(A)/3:107312980*	BBX	(0.3, 0.015, P = 1.9e-05, N = 7824)	(0.28, -0.065, P = 0.21, N = 859)
rs1568101(T)/3:148590090	CPA3	(0.91, -0.025, P = 8.6e-06, N = 7824)	(0.93, -0.042, P = 0.64, N = 859)
rs11915217(A)/3:174027279*	intergenic	(0.31, -0.18, P = 5.9e-06, N = 1945)	(0.13, 0.074, P = 0.3, N = 859)
rs16832543(C)/3:181272496	SOX2-OT	(0.9, -0.021, P = 3.1e-05, N = 7824)	(0.8, 0.032, P = 0.6, N = 859)
rs12497680(A)/3:194573366	intergenic	(0.075, -0.35, P = 4.6e-07, N = 1945)	(0.081, 0.13, P = 0.15, N = 859)
rs73890624(A)/3:194752697	intergenic	(0.02, -0.58, P = 1.1e-06, N = 1945)	(0.15, -0.16, P = 0.022, N = 859)
rs17640193(A)/3:62569620*	CADPS	(0.07, 0.025, P = 2.1e-05, N = 7824)	(0.03, 0.28, P = 0.049, N = 859)
rs2575453(A)/4:42685758	intergenic	(0.75, 0.014, P = 4.8e-05, N = 7824)	(0.53, 0.024, P = 0.64, N = 859)
rs6834396(C)/4:5403998*	STK32B	(0.17, 0.035, P = 1.9e-05, N = 7824)	(0.71, -0.057, P = 0.28, N = 859)
rs344130(T)/4:77647590*	SHROOM3	(0.37, -0.014, P = 1.6e-05, N = 7824)	(0.56, 0.013, P = 0.79, N = 859)
rs6876258(A)/5:151191673	G3BP1	(0.18, 0.017, P = 4.7e-05, N = 7824)	(0.34, 0.061, P = 0.24, N = 859)
rs10475642(A)/5:157325495*	intergenic	(0.46, -0.014, P = 1.2e-05, N = 7824)	(0.6, 0.018, P = 0.71, N = 859)
rs7702827(C)/5:158879869	AC008703.1	(0.3, -0.015, P = 6.3e-06, N = 7824)	(0.17, -0.02, P = 0.75, N = 859)
rs17060337(A)/5:161872504*	intergenic	(0.011, -0.1, P = 9e-06, N = 7824)	(0.09, 0.041, P = 0.62, N = 859)
rs2122552(C)/5:165957260	intergenic	(0.028, -0.065, P = 4.3e-05, N = 7824)	(0.47, 0.0084, P = 0.86, N = 859)
rs6451885(C)/5:20715134*	RP11-774D14.1	(0.85, -0.27, P = 5.4e-06, N = 1945)	(0.9, 0.04, P = 0.62, N = 859)
rs7725624(A)/5:63010725*	intergenic	(0.086, -0.044, P = 3e-06, N = 7824)	(0.23, 0.051, P = 0.36, N = 859)
rs114947484(C)/6:121292872	intergenic	(0.058, 0.33, P = 3.9e-06, N = 1945)	(0.023, -0.13, P = 0.44, N = 859)
rs11964335(A)/6:149658101	TAB2	(0.49, -0.014, P = 1.2e-05, N = 7824)	(0.69, -0.023, P = 0.67, N = 859)
rs3757187(C)/6:28107654	ZKSCAN8	(0.22, 0.16, P = 1.9e-06, N = 1945)	(0.32, -0.023, P = 0.66, N = 859)
rs9395212(C)/6:46726441*	ANKRD66	(0.74, 0.23, P = 8.1e-07, N = 1945)	(0.92, -0.082, P = 0.33, N = 859)
rs10806320(A)/6:86000465	RP11-30P6.1	(0.22, 0.17, P = 5.7e-06, N = 1945)	(0.11, -0.024, P = 0.75, N = 859)
rs12174071(A)/6:98204538	intergenic	(0.88, 0.022, P = 1.6e-05, N = 7824)	(0.9, -0.035, P = 0.66, N = 859)
rs8176023(A)/7:142642596	KEL	(0.93, -0.041, P = 2.5e-06, N = 7824)	(0.99, -0.15, P = 0.52, N = 859)
rs17154808(T)/7:80788160	intergenic	(0.016, -0.089, P = 4.4e-05, N = 7824)	(0.13, -0.038, P = 0.59, N = 859)
rs933341(A)/7:83743619	SEMA3A	(0.24, 0.017, P = 1.6e-06, N = 7824)	(0.4, -0.01, P = 0.83, N = 859)
rs6558423(A)/8:1145909*	CTD-2281E23.2	(0.2, -0.018, P = 1.8e-05, N = 7824)	(0.42, -0.014, P = 0.78, N = 859)
rs11998124(T)/8:128085480	PCAT2	(0.053, 0.03, P = 4.9e-05, N = 7824)	(0.45, -0.0036, P = 0.94, N = 859)
rs890519(A)/8:18905049*	PSD3	(0.42, 0.015, P = 9.1e-06, N = 7824)	(0.38, -0.028, P = 0.57, N = 859)
rs11991231(C)/8:19907912*	intergenic	(0.11, -0.39, P = 1e-08, N = 1945)	(0.074, 0.11, P = 0.25, N = 859)
rs199605811(C)/8:54204040	intergenic	(0.027, 0.3, P = 3.4e-06, N = 1945)	(0.036, 0.15, P = 0.26, N = 859)
rs4837718(A)/9:122918241	intergenic	(0.75, -0.014, P = 4.8e-05, N = 7824)	(0.3, 0.089, P = 0.094, N = 859)
rs12341112(A)/9:22790893	RP11-399D6.2	(0.11, 0.021, P = 3.3e-05, N = 7824)	(0.4, 0.065, P = 0.18, N = 859)
rs10966201(T)/9:24079188	intergenic	(0.66, 0.015, P = 7.1e-06, N = 7824)	(0.66, 0.031, P = 0.54, N = 859)
rs10816013(T)/9:8942036*	PTPRD	(0.14, -0.19, P = 8.6e-06, N = 1945)	(0.035, -0.023, P = 0.86, N = 859)
rs1412466(T)/9:94282510	intergenic	(0.23, 0.19, P = 2.8e-07, N = 1945)	(0.29, 0.03, P = 0.58, N = 859)
rs4744059(C)/9:94337776	ROR2	(0.27, 0.18, P = 1.6e-07, N = 1945)	(0.74, 0.009, P = 0.87, N = 859)

Results from Univariable Mendelian Randomization of 2-Hydroxyglutarate & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	72	0.011 (-0.087- 0.11) P=0.82	9.5	33	4.61 (0- 4.54)	NA	NA	0.0028 P=0.76
MR-Egger	72	-0.0027 (-0.15- 0.14) P=0.97	9.5	33	4.61 (0- 4.54)	53	0.93	0.0028 P=0.76
Weighted median	72	-0.06 (-0.24- 0.12) P=0.52	9.5	33	4.61 (0- 4.54)	NA	NA	0.0028 P=0.76

Results from Univariable MRPRESSO of 2-Hydroxyglutarate & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.01	0.05	0.23	0.82
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of 2-Hydroxyglutarate & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	46	0.072 (-0.038- 0.18) P=0.2	9.8	22	4.72 (0- 16.7)	NA	NA	0.0054 P=0.65
MR-Egger	46	0.047 (-0.12- 0.21) P=0.58	9.8	22	4.72 (0- 16.7)	34	0.86	0.0054 P=0.65
Weighted median	46	0.015 (-0.19- 0.22) P=0.89	9.8	22	4.72 (0- 16.7)	NA	NA	0.0054 P=0.65

Results from Univariable MRPRESSO of 2-Hydroxyglutarate & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.07	0.06	1.29	0.2
beta.exposure	Outlier-corrected	NA	NA	NA	NA

3-Methyladipic acid

Instruments Associations with 3-Methyladipic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	3-Methyladipic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs10908821(G)/1:161008535*	TSTD1	(0.12, -0.19, P = 1.7e-07, N = 1947)	(0.08, 0.19, P = 0.035, N = 859)
rs76552190(C)/14:28430652	intergenic	(0.016, 0.65, P = 5.8e-06, N = 1947)	(0.019, 0.35, P = 0.05, N = 859)
rs7143798(G)/14:33637107*	NPAS3	(0.27, 0.2, P = 7.8e-06, N = 1947)	(0.47, 0.015, P = 0.76, N = 859)
rs2460846(C)/15:36035176	DPH6-AS1	(0.41, -0.13, P = 5.7e-06, N = 1947)	(0.63, -0.024, P = 0.62, N = 859)
rs11638741(C)/15:68734727*	intergenic	(0.98, -0.62, P = 7.7e-06, N = 1947)	(0.83, -0.092, P = 0.14, N = 859)
rs1694246(G)/18:51401250*	intergenic	(0.89, -0.17, P = 7.6e-06, N = 1947)	(0.73, -0.13, P = 0.022, N = 859)
rs637188(C)/18:58207240*	intergenic	(0.63, -0.11, P = 7.6e-06, N = 1947)	(0.45, -0.00074, P = 0.99, N = 859)
rs536042327(CT)/2:188187872	AC007319.1	(0.01, 0.48, P = 8.7e-06, N = 1947)	(0.4, -0.058, P = 0.24, N = 859)
rs6545578(C)/2:56784495*	intergenic	(0.84, 0.28, P = 1.2e-08, N = 1947)	(0.97, -0.0061, P = 0.96, N = 859)
rs10805124(C)/4:44310296	KCTD8	(0.67, -0.2, P = 9.7e-06, N = 1947)	(0.75, -0.028, P = 0.61, N = 859)
rs9292558(T)/5:34663830*	RAI14	(0.075, -0.27, P = 3.9e-06, N = 1947)	(0.052, 0.0091, P = 0.93, N = 859)
rs142983506(CAT)/6:126003666	RP1-293L8.2	(0.4, -0.13, P = 2.5e-06, N = 1947)	(0.24, -0.0098, P = 0.86, N = 859)
rs1185568(A)/6:25834428*	SLC17A1	(0.55, 0.4, P = 2.7e-30, N = 1947)	(0.89, -0.039, P = 0.62, N = 859)
rs56144311(C)/7:21660173*	DNAH11	(0.077, 0.26, P = 9.1e-06, N = 1947)	(0.27, 0.048, P = 0.38, N = 859)
rs113283332(A)/7:36047671	intergenic	(0.014, 0.73, P = 1e-06, N = 1947)	(0.25, -0.012, P = 0.83, N = 859)
rs112212379(A)/7:36052900	intergenic	(0.013, 0.69, P = 8.6e-06, N = 1947)	(0.067, 0.11, P = 0.24, N = 859)

Results from Univariable Mendelian Randomization of 3-Methyladipic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	16	0.046 (-0.048- 0.14) P=0.34	31	25	14.6 (0- 82.7)	NA	NA	0.015 P=0.66
MR-Egger	16	0.013 (-0.16- 0.19) P=0.89	31	25	14.6 (0- 82.7)	19	0.18	0.015 P=0.66
Weighted median	16	-0.0021 (-0.13- 0.13) P=0.97	31	25	14.6 (0- 82.7)	NA	NA	0.015 P=0.66

Results from Univariable MRPRESSO of 3-Methyladipic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.05	0.05	0.96	0.35
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of 3-Methyladipic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	7	0.015 (-0.099- 0.13) P=0.8	22	7.9	23.8 (0- 86.3)	NA	NA	0.014 P=0.78
MR-Egger	7	-0.013 (-0.23- 0.21) P=0.91	22	7.9	23.8 (0- 86.3)	6.9	0.23	0.014 P=0.78
Weighted median	7	-0.011 (-0.16- 0.13) P=0.88	22	7.9	23.8 (0- 86.3)	NA	NA	0.014 P=0.78

Results from Univariable MRPRESSO of 3-Methyladipic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.02	0.06	0.26	0.8
beta.exposure	Outlier-corrected	NA	NA	NA	NA

4-Pyridoxic acid

Instruments Associations with 4-Pyridoxic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	X4.pyridoxate (Shin et al/Long et al)	eGFR (CSSCD)
rs66994930(G)/1:14288571	intergenic	(0.098, 0.2, P = 3.7e-06, N = 1938)	(0.097, -0.08, P = 0.32, N = 859)
rs7531679(T)/1:160634341	intergenic	(0.9, 0.049, P = 9e-06, N = 7824)	(0.96, -0.18, P = 0.17, N = 859)
rs670874(A)/1:182678213	RP11-317P15.3	(0.42, -0.17, P = 1.3e-07, N = 1938)	(0.58, -0.042, P = 0.4, N = 859)
rs11119975(T)/1:212747722	ATF3	(0.15, -0.022, P = 1.4e-05, N = 7824)	(0.02, -0.089, P = 0.6, N = 859)
rs11118327(T)/1:219692313*	intergenic	(0.36, -0.017, P = 2.4e-05, N = 7824)	(0.067, 0.11, P = 0.22, N = 859)
rs11118329(A)/1:219701961	intergenic	(0.64, 0.016, P = 4.6e-05, N = 7824)	(0.93, -0.15, P = 0.12, N = 859)
rs1877156(G)/1:226313671	RP11-396C23.3	(0.59, 0.17, P = 8.3e-06, N = 1938)	(0.36, 0.061, P = 0.23, N = 859)
rs77069129(T)/1:246823978	CNST	(0.015, 0.51, P = 6.5e-06, N = 1938)	(0.21, -0.022, P = 0.72, N = 859)
rs1392744(C)/1:37327225	GRIK3	(0.94, 0.31, P = 6e-06, N = 1938)	(0.59, -0.025, P = 0.61, N = 859)
rs12025777(T)/1:41748897*	RP11-399E6.1	(0.072, -0.33, P = 6.5e-06, N = 1938)	(0.077, -0.091, P = 0.3, N = 859)
rs2125421(T)/1:96458324	RP11-147C23.1	(0.17, 0.02, P = 4.8e-05, N = 7824)	(0.37, 0.06, P = 0.23, N = 859)
rs6696033(T)/1:97595784	DPYD	(0.96, -0.055, P = 4.3e-06, N = 7824)	(0.81, -0.041, P = 0.5, N = 859)
rs12573136(C)/10:28303355	RP11-218D6.4	(0.11, 0.32, P = 9.8e-06, N = 1938)	(0.21, -0.064, P = 0.28, N = 859)
rs2123348(T)/10:4779211	intergenic	(0.78, 0.018, P = 1.3e-05, N = 7824)	(0.51, -0.047, P = 0.31, N = 859)
rs11214633(A)/11:113382519	intergenic	(0.022, 0.053, P = 3e-05, N = 7824)	(0.015, -0.038, P = 0.85, N = 859)
rs4755281(T)/11:44758398	RP11-45A12.2	(0.92, -0.03, P = 1.6e-05, N = 7824)	(0.72, -0.036, P = 0.5, N = 859)
rs111633747(A)/11:80237332	RNU6-544P	(0.092, -0.27, P = 8.6e-06, N = 1938)	(0.07, -0.03, P = 0.75, N = 859)
rs55995000(T)/12:33046205	PKP2	(0.15, 0.3, P = 5e-07, N = 1938)	(0.022, 0.23, P = 0.17, N = 859)
rs400120(A)/12:52831340*	KRT75	(0.65, 0.019, P = 1.3e-06, N = 7824)	(0.94, 0.074, P = 0.46, N = 859)
rs12814098(G)/12:5521537*	intergenic	(0.46, -0.17, P = 4.5e-07, N = 1938)	(0.17, -0.0078, P = 0.9, N = 859)
rs35619331(A)/12:5526184	intergenic	(0.21, 0.2, P = 6.8e-06, N = 1938)	(0.043, 0.067, P = 0.58, N = 859)
rs2183242(C)/13:21271776*	IL17D	(0.042, 0.04, P = 3.5e-05, N = 7824)	(0.11, 0.024, P = 0.76, N = 859)
rs1571295(T)/13:93116692	GPC5	(0.54, 0.014, P = 4.6e-05, N = 7824)	(0.74, -0.027, P = 0.62, N = 859)
rs9556658(A)/13:97678251*	intergenic	(0.87, 0.023, P = 4e-05, N = 7824)	(0.44, 0.034, P = 0.47, N = 859)
rs17750938(G)/14:94356089	intergenic	(0.091, -0.25, P = 5.6e-06, N = 1938)	(0.026, 0.063, P = 0.68, N = 859)
rs1370431(T)/15:61472687*	RP11-39M21.1	(0.63, -0.017, P = 1.4e-05, N = 7824)	(0.46, -0.056, P = 0.24, N = 859)
rs2572207(T)/15:66070693*	DENND4A	(0.25, -0.017, P = 4.3e-05, N = 7824)	(0.38, 0.13, P = 0.0088, N = 859)
rs10500486(A)/16:64027542*	intergenic	(0.057, 0.034, P = 3.5e-05, N = 7824)	(0.1, 0.064, P = 0.42, N = 859)
rs12931734(T)/16:8296086*	intergenic	(0.21, 0.022, P = 3.8e-06, N = 7824)	(0.088, -0.00049, P = 1, N = 859)
rs8097(G)/16:8953081	CARHSP1	(0.65, 0.18, P = 1.3e-06, N = 1938)	(0.35, -0.033, P = 0.53, N = 859)
rs13381663(T)/18:22860759	ZNF521	(0.79, -0.019, P = 3.7e-05, N = 7824)	(0.72, -0.11, P = 0.042, N = 859)
rs28367036(C)/18:23029962	intergenic	(0.093, 0.19, P = 3.3e-06, N = 1938)	(0.059, -0.063, P = 0.52, N = 859)
rs12965568(A)/18:31034308	intergenic	(0.34, 0.017, P = 1.4e-05, N = 7824)	(0.36, -0.029, P = 0.56, N = 859)
rs1431844(T)/18:40071148	LINC00907	(0.026, 0.056, P = 2.3e-06, N = 7824)	(0.11, 0.023, P = 0.76, N = 859)
rs12953402(T)/18:45852017*	ZBTB7C	(0.19, 0.021, P = 2.2e-05, N = 7824)	(0.16, 0.061, P = 0.35, N = 859)
rs73936950(C)/19:45241350	intergenic	(0.013, 0.72, P = 3.1e-06, N = 1938)	(0.11, -0.0054, P = 0.95, N = 859)
rs6752425(T)/2:159323562*	PKP4	(0.031, 0.097, P = 3.8e-06, N = 7824)	(0.16, 0.092, P = 0.15, N = 859)
rs4674858(T)/2:224916420	intergenic	(0.01, 0.15, P = 6.6e-06, N = 7824)	(0.038, -0.17, P = 0.18, N = 859)
rs11125947(T)/2:63334101*	RP11-511I11.1	(0.32, 0.018, P = 9.8e-06, N = 7824)	(0.4, 0.011, P = 0.82, N = 859)
rs6013068(C)/20:49662264	intergenic	(0.87, -0.19, P = 8.9e-06, N = 1938)	(0.98, -0.12, P = 0.45, N = 859)
rs6127732(T)/20:54933104	FAM210B	(0.052, 0.035, P = 2.8e-05, N = 7824)	(0.019, -0.14, P = 0.44, N = 859)
rs11908680(A)/20:6681348	intergenic	(0.96, -0.04, P = 2.8e-05, N = 7824)	(0.91, 0.071, P = 0.41, N = 859)
rs4817986(T)/21:40465512*	intergenic	(0.26, 0.018, P = 2e-05, N = 7824)	(0.13, 0.039, P = 0.58, N = 859)
rs5758632(T)/22:42578054	TCF20	(0.023, 0.053, P = 3e-05, N = 7824)	(0.072, -0.055, P = 0.55, N = 859)
rs7510746(A)/22:49796563	intergenic	(0.026, 0.6, P = 7.2e-06, N = 1938)	(0.39, 0.049, P = 0.32, N = 859)
rs1350932(C)/3:110527632	intergenic	(0.97, 0.5, P = 6.8e-07, N = 1938)	(0.72, -0.093, P = 0.086, N = 859)
rs10001753(T)/4:27786481*	intergenic	(0.021, 0.75, P = 6.3e-06, N = 1938)	(0.027, -0.15, P = 0.32, N = 859)
rs113718328(T)/5:178273952	intergenic	(0.017, 0.58, P = 4.9e-06, N = 1938)	(0.066, 0.056, P = 0.57, N = 859)
rs1878728(T)/6:118117328*	intergenic	(0.68, -0.017, P = 3.8e-05, N = 7824)	(0.63, 0.098, P = 0.041, N = 859)
rs11758777(T)/6:153798688*	intergenic	(0.77, 0.018, P = 7.7e-06, N = 7824)	(0.7, -0.056, P = 0.3, N = 859)
rs2197296(A)/6:160568997*	SLC22A1	(0.25, 0.021, P = 4.7e-06, N = 7824)	(0.12, -0.016, P = 0.83, N = 859)
rs7742715(A)/6:165298415*	intergenic	(0.36, 0.029, P = 6.6e-06, N = 7824)	(0.38, -0.03, P = 0.54, N = 859)
rs9393768(A)/6:26885619*	GUSBP2	(0.36, -0.017, P = 3.4e-05, N = 7824)	(0.59, 0.00081, P = 0.99, N = 859)
rs4959343(T)/6:5669950*	FARS2	(0.97, 0.37, P = 3.1e-06, N = 1938)	(0.65, -0.027, P = 0.59, N = 859)
rs2643196(G)/6:74262700*	RP11-505P4.7	(0.064, 0.3, P = 3.1e-06, N = 1938)	(0.17, 0.045, P = 0.49, N = 859)
rs6464172(A)/7:151506039	PRKAG2	(0.45, 0.027, P = 2.9e-05, N = 7824)	(0.63, -0.043, P = 0.38, N = 859)
rs4588750(A)/7:3403049	SDK1	(0.15, -0.23, P = 6.2e-06, N = 1938)	(0.17, -0.0079, P = 0.9, N = 859)
rs11761829(A)/7:36556697*	AOAH	(0.96, -0.062, P = 4.9e-05, N = 7824)	(0.64, 0.02, P = 0.69, N = 859)
rs4723965(A)/7:40540407	SUGCT	(0.86, 0.23, P = 6.1e-06, N = 1938)	(0.99, 0.047, P = 0.82, N = 859)
rs10950112(A)/7:67642170*	RP5-945F2.3	(0.71, 0.017, P = 4.7e-05, N = 7824)	(0.85, 0.0014, P = 0.98, N = 859)
rs6466258(A)/7:78143956	MAGI2	(0.57, 0.19, P = 9.8e-06, N = 1938)	(0.83, -0.017, P = 0.79, N = 859)
rs7842609(A)/8:105697775*	RP11-127H5.1	(0.48, -0.016, P = 3.4e-05, N = 7824)	(0.67, 0.066, P = 0.19, N = 859)
rs11984592(C)/8:16367919*	MSR1	(0.029, 0.49, P = 1.9e-06, N = 1938)	(0.57, -0.035, P = 0.48, N = 859)
rs62490090(G)/8:16376078	MSR1	(0.029, 0.46, P = 6.3e-06, N = 1938)	(0.011, 0.0045, P = 0.98, N = 859)
rs11204173(T)/8:21333478	intergenic	(0.82, -0.025, P = 2.4e-05, N = 7824)	(0.93, -0.022, P = 0.82, N = 859)
rs9314336(A)/8:26879523	intergenic	(0.19, 0.033, P = 2.5e-05, N = 7824)	(0.47, -0.014, P = 0.77, N = 859)
rs10099954(C)/8:27715891	intergenic	(0.34, 0.18, P = 8.2e-06, N = 1938)	(0.63, 0.025, P = 0.61, N = 859)
rs6988929(A)/8:38418517*	RP11-675F6.4	(0.034, 0.089, P = 2.9e-05, N = 7824)	(0.034, -0.089, P = 0.5, N = 859)
rs10820118(A)/9:105036692*	intergenic	(0.25, -0.018, P = 1.6e-05, N = 7824)	(0.33, 0.006, P = 0.91, N = 859)
rs4740188(T)/9:134698342	RP11-323H21.3	(0.4, 0.016, P = 4.7e-05, N = 7824)	(0.45, 0.017, P = 0.74, N = 859)
rs2383141(A)/9:20641181*	intergenic	(0.44, 0.016, P = 3.3e-05, N = 7824)	(0.68, 0.01, P = 0.84, N = 859)
rs1927938(T)/9:73921879	TRPM3	(0.15, -0.024, P = 1.4e-06, N = 7824)	(0.42, 0.014, P = 0.78, N = 859)

Results from Univariable Mendelian Randomization of 4-Pyridoxic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	72	-0.019 (-0.08- 0.042) P=0.54	11	38	0 (0- 25.9)	NA	NA	-0.0057 P=0.55
MR-Egger	72	-0.0033 (-0.089- 0.082) P=0.94	11	38	0 (0- 25.9)	56	0.89	-0.0057 P=0.55
Weighted median	72	-0.034 (-0.14- 0.067) P=0.5	11	38	0 (0- 25.9)	NA	NA	-0.0057 P=0.55

Results from Univariable MRPRESSO of 4-Pyridoxic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.02	0.03	-0.62	0.54
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of 4-Pyridoxic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	43	-0.013 (-0.081- 0.055) P=0.72	14	29	0.13 (0- 22.4)	NA	NA	-0.0021 P=0.88
MR-Egger	43	-0.007 (-0.11- 0.1) P=0.9	14	29	0.13 (0- 22.4)	31	0.88	-0.0021 P=0.88
Weighted median	43	-0.007 (-0.13- 0.11) P=0.91	14	29	0.13 (0- 22.4)	NA	NA	-0.0021 P=0.88

Results from Univariable MRPRESSO of 4-Pyridoxic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.03	-0.36	0.72
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Allantoin

Instruments Associations with Allantoin & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Allantoin (Shin et al/Long et al)	eGFR (CSSCD)
rs12136839(A)/1:147232488	GJA5	(0.95, -0.037, P = 4.4e-05, N = 7824)	(0.99, 0.11, P = 0.65, N = 859)
rs12132798(C)/1:216020536	USH2A	(0.97, 0.061, P = 2.1e-06, N = 7824)	(0.96, 0.057, P = 0.65, N = 859)
rs4579742(A)/1:239460167	intergenic	(0.13, 0.029, P = 5.2e-06, N = 7824)	(0.51, 0.065, P = 0.18, N = 859)
rs10799024(A)/1:30510681*	RP11-111I12.1	(0.32, 0.019, P = 4.2e-05, N = 7824)	(0.5, 0.011, P = 0.82, N = 859)
rs6659223(A)/1:39076845	intergenic	(0.68, -0.019, P = 3.9e-05, N = 7824)	(0.74, 0.12, P = 0.027, N = 859)
rs11211464(T)/1:47598032*	CYP4A22-AS1	(0.69, 0.046, P = 4.7e-05, N = 7824)	(0.68, 0.026, P = 0.61, N = 859)
rs2420679(A)/10:122035596*	intergenic	(0.26, 0.019, P = 4.1e-05, N = 7824)	(0.19, -0.0079, P = 0.9, N = 859)
rs7917625(T)/10:19294417*	intergenic	(0.63, -0.018, P = 4.5e-05, N = 7824)	(0.67, -0.004, P = 0.94, N = 859)
rs2388712(A)/10:8382503*	intergenic	(0.16, 0.024, P = 2.1e-05, N = 7824)	(0.025, 0.0037, P = 0.98, N = 859)
rs7122363(T)/11:116449283	intergenic	(0.17, -0.025, P = 4.5e-05, N = 7824)	(0.12, -0.017, P = 0.82, N = 859)
rs496084(A)/11:128976002*	ARHGAP32	(0.14, -0.063, P = 3.4e-05, N = 7824)	(0.09, 0.057, P = 0.51, N = 859)
rs895797(A)/11:131264611*	NTM	(0.22, -0.02, P = 4e-05, N = 7824)	(0.23, -0.019, P = 0.74, N = 859)
rs10492266(T)/12:115605697*	intergenic	(0.43, -0.017, P = 8.8e-06, N = 7824)	(0.74, -0.024, P = 0.67, N = 859)
rs10771223(A)/12:25651899*	IFLTD1	(0.78, 0.024, P = 2.9e-07, N = 7824)	(0.7, 0.076, P = 0.15, N = 859)
rs11171691(A)/12:39699101	KIF21A	(0.062, -0.088, P = 3.6e-05, N = 7824)	(0.012, -0.047, P = 0.84, N = 859)
rs699634(T)/12:64546423*	SRGAP1	(0.98, 0.23, P = 1.2e-05, N = 7824)	(0.81, 0.044, P = 0.47, N = 859)
rs167277(A)/12:78483079*	NAV3	(0.78, -0.021, P = 7.9e-06, N = 7824)	(0.83, -0.049, P = 0.45, N = 859)
rs9301035(A)/13:106155027*	DAOA-AS1	(0.43, 0.058, P = 1.8e-05, N = 7824)	(0.88, -0.066, P = 0.37, N = 859)
rs7985555(T)/13:24660336*	SPATA13	(0.55, -0.019, P = 4.3e-05, N = 7824)	(0.43, 0.029, P = 0.54, N = 859)
rs11147404(T)/13:30539456	intergenic	(0.89, 0.028, P = 8.7e-06, N = 7824)	(0.81, 0.03, P = 0.64, N = 859)
rs2480555(T)/13:71887309*	intergenic	(0.85, 0.023, P = 4.2e-05, N = 7824)	(0.75, 0.026, P = 0.65, N = 859)
rs17294670(T)/13:82296976*	intergenic	(0.96, -0.045, P = 3.2e-05, N = 7824)	(0.89, -0.043, P = 0.57, N = 859)
rs2329277(T)/13:84131308	intergenic	(0.17, 0.023, P = 2.2e-05, N = 7824)	(0.29, -0.11, P = 0.038, N = 859)
rs9555859(T)/13:89862800*	LINC01047	(0.97, -0.046, P = 3.7e-05, N = 7824)	(0.92, -0.0043, P = 0.96, N = 859)
rs8020559(T)/14:52490690	NID2	(0.84, -0.024, P = 2.2e-05, N = 7824)	(0.84, 0.012, P = 0.85, N = 859)
rs9323272(A)/14:55288924	intergenic	(0.33, 0.045, P = 3.8e-05, N = 7824)	(0.58, -0.029, P = 0.55, N = 859)
rs2293319(T)/15:31235357*	MTMR10	(0.79, -0.022, P = 3.6e-06, N = 7824)	(0.6, -0.0038, P = 0.94, N = 859)
rs2719726(A)/16:10779741*	TEKT5	(0.52, 0.02, P = 1e-05, N = 7824)	(0.3, 0.01, P = 0.85, N = 859)
rs9788926(A)/16:1807780*	MAPK8IP3	(0.76, 0.019, P = 4.9e-05, N = 7824)	(0.47, 0.00074, P = 0.99, N = 859)
rs11646986(T)/16:80855611	intergenic	(0.82, -0.023, P = 2.1e-05, N = 7824)	(0.77, 0.08, P = 0.16, N = 859)
rs2549842(T)/16:81023659*	CMC2	(0.79, -0.021, P = 8.7e-06, N = 7824)	(0.41, -0.023, P = 0.64, N = 859)
rs8064075(A)/16:87175636	C16orf95	(0.64, 0.047, P = 3.2e-05, N = 7824)	(0.22, -0.002, P = 0.97, N = 859)
rs11658900(A)/17:27095485*	FAM222B	(0.56, -0.016, P = 1e-05, N = 7824)	(0.096, -0.062, P = 0.46, N = 859)
rs8076290(A)/17:828023	NXN	(0.048, 0.061, P = 3.9e-05, N = 7824)	(0.33, 0.0063, P = 0.9, N = 859)
rs402573(T)/18:65248521*	RP11-638L3.1	(0.15, -0.024, P = 1.8e-05, N = 7824)	(0.21, 0.068, P = 0.23, N = 859)
rs8108144(T)/19:23373200	AC092329.1	(0.79, -0.023, P = 6.4e-07, N = 7824)	(0.83, 0.04, P = 0.52, N = 859)
rs2972521(A)/19:48476964*	BSPH1	(0.56, 0.02, P = 1.2e-05, N = 7824)	(0.22, -0.012, P = 0.83, N = 859)
rs11564620(T)/19:48571072	PLA2G4C	(0.9, -0.029, P = 3.4e-05, N = 7824)	(0.77, 0.07, P = 0.21, N = 859)
rs4347830(A)/2:228058016*	COL4A3	(0.34, 0.021, P = 2.7e-05, N = 7824)	(0.58, 0.0042, P = 0.93, N = 859)
rs1431793(A)/2:236173098	intergenic	(0.75, -0.022, P = 2.9e-06, N = 7824)	(0.71, 0.12, P = 0.027, N = 859)
rs17398510(A)/2:35129873*	AC012593.1	(0.88, -0.034, P = 2.2e-05, N = 7824)	(0.98, -0.0049, P = 0.97, N = 859)
rs8184921(T)/21:22372723*	NCAM2	(0.51, 0.017, P = 9.8e-06, N = 7824)	(0.36, 0.096, P = 0.056, N = 859)
rs5767976(A)/22:48158986	RP11-191L9.4	(0.53, -0.045, P = 1.6e-05, N = 7824)	(0.83, -0.045, P = 0.49, N = 859)
rs1499094(T)/3:1244434	CNTN6	(0.77, 0.021, P = 7.7e-06, N = 7824)	(0.61, 0.046, P = 0.34, N = 859)
rs4894514(A)/3:171558472*	TMEM212	(0.53, 0.018, P = 3.6e-05, N = 7824)	(0.68, -0.021, P = 0.69, N = 859)
rs6804104(A)/3:1756711*	intergenic	(0.85, -0.026, P = 1.5e-05, N = 7824)	(0.75, 0.04, P = 0.46, N = 859)
rs1799412(C)/3:40210125	MYRIP	(0.84, -0.026, P = 2.3e-06, N = 7824)	(0.82, 0.066, P = 0.29, N = 859)
rs1320934(A)/3:61884650	PTPRG	(0.96, 0.12, P = 1.5e-06, N = 7824)	(0.69, -0.039, P = 0.44, N = 859)
rs9834988(T)/3:79630364*	ROBO1	(0.53, 0.018, P = 8e-07, N = 7824)	(0.48, 0.011, P = 0.82, N = 859)
rs4698025(A)/4:10305157*	intergenic	(0.3, 0.019, P = 2.2e-05, N = 7824)	(0.27, -0.013, P = 0.81, N = 859)
rs312360(T)/4:19259131*	RP11-3J1.1	(0.82, 0.022, P = 4.7e-05, N = 7824)	(0.88, -0.043, P = 0.54, N = 859)
rs544236(T)/4:20235828*	intergenic	(0.82, 0.023, P = 2.2e-05, N = 7824)	(0.82, 0.027, P = 0.67, N = 859)
rs17553672(T)/4:24839564*	CCDC149	(0.82, 0.023, P = 2.1e-05, N = 7824)	(0.97, 0.2, P = 0.2, N = 859)
rs13117183(C)/4:43156439*	RP11-395F4.1	(0.14, -0.028, P = 1.3e-05, N = 7824)	(0.022, -0.25, P = 0.13, N = 859)
rs4705317(A)/5:148500566*	RN7SKP145	(0.61, 0.019, P = 2.6e-05, N = 7824)	(0.36, 0.064, P = 0.19, N = 859)
rs7723208(T)/5:174038768*	intergenic	(0.18, 0.023, P = 4.3e-05, N = 7824)	(0.2, -0.0099, P = 0.87, N = 859)
rs16867673(A)/5:38730230	intergenic	(0.96, 0.044, P = 3.4e-05, N = 7824)	(0.86, 0.079, P = 0.26, N = 859)
rs27223(T)/5:59752640*	SETP21	(0.64, -0.019, P = 3.5e-05, N = 7824)	(0.89, -0.12, P = 0.12, N = 859)
rs2068093(C)/6:114097900*	U3	(0.43, 0.044, P = 1.4e-05, N = 7824)	(0.52, -0.055, P = 0.26, N = 859)
rs12203935(A)/6:121276377*	intergenic	(0.17, -0.023, P = 3.5e-05, N = 7824)	(0.027, 0.08, P = 0.59, N = 859)
rs4869723(T)/6:151579432*	AKAP12	(0.44, -0.016, P = 4e-05, N = 7824)	(0.56, 0.068, P = 0.16, N = 859)
rs2064599(T)/6:47259683*	TNFRSF21	(0.54, 0.016, P = 2e-05, N = 7824)	(0.1, 0.018, P = 0.82, N = 859)
rs972709(A)/6:66255788	EYS	(0.65, 0.048, P = 6.7e-06, N = 7824)	(0.89, -0.07, P = 0.37, N = 859)
rs2875567(A)/6:90100643*	RRAGD	(0.89, 0.027, P = 2.2e-05, N = 7824)	(0.83, 0.053, P = 0.43, N = 859)
rs12189555(A)/6:91104402	intergenic	(0.77, 0.021, P = 5.1e-06, N = 7824)	(0.94, 0.07, P = 0.48, N = 859)
rs9377577(A)/6:96666785	FUT9	(0.21, -0.052, P = 2.2e-05, N = 7824)	(0.07, -0.14, P = 0.14, N = 859)
rs10953522(A)/7:106588426	intergenic	(0.53, 0.018, P = 4.3e-05, N = 7824)	(0.64, 0.067, P = 0.18, N = 859)
rs12718598(T)/7:50428445*	IKZF1	(0.52, 0.018, P = 1.5e-06, N = 7824)	(0.48, 0.01, P = 0.83, N = 859)
rs10505632(T)/8:135892340*	RP11-1057B8.2	(0.17, -0.023, P = 3e-05, N = 7824)	(0.083, 0.072, P = 0.39, N = 859)
rs965525(T)/8:22579627	PEBP4	(0.71, -0.019, P = 4.1e-05, N = 7824)	(0.5, 0.09, P = 0.055, N = 859)
rs17069778(A)/8:4121520*	CSMD1	(0.94, 0.034, P = 3.5e-05, N = 7824)	(0.82, 0.0015, P = 0.98, N = 859)
rs1447307(T)/8:94286040	RP11-388K12.2	(0.23, -0.021, P = 5.7e-06, N = 7824)	(0.21, 0.00097, P = 0.99, N = 859)
rs2781102(A)/9:122558384*	intergenic	(0.52, 0.016, P = 4.3e-05, N = 7824)	(0.66, -0.015, P = 0.77, N = 859)
rs12352353(A)/9:4743341*	AK3	(0.88, -0.027, P = 2.2e-05, N = 7824)	(0.87, 0.0049, P = 0.94, N = 859)

Results from Univariable Mendelian Randomization of Allantoin & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	74	-0.011 (-0.31- 0.29) P=0.94	2.4	2.3	0 (0- 26.7)	NA	NA	-0.0048 P=0.64
MR-Egger	74	0.072 (-0.4- 0.55) P=0.77	2.4	2.3	0 (0- 26.7)	60	0.83	-0.0048 P=0.64
Weighted median	74	0.18 (-0.35- 0.71) P=0.5	2.4	2.3	0 (0- 26.7)	NA	NA	-0.0048 P=0.64

Results from Univariable MRPRESSO of Allantoin & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.15	-0.07	0.94
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Allantoin & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	27	-0.28 (-0.89- 0.32) P=0.36	3	1	4.65e-05 (0- 74.7)	NA	NA	-0.029 P=0.22
MR-Egger	27	0.28 (-0.79- 1.4) P=0.61	3	1	4.65e-05 (0- 74.7)	31	0.18	-0.029 P=0.22
Weighted median	27	-0.22 (-1.1- 0.64) P=0.62	3	1	4.65e-05 (0- 74.7)	NA	NA	-0.029 P=0.22

Results from Univariable MRPRESSO of Allantoin & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.28	0.31	-0.91	0.37
beta.exposure	Outlier-corrected	NA	NA	NA	NA

2-Hydroxybutyric acid

Instruments Associations with 2-Hydroxybutyric acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	2-Hydroxybutyric acid (Shin et al/Long et al)	eGFR (CSSCD)
rs1517432(T)/1:103100912*	intergenic	(0.57, 0.011, P = 4.7e-05, N = 7824)	(0.14, -0.065, P = 0.35, N = 859)
rs12240227(A)/1:168586539	intergenic	(0.02, 0.085, P = 4.1e-05, N = 7824)	(0.15, 0.013, P = 0.85, N = 859)
rs627629(T)/1:238255344*	intergenic	(0.99, -0.11, P = 1e-05, N = 7824)	(0.78, -0.057, P = 0.31, N = 859)
rs3956419(A)/1:83836149	intergenic	(0.25, 0.017, P = 2.3e-05, N = 7824)	(0.056, 0.026, P = 0.81, N = 859)
rs7895521(A)/10:55856021*	PCDH15	(0.24, -0.014, P = 3.6e-05, N = 7824)	(0.075, -0.018, P = 0.85, N = 859)
rs224069(T)/10:64508126*	intergenic	(0.6, 0.011, P = 2.4e-05, N = 7824)	(0.93, 0.029, P = 0.77, N = 859)
rs10822058(A)/10:64523582*	intergenic	(0.55, -0.011, P = 3.4e-05, N = 7824)	(0.9, 0.0063, P = 0.94, N = 859)
rs1509960(A)/10:64620689	EGR2	(0.083, 0.026, P = 9.6e-06, N = 7824)	(0.095, -0.16, P = 0.059, N = 859)
rs7100223(T)/10:72788676*	intergenic	(0.55, 0.011, P = 3.4e-05, N = 7824)	(0.45, -0.0041, P = 0.93, N = 859)
rs11255096(T)/10:7418393	SFMBT2	(0.61, 0.012, P = 1e-05, N = 7824)	(0.41, 0.018, P = 0.72, N = 859)
rs1832826(T)/10:92122362*	intergenic	(0.92, -0.021, P = 3.8e-05, N = 7824)	(0.97, -0.17, P = 0.27, N = 859)
rs12808830(A)/11:134735855	intergenic	(0.93, -0.025, P = 4.6e-05, N = 7824)	(0.97, -0.004, P = 0.98, N = 859)
rs4388837(T)/11:26722592	SLC5A12	(0.98, 0.11, P = 4.2e-06, N = 7824)	(0.84, 0.13, P = 0.045, N = 859)
rs10161318(T)/12:107551308*	intergenic	(0.96, 0.032, P = 5.1e-06, N = 7824)	(0.74, 0.022, P = 0.69, N = 859)
rs3851600(C)/12:13040944*	GPRC5A	(0.78, -0.015, P = 1.3e-05, N = 7824)	(0.65, -0.016, P = 0.74, N = 859)
rs17122565(T)/12:48412410*	RP1-228P16.5	(0.25, -0.016, P = 2.8e-06, N = 7824)	(0.4, 0.056, P = 0.25, N = 859)
rs7985908(T)/13:100186218*	TM9SF2	(0.12, 0.019, P = 1e-05, N = 7824)	(0.18, -0.033, P = 0.6, N = 859)
rs4771522(A)/13:106774078*	intergenic	(0.58, 0.011, P = 2.6e-05, N = 7824)	(0.66, -0.001, P = 0.98, N = 859)
rs2146690(A)/13:108403984	FAM155A	(0.85, -0.025, P = 1.2e-05, N = 7824)	(0.8, 0.049, P = 0.42, N = 859)
rs4943375(T)/13:31985820*	intergenic	(0.57, 0.012, P = 1.6e-05, N = 7824)	(0.92, -0.071, P = 0.41, N = 859)
rs9532194(A)/13:38836709*	intergenic	(0.19, 0.017, P = 2.3e-05, N = 7824)	(0.02, -0.16, P = 0.37, N = 859)
rs4883910(A)/13:72997704*	intergenic	(0.56, -0.011, P = 3.4e-05, N = 7824)	(0.62, 0.017, P = 0.73, N = 859)
rs7141156(A)/14:33825093*	NPAS3	(0.3, -0.015, P = 1.8e-05, N = 7824)	(0.31, -0.063, P = 0.22, N = 859)
rs17101344(A)/14:33970832*	NPAS3	(0.78, -0.019, P = 5.6e-08, N = 7824)	(0.91, 0.1, P = 0.23, N = 859)
rs1959592(A)/14:43969823	intergenic	(0.6, 0.012, P = 1.4e-05, N = 7824)	(0.6, 0.014, P = 0.78, N = 859)
rs7401717(A)/14:54393139*	intergenic	(0.042, 0.037, P = 1.2e-05, N = 7824)	(0.3, 0.08, P = 0.13, N = 859)
rs9652375(C)/14:76781841*	ESRRB	(0.57, 0.011, P = 3.1e-05, N = 7824)	(0.53, -0.055, P = 0.25, N = 859)
rs2680344(A)/15:73653485	HCN4	(0.78, -0.015, P = 2.1e-05, N = 7824)	(0.39, 0.027, P = 0.59, N = 859)
rs7205092(T)/16:80945538*	intergenic	(0.79, -0.015, P = 3.4e-05, N = 7824)	(0.77, 0.059, P = 0.3, N = 859)
rs872745(A)/16:82578355*	intergenic	(0.41, -0.013, P = 4.9e-07, N = 7824)	(0.46, -0.05, P = 0.31, N = 859)
rs9303041(T)/17:11786569	DNAH9	(0.17, -0.017, P = 4.2e-05, N = 7824)	(0.17, -0.0091, P = 0.88, N = 859)
rs1684660(A)/17:42108351*	LSM12	(0.54, -0.012, P = 1.3e-05, N = 7824)	(0.14, 0.074, P = 0.28, N = 859)
rs473719(C)/18:22086993*	intergenic	(0.49, -0.012, P = 1.1e-05, N = 7824)	(0.15, -0.089, P = 0.19, N = 859)
rs7228646(C)/18:23027460	intergenic	(0.042, -0.031, P = 1.3e-05, N = 7824)	(0.13, -0.052, P = 0.47, N = 859)
rs1791285(T)/18:57366183	CCBE1	(0.85, 0.019, P = 2.6e-05, N = 7824)	(0.86, 0.069, P = 0.34, N = 859)
rs8085727(T)/18:72768073*	ZNF407	(0.82, -0.015, P = 1.4e-05, N = 7824)	(0.72, -0.031, P = 0.56, N = 859)
rs304729(A)/19:44084403*	XRCC1	(0.2, 0.015, P = 9.2e-06, N = 7824)	(0.15, -0.03, P = 0.65, N = 859)
rs729253(T)/2:117932237	intergenic	(0.58, 0.026, P = 7.5e-06, N = 7824)	(0.19, 0.019, P = 0.75, N = 859)
rs13430006(T)/2:219113089*	ARPC2	(0.5, -0.012, P = 1.4e-05, N = 7824)	(0.11, 0.1, P = 0.19, N = 859)
rs12470565(T)/2:240640112	intergenic	(0.57, 0.017, P = 1.1e-06, N = 7824)	(0.64, 0.03, P = 0.56, N = 859)
rs1260326(T)/2:27730940*	GCKR	(0.4, 0.014, P = 7.9e-08, N = 7824)	(0.14, -0.019, P = 0.79, N = 859)
rs3817588(T)/2:27731212*	GCKR	(0.81, 0.016, P = 4.6e-06, N = 7824)	(0.97, 0.1, P = 0.46, N = 859)
rs4477896(T)/2:33952413*	MYADML	(0.22, 0.015, P = 2.8e-05, N = 7824)	(0.38, -0.008, P = 0.88, N = 859)
rs4521014(A)/2:35539417*	intergenic	(0.4, -0.017, P = 5.2e-07, N = 7824)	(0.36, 0.045, P = 0.37, N = 859)
rs4670465(T)/2:35621644	intergenic	(0.55, -0.014, P = 6.4e-08, N = 7824)	(0.8, 0.056, P = 0.34, N = 859)
rs2861960(T)/2:80185514	CTNNA2	(0.87, -0.019, P = 8e-06, N = 7824)	(0.94, -0.087, P = 0.39, N = 859)
rs7579456(T)/2:84362453*	intergenic	(0.42, -0.012, P = 1.3e-05, N = 7824)	(0.73, -0.027, P = 0.62, N = 859)
rs16991515(A)/20:5915922	TRMT6	(0.95, 0.027, P = 4e-05, N = 7824)	(0.97, -0.097, P = 0.45, N = 859)
rs1560921(T)/3:10674308*	ATP2B2	(0.61, 0.011, P = 2.4e-05, N = 7824)	(0.56, 0.015, P = 0.76, N = 859)
rs9847650(A)/3:137301920	intergenic	(0.54, 0.011, P = 3e-05, N = 7824)	(0.29, 0.037, P = 0.49, N = 859)
rs4683620(A)/3:141410864*	RP11-340E6.1	(0.093, -0.025, P = 3.1e-05, N = 7824)	(0.1, 0.075, P = 0.35, N = 859)
rs4680105(A)/3:153553043*	RP11-23D24.2	(0.89, 0.019, P = 2.1e-05, N = 7824)	(0.98, -0.037, P = 0.82, N = 859)
rs7614971(A)/3:34187468	intergenic	(0.94, -0.025, P = 4.3e-05, N = 7824)	(0.9, -0.061, P = 0.45, N = 859)
rs11721212(T)/3:53639939*	CACNA1D	(0.77, 0.014, P = 3.3e-05, N = 7824)	(0.89, -0.078, P = 0.32, N = 859)
rs4697735(T)/4:10256289	AC006499.8	(0.017, 0.096, P = 5e-05, N = 7824)	(0.31, 0.021, P = 0.68, N = 859)
rs4692861(A)/4:169061427	ANXA10	(0.41, -0.012, P = 1.5e-05, N = 7824)	(0.53, 0.05, P = 0.3, N = 859)
rs2130909(A)/4:187588477	FAT1	(0.29, -0.018, P = 6.8e-06, N = 7824)	(0.5, 0.046, P = 0.35, N = 859)
rs12503695(C)/4:86925463*	ARHGAP24	(0.22, 0.029, P = 2.5e-05, N = 7824)	(0.48, 0.031, P = 0.52, N = 859)
rs5745297(A)/5:10680997*	DAP	(0.08, -0.022, P = 2e-05, N = 7824)	(0.013, 0.075, P = 0.72, N = 859)
rs40104(T)/5:115795101*	SEMA6A	(0.91, 0.029, P = 2.6e-05, N = 7824)	(0.75, -0.056, P = 0.32, N = 859)
rs163920(T)/5:141397272*	GNPDA1	(0.067, 0.029, P = 1.2e-05, N = 7824)	(0.061, 0.16, P = 0.11, N = 859)
rs864969(A)/5:56364907*	intergenic	(0.8, 0.015, P = 1.4e-05, N = 7824)	(0.71, 0.071, P = 0.18, N = 859)
rs287884(A)/6:157124080*	ARID1B	(0.44, -0.014, P = 2.4e-05, N = 7824)	(0.54, 0.035, P = 0.47, N = 859)
rs9347438(T)/6:161083633*	LPA	(0.44, 0.011, P = 3.9e-05, N = 7824)	(0.55, -0.01, P = 0.83, N = 859)
rs9477241(T)/6:16873952*	intergenic	(0.026, 0.041, P = 4.5e-05, N = 7824)	(0.15, 0.00062, P = 0.99, N = 859)
rs6934188(T)/6:19611159*	RP1-167F1.2	(0.5, 0.011, P = 3.8e-05, N = 7824)	(0.48, -0.031, P = 0.53, N = 859)
rs2067997(T)/6:35471246*	TULP1	(0.87, -0.021, P = 9.4e-07, N = 7824)	(0.8, 0.076, P = 0.21, N = 859)
rs2073465(A)/6:74229792*	EEF1A1	(0.81, 0.014, P = 4.2e-05, N = 7824)	(0.91, -0.18, P = 0.04, N = 859)
rs9389466(A)/6:96245744*	intergenic	(0.028, 0.043, P = 8e-06, N = 7824)	(0.057, -0.3, P = 0.0046, N = 859)
rs12542467(A)/8:124624056*	CTD-2552K11.2	(0.54, 0.011, P = 4.9e-05, N = 7824)	(0.25, -0.092, P = 0.1, N = 859)
rs13282582(T)/8:128577283*	intergenic	(0.045, 0.059, P = 2.4e-05, N = 7824)	(0.046, 0.14, P = 0.23, N = 859)
rs12677068(T)/8:29787927*	FAM183CP	(0.97, 0.038, P = 3.3e-05, N = 7824)	(0.98, 0.14, P = 0.45, N = 859)
rs2719320(A)/8:34187152*	RP1-84O15.2	(0.81, -0.015, P = 2.4e-05, N = 7824)	(0.52, -2.7e-05, P = 1, N = 859)
rs4376550(T)/9:109178658*	RP11-308N19.1	(0.34, -0.014, P = 4.5e-05, N = 7824)	(0.48, 0.0021, P = 0.97, N = 859)
rs7867311(A)/9:11790536*	intergenic	(0.59, 0.014, P = 1.7e-05, N = 7824)	(0.69, -0.0011, P = 0.98, N = 859)
rs10975189(T)/9:5590953	RP11-574F11.3	(0.059, 0.026, P = 1.9e-05, N = 7824)	(0.072, 0.085, P = 0.37, N = 859)
rs952045(T)/9:73161881*	TRPM3	(0.95, -0.029, P = 2e-05, N = 7824)	(0.77, -0.046, P = 0.42, N = 859)
rs2224580(A)/9:8142291*	intergenic	(0.22, 0.016, P = 1.1e-05, N = 7824)	(0.34, 0.033, P = 0.5, N = 859)
rs11788042(A)/9:81650381	KRT18P24	(0.24, 0.016, P = 1.9e-06, N = 7824)	(0.59, -0.0091, P = 0.86, N = 859)
rs876927(T)/9:88117073*	intergenic	(0.21, 0.016, P = 5.4e-06, N = 7824)	(0.29, -0.1, P = 0.059, N = 859)
rs2841680(A)/9:96161642	intergenic	(0.77, 0.015, P = 2e-05, N = 7824)	(0.82, 0.068, P = 0.3, N = 859)

Results from Univariable Mendelian Randomization of 2-Hydroxybutyric acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	81	0.26 (-0.16- 0.69) P=0.23	0.81	0.84	0 (0- 29.5)	NA	NA	-0.022 P=0.032
MR-Egger	81	0.79 (0.14- 1.5) P=0.021	0.81	0.84	0 (0- 29.5)	66	0.85	-0.022 P=0.032
Weighted median	81	0.41 (-0.29- 1.1) P=0.25	0.81	0.84	0 (0- 29.5)	NA	NA	-0.022 P=0.032

Results from Univariable MRPRESSO of 2-Hydroxybutyric acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.26	0.22	1.2	0.23
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of 2-Hydroxybutyric acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	25	0.45 (-0.064- 0.97) P=0.086	1	0.32	0 (0- 37.1)	NA	NA	-0.012 P=0.5
MR-Egger	25	0.67 (-0.22- 1.6) P=0.15	1	0.32	0 (0- 37.1)	16	0.87	-0.012 P=0.5
Weighted median	25	0.31 (-0.58- 1.2) P=0.5	1	0.32	0 (0- 37.1)	NA	NA	-0.012 P=0.5

Results from Univariable MRPRESSO of 2-Hydroxybutyric acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.45	0.26	1.72	0.1
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Beta-Alanine

Instruments Associations with Beta-Alanine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Beta-Alanine (Shin et al/Long et al)	eGFR (CSSCD)
rs4655453(T)/1:213785004*	AL592063.1	(0.091, 0.8, P = 3e-06, N = 1950)	(0.031, -0.083, P = 0.54, N = 859)
rs34954945(T)/1:34259238	CSMD2	(0.065, 0.17, P = 2.1e-06, N = 1950)	(0.16, 0.097, P = 0.15, N = 859)
rs10915665(T)/1:4093717	intergenic	(0.13, -0.2, P = 6.9e-06, N = 1950)	(0.3, 0.013, P = 0.81, N = 859)
rs7911319(G)/10:133273482	intergenic	(0.083, 0.58, P = 3.7e-06, N = 1950)	(0.073, -0.088, P = 0.35, N = 859)
rs79254065(A)/10:71415238	intergenic	(0.015, -0.26, P = 1.6e-06, N = 1950)	(0.097, -0.13, P = 0.11, N = 859)
rs12560861(G)/13:21073518	CRYL1	(0.2, -0.46, P = 4e-06, N = 1950)	(0.15, 0.0028, P = 0.97, N = 859)
rs7150563(C)/14:98762345*	intergenic	(0.4, -0.29, P = 2.8e-06, N = 1950)	(0.37, 0.076, P = 0.13, N = 859)
rs4558436(C)/16:7336322	RBFOX1	(0.88, -0.66, P = 5.5e-06, N = 1950)	(0.92, -0.27, P = 0.0028, N = 859)
rs62079516(G)/17:80341546	RP13-20L14.1	(0.19, -0.27, P = 8e-06, N = 1950)	(0.085, -0.048, P = 0.58, N = 859)
rs62132077(C)/2:17766094*	VSNL1	(0.017, 0.17, P = 4.7e-06, N = 1950)	(0.028, 0.25, P = 0.08, N = 859)
rs2327549(T)/20:12354153*	intergenic	(0.98, 0.81, P = 7.5e-06, N = 1950)	(0.54, 0.063, P = 0.19, N = 859)
rs5753833(T)/22:32355076	YWHAH	(0.17, -0.28, P = 7.5e-06, N = 1950)	(0.096, -0.018, P = 0.83, N = 859)
rs6800284(T)/3:30758956*	intergenic	(0.44, 0.22, P = 1.2e-21, N = 1950)	(0.79, 0.0081, P = 0.89, N = 859)
rs10676924(TTG)/3:30798395	GADL1	(0.78, 0.35, P = 1.3e-06, N = 1950)	(0.96, 0.31, P = 0.011, N = 859)
rs58714970(TC)/3:30808056*	GADL1	(0.43, -0.17, P = 7.4e-07, N = 1950)	(0.47, 0.011, P = 0.83, N = 859)
rs9968671(T)/5:39141990*	FYB	(0.2, -0.17, P = 6.8e-06, N = 1950)	(0.37, -0.057, P = 0.28, N = 859)
rs535532587(CA)/5:79976241	MSH3	(0.066, 0.52, P = 7.1e-06, N = 1950)	(0.18, 0.017, P = 0.79, N = 859)
rs7037419(T)/9:103103281	TEX10	(0.14, 0.16, P = 4.3e-06, N = 1950)	(0.16, 0.015, P = 0.82, N = 859)
rs12341435(G)/9:38575602	ANKRD18A	(0.027, -0.65, P = 2.4e-06, N = 1950)	(0.068, 0.017, P = 0.86, N = 859)

Results from Univariable Mendelian Randomization of Beta-Alanine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	19	0.07 (-0.02- 0.16) P=0.13	65	60	28.1 (0- 83.2)	NA	NA	0.013 P=0.72
MR-Egger	19	0.043 (-0.13- 0.22) P=0.64	65	60	28.1 (0- 83.2)	27	0.065	0.013 P=0.72
Weighted median	19	0.064 (-0.048- 0.18) P=0.26	65	60	28.1 (0- 83.2)	NA	NA	0.013 P=0.72

Results from Univariable MRPRESSO of Beta-Alanine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.07	0.05	1.53	0.14
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Beta-Alanine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	12	0.11 (-0.031- 0.25) P=0.13	65	38	37.9 (0- 83.2)	NA	NA	0.033 P=0.61
MR-Egger	12	0.032 (-0.29- 0.35) P=0.85	65	38	37.9 (0- 83.2)	17	0.069	0.033 P=0.61
Weighted median	12	0.0066 (-0.16- 0.17) P=0.94	65	38	37.9 (0- 83.2)	NA	NA	0.033 P=0.61

Results from Univariable MRPRESSO of Beta-Alanine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.11	0.07	1.52	0.16
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Betaine

Instruments Associations with Betaine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Betaine (Shin et al/Long et al)	eGFR (CSSCD)
rs1538475(A)/1:187534056	FDPSP1	(0.68, 0.01, P = 2.4e-05, N = 7824)	(0.77, 0.036, P = 0.53, N = 859)
rs12569219(A)/1:203762990*	ZBED6	(0.16, -0.012, P = 5.8e-06, N = 7824)	(0.14, -0.064, P = 0.35, N = 859)
rs650264(T)/1:20911830	CDA	(0.097, -0.015, P = 2.1e-05, N = 7824)	(0.25, 0.065, P = 0.24, N = 859)
rs943523(A)/1:53947922	intergenic	(0.89, -0.014, P = 4.7e-05, N = 7824)	(0.44, 0.081, P = 0.094, N = 859)
rs232782(A)/1:59128237*	MYSM1	(0.17, 0.011, P = 3e-05, N = 7824)	(0.41, -0.026, P = 0.57, N = 859)
rs7896866(A)/10:101339828	intergenic	(0.3, 0.011, P = 8.3e-06, N = 7824)	(0.42, -0.046, P = 0.35, N = 859)
rs1926205(A)/10:20210789	PLXDC2	(0.029, 0.38, P = 4.9e-06, N = 1958)	(0.065, 0.075, P = 0.45, N = 859)
rs7126003(T)/11:10888433*	ZBED5-AS1	(0.63, 0.018, P = 2.6e-06, N = 7824)	(0.79, 0.013, P = 0.82, N = 859)
rs7931762(A)/11:43197753*	HNRNPKP3	(0.84, -0.011, P = 3.6e-05, N = 7824)	(0.81, -0.01, P = 0.87, N = 859)
rs11111121(A)/12:102397730	DRAM1	(0.99, -0.066, P = 3.8e-05, N = 7824)	(0.95, 0.065, P = 0.57, N = 859)
rs2291918(T)/12:280761	IQSEC3	(0.38, 0.011, P = 1.1e-05, N = 7824)	(0.4, 0.052, P = 0.3, N = 859)
rs709217(T)/12:92526809	C12orf79	(0.5, -0.0073, P = 3.8e-05, N = 7824)	(0.51, 0.085, P = 0.079, N = 859)
rs8002031(A)/13:113285643*	intergenic	(0.026, 0.16, P = 7.8e-07, N = 1958)	(0.19, -0.0084, P = 0.89, N = 859)
rs9600122(C)/13:73968602	intergenic	(0.92, -0.017, P = 4.3e-05, N = 7824)	(0.84, -0.035, P = 0.58, N = 859)
rs3861122(T)/13:74076150	LINC00393	(0.16, -0.011, P = 3.4e-05, N = 7824)	(0.1, -0.16, P = 0.039, N = 859)
rs16944928(A)/13:91572636	LINC00410	(0.98, -0.037, P = 3.8e-05, N = 7824)	(0.86, 0.013, P = 0.85, N = 859)
rs12887798(T)/14:87693931	intergenic	(0.19, -0.17, P = 1.9e-06, N = 1958)	(0.2, 0.023, P = 0.7, N = 859)
rs17223831(A)/14:90601920	KCNK13	(0.11, 0.014, P = 4.9e-05, N = 7824)	(0.072, 0.037, P = 0.7, N = 859)
rs1285777(A)/14:91802285*	CCDC88C	(0.92, -0.016, P = 1.1e-05, N = 7824)	(0.9, 0.0015, P = 0.99, N = 859)
rs8021497(A)/14:93567618*	ITPK1	(0.21, 0.019, P = 4.7e-05, N = 7824)	(0.45, -0.0079, P = 0.87, N = 859)
rs5814078(GTTGT)/15:81935875	CTD-2034I4.1	(0.49, 0.2, P = 8.8e-06, N = 1958)	(0.93, -0.023, P = 0.8, N = 859)
rs6602982(A)/15:84257744*	SH3GL3	(0.49, -0.0074, P = 3.4e-05, N = 7824)	(0.54, 0.0018, P = 0.97, N = 859)
rs12447365(A)/16:14462949*	RP11-65J21.1	(0.21, -0.011, P = 2.9e-05, N = 7824)	(0.069, 0.061, P = 0.52, N = 859)
rs10153066(T)/16:7257971*	RBFOX1	(0.44, 0.0085, P = 2.1e-06, N = 7824)	(0.45, -0.088, P = 0.07, N = 859)
rs984327(A)/16:7772217*	SNORA40	(0.71, -0.017, P = 4e-05, N = 7824)	(0.56, -0.0077, P = 0.87, N = 859)
rs8059060(A)/16:89191264	ACSF3	(0.89, 0.025, P = 3.5e-05, N = 7824)	(0.61, -0.049, P = 0.31, N = 859)
rs4646359(T)/17:17470609*	PEMT	(0.53, -0.0083, P = 3.2e-06, N = 7824)	(0.32, -0.016, P = 0.76, N = 859)
rs2345424(A)/17:71233783	C17orf80	(0.99, -0.079, P = 2.3e-05, N = 7824)	(0.8, 0.022, P = 0.71, N = 859)
rs2729411(T)/18:28142042	intergenic	(0.24, 0.018, P = 4.9e-05, N = 7824)	(0.54, -0.0054, P = 0.91, N = 859)
rs8090293(A)/18:4031916	DLGAP1	(0.53, -0.019, P = 2e-05, N = 7824)	(0.52, 0.061, P = 0.2, N = 859)
rs7229475(G)/18:6514018*	C18orf64	(0.29, -1, P = 3.4e-06, N = 1958)	(0.66, 0.025, P = 0.62, N = 859)
rs7246788(T)/19:18575450*	ELL	(0.2, 0.011, P = 1.4e-05, N = 7824)	(0.22, -0.13, P = 0.024, N = 859)
rs9305014(A)/19:24306763	ZNF254	(0.92, 0.017, P = 4.7e-05, N = 7824)	(0.65, 0.072, P = 0.16, N = 859)
rs12151827(T)/2:135673387*	CCNT2	(0.82, -0.014, P = 6.3e-08, N = 7824)	(0.76, 0.044, P = 0.43, N = 859)
rs724394(A)/2:139854856	intergenic	(0.82, -0.011, P = 2e-05, N = 7824)	(0.93, 0.09, P = 0.33, N = 859)
rs78989095(A)/2:211534417*	CPS1	(0.037, 0.12, P = 4.1e-06, N = 1958)	(0.066, -0.096, P = 0.32, N = 859)
rs715(T)/2:211543055*	CPS1	(0.71, 0.022, P = 2.1e-19, N = 7824)	(0.81, -0.061, P = 0.33, N = 859)
rs11887861(A)/2:211548693*	CPS1	(0.34, 0.013, P = 1.4e-07, N = 7824)	(0.37, -0.11, P = 0.026, N = 859)
rs13021675(T)/2:211661935*	intergenic	(0.2, -0.012, P = 1.8e-06, N = 7824)	(0.16, -0.072, P = 0.28, N = 859)
rs11685209(T)/2:77658045	LRRTM4	(0.37, -0.016, P = 2.9e-05, N = 7824)	(0.51, -0.032, P = 0.5, N = 859)
rs6118048(A)/20:8051081	intergenic	(0.16, 0.011, P = 4.5e-05, N = 7824)	(0.16, -0.017, P = 0.79, N = 859)
rs8131547(T)/21:44320989	NDUFV3	(0.53, 0.01, P = 1.3e-05, N = 7824)	(0.71, -0.0069, P = 0.89, N = 859)
rs2851391(T)/21:44487404*	CBS	(0.46, -0.012, P = 1.1e-11, N = 7824)	(0.24, -0.027, P = 0.63, N = 859)
rs134790(T)/22:27653397*	intergenic	(0.84, -0.011, P = 1.9e-05, N = 7824)	(0.91, -0.17, P = 0.049, N = 859)
rs2227089(T)/22:36645089*	APOL1	(0.4, -0.2, P = 3.9e-07, N = 1958)	(0.28, 0.0031, P = 0.95, N = 859)
rs16835527(C)/3:124205980	KALRN	(0.82, -0.011, P = 1.8e-05, N = 7824)	(0.95, 0.1, P = 0.35, N = 859)
rs2700868(T)/3:182440135*	intergenic	(0.15, 0.26, P = 5.9e-06, N = 1958)	(0.2, 0.095, P = 0.11, N = 859)
rs11410898(AT)/3:184771382	VPS8	(0.26, -0.17, P = 8.7e-06, N = 1958)	(0.15, 0.022, P = 0.75, N = 859)
rs10937433(C)/3:190177112	intergenic	(0.5, 0.008, P = 6.6e-06, N = 7824)	(0.68, 0.069, P = 0.18, N = 859)
rs1195362(A)/3:190823801	intergenic	(0.95, -0.041, P = 3.4e-05, N = 7824)	(0.99, 0.062, P = 0.78, N = 859)
rs7668550(T)/4:104384356*	intergenic	(0.016, -0.037, P = 5.5e-06, N = 7824)	(0.24, -0.064, P = 0.25, N = 859)
rs13104073(T)/4:127695984	intergenic	(0.01, -0.087, P = 3.5e-05, N = 7824)	(0.069, 0.049, P = 0.61, N = 859)
rs10033669(T)/4:177189004	ASB5	(0.089, 0.017, P = 1.5e-05, N = 7824)	(0.08, -0.059, P = 0.51, N = 859)
rs17494639(T)/4:80218062	LINC01088	(0.83, -0.011, P = 3.2e-05, N = 7824)	(0.97, 0.21, P = 0.1, N = 859)
rs11943623(A)/4:86554948	ARHGAP24	(0.17, -0.011, P = 8.4e-06, N = 7824)	(0.17, -0.11, P = 0.081, N = 859)
rs17481649(T)/5:115305573*	AQPEP	(0.063, -0.019, P = 1.1e-05, N = 7824)	(0.078, 0.063, P = 0.48, N = 859)
rs154555(G)/5:115797852	SEMA6A	(0.57, -0.46, P = 1.7e-06, N = 1958)	(0.26, -0.052, P = 0.34, N = 859)
rs4476723(T)/5:11796865*	CTNND2	(0.98, -0.16, P = 5.7e-06, N = 1958)	(0.63, -0.081, P = 0.11, N = 859)
rs34199803(CTT)/5:122043333	RP11-166A12.1	(0.014, -0.9, P = 7.9e-07, N = 1958)	(0.48, 0.024, P = 0.62, N = 859)
rs164372(T)/5:160621043	intergenic	(0.8, 0.012, P = 2.6e-06, N = 7824)	(0.63, -0.022, P = 0.66, N = 859)
rs2319470(A)/5:24532664	CDH10	(0.51, -0.0074, P = 3.3e-05, N = 7824)	(0.29, -0.046, P = 0.39, N = 859)
rs3797248(A)/5:53509186*	ARL15	(0.17, 0.012, P = 4.6e-06, N = 7824)	(0.1, -0.086, P = 0.29, N = 859)
rs6862283(T)/5:78319638*	DMGDH	(0.7, 0.019, P = 7.9e-16, N = 7824)	(0.34, 0.043, P = 0.4, N = 859)
rs16876394(T)/5:78346769*	DMGDH	(0.9, 0.03, P = 1.5e-19, N = 7824)	(0.91, -0.064, P = 0.44, N = 859)
rs16876498(T)/5:78402594*	DMGDH	(0.9, 0.03, P = 2.5e-19, N = 7824)	(0.89, 0.00093, P = 0.99, N = 859)
rs1275103(C)/5:78448105*	DMGDH	(0.61, -0.015, P = 6.8e-11, N = 7824)	(0.35, -0.051, P = 0.31, N = 859)
rs17206977(A)/5:85387218	PTP4A1P4	(0.92, -0.017, P = 2.9e-05, N = 7824)	(0.97, -0.052, P = 0.69, N = 859)
rs7763624(A)/6:157418960	ARID1B	(0.56, -0.2, P = 5e-06, N = 1958)	(0.53, 0.013, P = 0.79, N = 859)
rs9457843(T)/6:160560933*	SLC22A1	(0.12, 0.015, P = 1.1e-05, N = 7824)	(0.14, 0.016, P = 0.82, N = 859)
rs662138(C)/6:160564476*	SLC22A1	(0.83, 0.011, P = 1.3e-05, N = 7824)	(0.95, 0.099, P = 0.35, N = 859)
rs203887(T)/6:28021269	OR2B8P	(0.23, -0.011, P = 2.3e-05, N = 7824)	(0.39, -0.016, P = 0.75, N = 859)
rs1535039(T)/6:29411432*	OR11A1	(0.91, 0.018, P = 4.5e-07, N = 7824)	(0.99, 0.16, P = 0.45, N = 859)
rs7751856(A)/6:32698988*	HLA-DQB3	(0.52, 0.0074, P = 3.7e-05, N = 7824)	(0.31, 0.051, P = 0.33, N = 859)
rs9462856(T)/6:42926024*	GNMT	(0.47, -0.0093, P = 2e-07, N = 7824)	(0.14, -0.089, P = 0.19, N = 859)
rs4327704(A)/6:57920632	intergenic	(0.95, -0.022, P = 9.9e-06, N = 7824)	(0.98, -0.15, P = 0.36, N = 859)
rs410300(G)/6:9030949	intergenic	(0.25, -0.23, P = 8.3e-06, N = 1958)	(0.18, 0.038, P = 0.53, N = 859)
rs9445037(T)/6:93587599*	intergenic	(0.53, -0.0077, P = 1.7e-05, N = 7824)	(0.16, -0.1, P = 0.12, N = 859)
rs2396726(T)/7:114021410	FOXP2	(0.54, -0.018, P = 4.5e-06, N = 7824)	(0.21, 0.04, P = 0.5, N = 859)
rs7781104(T)/7:145158487	intergenic	(0.27, 0.021, P = 7.8e-06, N = 7824)	(0.51, 0.035, P = 0.46, N = 859)
rs2304396(C)/8:131833823*	ADCY8	(0.083, 0.26, P = 4e-06, N = 1958)	(0.092, -0.012, P = 0.88, N = 859)
rs2705084(A)/8:17386831*	SLC7A2	(0.44, 0.0073, P = 4e-05, N = 7824)	(0.62, -0.012, P = 0.81, N = 859)
rs7822571(T)/8:40576179*	ZMAT4	(0.46, -0.0074, P = 3.1e-05, N = 7824)	(0.4, -0.057, P = 0.25, N = 859)
rs9886534(T)/8:40676655*	ZMAT4	(0.51, -0.0079, P = 8.7e-06, N = 7824)	(0.29, 0.0047, P = 0.93, N = 859)
rs12708158(T)/8:54835697	RGS20	(0.91, 0.026, P = 4.3e-05, N = 7824)	(0.97, 0.14, P = 0.37, N = 859)
rs523224(T)/8:93522691*	RP11-587H10.1	(0.19, -0.011, P = 2.2e-05, N = 7824)	(0.042, -0.14, P = 0.26, N = 859)
rs1545203(T)/9:112119690*	intergenic	(0.081, -0.017, P = 3.1e-05, N = 7824)	(0.022, -0.26, P = 0.12, N = 859)
rs2249768(A)/9:24542184	IZUMO3	(0.3, 0.19, P = 7.7e-06, N = 1958)	(0.31, 0.019, P = 0.71, N = 859)
rs13292748(C)/9:8727087	PTPRD	(0.14, -0.21, P = 9.9e-06, N = 1958)	(0.026, -0.084, P = 0.58, N = 859)

Results from Univariable Mendelian Randomization of Betaine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	88	-0.0034 (-0.064- 0.058) P=0.91	23	71	3.69e-05 (0- 96.4)	NA	NA	0.0026 P=0.72
MR-Egger	88	-0.0085 (-0.077- 0.06) P=0.81	23	71	3.69e-05 (0- 96.4)	82	0.6	0.0026 P=0.72
Weighted median	88	-0.026 (-0.11- 0.058) P=0.55	23	71	3.69e-05 (0- 96.4)	NA	NA	0.0026 P=0.72

Results from Univariable MRPRESSO of Betaine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.03	-0.11	0.91
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Betaine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	45	-0.0076 (-0.088- 0.073) P=0.85	11	24	0.00206 (0- 96.3)	NA	NA	-0.0026 P=0.8
MR-Egger	45	-0.002 (-0.1- 0.096) P=0.97	11	24	0.00206 (0- 96.3)	37	0.74	-0.0026 P=0.8
Weighted median	45	-0.013 (-0.14- 0.12) P=0.85	11	24	0.00206 (0- 96.3)	NA	NA	-0.0026 P=0.8

Results from Univariable MRPRESSO of Betaine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.04	-0.19	0.85
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Carnitine

Instruments Associations with L-Carnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Carnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs12725366(A)/1:105904171	intergenic	(0.48, -0.0041, P = 5.5e-06, N = 7824)	(0.37, 0.031, P = 0.53, N = 859)
rs3754439(A)/1:110615094	ALX3	(0.4, -0.0066, P = 2.3e-13, N = 7824)	(0.26, -0.02, P = 0.72, N = 859)
rs1466788(A)/1:110618730	STRIP1	(0.41, -0.0074, P = 3.1e-16, N = 7824)	(0.3, -0.013, P = 0.8, N = 859)
rs17032183(A)/1:114603297	intergenic	(0.096, -0.0071, P = 3.9e-05, N = 7824)	(0.21, 0.044, P = 0.45, N = 859)
rs61810757(C)/1:115846181	NGF	(0.81, -0.24, P = 8.8e-06, N = 1954)	(0.91, -0.0089, P = 0.92, N = 859)
rs17370344(A)/1:164263810	intergenic	(0.64, -0.0047, P = 1.7e-07, N = 7824)	(0.84, 0.12, P = 0.082, N = 859)
rs4534357(A)/1:168167139	TIPRL	(0.84, 0.0069, P = 1.8e-05, N = 7824)	(0.61, 0.03, P = 0.56, N = 859)
rs17613936(T)/1:193938169	intergenic	(0.16, 0.19, P = 8.2e-06, N = 1954)	(0.027, 0.064, P = 0.66, N = 859)
rs10920115(T)/1:201071884	CACNA1S	(0.55, 0.0044, P = 1.6e-06, N = 7824)	(0.34, 0.0011, P = 0.98, N = 859)
rs10800765(T)/1:201216597	intergenic	(0.46, -0.0039, P = 1.8e-05, N = 7824)	(0.12, -0.074, P = 0.31, N = 859)
rs7551550(A)/1:20437764	PLA2G2D	(0.47, -0.004, P = 1.1e-05, N = 7824)	(0.66, -0.02, P = 0.69, N = 859)
rs12722987(A)/1:20455220*	intergenic	(0.13, -0.0071, P = 1.7e-05, N = 7824)	(0.18, 0.024, P = 0.71, N = 859)
rs1762470(T)/1:208423850*	RP11-2P2.1	(0.55, 0.0037, P = 4.1e-05, N = 7824)	(0.81, 0.022, P = 0.72, N = 859)
rs1999890(A)/1:210510894	HHAT	(0.5, 0.004, P = 1e-05, N = 7824)	(0.21, -0.012, P = 0.85, N = 859)
rs2165993(A)/1:211730036	intergenic	(0.47, -0.004, P = 1.5e-05, N = 7824)	(0.18, 0.0019, P = 0.98, N = 859)
rs4638188(T)/1:212045896	intergenic	(0.47, -0.0037, P = 4.2e-05, N = 7824)	(0.16, 0.046, P = 0.48, N = 859)
rs2492788(T)/1:212844187*	intergenic	(0.55, 0.0049, P = 4.6e-08, N = 7824)	(0.75, 0.076, P = 0.17, N = 859)
rs1910488(T)/1:213524165	intergenic	(0.6, 0.0037, P = 4.1e-05, N = 7824)	(0.34, 0.081, P = 0.12, N = 859)
rs4504898(T)/1:221831403*	intergenic	(0.39, -0.0041, P = 7e-06, N = 7824)	(0.48, 0.03, P = 0.53, N = 859)
rs309517(A)/1:23251592	RP1-74M1.3	(0.62, -1.1, P = 4.8e-06, N = 1954)	(0.77, -0.027, P = 0.64, N = 859)
rs6426779(T)/1:23310485	intergenic	(0.49, -0.0039, P = 1.3e-05, N = 7824)	(0.67, 0.04, P = 0.44, N = 859)
rs10802528(T)/1:236506815	EDARADD	(0.45, -0.0047, P = 2e-07, N = 7824)	(0.62, -0.046, P = 0.36, N = 859)
rs12128699(C)/1:238258461	intergenic	(0.65, -0.24, P = 5.5e-06, N = 1954)	(0.37, -0.023, P = 0.64, N = 859)
rs259615(C)/1:238433753	RP11-136B18.1	(0.66, 0.16, P = 2.8e-06, N = 1954)	(0.95, 0.23, P = 0.036, N = 859)
rs879067(T)/1:244392816*	intergenic	(0.44, 0.004, P = 7.5e-06, N = 7824)	(0.5, -0.029, P = 0.55, N = 859)
rs1507101(A)/1:25251326*	RUNX3	(0.57, 0.004, P = 9.6e-06, N = 7824)	(0.28, 0.12, P = 0.031, N = 859)
rs3480(A)/1:33328165	S100PBP	(0.6, 0.0037, P = 4.4e-05, N = 7824)	(0.49, 0.033, P = 0.49, N = 859)
rs2359233(A)/1:34770104	intergenic	(0.37, 0.0038, P = 2.9e-05, N = 7824)	(0.7, -0.084, P = 0.12, N = 859)
rs10890169(T)/1:42392584	HIVEP3	(0.53, 0.0038, P = 2.9e-05, N = 7824)	(0.61, 0.068, P = 0.17, N = 859)
rs778423(C)/1:56656812	intergenic	(0.53, -0.0043, P = 2.3e-06, N = 7824)	(0.21, 0.047, P = 0.43, N = 859)
rs844072(T)/1:64755056	intergenic	(0.44, -0.85, P = 4.2e-06, N = 1954)	(0.68, 0.011, P = 0.82, N = 859)
rs1034251(A)/1:64905833	intergenic	(0.34, -0.24, P = 5.2e-06, N = 1954)	(0.15, 0.0097, P = 0.88, N = 859)
rs17127807(A)/1:66088370*	LEPR	(0.99, 0.036, P = 4.8e-05, N = 7824)	(0.86, -0.037, P = 0.59, N = 859)
rs12135162(T)/1:91905203	intergenic	(0.62, 0.0037, P = 4e-05, N = 7824)	(0.52, -0.012, P = 0.8, N = 859)
rs12744011(A)/1:92086966	intergenic	(0.48, -0.0039, P = 2.3e-05, N = 7824)	(0.74, -0.029, P = 0.6, N = 859)
rs11589858(T)/1:92786742	RPAP2	(0.36, -0.0041, P = 5.3e-06, N = 7824)	(0.12, -0.058, P = 0.44, N = 859)
rs10875102(A)/1:98159558	DPYD	(0.54, -0.0042, P = 4.6e-06, N = 7824)	(0.18, -0.049, P = 0.43, N = 859)
rs10883890(C)/10:105390021	SH3PXD2A	(0.45, 0.0046, P = 4.3e-07, N = 7824)	(0.43, -0.051, P = 0.31, N = 859)
rs4284335(A)/10:109888793	intergenic	(0.41, -0.0046, P = 3.5e-07, N = 7824)	(0.75, -0.08, P = 0.15, N = 859)
rs4451642(A)/10:113111516	RP11-381K7.1	(0.11, 0.0071, P = 4e-05, N = 7824)	(0.083, -0.022, P = 0.8, N = 859)
rs2254426(A)/10:119683609	intergenic	(0.4, 0.0037, P = 3.9e-05, N = 7824)	(0.44, -0.011, P = 0.82, N = 859)
rs1929667(T)/10:121966798	intergenic	(0.99, -0.2, P = 2.1e-06, N = 1954)	(0.71, -0.15, P = 0.0041, N = 859)
rs10749365(C)/10:122005859	intergenic	(0.99, 0.42, P = 1e-06, N = 1954)	(0.92, -0.17, P = 0.05, N = 859)
rs11257841(T)/10:12550970	CAMK1D	(0.56, -0.0039, P = 1.3e-05, N = 7824)	(0.67, 0.074, P = 0.15, N = 859)
rs4929820(A)/10:125828819*	CHST15	(0.34, -0.0039, P = 1.4e-05, N = 7824)	(0.3, -0.021, P = 0.69, N = 859)
rs4531372(A)/10:128257882	C10orf90	(0.43, -0.0045, P = 7.1e-07, N = 7824)	(0.13, 0.0096, P = 0.89, N = 859)
rs2225978(A)/10:130286830*	intergenic	(0.52, -0.004, P = 9.1e-06, N = 7824)	(0.75, 0.02, P = 0.72, N = 859)
rs2767290(A)/10:130470565	intergenic	(0.35, 0.004, P = 8.3e-06, N = 7824)	(0.44, -0.032, P = 0.5, N = 859)
rs6602640(T)/10:13227604	MCM10	(0.88, 0.008, P = 2.5e-06, N = 7824)	(0.77, -0.063, P = 0.27, N = 859)
rs12245254(T)/10:132500555*	intergenic	(0.44, 0.0043, P = 1.9e-06, N = 7824)	(0.29, 0.14, P = 0.01, N = 859)
rs3810964(A)/10:135000159	KNDC1	(0.53, -0.0038, P = 2.4e-05, N = 7824)	(0.85, -0.007, P = 0.92, N = 859)
rs1218444(T)/10:14368831	FRMD4A	(0.86, 0.2, P = 9e-06, N = 1954)	(0.82, 0.049, P = 0.42, N = 859)
rs10828408(A)/10:23372303	intergenic	(0.6, -0.0037, P = 4.9e-05, N = 7824)	(0.63, -0.037, P = 0.47, N = 859)
rs377294850(TA)/10:24441655	KIAA1217	(0.089, -0.55, P = 7.8e-06, N = 1954)	(0.85, 0.0016, P = 0.98, N = 859)
rs9419445(T)/10:2529326	intergenic	(0.53, 0.0042, P = 3.5e-06, N = 7824)	(0.8, 0.063, P = 0.29, N = 859)
rs645838(A)/10:3560515	intergenic	(0.13, 0.0067, P = 4.9e-05, N = 7824)	(0.16, 0.038, P = 0.57, N = 859)
rs12246131(A)/10:45993782*	MARCH8	(0.78, 0.008, P = 2.4e-07, N = 7824)	(0.79, 0.11, P = 0.058, N = 859)
rs4319434(A)/10:50345140	FAM170B	(0.4, 0.0037, P = 3.7e-05, N = 7824)	(0.091, -0.011, P = 0.89, N = 859)
rs6481417(A)/10:60405788	BICC1	(0.97, -0.18, P = 5.4e-06, N = 1954)	(0.96, 0.035, P = 0.78, N = 859)
rs1981138(T)/10:61303642	intergenic	(0.43, 0.0046, P = 3.3e-07, N = 7824)	(0.8, 0.14, P = 0.022, N = 859)
rs12356193(A)/10:61413353*	SLC16A9	(0.84, 0.027, P = 3.7e-63, N = 7824)	(0.92, 0.016, P = 0.86, N = 859)
rs2242206(T)/10:61414011*	SLC16A9	(0.26, 0.012, P = 4.7e-16, N = 7824)	(0.09, 0.076, P = 0.36, N = 859)
rs1171610(T)/10:61477697*	SLC16A9	(0.62, 0.0081, P = 2.5e-19, N = 7824)	(0.54, 0.0046, P = 0.93, N = 859)
rs6479648(A)/10:61510559*	LINC00948	(0.42, -0.0087, P = 8.4e-22, N = 7824)	(0.57, 0.018, P = 0.72, N = 859)
rs10994097(A)/10:61730651	intergenic	(0.48, -0.0038, P = 2.4e-05, N = 7824)	(0.28, -0.076, P = 0.15, N = 859)
rs2394298(A)/10:68462751*	CTNNA3	(0.59, 0.0047, P = 1.5e-07, N = 7824)	(0.65, 0.048, P = 0.34, N = 859)
rs1925611(A)/10:68756918	CTNNA3	(0.47, -0.0048, P = 2e-07, N = 7824)	(0.66, -0.016, P = 0.75, N = 859)
rs2762613(T)/10:7225045	SFMBT2	(0.61, -0.0037, P = 4e-05, N = 7824)	(0.72, -0.027, P = 0.61, N = 859)
rs9415053(C)/10:73575910	CDH23	(0.47, -0.0042, P = 2.8e-06, N = 7824)	(0.28, 0.059, P = 0.27, N = 859)
rs11596100(A)/10:78612153	intergenic	(0.4, 0.0039, P = 2.2e-05, N = 7824)	(0.21, -0.049, P = 0.39, N = 859)
rs4881523(T)/10:801945	intergenic	(0.54, 0.0045, P = 6e-07, N = 7824)	(0.82, -0.0069, P = 0.92, N = 859)
rs478982(A)/10:84585708	NRG3	(0.34, 0.004, P = 9.1e-06, N = 7824)	(0.52, -0.017, P = 0.73, N = 859)
rs11253451(T)/10:852885	LARP4B	(0.42, 0.004, P = 1.3e-05, N = 7824)	(0.17, 0.076, P = 0.22, N = 859)
rs1936602(T)/10:92445253	intergenic	(0.42, 0.0043, P = 2.5e-06, N = 7824)	(0.71, -0.0022, P = 0.97, N = 859)
rs6583992(T)/10:97086735*	SORBS1	(0.52, -0.0038, P = 2.5e-05, N = 7824)	(0.34, 0.052, P = 0.3, N = 859)
rs11601438(A)/11:101955932	C11orf70	(0.39, -0.0042, P = 2.9e-06, N = 7824)	(0.48, -9e-04, P = 0.98, N = 859)
rs470747(A)/11:102661595	MMP1	(0.64, 0.0038, P = 2.8e-05, N = 7824)	(0.65, -0.023, P = 0.65, N = 859)
rs4075679(T)/11:11318921	GALNT18	(0.56, -0.0037, P = 3.7e-05, N = 7824)	(0.67, -0.042, P = 0.42, N = 859)
rs10789970(T)/11:113773946*	HTR3B	(0.41, -0.0041, P = 6.6e-06, N = 7824)	(0.64, -0.054, P = 0.3, N = 859)
rs2702023(C)/11:125465020	STT3A	(0.4, 0.0045, P = 8.6e-07, N = 7824)	(0.7, 0.046, P = 0.38, N = 859)
rs4937076(A)/11:125826702*	CDON	(0.53, 0.0039, P = 1.6e-05, N = 7824)	(0.37, 0.023, P = 0.65, N = 859)
rs11022568(A)/11:12966883	TEAD1	(0.36, 0.0039, P = 1.5e-05, N = 7824)	(0.5, -0.065, P = 0.19, N = 859)
rs923075(T)/11:130311545	intergenic	(0.61, -0.0041, P = 4.8e-06, N = 7824)	(0.34, -0.06, P = 0.26, N = 859)
rs11223211(A)/11:132663965*	OPCML	(0.47, 0.0047, P = 1.7e-07, N = 7824)	(0.42, 0.0076, P = 0.87, N = 859)
rs2793471(T)/11:29387798	RP11-460B17.3	(0.57, 0.0041, P = 7.2e-06, N = 7824)	(0.82, 0.064, P = 0.31, N = 859)
rs2295756(T)/11:35241229	CD44	(0.65, -0.0038, P = 3.3e-05, N = 7824)	(0.76, 0.0011, P = 0.98, N = 859)
rs11033087(T)/11:35374044	SLC1A2	(0.39, 0.0038, P = 3.4e-05, N = 7824)	(0.36, -0.031, P = 0.54, N = 859)
rs10501155(A)/11:36445197	PRR5L	(0.64, -0.0038, P = 4e-05, N = 7824)	(0.57, -0.058, P = 0.25, N = 859)
rs12283045(A)/11:39593279	intergenic	(0.023, -0.03, P = 3.6e-05, N = 7824)	(0.026, -0.1, P = 0.52, N = 859)
rs4313557(A)/11:39601993	intergenic	(0.98, 0.03, P = 3.3e-05, N = 7824)	(0.88, -0.072, P = 0.33, N = 859)
rs2595993(A)/11:4964627*	MMP26	(0.5, -0.0042, P = 2.9e-06, N = 7824)	(0.67, 0.053, P = 0.29, N = 859)
rs7940551(T)/11:60592783	RP11-804A23.1	(0.44, -0.004, P = 8.3e-06, N = 7824)	(0.57, 0.055, P = 0.26, N = 859)
rs561895(T)/11:64602757	CDC42BPG	(0.66, -0.0042, P = 6.6e-06, N = 7824)	(0.39, -0.024, P = 0.63, N = 859)
rs2009453(T)/11:65399528	PCNXL3	(0.56, 0.0038, P = 2.5e-05, N = 7824)	(0.4, -0.012, P = 0.81, N = 859)
rs2170082(A)/11:65454795*	intergenic	(0.52, -0.0047, P = 2.2e-07, N = 7824)	(0.39, -0.013, P = 0.79, N = 859)
rs4078258(T)/11:7542298*	PPFIBP2	(0.63, -0.0041, P = 6.1e-06, N = 7824)	(0.9, 0.076, P = 0.34, N = 859)
rs575929(T)/11:78888265*	TENM4	(0.63, 0.0039, P = 1.3e-05, N = 7824)	(0.86, 0.014, P = 0.84, N = 859)
rs2508305(T)/11:86410402	CTD-2005H7.1	(0.89, -0.0079, P = 4.1e-06, N = 7824)	(0.85, -0.031, P = 0.65, N = 859)
rs12417365(T)/11:93903770	PANX1	(0.52, -0.004, P = 7.8e-06, N = 7824)	(0.52, -0.0053, P = 0.91, N = 859)
rs1541301(T)/11:93926656	RP11-680H20.1	(0.41, -0.0037, P = 3.6e-05, N = 7824)	(0.51, 0.032, P = 0.51, N = 859)
rs10840262(C)/11:9589840	intergenic	(0.52, 0.0041, P = 3.4e-06, N = 7824)	(0.74, -0.12, P = 0.035, N = 859)
rs7929841(T)/11:96195715*	JRKL-AS1	(0.65, 0.0043, P = 2.1e-06, N = 7824)	(0.47, 0.03, P = 0.54, N = 859)
rs996408(T)/12:100051003	ANKS1B	(0.52, -0.0046, P = 3.7e-07, N = 7824)	(0.75, 0.088, P = 0.12, N = 859)
rs844016(T)/12:101592689*	SLC5A8	(0.58, 0.0047, P = 2.2e-07, N = 7824)	(0.44, -0.031, P = 0.53, N = 859)
rs7956795(T)/12:107536076	intergenic	(0.63, 0.0037, P = 3.2e-05, N = 7824)	(0.51, 0.013, P = 0.79, N = 859)
rs11066777(T)/12:109478352	USP30	(0.14, -0.007, P = 1.4e-05, N = 7824)	(0.034, -0.052, P = 0.7, N = 859)
rs2062713(T)/12:115176552	RP4-601P9.2	(0.47, -0.0038, P = 2.7e-05, N = 7824)	(0.24, 0.0066, P = 0.91, N = 859)
rs1391715(T)/12:115821235	intergenic	(0.59, -0.0037, P = 3.7e-05, N = 7824)	(0.66, -0.066, P = 0.19, N = 859)
rs514826(A)/12:118809303*	TAOK3	(0.34, 0.0038, P = 3.5e-05, N = 7824)	(0.27, 0.017, P = 0.75, N = 859)
rs10734956(A)/12:128653360	intergenic	(0.034, -0.018, P = 2e-05, N = 7824)	(0.11, 0.11, P = 0.14, N = 859)
rs12370755(A)/12:16664330	RP11-424M22.1	(0.49, -0.0039, P = 1.5e-05, N = 7824)	(0.8, -0.027, P = 0.65, N = 859)
rs4764292(T)/12:16937829	RP11-239A17.1	(0.58, 0.0044, P = 9.8e-07, N = 7824)	(0.48, -0.077, P = 0.11, N = 859)
rs4931109(T)/12:29005992*	intergenic	(0.097, -0.0072, P = 3.5e-05, N = 7824)	(0.16, 0.073, P = 0.28, N = 859)
rs12825454(T)/12:29296989*	RP11-946L16.1	(0.95, 0.02, P = 1.2e-05, N = 7824)	(0.99, 0.024, P = 0.91, N = 859)
rs11052839(C)/12:33836056	intergenic	(0.4, 0.0037, P = 3.9e-05, N = 7824)	(0.61, -1e-04, P = 1, N = 859)
rs1449844(C)/12:39521446	intergenic	(0.4, -0.0048, P = 9.2e-08, N = 7824)	(0.51, -0.03, P = 0.53, N = 859)
rs11183620(A)/12:47212370*	SLC38A4	(0.47, 0.005, P = 3e-08, N = 7824)	(0.8, -0.00048, P = 0.99, N = 859)
rs3825192(A)/12:54778823	ZNF385A	(0.56, -0.0038, P = 2.8e-05, N = 7824)	(0.22, 0.0063, P = 0.91, N = 859)
rs1716342(A)/12:54998214	GLYCAM1	(0.34, -0.0092, P = 2.6e-05, N = 7824)	(0.42, -0.075, P = 0.12, N = 859)
rs10876579(T)/12:55051647	intergenic	(0.51, 0.0037, P = 3.9e-05, N = 7824)	(0.32, 0.026, P = 0.62, N = 859)
rs10784558(T)/12:67003883	GRIP1	(0.48, -0.0048, P = 1.1e-07, N = 7824)	(0.72, 0.11, P = 0.04, N = 859)
rs6581712(A)/12:67066139	GRIP1	(0.61, 0.0043, P = 2.5e-06, N = 7824)	(0.89, -0.13, P = 0.09, N = 859)
rs1144963(T)/12:69335625	CPM	(0.56, -0.0046, P = 2.5e-07, N = 7824)	(0.86, -0.053, P = 0.44, N = 859)
rs10784751(A)/12:69447462	intergenic	(0.51, 0.004, P = 9.3e-06, N = 7824)	(0.62, -0.0065, P = 0.9, N = 859)
rs10772367(C)/12:7278538	RBP5	(0.6, -0.004, P = 8.6e-06, N = 7824)	(0.68, 0.021, P = 0.68, N = 859)
rs6539588(T)/12:82269057*	intergenic	(0.39, 0.0043, P = 1.9e-06, N = 7824)	(0.23, 0.011, P = 0.85, N = 859)
rs7961308(T)/12:82404500	intergenic	(0.65, 0.0039, P = 1.4e-05, N = 7824)	(0.73, 0.028, P = 0.6, N = 859)
rs9651972(A)/12:83861845*	intergenic	(0.54, -0.0037, P = 4e-05, N = 7824)	(0.53, 0.047, P = 0.33, N = 859)
rs36110904(G)/13:101621161	NALCN-AS1	(0.12, -0.55, P = 8e-06, N = 1954)	(0.075, -0.024, P = 0.8, N = 859)
rs9557806(A)/13:102762742	FGF14	(0.55, -0.0042, P = 2.4e-06, N = 7824)	(0.16, 0.018, P = 0.78, N = 859)
rs7981434(T)/13:105494343	intergenic	(0.13, -0.0072, P = 1.4e-05, N = 7824)	(0.14, -0.07, P = 0.32, N = 859)
rs1771142(T)/13:108581825	intergenic	(0.94, 0.01, P = 4.2e-05, N = 7824)	(0.83, 0.059, P = 0.36, N = 859)
rs1223979(A)/13:108775403	intergenic	(0.34, 0.0039, P = 2.4e-05, N = 7824)	(0.26, -0.086, P = 0.11, N = 859)
rs7334548(A)/13:20131135	MRPS31P2	(0.1, -0.007, P = 3.5e-05, N = 7824)	(0.18, 0.025, P = 0.68, N = 859)
rs7331418(T)/13:20880993*	intergenic	(0.49, -0.0037, P = 3.3e-05, N = 7824)	(0.24, 0.046, P = 0.42, N = 859)
rs9578362(T)/13:21882381	LINC00422	(0.42, 0.0037, P = 4.2e-05, N = 7824)	(0.35, -0.0048, P = 0.92, N = 859)
rs9552478(T)/13:22306355*	intergenic	(0.41, 0.0037, P = 4.9e-05, N = 7824)	(0.38, 0.13, P = 0.011, N = 859)
rs2133813(T)/13:27199422	WASF3	(0.44, 0.0041, P = 9.5e-06, N = 7824)	(0.75, -0.056, P = 0.31, N = 859)
rs4769648(T)/13:29518969	intergenic	(0.54, -0.0041, P = 2e-05, N = 7824)	(0.86, 0.096, P = 0.17, N = 859)
rs9508555(C)/13:30372036	UBL3	(0.6, 0.004, P = 1.2e-05, N = 7824)	(0.34, 0.055, P = 0.29, N = 859)
rs7325107(A)/13:31513425	TEX26	(0.65, -0.0037, P = 4.6e-05, N = 7824)	(0.55, 0.088, P = 0.071, N = 859)
rs10507402(C)/13:31859378	B3GALTL	(0.061, 0.0099, P = 4.3e-05, N = 7824)	(0.013, -0.14, P = 0.51, N = 859)
rs1869800(T)/13:32180136	intergenic	(0.51, -0.004, P = 1e-05, N = 7824)	(0.25, 0.0026, P = 0.96, N = 859)
rs7991989(T)/13:37947132	intergenic	(0.61, 0.0041, P = 4.3e-06, N = 7824)	(0.58, -0.12, P = 0.018, N = 859)
rs11618539(T)/13:39470388	intergenic	(0.34, -0.0038, P = 2.9e-05, N = 7824)	(0.21, -0.1, P = 0.095, N = 859)
rs238340(A)/13:42821270	DGKH	(0.57, -0.0042, P = 4.8e-06, N = 7824)	(0.77, 0.021, P = 0.72, N = 859)
rs2260128(A)/13:51301137	DLEU7	(0.5, 0.0039, P = 2.3e-05, N = 7824)	(0.14, 0.061, P = 0.39, N = 859)
rs1326095(T)/13:59921558	intergenic	(0.6, -0.0038, P = 2.8e-05, N = 7824)	(0.57, -0.0073, P = 0.89, N = 859)
rs3127274(T)/13:61757866	intergenic	(0.42, 0.0043, P = 2.1e-06, N = 7824)	(0.75, -0.045, P = 0.42, N = 859)
rs3128061(T)/13:62843923	intergenic	(0.4, -0.0049, P = 5.7e-08, N = 7824)	(0.65, 0.05, P = 0.32, N = 859)
rs1537385(T)/13:73655521	KLF5	(0.96, 0.032, P = 1.2e-06, N = 7824)	(0.82, -0.06, P = 0.34, N = 859)
rs9318214(T)/13:74344393	KLF12	(0.6, -0.0039, P = 1.8e-05, N = 7824)	(0.57, -0.016, P = 0.73, N = 859)
rs9530362(T)/13:75230797	intergenic	(0.57, -0.0044, P = 1.2e-06, N = 7824)	(0.49, 0.06, P = 0.22, N = 859)
rs9530483(C)/13:76460888	C13orf45	(0.56, -0.0039, P = 1.5e-05, N = 7824)	(0.2, 0.1, P = 0.083, N = 859)
rs12427799(T)/13:76469472	intergenic	(0.33, -0.0038, P = 3.4e-05, N = 7824)	(0.34, 0.043, P = 0.4, N = 859)
rs17065231(T)/13:76478084	intergenic	(0.094, -0.0092, P = 7.2e-08, N = 7824)	(0.19, -0.055, P = 0.37, N = 859)
rs2000364(T)/13:83157116	intergenic	(0.63, 0.0041, P = 5.7e-06, N = 7824)	(0.54, -0.029, P = 0.54, N = 859)
rs2390038(A)/13:98960113	FARP1	(0.52, 0.004, P = 1.9e-05, N = 7824)	(0.66, 0.0044, P = 0.93, N = 859)
rs2297732(A)/14:20781361	CCNB1IP1	(0.39, -0.0039, P = 1.9e-05, N = 7824)	(0.59, 0.067, P = 0.17, N = 859)
rs1760903(A)/14:20852817*	TEP1	(0.44, -0.0045, P = 1e-06, N = 7824)	(0.76, 0.078, P = 0.17, N = 859)
rs2204941(T)/14:22364012	TRAV8-4	(0.37, -0.0039, P = 1.6e-05, N = 7824)	(0.56, 0.028, P = 0.56, N = 859)
rs979027(A)/14:22488509	intergenic	(0.36, -0.0039, P = 1.7e-05, N = 7824)	(0.65, 0.059, P = 0.24, N = 859)
rs12891757(C)/14:24758467	DHRS1	(0.5, -0.13, P = 2.1e-06, N = 1954)	(0.25, -0.12, P = 0.035, N = 859)
rs11159415(A)/14:26098033	intergenic	(0.39, -0.0039, P = 1.9e-05, N = 7824)	(0.3, 0.08, P = 0.14, N = 859)
rs10136635(A)/14:26567277*	RP11-314P15.2	(0.55, 0.0041, P = 6e-06, N = 7824)	(0.57, -0.033, P = 0.51, N = 859)
rs2807822(T)/14:28484921	intergenic	(0.45, -0.0039, P = 1.7e-05, N = 7824)	(0.27, 0.0084, P = 0.88, N = 859)
rs11844637(T)/14:30023621	intergenic	(0.53, -0.0036, P = 5e-05, N = 7824)	(0.64, 0.013, P = 0.79, N = 859)
rs4981891(A)/14:32193959	NUBPL	(0.37, 0.0037, P = 3.5e-05, N = 7824)	(0.68, 0.093, P = 0.07, N = 859)
rs10147032(A)/14:34395888	EGLN3	(0.52, 0.0038, P = 2.1e-05, N = 7824)	(0.44, -0.053, P = 0.28, N = 859)
rs17557823(T)/14:38628997	CTD-2058B24.2	(0.64, -0.0037, P = 3.9e-05, N = 7824)	(0.89, -0.0056, P = 0.94, N = 859)
rs2022681(A)/14:48147028	MDGA2	(0.52, -0.0039, P = 1.9e-05, N = 7824)	(0.45, 0.064, P = 0.19, N = 859)
rs4901008(A)/14:50737669*	L2HGDH	(0.55, -0.0039, P = 1.6e-05, N = 7824)	(0.77, -0.017, P = 0.77, N = 859)
rs10130689(T)/14:51391471	PYGL	(0.16, -0.0075, P = 5e-06, N = 7824)	(0.064, -0.092, P = 0.34, N = 859)
rs10131515(A)/14:59315152	RP11-112J1.2	(0.86, 0.0072, P = 3.1e-05, N = 7824)	(0.82, 0.026, P = 0.68, N = 859)
rs1256061(T)/14:64703593*	ESR2	(0.47, -0.0038, P = 3.1e-05, N = 7824)	(0.33, 0.062, P = 0.23, N = 859)
rs11620955(A)/14:65491255*	FNTB	(0.48, -0.0051, P = 1.6e-08, N = 7824)	(0.29, -0.016, P = 0.76, N = 859)
rs2526920(A)/14:73101727	DPF3	(0.44, 0.0039, P = 1.7e-05, N = 7824)	(0.37, -0.05, P = 0.32, N = 859)
rs740974(A)/14:73188074	DPF3	(0.64, -0.0038, P = 3.3e-05, N = 7824)	(0.86, -0.0062, P = 0.93, N = 859)
rs6637(T)/14:77801431	TMED8	(0.62, -0.0038, P = 3.8e-05, N = 7824)	(0.86, -0.057, P = 0.42, N = 859)
rs2210185(T)/14:84438761*	intergenic	(0.53, -0.0039, P = 1.8e-05, N = 7824)	(0.54, -0.041, P = 0.39, N = 859)
rs4643242(A)/14:84831048	intergenic	(0.47, -0.0038, P = 2.7e-05, N = 7824)	(0.61, 0.048, P = 0.3, N = 859)
rs2474028(T)/14:92403660*	FBLN5	(0.36, 0.0037, P = 4.5e-05, N = 7824)	(0.27, -0.042, P = 0.44, N = 859)
rs11620973(A)/14:96018052	intergenic	(0.63, -0.0051, P = 2.3e-08, N = 7824)	(0.61, -0.0076, P = 0.88, N = 859)
rs11630130(A)/15:26000551*	ATP10A	(0.14, 0.0092, P = 5.8e-06, N = 7824)	(0.26, 0.043, P = 0.44, N = 859)
rs11070560(A)/15:47256943*	intergenic	(0.34, -0.0039, P = 1.6e-05, N = 7824)	(0.29, -0.032, P = 0.53, N = 859)
rs809760(G)/15:49011421*	CEP152	(0.7, 0.12, P = 2.3e-06, N = 1954)	(0.69, -0.048, P = 0.34, N = 859)
rs496150(A)/15:53410502	RP11-209E8.1	(0.63, -0.004, P = 9.9e-06, N = 7824)	(0.29, 0.039, P = 0.46, N = 859)
rs1189402(A)/15:53728154*	intergenic	(0.62, 0.0037, P = 4.4e-05, N = 7824)	(0.77, 0.03, P = 0.61, N = 859)
rs7162803(A)/15:60160944	RP11-568G20.2	(0.5, 0.0048, P = 8.5e-08, N = 7824)	(0.4, 0.062, P = 0.21, N = 859)
rs12595347(T)/15:60284511*	intergenic	(0.54, -0.0037, P = 3.8e-05, N = 7824)	(0.59, -0.092, P = 0.058, N = 859)
rs11635276(C)/15:68757515*	intergenic	(0.52, -0.0041, P = 5.4e-06, N = 7824)	(0.32, -0.088, P = 0.091, N = 859)
rs2114713(T)/15:80528373	RP11-2E17.1	(0.58, -0.005, P = 2.7e-08, N = 7824)	(0.43, -0.063, P = 0.21, N = 859)
rs7175825(C)/15:80795419	ARNT2	(0.38, -0.0037, P = 4.2e-05, N = 7824)	(0.38, -0.026, P = 0.61, N = 859)
rs11630705(C)/15:84614800	ADAMTSL3	(0.41, 0.0045, P = 5.1e-07, N = 7824)	(0.15, -0.0011, P = 0.99, N = 859)
rs12443054(T)/15:89711479	ABHD2	(0.65, 0.0037, P = 4e-05, N = 7824)	(0.61, -0.12, P = 0.01, N = 859)
rs7174567(A)/15:94669167*	intergenic	(0.56, 0.0037, P = 4e-05, N = 7824)	(0.58, 0.022, P = 0.65, N = 859)
rs2130882(T)/15:98513845	ARRDC4	(0.49, 0.0044, P = 1.1e-06, N = 7824)	(0.89, 0.0049, P = 0.95, N = 859)
rs3743582(A)/16:11650325	LITAF	(0.48, -0.0037, P = 3.4e-05, N = 7824)	(0.36, 0.016, P = 0.75, N = 859)
rs4633738(A)/16:11742027	intergenic	(0.48, 0.0041, P = 5.4e-06, N = 7824)	(0.29, -0.047, P = 0.38, N = 859)
rs7500049(A)/16:23006790	intergenic	(0.39, 0.004, P = 1e-05, N = 7824)	(0.85, 0.079, P = 0.25, N = 859)
rs11863492(A)/16:23044175	intergenic	(0.37, 0.0037, P = 4.2e-05, N = 7824)	(0.22, -0.04, P = 0.49, N = 859)
rs2014139(T)/16:25433163	CTA-249B10.1	(0.47, -0.0037, P = 3.9e-05, N = 7824)	(0.29, -0.049, P = 0.36, N = 859)
rs205120(A)/16:25668663	intergenic	(0.44, 0.0039, P = 1.2e-05, N = 7824)	(0.28, -0.054, P = 0.31, N = 859)
rs10871453(C)/16:30536918	ZNF768	(0.61, -0.0038, P = 2.8e-05, N = 7824)	(0.53, -0.066, P = 0.17, N = 859)
rs2192858(T)/16:51992615*	intergenic	(0.64, 0.004, P = 1.2e-05, N = 7824)	(0.23, -0.061, P = 0.29, N = 859)
rs2432560(T)/16:58533709	NDRG4	(0.63, 0.0042, P = 6.1e-06, N = 7824)	(0.64, 0.0099, P = 0.85, N = 859)
rs73549090(T)/16:59454967	intergenic	(0.023, -0.83, P = 3.7e-06, N = 1954)	(0.13, -0.011, P = 0.87, N = 859)
rs12926141(T)/16:62411321	intergenic	(0.37, 0.0039, P = 2e-05, N = 7824)	(0.3, -0.056, P = 0.29, N = 859)
rs1544811(A)/16:62656937	intergenic	(0.46, 0.004, P = 9e-06, N = 7824)	(0.48, -0.0028, P = 0.95, N = 859)
rs2274239(A)/16:68725783	CDH3	(0.61, 0.0039, P = 1.3e-05, N = 7824)	(0.67, 0.03, P = 0.56, N = 859)
rs4888504(T)/16:76465969	CNTNAP4	(0.42, 0.0046, P = 2.7e-07, N = 7824)	(0.58, -0.11, P = 0.023, N = 859)
rs12934986(A)/16:81553070	CMIP	(0.14, -0.0072, P = 1.2e-05, N = 7824)	(0.14, 0.065, P = 0.35, N = 859)
rs12931303(C)/16:83613314	CDH13	(0.1, -0.012, P = 1.3e-05, N = 7824)	(0.061, -0.19, P = 0.068, N = 859)
rs13330994(C)/16:84414741	ATP2C2	(0.57, 1.2, P = 4.8e-06, N = 1954)	(0.57, 0.0012, P = 0.98, N = 859)
rs2132850(A)/16:84975550*	RP11-254F19.3	(0.5, 0.0038, P = 2.3e-05, N = 7824)	(0.34, 0.029, P = 0.57, N = 859)
rs7203110(A)/16:8523542	intergenic	(0.44, -0.0038, P = 2.4e-05, N = 7824)	(0.4, 0.034, P = 0.49, N = 859)
rs556436666(CT)/17:1965296	SMG6	(0.08, -1.2, P = 8.8e-06, N = 1954)	(0.027, 0.25, P = 0.091, N = 859)
rs2066713(A)/17:28551665	SLC6A4	(0.4, 0.0038, P = 2.4e-05, N = 7824)	(0.25, -0.093, P = 0.095, N = 859)
rs4305127(T)/17:31817874	ASIC2	(0.4, -0.005, P = 5.7e-07, N = 7824)	(0.86, 0.0037, P = 0.96, N = 859)
rs2158298(T)/17:39072234*	intergenic	(0.59, 0.0039, P = 1.4e-05, N = 7824)	(0.34, 0.0045, P = 0.93, N = 859)
rs3736438(T)/17:45486651	EFCAB13	(0.39, -0.0057, P = 3.2e-10, N = 7824)	(0.29, 0.026, P = 0.63, N = 859)
rs12709393(T)/17:55292115	intergenic	(0.63, 0.0053, P = 6.4e-09, N = 7824)	(0.28, 0.00086, P = 0.99, N = 859)
rs989681(T)/17:67542493	MAP2K6	(0.52, 0.0041, P = 7.4e-06, N = 7824)	(0.41, -0.016, P = 0.74, N = 859)
rs4793395(T)/17:68509948	intergenic	(0.47, 0.0041, P = 6.6e-06, N = 7824)	(0.3, -0.039, P = 0.46, N = 859)
rs12938026(T)/17:68582006	intergenic	(0.61, 0.0046, P = 2.8e-07, N = 7824)	(0.84, -0.064, P = 0.32, N = 859)
rs8070753(A)/17:9264728*	STX8	(0.37, -0.0038, P = 2.8e-05, N = 7824)	(0.59, -0.094, P = 0.063, N = 859)
rs12607576(T)/18:13246168	LDLRAD4	(0.54, -0.004, P = 6.7e-06, N = 7824)	(0.88, -0.036, P = 0.63, N = 859)
rs9947578(A)/18:14773230	ANKRD30B	(0.56, 0.0043, P = 3.9e-06, N = 7824)	(0.75, 0.037, P = 0.52, N = 859)
rs175776(C)/18:28624148	DSC3	(0.58, 0.0037, P = 4e-05, N = 7824)	(0.68, -0.094, P = 0.071, N = 859)
rs1786077(A)/18:34867844	CELF4	(0.55, 0.0038, P = 2.2e-05, N = 7824)	(0.32, 0.0016, P = 0.97, N = 859)
rs1358331(T)/18:41180458	intergenic	(0.51, -0.0039, P = 1.7e-05, N = 7824)	(0.67, 0.044, P = 0.38, N = 859)
rs2362839(A)/18:42991252*	SLC14A2	(0.6, -0.0041, P = 5.1e-06, N = 7824)	(0.55, 0.042, P = 0.37, N = 859)
rs9960949(A)/18:46209558	CTIF	(0.48, -0.0042, P = 8.8e-06, N = 7824)	(0.72, 0.039, P = 0.47, N = 859)
rs515897(A)/18:55209506	intergenic	(0.62, -0.0037, P = 4.8e-05, N = 7824)	(0.28, -0.0084, P = 0.88, N = 859)
rs4940563(A)/18:60277715	intergenic	(0.53, -0.005, P = 5.7e-07, N = 7824)	(0.74, -0.037, P = 0.5, N = 859)
rs4436868(T)/18:61958609*	RP11-146N18.1	(0.5, 0.0045, P = 4.3e-07, N = 7824)	(0.37, -0.0061, P = 0.91, N = 859)
rs618153(A)/18:62753986	intergenic	(0.35, 0.0039, P = 2e-05, N = 7824)	(0.39, -0.061, P = 0.22, N = 859)
rs536279(A)/18:65497981	RP11-638L3.2	(0.39, -0.004, P = 1.3e-05, N = 7824)	(0.16, -0.039, P = 0.55, N = 859)
rs8086262(A)/18:69227590	RP11-510D19.1	(0.66, -0.004, P = 1.5e-05, N = 7824)	(0.61, -0.041, P = 0.42, N = 859)
rs492522(T)/18:6986638*	LAMA1	(0.55, -0.0037, P = 3.6e-05, N = 7824)	(0.46, 0.096, P = 0.041, N = 859)
rs12232577(A)/18:69966132	intergenic	(0.91, -0.0074, P = 3.8e-05, N = 7824)	(0.92, 0.018, P = 0.83, N = 859)
rs9952198(T)/18:71878838	RP11-669I1.1	(0.53, -0.0039, P = 2e-05, N = 7824)	(0.45, -0.048, P = 0.34, N = 859)
rs1866732(A)/18:72933187	TSHZ1	(0.66, 0.0037, P = 4.7e-05, N = 7824)	(0.42, 0.0042, P = 0.93, N = 859)
rs6506736(A)/18:76940235	ATP9B	(0.52, 0.0042, P = 2.6e-06, N = 7824)	(0.2, 0.038, P = 0.52, N = 859)
rs11085752(A)/19:11065409*	intergenic	(0.58, -0.004, P = 9.5e-06, N = 7824)	(0.62, 0.016, P = 0.75, N = 859)
rs11085914(T)/19:14978191*	AC005255.6	(0.55, -0.0042, P = 2.9e-06, N = 7824)	(0.83, -0.11, P = 0.073, N = 859)
rs8099879(A)/19:17230287	MYO9B	(0.38, 0.005, P = 5.7e-07, N = 7824)	(0.24, -0.007, P = 0.9, N = 859)
rs287104(A)/19:34290995*	KCTD15	(0.65, 0.0038, P = 4.1e-05, N = 7824)	(0.79, 0.029, P = 0.61, N = 859)
rs2451996(A)/19:35544963	HPN	(0.58, 0.0043, P = 1.7e-06, N = 7824)	(0.27, 0.072, P = 0.19, N = 859)
rs1820690(A)/19:48490006	BSPH1	(0.61, -0.15, P = 2.7e-06, N = 1954)	(0.77, 0.14, P = 0.013, N = 859)
rs1513628(A)/2:101338644*	AC092168.4	(0.37, -0.004, P = 1.3e-05, N = 7824)	(0.11, 0.07, P = 0.38, N = 859)
rs6542041(A)/2:112911923	FBLN7	(0.49, -0.0037, P = 4.6e-05, N = 7824)	(0.52, 0.059, P = 0.22, N = 859)
rs17355679(T)/2:115964965	DPP10	(0.36, -0.004, P = 1e-05, N = 7824)	(0.59, -0.034, P = 0.49, N = 859)
rs2577264(A)/2:11936798*	LPIN1	(0.38, 0.0043, P = 2.1e-06, N = 7824)	(0.11, 0.02, P = 0.8, N = 859)
rs2043885(T)/2:124856339	CNTNAP5	(0.42, 0.0038, P = 2.9e-05, N = 7824)	(0.26, 0.022, P = 0.68, N = 859)
rs11899152(A)/2:125483741	CNTNAP5	(0.54, -0.0037, P = 4.7e-05, N = 7824)	(0.45, -0.049, P = 0.3, N = 859)
rs7587616(A)/2:134708496*	intergenic	(0.47, -0.0037, P = 4.7e-05, N = 7824)	(0.37, 0.067, P = 0.17, N = 859)
rs1427617(T)/2:137487339	intergenic	(0.37, 0.0038, P = 2.9e-05, N = 7824)	(0.39, -0.024, P = 0.64, N = 859)
rs6721330(A)/2:149858906	KIF5C	(0.55, -0.0041, P = 4.9e-06, N = 7824)	(0.19, 0.018, P = 0.78, N = 859)
rs2881873(T)/2:154524124	intergenic	(0.46, -0.0037, P = 4e-05, N = 7824)	(0.57, 0.011, P = 0.82, N = 859)
rs1446555(A)/2:158109405	GALNT5	(0.9, 0.008, P = 3.2e-06, N = 7824)	(0.79, -0.00072, P = 0.99, N = 859)
rs1424937(A)/2:169566184	CERS6	(0.46, 0.0042, P = 2.3e-06, N = 7824)	(0.16, 0.019, P = 0.77, N = 859)
rs2544371(A)/2:170227070	intergenic	(0.56, 0.004, P = 8.7e-06, N = 7824)	(0.58, -0.02, P = 0.69, N = 859)
rs2969327(T)/2:177422617*	intergenic	(0.43, -0.0039, P = 1.8e-05, N = 7824)	(0.52, -0.033, P = 0.51, N = 859)
rs262273(C)/2:180911563	intergenic	(0.39, -0.0042, P = 2.8e-06, N = 7824)	(0.53, -0.051, P = 0.29, N = 859)
rs288332(A)/2:183625350*	DNAJC10	(0.63, -0.0043, P = 1.8e-06, N = 7824)	(0.81, -0.00021, P = 1, N = 859)
rs1981913(T)/2:205169149	DSTNP5	(0.62, 0.0039, P = 2.1e-05, N = 7824)	(0.53, 0.035, P = 0.47, N = 859)
rs6435389(T)/2:208696325	PLEKHM3	(0.34, 0.0039, P = 2.1e-05, N = 7824)	(0.22, 0.09, P = 0.14, N = 859)
rs7570090(T)/2:210880893*	RPE	(0.46, -0.0038, P = 3e-05, N = 7824)	(0.38, 0.012, P = 0.8, N = 859)
rs12994785(A)/2:212857425*	ERBB4	(0.55, 0.0039, P = 1.8e-05, N = 7824)	(0.28, -0.044, P = 0.42, N = 859)
rs1250070(A)/2:216557733	LINC00607	(0.39, -0.0042, P = 8.6e-06, N = 7824)	(0.28, 0.019, P = 0.72, N = 859)
rs2279014(T)/2:219261176*	SLC11A1	(0.37, -0.005, P = 4.9e-08, N = 7824)	(0.4, -0.12, P = 0.016, N = 859)
rs526897(A)/2:219433597	RQCD1	(0.61, 0.0038, P = 3.1e-05, N = 7824)	(0.75, -0.05, P = 0.36, N = 859)
rs4674438(T)/2:220643119	intergenic	(0.36, 0.0046, P = 2.9e-07, N = 7824)	(0.6, -0.0078, P = 0.87, N = 859)
rs2710503(C)/2:222374699	EPHA4	(0.44, -0.0044, P = 1.7e-06, N = 7824)	(0.13, -0.006, P = 0.94, N = 859)
rs9784110(T)/2:230215502	intergenic	(0.61, -0.0042, P = 4e-06, N = 7824)	(0.57, -0.11, P = 0.03, N = 859)
rs977041(A)/2:230350848	DNER	(0.44, 0.0044, P = 1.3e-06, N = 7824)	(0.47, -0.018, P = 0.71, N = 859)
rs2292871(A)/2:238499690	RAB17	(0.58, 0.0045, P = 7.7e-07, N = 7824)	(0.22, 0.07, P = 0.23, N = 859)
rs12987376(T)/2:242917306	AC093642.3	(0.45, 0.0037, P = 3.6e-05, N = 7824)	(0.2, -0.047, P = 0.43, N = 859)
rs4665406(T)/2:28445438	BRE	(0.37, -0.0043, P = 1.9e-06, N = 7824)	(0.25, 0.027, P = 0.63, N = 859)
rs7592700(A)/2:3480563*	TRAPPC12	(0.47, -0.0037, P = 4.3e-05, N = 7824)	(0.86, 0.15, P = 0.026, N = 859)
rs8179836(C)/2:42903239	MTA3	(0.63, 0.0048, P = 1.5e-07, N = 7824)	(0.69, 0.014, P = 0.79, N = 859)
rs940052(A)/2:45981142	PRKCE	(0.44, -0.0038, P = 2.2e-05, N = 7824)	(0.52, -0.011, P = 0.82, N = 859)
rs1374749(A)/2:46596433*	EPAS1	(0.44, 0.0037, P = 4.4e-05, N = 7824)	(0.5, 0.053, P = 0.27, N = 859)
rs12473182(C)/2:49427446	intergenic	(0.4, 0.0038, P = 2.4e-05, N = 7824)	(0.45, 0.024, P = 0.61, N = 859)
rs735315(T)/2:51331157	AC007682.1	(0.49, 0.0054, P = 1.9e-09, N = 7824)	(0.69, 0.0034, P = 0.95, N = 859)
rs7564248(A)/2:51379098	AC007682.1	(0.6, 0.0045, P = 7.4e-07, N = 7824)	(0.56, 0.11, P = 0.024, N = 859)
rs7604464(A)/2:54389318	ACYP2	(0.97, 0.015, P = 5.9e-06, N = 7824)	(0.67, 0.0079, P = 0.88, N = 859)
rs4669392(A)/2:5620952*	intergenic	(0.43, -0.004, P = 9.3e-06, N = 7824)	(0.34, 0.011, P = 0.82, N = 859)
rs4672450(T)/2:61944571	intergenic	(0.48, 0.0044, P = 1.4e-06, N = 7824)	(0.2, 0.0017, P = 0.98, N = 859)
rs549386(T)/2:70667125	intergenic	(0.61, -0.0043, P = 1.6e-06, N = 7824)	(0.8, 0.019, P = 0.76, N = 859)
rs1345836(T)/2:8200042	LINC00299	(0.45, 0.0038, P = 2.9e-05, N = 7824)	(0.64, 0.0087, P = 0.86, N = 859)
rs3097281(A)/2:8508404	LINC00299	(0.58, 0.0038, P = 2.3e-05, N = 7824)	(0.56, 0.00028, P = 1, N = 859)
rs6709816(A)/2:85343124*	intergenic	(0.15, -0.0077, P = 1.9e-06, N = 7824)	(0.22, -0.085, P = 0.15, N = 859)
rs7355681(A)/2:85911339	AC012454.4	(0.59, 0.0041, P = 4.9e-06, N = 7824)	(0.72, 0.059, P = 0.27, N = 859)
rs6131084(T)/20:1090381	PSMF1	(0.56, 0.0038, P = 2.7e-05, N = 7824)	(0.33, 0.041, P = 0.43, N = 859)
rs2327855(A)/20:14477175*	MACROD2	(0.58, 0.004, P = 9.6e-06, N = 7824)	(0.76, 0.00022, P = 1, N = 859)
rs8120307(T)/20:35803188	RPN2	(0.62, -0.0038, P = 2.5e-05, N = 7824)	(0.35, 0.018, P = 0.71, N = 859)
rs6129167(T)/20:37689228	intergenic	(0.57, 0.0039, P = 1.1e-05, N = 7824)	(0.58, 0.052, P = 0.28, N = 859)
rs6129620(A)/20:39144286*	intergenic	(0.33, 0.0038, P = 4.6e-05, N = 7824)	(0.15, 9.3e-05, P = 1, N = 859)
rs241642(A)/20:3929299	RNF24	(0.44, 0.0038, P = 2.2e-05, N = 7824)	(0.71, -0.056, P = 0.28, N = 859)
rs3848713(T)/20:44470676*	ACOT8	(0.41, -0.0044, P = 1.1e-06, N = 7824)	(0.61, 0.043, P = 0.38, N = 859)
rs4811828(T)/20:55809047	BMP7	(0.88, 0.0077, P = 5.9e-06, N = 7824)	(0.78, -0.081, P = 0.17, N = 859)
rs6025935(A)/20:56536168	RP13-379L11.2	(0.38, -0.0038, P = 3.4e-05, N = 7824)	(0.24, 0.03, P = 0.59, N = 859)
rs163787(A)/20:57574463*	CTSZ	(0.18, 0.0065, P = 4.7e-05, N = 7824)	(0.14, -0.023, P = 0.75, N = 859)
rs3905228(A)/20:58105747	intergenic	(0.47, 0.0041, P = 9e-06, N = 7824)	(0.32, 0.0032, P = 0.95, N = 859)
rs4591420(A)/21:16077143*	intergenic	(0.33, -0.0037, P = 4.6e-05, N = 7824)	(0.19, -0.098, P = 0.12, N = 859)
rs1028981(A)/21:21668483	intergenic	(0.39, -0.005, P = 5.7e-07, N = 7824)	(0.41, -0.0064, P = 0.9, N = 859)
rs1041755(T)/21:33238952*	intergenic	(0.37, 0.004, P = 1.2e-05, N = 7824)	(0.49, 0.074, P = 0.13, N = 859)
rs8134847(T)/21:35020161	ITSN1	(0.4, 0.0041, P = 8.4e-06, N = 7824)	(0.34, -0.038, P = 0.45, N = 859)
rs2156411(A)/21:37580807	DOPEY2	(0.64, 0.0038, P = 3.1e-05, N = 7824)	(0.85, 0.027, P = 0.69, N = 859)
rs378999(T)/21:40434320	intergenic	(0.64, -0.0044, P = 1.2e-06, N = 7824)	(0.62, 0.029, P = 0.56, N = 859)
rs8127674(A)/21:42882003	TMPRSS2	(0.59, -0.0041, P = 5.9e-06, N = 7824)	(0.67, 0.063, P = 0.22, N = 859)
rs220168(A)/21:43554571*	UMODL1	(0.52, -0.004, P = 9.3e-06, N = 7824)	(0.52, 0.061, P = 0.2, N = 859)
rs12627165(A)/21:46736694	intergenic	(0.35, 0.0044, P = 3.5e-06, N = 7824)	(0.64, 0.061, P = 0.2, N = 859)
rs9613019(T)/22:26174397	MYO18B	(0.41, -0.0041, P = 7.4e-06, N = 7824)	(0.72, -0.019, P = 0.73, N = 859)
rs137181(A)/22:26666246	SEZ6L	(0.51, -0.0037, P = 3.5e-05, N = 7824)	(0.61, -0.061, P = 0.23, N = 859)
rs5999027(T)/22:33989858*	LARGE	(0.43, -0.004, P = 9.5e-06, N = 7824)	(0.29, -0.0044, P = 0.93, N = 859)
rs132667(A)/22:36565029*	Z95114.3	(0.54, 0.0038, P = 2.4e-05, N = 7824)	(0.64, -0.026, P = 0.6, N = 859)
rs10854693(A)/22:37252010*	CTA-833B7.2	(0.56, -0.0039, P = 3.4e-05, N = 7824)	(0.89, -0.059, P = 0.45, N = 859)
rs140572(A)/22:45451727*	intergenic	(0.51, 0.0047, P = 2.2e-07, N = 7824)	(0.15, -0.035, P = 0.61, N = 859)
rs131919(T)/22:47447437*	TBC1D22A	(0.33, -0.0046, P = 9e-07, N = 7824)	(0.41, -0.0032, P = 0.95, N = 859)
rs9838540(A)/3:101986003*	ZPLD1	(0.61, 0.0047, P = 1.8e-07, N = 7824)	(0.21, 0.064, P = 0.27, N = 859)
rs6437539(T)/3:104513265	intergenic	(0.63, -0.0039, P = 2e-05, N = 7824)	(0.66, 0.00063, P = 0.99, N = 859)
rs2924149(T)/3:10991346	intergenic	(0.38, 0.0038, P = 2.6e-05, N = 7824)	(0.1, -0.051, P = 0.52, N = 859)
rs4831113(T)/3:115308015*	intergenic	(0.39, -0.0038, P = 2.8e-05, N = 7824)	(0.87, 0.032, P = 0.65, N = 859)
rs201908613(CT)/3:116189185	LSAMP	(0.017, 0.29, P = 2.3e-06, N = 1954)	(0.041, 0.044, P = 0.72, N = 859)
rs9873519(T)/3:124921457*	SLC12A8	(0.54, 0.0037, P = 3.4e-05, N = 7824)	(0.31, 0.075, P = 0.15, N = 859)
rs1225019(A)/3:131669077	CPNE4	(0.58, -0.0043, P = 1.6e-06, N = 7824)	(0.32, -0.067, P = 0.19, N = 859)
rs13059536(T)/3:139578650	RP11-166D18.1	(0.11, 0.007, P = 4.1e-05, N = 7824)	(0.14, 0.067, P = 0.34, N = 859)
rs6795522(T)/3:143101289*	SLC9A9	(0.61, 0.0037, P = 4.9e-05, N = 7824)	(0.63, -0.035, P = 0.49, N = 859)
rs9872790(T)/3:143238874	SLC9A9	(0.5, -0.0039, P = 1.9e-05, N = 7824)	(0.4, 0.028, P = 0.56, N = 859)
rs355748(T)/3:153964496	ARHGEF26	(0.38, -0.0038, P = 3.3e-05, N = 7824)	(0.41, 0.0072, P = 0.88, N = 859)
rs9942113(A)/3:156231801	KCNAB1	(0.38, -0.0049, P = 6e-08, N = 7824)	(0.55, 0.0036, P = 0.94, N = 859)
rs11707952(A)/3:158665225	intergenic	(0.57, -0.0046, P = 3.9e-07, N = 7824)	(0.56, -0.042, P = 0.38, N = 859)
rs4525910(A)/3:159646612	IL12A-AS1	(0.41, -0.0043, P = 2.2e-06, N = 7824)	(0.22, -0.071, P = 0.23, N = 859)
rs17236487(T)/3:160171926	TRIM59	(0.78, 0.0062, P = 4.7e-05, N = 7824)	(0.83, -0.061, P = 0.34, N = 859)
rs9863328(T)/3:164360829	intergenic	(0.43, 0.004, P = 9.1e-06, N = 7824)	(0.34, -0.052, P = 0.29, N = 859)
rs1430435(T)/3:169079193	MECOM	(0.49, 0.0044, P = 1.3e-06, N = 7824)	(0.38, -0.021, P = 0.67, N = 859)
rs6793266(T)/3:175102338*	NAALADL2	(0.39, -0.0043, P = 2.9e-06, N = 7824)	(0.34, 0.13, P = 0.011, N = 859)
rs9842133(T)/3:179664102	PEX5L	(0.66, 0.0064, P = 4.2e-12, N = 7824)	(0.47, 0.033, P = 0.5, N = 859)
rs6785807(A)/3:181718601	RP11-416O18.1	(0.12, -0.0068, P = 3.6e-05, N = 7824)	(0.054, -0.094, P = 0.38, N = 859)
rs1026527(T)/3:22609529	intergenic	(0.58, 0.0038, P = 2e-05, N = 7824)	(0.62, -0.07, P = 0.16, N = 859)
rs6550934(A)/3:25052333*	AC133680.1	(0.47, 0.0038, P = 2.3e-05, N = 7824)	(0.76, -0.036, P = 0.52, N = 859)
rs294280(T)/3:31131692	intergenic	(0.39, 0.0042, P = 3.4e-06, N = 7824)	(0.52, 0.057, P = 0.25, N = 859)
rs968103(T)/3:34234573	AC018359.1	(0.45, 0.0043, P = 1.5e-06, N = 7824)	(0.78, -0.02, P = 0.72, N = 859)
rs1916227(A)/3:34847097	intergenic	(0.48, -0.004, P = 1e-05, N = 7824)	(0.6, 0.043, P = 0.38, N = 859)
rs7632967(A)/3:34906302	intergenic	(0.55, -0.0043, P = 1.7e-06, N = 7824)	(0.31, 6.6e-05, P = 1, N = 859)
rs769809(A)/3:3767212	SUMF1	(0.57, 0.0046, P = 3.5e-07, N = 7824)	(0.75, -0.0082, P = 0.88, N = 859)
rs533980308(AT)/3:49106976	QRICH1	(0.021, -0.86, P = 9.9e-06, N = 1954)	(0.41, 0.061, P = 0.22, N = 859)
rs11915024(T)/3:59492480*	RP11-719N22.2	(0.4, -0.0044, P = 9.6e-07, N = 7824)	(0.61, -0.013, P = 0.8, N = 859)
rs9874660(A)/3:61931353	PTPRG	(0.91, 0.015, P = 2.2e-05, N = 7824)	(0.84, 0.064, P = 0.34, N = 859)
rs6797048(A)/3:68904763	FAM19A4	(0.62, -0.0038, P = 3e-05, N = 7824)	(0.8, 0.024, P = 0.69, N = 859)
rs6798065(T)/3:75388243	MYLKP1	(0.34, -0.0038, P = 2.6e-05, N = 7824)	(0.58, -0.011, P = 0.82, N = 859)
rs9880736(A)/3:79318988	ROBO1	(0.54, -0.0044, P = 1.5e-06, N = 7824)	(0.91, -0.054, P = 0.5, N = 859)
rs1431156(G)/3:88082149	intergenic	(0.98, -0.35, P = 3.6e-06, N = 1954)	(0.72, 0.074, P = 0.18, N = 859)
rs9829940(T)/3:96167649	intergenic	(0.56, 0.0038, P = 2e-05, N = 7824)	(0.83, -0.00075, P = 0.99, N = 859)
rs9819702(T)/3:97886592	OR5H15	(0.36, -0.0042, P = 5.2e-06, N = 7824)	(0.37, -0.058, P = 0.24, N = 859)
rs1114130(T)/4:101363516*	EMCN	(0.34, -0.0042, P = 4.3e-06, N = 7824)	(0.41, -0.088, P = 0.069, N = 859)
rs11722041(T)/4:115411284	intergenic	(0.41, 0.0039, P = 1.8e-05, N = 7824)	(0.061, 0.061, P = 0.55, N = 859)
rs12510909(T)/4:139206509	RP11-733C7.1	(0.53, -0.0043, P = 1.8e-06, N = 7824)	(0.72, -0.027, P = 0.61, N = 859)
rs11930385(T)/4:146845752*	ZNF827	(0.4, -0.0043, P = 2.1e-06, N = 7824)	(0.69, -0.045, P = 0.4, N = 859)
rs7662505(A)/4:147982321	intergenic	(0.4, -0.004, P = 1e-05, N = 7824)	(0.39, 0.018, P = 0.72, N = 859)
rs9997562(T)/4:14896179*	intergenic	(0.52, 0.0043, P = 1.9e-06, N = 7824)	(0.27, -0.075, P = 0.18, N = 859)
rs6535870(T)/4:153639925	intergenic	(0.65, -0.005, P = 5.5e-08, N = 7824)	(0.42, 0.038, P = 0.43, N = 859)
rs2286460(A)/4:15964040*	FGFBP2	(0.54, -0.0045, P = 8.4e-07, N = 7824)	(0.43, 0.012, P = 0.8, N = 859)
rs195934(A)/4:163582000	intergenic	(0.64, 0.0039, P = 2e-05, N = 7824)	(0.71, 0.027, P = 0.62, N = 859)
rs4860022(T)/4:167693875	SPOCK3	(0.34, -0.0055, P = 9.6e-10, N = 7824)	(0.28, 0.066, P = 0.24, N = 859)
rs12503744(A)/4:172203928*	intergenic	(0.02, -0.034, P = 4.8e-06, N = 7824)	(0.32, -0.014, P = 0.78, N = 859)
rs7686890(T)/4:178411431	RP11-130F10.1	(0.39, 0.004, P = 8e-06, N = 7824)	(0.74, -0.057, P = 0.3, N = 859)
rs2309339(C)/4:181350035	intergenic	(0.65, 0.0041, P = 7.1e-06, N = 7824)	(0.73, 0.0019, P = 0.97, N = 859)
rs1872445(T)/4:186504058*	SORBS2	(0.55, -0.0039, P = 1.3e-05, N = 7824)	(0.87, 0.068, P = 0.34, N = 859)
rs10489008(A)/4:31718284*	intergenic	(0.49, 0.0045, P = 4.6e-07, N = 7824)	(0.87, -0.047, P = 0.52, N = 859)
rs12500588(A)/4:37111552	RP11-103J17.1	(0.09, -0.0076, P = 1.5e-05, N = 7824)	(0.44, -0.095, P = 0.047, N = 859)
rs10517472(T)/4:38287333*	RP11-600L4.1	(0.38, 0.0037, P = 4.3e-05, N = 7824)	(0.19, -0.001, P = 0.99, N = 859)
rs7665019(T)/4:40600905	RBM47	(0.55, 0.0038, P = 2.2e-05, N = 7824)	(0.74, -0.016, P = 0.76, N = 859)
rs4861126(C)/4:41643057	LIMCH1	(0.41, 0.0043, P = 1.6e-06, N = 7824)	(0.47, -0.043, P = 0.38, N = 859)
rs7673523(C)/4:4688246	STX18-AS1	(0.53, 0.0037, P = 3.6e-05, N = 7824)	(0.61, -0.016, P = 0.75, N = 859)
rs1509657(T)/4:48213011*	TEC	(0.46, 0.0041, P = 6.3e-06, N = 7824)	(0.65, 0.015, P = 0.77, N = 859)
rs6554156(T)/4:55042554	FIP1L1	(0.4, 0.0044, P = 1.1e-06, N = 7824)	(0.42, 0.062, P = 0.21, N = 859)
rs2100765(C)/4:60855621	intergenic	(0.59, 0.0039, P = 1.5e-05, N = 7824)	(0.28, 0.026, P = 0.63, N = 859)
rs6852374(A)/4:61370159	intergenic	(0.51, 0.0041, P = 4.4e-06, N = 7824)	(0.44, 0.0034, P = 0.94, N = 859)
rs1390746(A)/4:79451461	FRAS1	(0.55, 0.0037, P = 3.3e-05, N = 7824)	(0.3, 0.022, P = 0.67, N = 859)
rs7435034(A)/4:88146267	KLHL8	(0.36, -0.0042, P = 3.4e-06, N = 7824)	(0.18, 0.0057, P = 0.93, N = 859)
rs13434630(A)/4:88464872*	intergenic	(0.46, -0.0039, P = 1.2e-05, N = 7824)	(0.47, -0.018, P = 0.7, N = 859)
rs2120372(A)/4:90983723*	intergenic	(0.59, -0.0037, P = 4.2e-05, N = 7824)	(0.61, 0.021, P = 0.68, N = 859)
rs7732790(A)/5:103428431*	RP11-138J23.1	(0.59, -0.0042, P = 3.7e-06, N = 7824)	(0.43, -0.013, P = 0.79, N = 859)
rs2962321(T)/5:10577895	ANKRD33B	(0.9, -0.0077, P = 6e-06, N = 7824)	(0.85, 0.044, P = 0.52, N = 859)
rs10065061(T)/5:107916909	intergenic	(0.52, 0.0037, P = 4.1e-05, N = 7824)	(0.3, -0.064, P = 0.22, N = 859)
rs461231(T)/5:110734739	CAMK4	(0.6, -0.0037, P = 4e-05, N = 7824)	(0.77, 0.033, P = 0.58, N = 859)
rs1366201(A)/5:115321833	AQPEP	(0.6, 0.0037, P = 3.9e-05, N = 7824)	(0.84, -0.051, P = 0.45, N = 859)
rs246946(T)/5:126652742	MEGF10	(0.68, 0.0041, P = 9.3e-06, N = 7824)	(0.69, 0.026, P = 0.62, N = 859)
rs6866597(T)/5:128877617*	ADAMTS19	(0.52, 0.0042, P = 3.6e-06, N = 7824)	(0.12, 0.064, P = 0.38, N = 859)
rs10900805(A)/5:131580851*	P4HA2	(0.1, -0.007, P = 3.8e-05, N = 7824)	(0.11, -0.076, P = 0.33, N = 859)
rs7737937(A)/5:131614981*	P4HA2	(0.15, -0.011, P = 4.9e-11, N = 7824)	(0.19, 0.066, P = 0.3, N = 859)
rs419291(T)/5:131633355*	SLC22A4	(0.37, 0.0079, P = 3.1e-18, N = 7824)	(0.22, 0.1, P = 0.086, N = 859)
rs6596361(T)/5:136311770	SPOCK1	(0.59, 0.0044, P = 9.2e-07, N = 7824)	(0.58, -0.033, P = 0.5, N = 859)
rs1368388(A)/5:147897161*	HTR4	(0.42, -0.0041, P = 4.6e-06, N = 7824)	(0.64, -0.035, P = 0.48, N = 859)
rs6862024(A)/5:150428871	TNIP1	(0.37, -0.0055, P = 9e-10, N = 7824)	(0.089, 0.0067, P = 0.94, N = 859)
rs6877344(T)/5:150742650*	CTB-23I7.1	(0.38, 0.004, P = 1e-05, N = 7824)	(0.3, -0.021, P = 0.69, N = 859)
rs1317661(A)/5:151647363	CTB-12O2.1	(0.48, 0.0043, P = 1.9e-06, N = 7824)	(0.35, -0.0035, P = 0.94, N = 859)
rs753768(A)/5:152516889	AC091969.1	(0.42, 0.0039, P = 1.4e-05, N = 7824)	(0.39, 2e-05, P = 1, N = 859)
rs9313491(C)/5:156621905	ITK	(0.64, 0.0047, P = 6.1e-07, N = 7824)	(0.7, 0.026, P = 0.62, N = 859)
rs17651643(A)/5:16892438*	MYO10	(0.1, -0.011, P = 1.3e-05, N = 7824)	(0.23, -0.065, P = 0.25, N = 859)
rs2471005(A)/5:174882207*	snoU13	(0.39, 0.004, P = 1e-05, N = 7824)	(0.14, 0.091, P = 0.18, N = 859)
rs4866725(T)/5:2164174	intergenic	(0.56, -0.0038, P = 2.3e-05, N = 7824)	(0.77, -0.02, P = 0.73, N = 859)
rs899584(T)/5:26826799	intergenic	(0.36, -0.0047, P = 2.9e-07, N = 7824)	(0.58, 0.07, P = 0.15, N = 859)
rs13162168(A)/5:30222534	intergenic	(0.38, -0.0041, P = 6.4e-06, N = 7824)	(0.24, -0.044, P = 0.45, N = 859)
rs4242263(A)/5:36415364	intergenic	(0.36, 0.0038, P = 2.7e-05, N = 7824)	(0.55, 0.079, P = 0.11, N = 859)
rs42864(C)/5:39283776	C9	(0.64, -0.0039, P = 2.4e-05, N = 7824)	(0.87, -0.0092, P = 0.9, N = 859)
rs1479614(A)/5:50823338	intergenic	(0.61, -0.0048, P = 9.9e-08, N = 7824)	(0.82, -0.097, P = 0.12, N = 859)
rs2291631(A)/5:75013036	POC5	(0.05, -0.011, P = 1.3e-05, N = 7824)	(0.038, -0.13, P = 0.31, N = 859)
rs1392482(T)/5:7555561	ADCY2	(0.4, -0.0039, P = 1.4e-05, N = 7824)	(0.25, -0.0029, P = 0.96, N = 859)
rs13182512(A)/5:78573790*	JMY	(0.38, -0.005, P = 3.4e-08, N = 7824)	(0.62, 0.057, P = 0.25, N = 859)
rs11750489(A)/5:80391253	RASGRF2	(0.89, 0.0097, P = 4.9e-05, N = 7824)	(0.98, 0.15, P = 0.36, N = 859)
rs1827396(A)/5:81975108	intergenic	(0.43, -0.0038, P = 3.2e-05, N = 7824)	(0.64, -0.054, P = 0.29, N = 859)
rs699554(T)/5:87022350	CTD-2316B1.2	(0.43, 0.0038, P = 3.2e-05, N = 7824)	(0.5, 0.016, P = 0.73, N = 859)
rs11267778(GCCTCTGCCCATGAC)/6:108384189	OSTM1	(0.019, -0.15, P = 4.5e-06, N = 1954)	(0.99, 0.013, P = 0.95, N = 859)
rs4713396(A)/6:11312130	NEDD9	(0.45, -0.0044, P = 1.2e-06, N = 7824)	(0.6, -0.044, P = 0.39, N = 859)
rs10872303(T)/6:126255034	NCOA7	(0.53, 0.004, P = 1.1e-05, N = 7824)	(0.42, -0.037, P = 0.44, N = 859)
rs6917098(A)/6:132925613	TAAR3	(0.61, 0.0038, P = 3.1e-05, N = 7824)	(0.57, 0.01, P = 0.83, N = 859)
rs459625(T)/6:134260676	intergenic	(0.43, -0.0049, P = 5.2e-08, N = 7824)	(0.84, 0.16, P = 0.017, N = 859)
rs6908972(T)/6:134684613*	intergenic	(0.082, -0.009, P = 8e-07, N = 7824)	(0.13, 0.062, P = 0.38, N = 859)
rs4267967(T)/6:135272477	ALDH8A1	(0.56, 0.0037, P = 3.3e-05, N = 7824)	(0.52, 0.064, P = 0.18, N = 859)
rs7760148(A)/6:140201675*	RP5-899B16.2	(0.36, -0.0042, P = 3.4e-06, N = 7824)	(0.52, 0.092, P = 0.055, N = 859)
rs1327674(T)/6:147100481*	ADGB	(0.43, -0.0037, P = 3.8e-05, N = 7824)	(0.24, -0.015, P = 0.79, N = 859)
rs12201109(A)/6:149240393	UST	(0.37, -0.0045, P = 1.1e-06, N = 7824)	(0.3, -0.044, P = 0.41, N = 859)
rs12197879(T)/6:151895777*	CCDC170	(0.6, -0.0044, P = 1.2e-06, N = 7824)	(0.16, -0.022, P = 0.73, N = 859)
rs9383693(T)/6:154474871	IPCEF1	(0.55, -0.0042, P = 3.6e-06, N = 7824)	(0.53, 0.073, P = 0.14, N = 859)
rs2504927(T)/6:160860430*	SLC22A3	(0.44, -0.0041, P = 4.3e-06, N = 7824)	(0.47, -0.092, P = 0.058, N = 859)
rs6915537(A)/6:16900872	intergenic	(0.41, 0.0038, P = 2.5e-05, N = 7824)	(0.31, -0.027, P = 0.6, N = 859)
rs9466453(A)/6:22735375	intergenic	(0.52, 0.0038, P = 2.1e-05, N = 7824)	(0.46, 0.036, P = 0.46, N = 859)
rs9467703(A)/6:26318903*	HIST1H3PS1	(0.37, -0.0045, P = 8.3e-07, N = 7824)	(0.098, -0.063, P = 0.44, N = 859)
rs2235232(A)/6:27326863	ZNF204P	(0.54, 0.0039, P = 1.3e-05, N = 7824)	(0.7, -0.031, P = 0.56, N = 859)
rs1610649(T)/6:29768917*	HLA-P	(0.61, -0.0049, P = 7.9e-08, N = 7824)	(0.52, 0.076, P = 0.12, N = 859)
rs9394368(C)/6:36630525	intergenic	(0.35, -0.0037, P = 4.7e-05, N = 7824)	(0.56, -0.034, P = 0.49, N = 859)
rs1109773(C)/6:39289164	KCNK16	(0.37, 0.004, P = 9e-06, N = 7824)	(0.47, 0.041, P = 0.4, N = 859)
rs2396004(A)/6:43355851*	intergenic	(0.44, 0.0049, P = 4.3e-08, N = 7824)	(0.86, 0.094, P = 0.16, N = 859)
rs6937910(T)/6:51682409	PKHD1	(0.53, -0.0043, P = 1.4e-06, N = 7824)	(0.53, 0.013, P = 0.79, N = 859)
rs685893(A)/6:53961784	MLIP	(0.64, -0.0037, P = 4.4e-05, N = 7824)	(0.53, 0.017, P = 0.73, N = 859)
rs852941(A)/6:72160400	RP1-288M22.2	(0.42, 0.0037, P = 3.7e-05, N = 7824)	(0.56, 0.049, P = 0.34, N = 859)
rs1482567(T)/6:72671565	RIMS1	(0.62, 0.004, P = 9.3e-06, N = 7824)	(0.62, -0.0029, P = 0.95, N = 859)
rs9351906(A)/6:72987855	RIMS1	(0.4, 0.0037, P = 4.1e-05, N = 7824)	(0.27, 0.032, P = 0.56, N = 859)
rs2789599(A)/6:73105163	RIMS1	(0.5, 0.0043, P = 2.2e-06, N = 7824)	(0.45, 0.095, P = 0.046, N = 859)
rs2173986(C)/6:8330781*	RP11-203H2.1	(0.5, -0.0039, P = 1.5e-05, N = 7824)	(0.22, -0.0065, P = 0.91, N = 859)
rs9450000(A)/6:85373267	intergenic	(0.89, -0.0072, P = 1.8e-05, N = 7824)	(0.77, 0.075, P = 0.19, N = 859)
rs998775(A)/6:93859619	intergenic	(0.59, -0.004, P = 1.2e-05, N = 7824)	(0.68, 0.0054, P = 0.92, N = 859)
rs2704975(A)/7:106065174	CTB-111H14.1	(0.39, 0.0037, P = 4.3e-05, N = 7824)	(0.58, 0.01, P = 0.83, N = 859)
rs2189438(A)/7:10719393	intergenic	(0.51, 0.0041, P = 4.5e-06, N = 7824)	(0.45, 0.041, P = 0.39, N = 859)
rs10255200(T)/7:123679743	RP5-921G16.1	(0.48, -0.0039, P = 1.1e-05, N = 7824)	(0.45, 0.022, P = 0.66, N = 859)
rs983849(T)/7:125248586	intergenic	(0.43, 0.0039, P = 1.3e-05, N = 7824)	(0.63, 0.011, P = 0.83, N = 859)
rs2106185(T)/7:127184315	intergenic	(0.39, 0.009, P = 1.9e-05, N = 7824)	(0.04, 0.034, P = 0.79, N = 859)
rs13231650(T)/7:141398942	KIAA1147	(0.43, 0.0041, P = 4.8e-06, N = 7824)	(0.19, -0.035, P = 0.58, N = 859)
rs6948399(C)/7:144175166	TPK1	(0.64, 0.54, P = 3.5e-06, N = 1954)	(0.31, 0.12, P = 0.022, N = 859)
rs17585288(T)/7:146226654	CNTNAP2	(0.91, -0.0099, P = 1.2e-05, N = 7824)	(0.98, 0.065, P = 0.73, N = 859)
rs2961253(T)/7:15175427	intergenic	(0.55, -0.005, P = 5.7e-07, N = 7824)	(0.67, 0.05, P = 0.32, N = 859)
rs9654697(T)/7:155395948	intergenic	(0.6, 0.004, P = 1.2e-05, N = 7824)	(0.31, 0.05, P = 0.34, N = 859)
rs115807806(T)/7:157921957	PTPRN2	(0.085, -0.15, P = 4.9e-06, N = 1954)	(0.02, 0.24, P = 0.16, N = 859)
rs10231585(T)/7:20182020	MACC1	(0.57, -0.0039, P = 1.8e-05, N = 7824)	(0.29, 0.041, P = 0.43, N = 859)
rs13238939(T)/7:21685861*	DNAH11	(0.51, 0.004, P = 1e-05, N = 7824)	(0.16, 0.01, P = 0.88, N = 859)
rs3757440(A)/7:2272936	MAD1L1	(0.62, 0.0037, P = 4.7e-05, N = 7824)	(0.65, -0.044, P = 0.38, N = 859)
rs1544412(T)/7:26498968	AC004540.5	(0.36, -0.0043, P = 2.7e-06, N = 7824)	(0.42, -0.06, P = 0.21, N = 859)
rs12484(T)/7:2768626*	GNA12	(0.43, -0.005, P = 5.7e-07, N = 7824)	(0.6, 0.015, P = 0.76, N = 859)
rs4259315(G)/7:28907437	intergenic	(0.49, -0.17, P = 7.9e-06, N = 1954)	(0.13, -0.014, P = 0.85, N = 859)
rs4722438(A)/7:3155813*	intergenic	(0.44, 0.0044, P = 1.2e-06, N = 7824)	(0.56, 0.061, P = 0.21, N = 859)
rs10275028(T)/7:34889222	NPSR1	(0.65, 0.0046, P = 4.9e-07, N = 7824)	(0.62, 0.0098, P = 0.84, N = 859)
rs4433042(A)/7:43522684	HECW1	(0.56, 0.0037, P = 3.4e-05, N = 7824)	(0.82, 0.057, P = 0.38, N = 859)
rs1866570(C)/7:45166118	intergenic	(0.58, -0.004, P = 7.8e-06, N = 7824)	(0.4, -0.014, P = 0.77, N = 859)
rs3973242(C)/7:75130325	AC018720.10	(0.87, -0.23, P = 8.6e-07, N = 1954)	(0.99, -0.13, P = 0.51, N = 859)
rs2714684(C)/7:79291370	intergenic	(0.54, -0.004, P = 8.8e-06, N = 7824)	(0.56, 0.024, P = 0.61, N = 859)
rs1285441(C)/7:9219283	intergenic	(0.061, -0.24, P = 4.6e-07, N = 1954)	(0.15, 0.0083, P = 0.9, N = 859)
rs4634560(T)/7:94332392	intergenic	(0.91, -0.009, P = 6.8e-06, N = 7824)	(0.85, 0.00044, P = 0.99, N = 859)
rs10239136(T)/7:9571623*	intergenic	(0.6, 0.0044, P = 1.5e-06, N = 7824)	(0.45, -0.051, P = 0.29, N = 859)
rs7799978(A)/7:9716062	intergenic	(0.82, 0.0072, P = 4.5e-06, N = 7824)	(0.63, -0.02, P = 0.7, N = 859)
rs724752(T)/7:98573295	TRRAP	(0.37, 0.0043, P = 2.7e-06, N = 7824)	(0.19, 0.14, P = 0.02, N = 859)
rs34742539(A)/8:113805521	CSMD3	(0.018, -0.032, P = 3.7e-05, N = 7824)	(0.017, 0.12, P = 0.52, N = 859)
rs2068985(C)/8:114053798	CSMD3	(0.35, -0.0041, P = 6.8e-06, N = 7824)	(0.72, 0.002, P = 0.97, N = 859)
rs7836397(A)/8:121875083	intergenic	(0.43, -0.0038, P = 3.4e-05, N = 7824)	(0.069, -0.081, P = 0.39, N = 859)
rs7461025(T)/8:127654091	RP11-89K10.1	(0.59, 0.0043, P = 2.7e-06, N = 7824)	(0.2, -0.021, P = 0.73, N = 859)
rs10481187(T)/8:132479119	intergenic	(0.37, 0.0045, P = 9.7e-07, N = 7824)	(0.36, 0.035, P = 0.49, N = 859)
rs273401(A)/8:132525949	intergenic	(0.41, 0.0039, P = 2.1e-05, N = 7824)	(0.4, -0.0068, P = 0.89, N = 859)
rs865488(T)/8:133938622	TG	(0.68, -0.0041, P = 6.6e-06, N = 7824)	(0.6, 0.041, P = 0.41, N = 859)
rs10111368(A)/8:134646398	intergenic	(0.55, -0.0041, P = 5e-06, N = 7824)	(0.75, 0.044, P = 0.43, N = 859)
rs10505611(T)/8:134662095	intergenic	(0.85, 0.0069, P = 2.3e-05, N = 7824)	(0.97, -0.12, P = 0.43, N = 859)
rs13275417(A)/8:138365307	intergenic	(0.53, 0.0038, P = 2.9e-05, N = 7824)	(0.38, -0.031, P = 0.53, N = 859)
rs6988796(T)/8:139312435	FAM135B	(0.36, 0.0093, P = 1.5e-05, N = 7824)	(0.42, -0.016, P = 0.74, N = 859)
rs7462991(T)/8:17934029*	ASAH1	(0.92, 0.0096, P = 4e-05, N = 7824)	(0.86, -0.16, P = 0.02, N = 859)
rs6984824(A)/8:1910078	ARHGEF10	(0.1, -0.0075, P = 1.5e-05, N = 7824)	(0.14, -0.057, P = 0.41, N = 859)
rs6988339(A)/8:32545916	NRG1	(0.61, -0.0039, P = 2.1e-05, N = 7824)	(0.9, -0.17, P = 0.034, N = 859)
rs7817745(T)/8:38550136	intergenic	(0.61, -0.0039, P = 1.8e-05, N = 7824)	(0.53, 0.032, P = 0.51, N = 859)
rs341815(A)/8:49978424*	C8orf22	(0.36, 0.0038, P = 3e-05, N = 7824)	(0.25, 0.057, P = 0.3, N = 859)
rs1160269(T)/8:5516034*	RP11-281H11.1	(0.44, -0.0039, P = 1.4e-05, N = 7824)	(0.17, -0.043, P = 0.48, N = 859)
rs761722563(CAATA)/8:59764368	TOX	(0.024, 0.14, P = 1.7e-06, N = 1954)	(0.22, 0.03, P = 0.6, N = 859)
rs12541401(A)/8:62805280*	RP11-705O24.2	(0.46, -0.0039, P = 1.1e-05, N = 7824)	(0.14, 0.026, P = 0.7, N = 859)
rs10095757(C)/8:73043160	intergenic	(0.6, 0.0038, P = 2.4e-05, N = 7824)	(0.54, 0.021, P = 0.66, N = 859)
rs4568622(T)/8:85779998	RALYL	(0.58, -0.0039, P = 1.4e-05, N = 7824)	(0.29, -0.023, P = 0.66, N = 859)
rs6468523(T)/8:87900893	CNBD1	(0.48, 0.0039, P = 1.9e-05, N = 7824)	(0.29, 0.071, P = 0.18, N = 859)
rs7837480(A)/8:94468378	LINC00535	(0.48, -0.004, P = 9.3e-06, N = 7824)	(0.64, -0.037, P = 0.48, N = 859)
rs6471514(T)/8:96100272	RP11-320N21.2	(0.54, -0.0042, P = 2.7e-06, N = 7824)	(0.61, 0.05, P = 0.31, N = 859)
rs7815790(A)/8:98902730	MATN2	(0.39, -0.0039, P = 1.8e-05, N = 7824)	(0.5, -0.0076, P = 0.87, N = 859)
rs2780956(A)/9:103348634	MURC	(0.43, -0.0037, P = 4.5e-05, N = 7824)	(0.26, -0.053, P = 0.34, N = 859)
rs10820588(T)/9:106722204	intergenic	(0.56, 0.0048, P = 1.6e-07, N = 7824)	(0.38, -0.059, P = 0.24, N = 859)
rs1507515(A)/9:106989653*	intergenic	(0.54, 0.0041, P = 5.2e-06, N = 7824)	(0.6, -0.015, P = 0.76, N = 859)
rs2777788(A)/9:107662701*	ABCA1	(0.64, -0.005, P = 5.7e-07, N = 7824)	(0.27, -0.021, P = 0.7, N = 859)
rs72694252(G)/9:11126335	intergenic	(0.18, 0.2, P = 3.4e-06, N = 1954)	(0.048, -0.033, P = 0.76, N = 859)
rs1339881(A)/9:111488532	intergenic	(0.68, -0.0038, P = 2.7e-05, N = 7824)	(0.58, -0.0021, P = 0.97, N = 859)
rs7026148(T)/9:115636588	SNX30	(0.39, -0.0045, P = 4.5e-07, N = 7824)	(0.33, -0.014, P = 0.8, N = 859)
rs80794(T)/9:118993074*	PAPPA	(0.41, 0.004, P = 1.1e-05, N = 7824)	(0.51, 0.078, P = 0.098, N = 859)
rs1929425(T)/9:12367988*	intergenic	(0.39, 0.0043, P = 2.1e-06, N = 7824)	(0.71, -0.066, P = 0.21, N = 859)
rs10818924(T)/9:126913862*	intergenic	(0.63, -0.0045, P = 6.1e-07, N = 7824)	(0.57, -0.021, P = 0.65, N = 859)
rs2491102(C)/9:130313343	FAM129B	(0.45, 0.0039, P = 2.1e-05, N = 7824)	(0.63, -0.011, P = 0.82, N = 859)
rs3003607(A)/9:130968398	DNM1	(0.39, -0.004, P = 1e-05, N = 7824)	(0.84, 0.021, P = 0.75, N = 859)
rs482275(T)/9:135351031	C9orf171	(0.57, 0.0041, P = 7.6e-06, N = 7824)	(0.84, 0.018, P = 0.78, N = 859)
rs13284789(T)/9:138581671	SOHLH1	(0.14, 0.0079, P = 9.2e-06, N = 7824)	(0.022, -0.12, P = 0.45, N = 859)
rs7867510(A)/9:15353410	RN7SL157P	(0.16, 0.0068, P = 1.7e-05, N = 7824)	(0.11, 0.084, P = 0.28, N = 859)
rs7038757(T)/9:16222474	C9orf92	(0.65, 0.0041, P = 6.1e-06, N = 7824)	(0.27, -0.00024, P = 1, N = 859)
rs641522(A)/9:22756895	RP11-399D6.2	(0.54, 0.004, P = 1.1e-05, N = 7824)	(0.88, -0.035, P = 0.64, N = 859)
rs3842979(A)/9:28359979*	LINGO2	(0.62, -0.0041, P = 1e-05, N = 7824)	(0.4, -0.026, P = 0.6, N = 859)
rs2164073(T)/9:28890746	MIR873	(0.1, -0.0073, P = 1.9e-05, N = 7824)	(0.2, -0.04, P = 0.5, N = 859)
rs7036584(A)/9:31022187	intergenic	(0.4, -0.0038, P = 3.2e-05, N = 7824)	(0.4, 0.021, P = 0.66, N = 859)
rs12377990(T)/9:32164142	intergenic	(0.54, -0.0038, P = 2.5e-05, N = 7824)	(0.55, -0.015, P = 0.75, N = 859)
rs7026407(T)/9:32502525	DDX58	(0.63, -0.0037, P = 4.7e-05, N = 7824)	(0.66, 0.099, P = 0.047, N = 859)
rs639102(T)/9:3270045	RFX3	(0.45, 0.0038, P = 2.4e-05, N = 7824)	(0.89, -0.055, P = 0.47, N = 859)
rs7850311(T)/9:38060968*	SHB	(0.42, -0.0039, P = 1.5e-05, N = 7824)	(0.5, -0.023, P = 0.64, N = 859)
rs62536941(A)/9:38194965	snoU13	(0.17, -0.55, P = 4.8e-06, N = 1954)	(0.1, -0.057, P = 0.49, N = 859)
rs945573(A)/9:71383888	PIP5K1B	(0.49, 0.0037, P = 4.1e-05, N = 7824)	(0.65, 0.075, P = 0.14, N = 859)
rs10869018(T)/9:74004478	TRPM3	(0.51, -0.0041, P = 5.2e-06, N = 7824)	(0.21, -0.00055, P = 0.99, N = 859)
rs1333342(A)/9:77502160	TRPM6	(0.44, 0.0037, P = 4.4e-05, N = 7824)	(0.13, -0.092, P = 0.22, N = 859)
rs7863838(T)/9:79425483	PRUNE2	(0.58, -0.0038, P = 2.8e-05, N = 7824)	(0.63, -0.0047, P = 0.92, N = 859)
rs273472(A)/9:81876910	intergenic	(0.58, -0.0039, P = 1.3e-05, N = 7824)	(0.51, -0.027, P = 0.57, N = 859)
rs2164183(T)/9:83127968*	intergenic	(0.51, -0.004, P = 9.8e-06, N = 7824)	(0.21, -0.022, P = 0.71, N = 859)
rs1246267(A)/9:86758069	intergenic	(0.59, 0.0045, P = 1.1e-06, N = 7824)	(0.62, -0.029, P = 0.57, N = 859)
rs700760(T)/9:88934624*	ZCCHC6	(0.55, -0.0042, P = 2.6e-06, N = 7824)	(0.81, -0.025, P = 0.69, N = 859)
rs11265783(T)/9:92121724	intergenic	(0.36, 0.0037, P = 4.8e-05, N = 7824)	(0.21, 0.015, P = 0.8, N = 859)
rs4743148(A)/9:98430574	RP11-180I4.2	(0.62, -0.0038, P = 3.2e-05, N = 7824)	(0.65, -0.13, P = 0.0096, N = 859)

Results from Univariable Mendelian Randomization of L-Carnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	535	5e-04 (-0.04- 0.041) P=0.98	19	243	0 (0- 31.6)	NA	NA	0.0019 P=0.44
MR-Egger	535	-0.0028 (-0.045- 0.04) P=0.9	19	243	0 (0- 31.6)	498	0.86	0.0019 P=0.44
Weighted median	535	0.00069 (-0.062- 0.063) P=0.98	19	243	0 (0- 31.6)	NA	NA	0.0019 P=0.44

Results from Univariable MRPRESSO of L-Carnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.02	0.02	0.98
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Carnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	399	0.00085 (-0.039- 0.04) P=0.97	25	243	0 (0- 3.58)	NA	NA	0.00017 P=0.95
MR-Egger	399	0.00058 (-0.042- 0.043) P=0.98	25	243	0 (0- 3.58)	352	0.95	0.00017 P=0.95
Weighted median	399	0.00071 (-0.062- 0.064) P=0.98	25	243	0 (0- 3.58)	NA	NA	0.00017 P=0.95

Results from Univariable MRPRESSO of L-Carnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.02	0.04	0.97
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Choline

Instruments Associations with Choline & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Choline (Shin et al/Long et al)	eGFR (CSSCD)
rs11804649(T)/1:113348570*	intergenic	(0.18, -0.0065, P = 4.5e-05, N = 7824)	(0.081, 0.026, P = 0.76, N = 859)
rs55934782(G)/1:182577385*	RGS16	(0.21, -0.19, P = 3e-06, N = 1955)	(0.042, 0.026, P = 0.83, N = 859)
rs3737875(A)/1:203140671	MYBPH	(0.087, -0.0093, P = 4.9e-05, N = 7824)	(0.09, 0.017, P = 0.84, N = 859)
rs12562454(T)/1:26671084*	AIM1L	(0.2, -0.0067, P = 1.7e-05, N = 7824)	(0.14, -0.09, P = 0.21, N = 859)
rs2666482(A)/1:62716806	KANK4	(0.74, -0.0063, P = 4.6e-05, N = 7824)	(0.69, -0.058, P = 0.28, N = 859)
rs12039115(T)/1:62995263*	DOCK7	(0.13, -0.0088, P = 1.9e-07, N = 7824)	(0.11, -0.037, P = 0.62, N = 859)
rs6577322(A)/1:99164434*	SNX7	(0.26, 0.0061, P = 2.9e-05, N = 7824)	(0.21, 0.012, P = 0.83, N = 859)
rs6584573(C)/10:105570406*	SH3PXD2A	(0.016, 0.024, P = 1.3e-05, N = 7824)	(0.13, -0.11, P = 0.14, N = 859)
rs17642749(T)/10:119647256*	intergenic	(0.95, -0.017, P = 2.7e-06, N = 7824)	(0.96, -0.15, P = 0.23, N = 859)
rs2616664(A)/10:61485660	SLC16A9	(0.94, 0.011, P = 4.6e-05, N = 7824)	(0.84, 0.054, P = 0.43, N = 859)
rs11253260(A)/10:625483*	DIP2C	(0.9, -0.0092, P = 3.6e-05, N = 7824)	(0.47, 0.068, P = 0.16, N = 859)
rs9663814(A)/10:77738382*	C10orf11	(0.62, 0.0069, P = 1.1e-06, N = 7824)	(0.4, -0.014, P = 0.77, N = 859)
rs12253556(A)/10:93285009*	intergenic	(0.036, 0.51, P = 3.6e-06, N = 1955)	(0.27, -0.026, P = 0.63, N = 859)
rs61878861(C)/11:337210	RP11-326C3.15	(0.32, -0.17, P = 4.9e-06, N = 1955)	(0.073, 0.0069, P = 0.94, N = 859)
rs116190469(A)/11:88461300	GRM5	(0.059, 0.42, P = 5.5e-06, N = 1955)	(0.033, 0.058, P = 0.67, N = 859)
rs10765693(A)/11:94403634*	RP11-867G2.8	(0.12, 0.25, P = 8.1e-07, N = 1955)	(0.097, -0.044, P = 0.59, N = 859)
rs11066907(A)/12:114486626*	intergenic	(0.19, -0.0065, P = 3.6e-05, N = 7824)	(0.28, -0.02, P = 0.7, N = 859)
rs4765152(T)/12:124985150*	NCOR2	(0.15, 0.0083, P = 2.3e-05, N = 7824)	(0.21, -0.05, P = 0.4, N = 859)
rs11058334(A)/12:126281125	intergenic	(0.023, -0.022, P = 4.3e-06, N = 7824)	(0.036, -0.07, P = 0.59, N = 859)
rs7984957(C)/13:60814970*	intergenic	(0.78, -0.0065, P = 1.9e-05, N = 7824)	(0.78, -0.026, P = 0.66, N = 859)
rs3904774(T)/13:74080133	LINC00393	(0.27, -0.0094, P = 5e-05, N = 7824)	(0.56, 0.068, P = 0.15, N = 859)
rs1417497(C)/13:88128461	MIR4500HG	(0.072, -0.011, P = 5.4e-06, N = 7824)	(0.12, -0.026, P = 0.73, N = 859)
rs34569161(C)/13:96140764	CLDN10-AS1	(0.43, 0.13, P = 2.3e-06, N = 1955)	(0.72, -0.11, P = 0.046, N = 859)
rs2297615(A)/14:20846521*	TEP1	(0.78, 0.007, P = 8.2e-06, N = 7824)	(0.67, -0.049, P = 0.32, N = 859)
rs1256105(T)/14:64826806	TEX21P	(0.96, 0.014, P = 3e-05, N = 7824)	(0.97, -0.14, P = 0.3, N = 859)
rs8003323(C)/14:70826166*	COX16	(0.99, 0.031, P = 9.5e-06, N = 7824)	(0.96, 0.0094, P = 0.94, N = 859)
rs11631911(A)/15:24915898	NPAP1	(0.85, 0.007, P = 2.4e-05, N = 7824)	(0.84, 0.0095, P = 0.88, N = 859)
rs1906159(T)/15:40019682*	FSIP1	(0.13, -0.0069, P = 3.5e-05, N = 7824)	(0.38, -0.055, P = 0.28, N = 859)
rs8033100(T)/15:71977446*	THSD4	(0.86, -0.0083, P = 4.9e-07, N = 7824)	(0.66, -0.016, P = 0.75, N = 859)
rs4784175(A)/16:62213038	intergenic	(0.86, -0.0091, P = 8.6e-06, N = 7824)	(0.98, -0.13, P = 0.44, N = 859)
rs4888896(A)/16:79006490*	WWOX	(0.5, 0.0084, P = 2.8e-05, N = 7824)	(0.34, -0.019, P = 0.71, N = 859)
rs11656215(T)/17:17453067*	PEMT	(0.5, -0.0079, P = 7.5e-08, N = 7824)	(0.32, -0.095, P = 0.076, N = 859)
rs11867208(T)/17:17504609*	RP11-524F11.2	(0.39, 0.0062, P = 1.4e-05, N = 7824)	(0.4, 0.11, P = 0.025, N = 859)
rs7215931(A)/17:30099125	RP11-805L22.3	(0.2, 0.0079, P = 1.3e-06, N = 7824)	(0.15, 0.032, P = 0.64, N = 859)
rs2053158(A)/17:73393459*	GRB2	(0.83, 0.0066, P = 4.3e-05, N = 7824)	(0.22, -0.019, P = 0.75, N = 859)
rs4789359(T)/17:74820027	intergenic	(0.76, 0.0065, P = 2.1e-05, N = 7824)	(0.85, 0.046, P = 0.49, N = 859)
rs3786284(A)/18:12010646*	IMPA2	(0.15, 0.0077, P = 2e-06, N = 7824)	(0.12, 0.1, P = 0.16, N = 859)
rs11663451(T)/18:2636605*	intergenic	(0.19, 0.25, P = 2.1e-06, N = 1955)	(0.47, 0.0016, P = 0.97, N = 859)
rs1600674(A)/18:49450206	intergenic	(0.83, 0.18, P = 1.5e-06, N = 1955)	(0.59, -0.08, P = 0.11, N = 859)
rs7231686(C)/18:56737737*	OACYLP	(0.44, -0.2, P = 9.4e-07, N = 1955)	(0.42, 0.0099, P = 0.84, N = 859)
rs12964226(T)/18:70957863*	intergenic	(0.21, -0.18, P = 5.7e-06, N = 1955)	(0.24, 0.08, P = 0.16, N = 859)
rs2032334(A)/18:71191392	intergenic	(0.79, -0.0068, P = 1.2e-05, N = 7824)	(0.71, 0.063, P = 0.24, N = 859)
rs6506578(A)/18:8375039	PTPRM	(0.017, -0.039, P = 3.9e-05, N = 7824)	(0.064, 0.12, P = 0.22, N = 859)
rs2158004(A)/19:19033089	DDX49	(0.14, -0.0077, P = 1.3e-05, N = 7824)	(0.42, 0.079, P = 0.11, N = 859)
rs321941(A)/19:52860348*	ZNF610	(0.16, -0.011, P = 4e-05, N = 7824)	(0.48, -0.0038, P = 0.94, N = 859)
rs7573335(T)/2:11127705*	intergenic	(0.89, -0.0088, P = 4.8e-05, N = 7824)	(0.76, -0.011, P = 0.85, N = 859)
rs4538138(T)/2:147285915	intergenic	(0.19, 0.0071, P = 6.1e-06, N = 7824)	(0.45, 0.02, P = 0.69, N = 859)
rs34658429(C)/2:16597553	AC010880.1	(0.68, -0.14, P = 1.6e-06, N = 1955)	(0.24, -0.057, P = 0.32, N = 859)
rs715(T)/2:211543055*	CPS1	(0.71, 0.008, P = 9.1e-08, N = 7824)	(0.81, -0.061, P = 0.33, N = 859)
rs16865057(A)/2:224529849*	intergenic	(0.97, -0.015, P = 3.8e-05, N = 7824)	(0.63, -0.13, P = 0.0065, N = 859)
rs10194073(A)/2:38117987*	intergenic	(0.79, -0.007, P = 6.3e-06, N = 7824)	(0.68, 0.075, P = 0.15, N = 859)
rs12105001(A)/2:44382375*	RNU6-566P	(0.049, -0.013, P = 7.5e-06, N = 7824)	(0.029, -0.22, P = 0.11, N = 859)
rs4293599(C)/2:48944744	LHCGR	(0.18, 0.0071, P = 5.9e-06, N = 7824)	(0.11, -0.006, P = 0.94, N = 859)
rs7574038(C)/2:5276851	intergenic	(0.077, 0.33, P = 5.3e-06, N = 1955)	(0.2, 0.13, P = 0.037, N = 859)
rs6716379(C)/2:6896086	LINC00487	(0.15, 0.22, P = 4.7e-06, N = 1955)	(0.16, 0.013, P = 0.84, N = 859)
rs6546697(T)/2:71707208	DYSF	(0.16, 0.0074, P = 1.3e-05, N = 7824)	(0.27, 0.075, P = 0.18, N = 859)
rs3856464(A)/2:9825974	RP11-521D12.2	(0.34, 0.18, P = 8e-06, N = 1955)	(0.3, 0.032, P = 0.54, N = 859)
rs6035707(A)/20:20822149*	intergenic	(0.91, 0.0097, P = 1.1e-05, N = 7824)	(0.84, 0.034, P = 0.6, N = 859)
rs2072241(A)/20:52561372	BCAS1	(0.78, 0.0067, P = 1.4e-05, N = 7824)	(0.85, -0.0091, P = 0.89, N = 859)
rs2824226(A)/21:18457828	intergenic	(0.82, 0.0074, P = 3.2e-06, N = 7824)	(0.81, 0.011, P = 0.85, N = 859)
rs2833296(A)/21:32509845	TIAM1	(0.85, -0.0071, P = 1.1e-05, N = 7824)	(0.5, -0.023, P = 0.63, N = 859)
rs2268241(A)/21:34781050	IFNGR2	(0.14, -0.007, P = 3.3e-05, N = 7824)	(0.35, 0.079, P = 0.11, N = 859)
rs2293370(A)/3:119219934*	TIMMDC1	(0.19, 0.0064, P = 4.2e-05, N = 7824)	(0.2, 0.014, P = 0.81, N = 859)
rs2049502(A)/3:119254385*	CD80	(0.83, -0.0065, P = 4.1e-05, N = 7824)	(0.88, -0.016, P = 0.82, N = 859)
rs7645964(A)/3:168709924	intergenic	(0.01, -0.79, P = 3.5e-06, N = 1955)	(0.12, 0.25, P = 0.00044, N = 859)
rs12485568(G)/3:26669772	LRRC3B	(0.54, 0.14, P = 9.1e-06, N = 1955)	(0.38, -0.023, P = 0.64, N = 859)
rs555638682(CGGCCG)/3:47517573	SCAP	(0.013, -0.64, P = 8.2e-06, N = 1955)	(0.019, -0.12, P = 0.5, N = 859)
rs71308083(A)/3:55170650	intergenic	(0.053, -0.42, P = 1.2e-06, N = 1955)	(0.016, 0.14, P = 0.45, N = 859)
rs1403072(T)/3:70373502*	intergenic	(0.77, 0.17, P = 8.5e-06, N = 1955)	(0.66, -0.023, P = 0.65, N = 859)
rs11930490(A)/4:131803692*	RP11-401I19.1	(0.8, -0.0076, P = 1.5e-06, N = 7824)	(0.79, -0.062, P = 0.29, N = 859)
rs2867675(A)/4:14214505	RP11-669M16.1	(0.044, -0.39, P = 9.1e-06, N = 1955)	(0.012, 0.032, P = 0.88, N = 859)
rs7687295(A)/4:182067936	LINC00290	(0.025, 0.021, P = 4.3e-06, N = 7824)	(0.21, -0.082, P = 0.16, N = 859)
rs16885645(A)/4:31678993	intergenic	(0.055, 0.011, P = 4.7e-05, N = 7824)	(0.14, -0.032, P = 0.64, N = 859)
rs9761879(A)/4:43860178	intergenic	(0.77, 0.23, P = 6.3e-06, N = 1955)	(0.55, 0.067, P = 0.17, N = 859)
rs12509841(T)/4:46578339	intergenic	(0.15, -0.0067, P = 3.1e-05, N = 7824)	(0.15, 0.0058, P = 0.93, N = 859)
rs959160(C)/4:47288955*	GABRB1	(0.8, -0.0069, P = 1.1e-05, N = 7824)	(0.97, 0.026, P = 0.87, N = 859)
rs2136209(A)/5:115384247*	ARL14EPL	(0.85, -0.0068, P = 2.2e-05, N = 7824)	(0.77, -0.04, P = 0.48, N = 859)
rs17140120(A)/5:115892364	SEMA6A	(0.16, 0.007, P = 1.1e-05, N = 7824)	(0.04, 0.1, P = 0.39, N = 859)
rs3798102(T)/5:132605601	FSTL4	(0.97, -0.025, P = 3.8e-05, N = 7824)	(0.38, 0.076, P = 0.12, N = 859)
rs4487482(A)/5:135201771*	SLC25A48	(0.8, 0.0081, P = 1.8e-07, N = 7824)	(0.9, 0.0042, P = 0.96, N = 859)
rs1573824(A)/5:170269857	intergenic	(0.17, -0.0067, P = 2.4e-05, N = 7824)	(0.3, 0.025, P = 0.63, N = 859)
rs224947(C)/5:81712715	intergenic	(0.28, -0.0059, P = 4.8e-05, N = 7824)	(0.25, 0.054, P = 0.34, N = 859)
rs111326958(T)/6:105755606	PREP	(0.051, -0.36, P = 5.9e-06, N = 1955)	(0.059, 0.033, P = 0.75, N = 859)
rs983669(T)/6:127122998*	intergenic	(0.55, 0.0063, P = 1.8e-05, N = 7824)	(0.64, -0.008, P = 0.87, N = 859)
rs9321388(A)/6:133384863*	intergenic	(0.18, -0.0072, P = 7.6e-06, N = 7824)	(0.74, 0.045, P = 0.4, N = 859)
rs17788268(T)/6:169477819	intergenic	(0.2, 0.0066, P = 2.1e-05, N = 7824)	(0.042, -0.059, P = 0.63, N = 859)
rs303000(A)/6:25057499	RP3-425P12.1	(0.17, 0.0069, P = 1.3e-05, N = 7824)	(0.081, 0.096, P = 0.29, N = 859)
rs7745768(T)/6:29314964*	intergenic	(0.14, -0.0069, P = 3.3e-05, N = 7824)	(0.16, 0.027, P = 0.68, N = 859)
rs2485074(A)/6:75350666	RP11-554D15.1	(0.094, 0.0096, P = 1.3e-05, N = 7824)	(0.019, 0.03, P = 0.87, N = 859)
rs2299554(T)/7:126857154*	GRM8	(0.96, 0.015, P = 3.6e-05, N = 7824)	(0.91, 0.018, P = 0.83, N = 859)
rs2080224(A)/7:19528604*	AC007091.1	(0.93, -0.011, P = 2e-06, N = 7824)	(0.68, 0.012, P = 0.81, N = 859)
rs156282(G)/7:24200098*	intergenic	(0.37, 0.2, P = 1.8e-06, N = 1955)	(0.67, -0.047, P = 0.36, N = 859)
rs2254363(A)/7:36122030*	PP13004	(0.14, 0.0076, P = 1.1e-05, N = 7824)	(0.41, 0.032, P = 0.5, N = 859)
rs2371208(T)/7:82337859*	intergenic	(0.22, -0.0062, P = 3.9e-05, N = 7824)	(0.49, -0.001, P = 0.98, N = 859)
rs4262299(A)/8:108342263	ANGPT1	(0.87, 0.0072, P = 1.5e-05, N = 7824)	(0.93, -0.04, P = 0.66, N = 859)
rs9694615(T)/8:21219361*	intergenic	(0.72, 0.0063, P = 3e-05, N = 7824)	(0.95, -0.067, P = 0.56, N = 859)
rs4242454(A)/8:50672477*	intergenic	(0.14, 0.0077, P = 3.2e-06, N = 7824)	(0.23, 0.14, P = 0.013, N = 859)
rs11791084(A)/9:138245834	RP11-555H7.2	(0.17, -0.0068, P = 3e-05, N = 7824)	(0.15, 0.046, P = 0.49, N = 859)
rs7860932(A)/9:16786898*	BNC2	(0.92, -0.0098, P = 1.5e-05, N = 7824)	(0.85, -0.00075, P = 0.99, N = 859)
rs10963078(T)/9:17394225	CNTLN	(0.3, 0.009, P = 2.7e-05, N = 7824)	(0.16, 0.0074, P = 0.91, N = 859)
rs2891282(C)/9:26227745*	intergenic	(0.85, -0.0067, P = 2.8e-05, N = 7824)	(0.74, -0.04, P = 0.46, N = 859)
rs12551252(T)/9:98438329	RP11-180I4.2	(0.075, -0.01, P = 1.5e-05, N = 7824)	(0.035, 0.064, P = 0.63, N = 859)

Results from Univariable Mendelian Randomization of Choline & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	102	-0.096 (-0.19- -0.0058) P=0.037	6.3	32	8.36 (0- 48.8)	NA	NA	0.0053 P=0.45
MR-Egger	102	-0.11 (-0.22- -0.011) P=0.032	6.3	32	8.36 (0- 48.8)	98	0.55	0.0053 P=0.45
Weighted median	102	-0.053 (-0.22- 0.12) P=0.54	6.3	32	8.36 (0- 48.8)	NA	NA	0.0053 P=0.45

Results from Univariable MRPRESSO of Choline & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.1	0.05	-2.09	0.04
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Choline & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	50	-0.1 (-0.23- 0.016) P=0.088	7.8	20	17.8 (0- 39.8)	NA	NA	-0.0077 P=0.49
MR-Egger	50	-0.08 (-0.22- 0.059) P=0.26	7.8	20	17.8 (0- 39.8)	50	0.38	-0.0077 P=0.49
Weighted median	50	-0.085 (-0.32- 0.15) P=0.47	7.8	20	17.8 (0- 39.8)	NA	NA	-0.0077 P=0.49

Results from Univariable MRPRESSO of Choline & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.1	0.06	-1.71	0.09
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Citric acid

Instruments Associations with Citric acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Citric acid (Shin et al/Long et al)	eGFR (CSSCD)
rs2392041(A)/1:100056225	intergenic	(0.66, -0.0075, P = 3.5e-05, N = 7824)	(0.46, -0.013, P = 0.79, N = 859)
rs3125672(T)/1:107822255*	NTNG1	(0.3, -0.0076, P = 2.7e-05, N = 7824)	(0.1, -0.11, P = 0.15, N = 859)
rs6604130(A)/1:109388656*	AKNAD1	(0.19, 0.15, P = 3.9e-06, N = 1958)	(0.52, -0.014, P = 0.76, N = 859)
rs17037696(T)/1:12243274	TNFRSF1B	(0.26, -0.011, P = 1.2e-05, N = 7824)	(0.19, 0.062, P = 0.31, N = 859)
rs12136772(A)/1:19901804	intergenic	(0.92, -0.014, P = 4e-05, N = 7824)	(0.93, -0.13, P = 0.18, N = 859)
rs6678076(A)/1:199233200*	RP11-382E9.1	(0.034, -0.025, P = 1.1e-06, N = 7824)	(0.24, -0.0069, P = 0.91, N = 859)
rs6655965(A)/1:203680492*	ATP2B4	(0.54, 0.0074, P = 3.6e-05, N = 7824)	(0.35, 0.0073, P = 0.88, N = 859)
rs11120725(A)/1:216206768	USH2A	(0.46, -0.018, P = 4.6e-06, N = 7824)	(0.34, 0.025, P = 0.63, N = 859)
rs265126(A)/1:217620203*	GPATCH2	(0.17, 0.011, P = 2.6e-05, N = 7824)	(0.35, 0.081, P = 0.11, N = 859)
rs2813960(T)/1:227402299	CDC42BPA	(0.67, -0.018, P = 2.5e-05, N = 7824)	(0.64, 0.016, P = 0.76, N = 859)
rs11584333(A)/1:230529619*	PGBD5	(0.32, -0.15, P = 5e-06, N = 1958)	(0.09, 0.081, P = 0.34, N = 859)
rs614612(T)/1:23422692*	LUZP1	(0.16, -0.022, P = 1.7e-05, N = 7824)	(0.19, 0.12, P = 0.051, N = 859)
rs12748947(T)/1:239463528	intergenic	(0.68, -0.0074, P = 4.7e-05, N = 7824)	(0.92, 0.068, P = 0.44, N = 859)
rs260969(T)/1:39551621	MACF1	(0.28, -0.0074, P = 4.8e-05, N = 7824)	(0.14, 0.068, P = 0.34, N = 859)
rs7512821(A)/1:62774469*	KANK4	(0.46, -0.0074, P = 3.2e-05, N = 7824)	(0.69, -0.061, P = 0.25, N = 859)
rs11492774(C)/10:109637548	RP11-215N21.1	(0.15, -0.24, P = 6.8e-06, N = 1958)	(0.14, 0.025, P = 0.73, N = 859)
rs10787308(A)/10:112908968*	intergenic	(0.27, -0.009, P = 6e-07, N = 7824)	(0.26, 0.016, P = 0.77, N = 859)
rs4880317(A)/10:133880163	intergenic	(0.32, -0.0074, P = 4.6e-05, N = 7824)	(0.13, -0.015, P = 0.83, N = 859)
rs3750870(T)/10:24548718*	KIAA1217	(0.36, 0.0077, P = 1.9e-05, N = 7824)	(0.14, 0.1, P = 0.14, N = 859)
rs4589188(A)/10:5567914	CALML3	(0.28, 0.012, P = 3.3e-06, N = 7824)	(0.29, 0.0042, P = 0.94, N = 859)
rs7919076(T)/10:68328936	CTNNA3	(0.34, -0.0081, P = 7.8e-06, N = 7824)	(0.22, 0.051, P = 0.38, N = 859)
rs2057440(A)/10:77758013	C10orf11	(0.72, 0.0079, P = 1.3e-05, N = 7824)	(0.39, -0.053, P = 0.27, N = 859)
rs10824358(T)/10:77827397	C10orf11	(0.55, -0.0072, P = 4.8e-05, N = 7824)	(0.75, -0.088, P = 0.11, N = 859)
rs4918082(A)/10:95859929*	PLCE1	(0.72, -0.0079, P = 1.3e-05, N = 7824)	(0.46, 0.036, P = 0.46, N = 859)
rs3193970(T)/10:97072008*	SORBS1	(0.58, 0.0081, P = 6.1e-06, N = 7824)	(0.63, 0.051, P = 0.31, N = 859)
rs1998911(T)/10:97266538*	SORBS1	(0.29, 0.0075, P = 4.4e-05, N = 7824)	(0.58, -0.0063, P = 0.9, N = 859)
rs527936(C)/11:100279586	intergenic	(0.88, 0.011, P = 4.5e-05, N = 7824)	(0.79, -0.057, P = 0.32, N = 859)
rs7105815(A)/11:12309693	MICALCL	(0.3, 0.0091, P = 4.9e-07, N = 7824)	(0.38, 0.00062, P = 0.99, N = 859)
rs7950818(T)/11:124385456*	OR8B10P	(0.12, -0.011, P = 2.1e-05, N = 7824)	(0.19, -0.045, P = 0.47, N = 859)
rs2878806(T)/11:17713507*	RP11-358H18.3	(0.75, -0.0078, P = 2e-05, N = 7824)	(0.17, 0.15, P = 0.02, N = 859)
rs7109624(A)/11:20836004	NELL1	(0.018, -0.031, P = 4.5e-05, N = 7824)	(0.036, 0.043, P = 0.74, N = 859)
rs2237897(T)/11:2858546	KCNQ1	(0.058, -0.038, P = 1e-05, N = 7824)	(0.086, -0.074, P = 0.39, N = 859)
rs13966(T)/11:61664992*	RAB3IL1	(0.47, 0.0082, P = 1e-05, N = 7824)	(0.54, 0.079, P = 0.11, N = 859)
rs12797573(T)/11:77255306*	CLNS1A	(0.69, -0.0076, P = 2.6e-05, N = 7824)	(0.87, -0.053, P = 0.45, N = 859)
rs12222578(T)/11:81696265	RP11-179A16.1	(0.29, -0.0073, P = 4.6e-05, N = 7824)	(0.11, 0.082, P = 0.29, N = 859)
rs12803308(A)/11:96180609*	JRKL-AS1	(0.68, -0.0081, P = 6e-06, N = 7824)	(0.82, 0.023, P = 0.71, N = 859)
rs1169072(A)/12:122401501*	WDR66	(0.42, 0.0078, P = 1.2e-05, N = 7824)	(0.16, 0.011, P = 0.87, N = 859)
rs79424089(G)/12:21485527	SLCO1A2	(0.061, 0.23, P = 2.5e-06, N = 1958)	(0.013, -0.11, P = 0.61, N = 859)
rs2080125(T)/12:7727544*	intergenic	(0.27, 0.0074, P = 4.8e-05, N = 7824)	(0.8, 0.079, P = 0.18, N = 859)
rs932829(A)/13:40828542	intergenic	(0.47, -0.0078, P = 1.3e-05, N = 7824)	(0.41, -0.21, P = 2.9e-05, N = 859)
rs35354791(TG)/13:46419404	SIAH3	(0.45, 0.18, P = 8.7e-06, N = 1958)	(0.82, -0.0025, P = 0.97, N = 859)
rs1953192(T)/14:40297539*	intergenic	(0.42, 0.0077, P = 1.3e-05, N = 7824)	(0.1, 0.0087, P = 0.91, N = 859)
rs2236299(A)/14:55255335	SAMD4A	(0.31, 0.0087, P = 1.7e-06, N = 7824)	(0.14, 0.051, P = 0.46, N = 859)
rs8017368(A)/14:63527183*	KCNH5	(0.65, -0.0083, P = 3.9e-06, N = 7824)	(0.52, 0.062, P = 0.2, N = 859)
rs10147304(A)/14:79079176	NRXN3	(0.052, 0.018, P = 1.6e-05, N = 7824)	(0.2, -0.011, P = 0.85, N = 859)
rs74686496(C)/14:98384933	intergenic	(0.12, 0.26, P = 9.5e-06, N = 1958)	(0.012, -0.17, P = 0.41, N = 859)
rs8025575(C)/15:26788083*	GABRB3	(0.46, -0.0073, P = 4.6e-05, N = 7824)	(0.59, -0.03, P = 0.54, N = 859)
rs4779800(A)/15:29411326*	APBA2	(0.88, -0.012, P = 6.1e-06, N = 7824)	(0.54, -0.021, P = 0.66, N = 859)
rs8025554(C)/15:32418417	CHRNA7	(0.52, -0.008, P = 6.6e-06, N = 7824)	(0.34, -0.091, P = 0.076, N = 859)
rs1530219(A)/15:39602380*	RP11-462P6.1	(0.48, -0.0078, P = 9.9e-06, N = 7824)	(0.16, -0.038, P = 0.56, N = 859)
rs3784283(A)/15:41867782	TYRO3	(0.61, 0.0076, P = 2.1e-05, N = 7824)	(0.5, -0.0078, P = 0.87, N = 859)
rs7179219(A)/15:42324479	PLA2G4E	(0.15, -0.011, P = 2.3e-05, N = 7824)	(0.26, 0.077, P = 0.15, N = 859)
rs2727091(T)/15:66124227*	RAB11A	(0.12, -0.012, P = 1.4e-05, N = 7824)	(0.12, 0.024, P = 0.75, N = 859)
rs11862304(A)/16:17191196	XYLT1	(0.28, 0.0077, P = 2e-05, N = 7824)	(0.42, 0.084, P = 0.083, N = 859)
rs2239337(C)/16:22911553	HS3ST2	(0.036, 0.023, P = 7.5e-06, N = 7824)	(0.29, 0.02, P = 0.7, N = 859)
rs6502405(A)/17:14834158	intergenic	(0.39, -0.0076, P = 2.3e-05, N = 7824)	(0.14, -0.045, P = 0.51, N = 859)
rs170149(A)/17:6595930	SLC13A5	(0.074, 0.026, P = 1.4e-13, N = 7824)	(0.25, -0.048, P = 0.37, N = 859)
rs218682(T)/17:6614288	SLC13A5	(0.4, 0.0093, P = 3e-07, N = 7824)	(0.78, -0.083, P = 0.16, N = 859)
rs4999864(C)/17:66786460	RP11-118B18.2	(0.93, 0.018, P = 4.8e-07, N = 7824)	(0.79, 0.026, P = 0.66, N = 859)
rs1509123(T)/17:6683878	FBXO39	(0.048, -0.025, P = 5.2e-09, N = 7824)	(0.04, 0.038, P = 0.76, N = 859)
rs12103645(T)/17:6721216*	TEKT1	(0.086, -0.018, P = 6.6e-08, N = 7824)	(0.18, -0.04, P = 0.51, N = 859)
rs9901983(A)/17:71816764*	LINC00469	(0.021, 0.062, P = 4.9e-05, N = 7824)	(0.42, 0.0065, P = 0.89, N = 859)
rs6507399(A)/18:38732045	intergenic	(0.67, -0.01, P = 1.7e-08, N = 7824)	(0.79, -0.025, P = 0.67, N = 859)
rs2552494(A)/18:38751633*	intergenic	(0.19, 0.011, P = 3.4e-05, N = 7824)	(0.41, -0.0041, P = 0.94, N = 859)
rs1792712(A)/18:53834119	CTD-2008L17.2	(0.41, 0.0075, P = 2.7e-05, N = 7824)	(0.71, 0.019, P = 0.71, N = 859)
rs17208063(T)/18:67557428	CD226	(0.076, 0.2, P = 9.1e-06, N = 1958)	(0.074, 0.044, P = 0.62, N = 859)
rs36013690(CA)/18:74632507	ZNF236	(0.079, -0.23, P = 9.1e-06, N = 1958)	(0.8, -0.055, P = 0.36, N = 859)
rs889128(T)/19:10131693	RDH8	(0.67, 0.0082, P = 6.8e-06, N = 7824)	(0.39, -0.048, P = 0.33, N = 859)
rs279220(A)/19:11990258	ZNF439	(0.33, 0.18, P = 9.4e-06, N = 1958)	(0.44, -0.017, P = 0.72, N = 859)
rs588973(A)/19:50736956*	MYH14	(0.65, 0.009, P = 6.8e-06, N = 7824)	(0.58, 0.11, P = 0.024, N = 859)
rs2370136(T)/19:57619241*	intergenic	(0.49, -0.0086, P = 1.2e-06, N = 7824)	(0.73, 0.0081, P = 0.88, N = 859)
rs6725836(T)/2:107862691*	intergenic	(0.7, -0.0077, P = 2e-05, N = 7824)	(0.34, -0.00076, P = 0.99, N = 859)
rs11693199(T)/2:119732042	MARCO	(0.59, -0.0079, P = 1e-05, N = 7824)	(0.92, 0.034, P = 0.7, N = 859)
rs3749114(A)/2:160832996*	PLA2R1	(0.46, 0.0078, P = 1.3e-05, N = 7824)	(0.9, -0.026, P = 0.74, N = 859)
rs17614686(C)/2:167808253*	XIRP2	(0.88, 0.012, P = 1.4e-05, N = 7824)	(0.95, 0.12, P = 0.29, N = 859)
rs6747034(A)/2:174238868	intergenic	(0.48, -0.0074, P = 3e-05, N = 7824)	(0.76, -0.039, P = 0.48, N = 859)
rs4470337(A)/2:228293381	intergenic	(0.42, -0.0074, P = 3.6e-05, N = 7824)	(0.48, -0.0017, P = 0.97, N = 859)
rs76848421(T)/2:240661614	RP11-315F22.1	(0.017, 0.66, P = 4.3e-06, N = 1958)	(0.13, 0.078, P = 0.28, N = 859)
rs4274563(T)/2:30157386	intergenic	(0.38, -0.0075, P = 3.3e-05, N = 7824)	(0.54, 0.021, P = 0.66, N = 859)
rs7584253(A)/2:48927246*	LHCGR	(0.7, 0.0083, P = 5e-06, N = 7824)	(0.74, 0.062, P = 0.26, N = 859)
rs193031(C)/2:64260458	intergenic	(0.18, 0.011, P = 1.2e-05, N = 7824)	(0.43, -0.069, P = 0.16, N = 859)
rs939136(C)/2:66677531	MEIS1	(0.67, -0.0076, P = 2.3e-05, N = 7824)	(0.48, 0.054, P = 0.26, N = 859)
rs6077792(T)/20:1096116	PSMF1	(0.3, -0.0085, P = 2.8e-06, N = 7824)	(0.26, -0.0064, P = 0.91, N = 859)
rs6121327(A)/20:30643515	HCK	(0.012, 0.68, P = 4e-06, N = 1958)	(0.059, 0.065, P = 0.52, N = 859)
rs1325760(T)/20:46740070	intergenic	(0.74, 0.0077, P = 1.8e-05, N = 7824)	(0.22, 0.074, P = 0.21, N = 859)
rs12625828(T)/20:48844585	intergenic	(0.34, 0.0086, P = 2.1e-06, N = 7824)	(0.18, 0.096, P = 0.13, N = 859)
rs11905229(C)/20:55151100	RP5-843L14.1	(0.43, 0.013, P = 5.8e-06, N = 7824)	(0.28, 0.032, P = 0.55, N = 859)
rs6133537(A)/20:8039501	intergenic	(0.061, 0.018, P = 1.8e-05, N = 7824)	(0.093, -0.051, P = 0.55, N = 859)
rs2836710(T)/21:40218782	AP001042.1	(0.63, 0.0077, P = 1.7e-05, N = 7824)	(0.75, 0.0025, P = 0.96, N = 859)
rs1125471(A)/22:17656724	CECR1	(0.29, -0.0085, P = 4.5e-06, N = 7824)	(0.19, -0.074, P = 0.22, N = 859)
rs807670(A)/22:19154608*	AC004463.6	(0.42, 0.011, P = 6.8e-10, N = 7824)	(0.44, -0.033, P = 0.49, N = 859)
rs723414(A)/22:19185736*	CLTCL1	(0.56, -0.0072, P = 4.6e-05, N = 7824)	(0.79, 0.042, P = 0.48, N = 859)
rs361787(T)/22:19263698*	CLTCL1	(0.61, -0.0091, P = 3.8e-07, N = 7824)	(0.75, 0.0011, P = 0.98, N = 859)
rs738809(A)/22:24405492*	CABIN1	(0.72, 0.0077, P = 2.1e-05, N = 7824)	(0.7, -0.068, P = 0.21, N = 859)
rs9624921(T)/22:26250248*	MYO18B	(0.3, 0.0074, P = 4.5e-05, N = 7824)	(0.14, 0.037, P = 0.6, N = 859)
rs2413380(T)/22:36519040*	intergenic	(0.6, -0.0076, P = 2.1e-05, N = 7824)	(0.86, -0.035, P = 0.6, N = 859)
rs133064(A)/22:41071731	MCHR1	(0.38, -0.0073, P = 4.6e-05, N = 7824)	(0.33, 0.041, P = 0.42, N = 859)
rs11706160(G)/3:1461452	intergenic	(0.27, 0.2, P = 6.5e-06, N = 1958)	(0.061, -0.0047, P = 0.96, N = 859)
rs11276214(TTTACTACAATTTAC)/3:183088540	MCF2L2	(0.062, -0.24, P = 2.1e-06, N = 1958)	(0.55, -0.023, P = 0.62, N = 859)
rs7623540(A)/3:188489540	LPP	(0.72, -0.0085, P = 3.4e-06, N = 7824)	(0.45, -0.019, P = 0.69, N = 859)
rs10514735(A)/3:85798950*	CADM2	(0.98, 0.035, P = 6.5e-06, N = 7824)	(0.97, 0.23, P = 0.092, N = 859)
rs17034684(T)/4:105511810	AC004053.1	(0.29, 0.0081, P = 7.9e-06, N = 7824)	(0.26, -0.038, P = 0.49, N = 859)
rs697365(A)/4:121377644	intergenic	(0.34, -0.0075, P = 3e-05, N = 7824)	(0.12, 0.032, P = 0.67, N = 859)
rs12499121(T)/4:12297535*	intergenic	(0.79, 0.011, P = 1.5e-05, N = 7824)	(0.73, -0.049, P = 0.36, N = 859)
rs13151462(A)/4:12670968*	intergenic	(0.58, 0.0081, P = 5.1e-06, N = 7824)	(0.39, -0.0099, P = 0.84, N = 859)
rs1033175(A)/4:128532930*	intergenic	(0.57, 0.0076, P = 2.1e-05, N = 7824)	(0.43, -0.00028, P = 1, N = 859)
rs28446988(T)/4:140140965*	intergenic	(0.24, 0.12, P = 7.9e-06, N = 1958)	(0.5, -0.031, P = 0.51, N = 859)
rs13130021(T)/4:2277763*	ZFYVE28	(0.43, -0.0089, P = 1.4e-06, N = 7824)	(0.18, 0.1, P = 0.1, N = 859)
rs13128174(C)/4:37739459	intergenic	(0.16, -0.21, P = 9.9e-06, N = 1958)	(0.065, 0.053, P = 0.59, N = 859)
rs4861079(A)/4:40371287	intergenic	(0.86, -0.011, P = 1.7e-05, N = 7824)	(0.43, 0.011, P = 0.81, N = 859)
rs1404373(T)/4:58204024	intergenic	(0.65, -0.0084, P = 2.9e-06, N = 7824)	(0.95, 0.12, P = 0.28, N = 859)
rs6854172(T)/4:6410288*	PPP2R2C	(0.16, 0.022, P = 2.1e-05, N = 7824)	(0.21, 0.027, P = 0.65, N = 859)
rs4235093(A)/4:72346252	SLC4A4	(0.29, -0.0083, P = 5e-06, N = 7824)	(0.78, 0.039, P = 0.49, N = 859)
rs13106792(A)/4:80239092	NAA11	(0.63, 0.0078, P = 1.4e-05, N = 7824)	(0.68, -0.056, P = 0.28, N = 859)
rs4693453(A)/4:83448507*	TMEM150C	(0.87, 0.011, P = 2.7e-05, N = 7824)	(0.45, 0.012, P = 0.8, N = 859)
rs12509601(A)/4:92222755	CCSER1	(0.71, -0.15, P = 3.7e-06, N = 1958)	(0.96, -0.1, P = 0.39, N = 859)
rs1230171(C)/4:99924278*	METAP1	(0.68, -0.0076, P = 2.8e-05, N = 7824)	(0.85, -0.046, P = 0.5, N = 859)
rs17595102(C)/4:99986316*	METAP1	(0.44, -0.0078, P = 1.3e-05, N = 7824)	(0.12, 0.032, P = 0.67, N = 859)
rs1549924(A)/5:107216209*	FBXL17	(0.079, -0.015, P = 2e-05, N = 7824)	(0.17, 0.044, P = 0.48, N = 859)
rs9327706(A)/5:134512608*	C5orf66	(0.59, 0.0081, P = 5.6e-06, N = 7824)	(0.55, 0.045, P = 0.35, N = 859)
rs111686785(G)/5:14738965	ANKH	(0.03, -0.61, P = 1.1e-07, N = 1958)	(0.019, 0.077, P = 0.66, N = 859)
rs835154(A)/5:14876569*	ANKH	(0.58, -0.011, P = 1.1e-10, N = 7824)	(0.88, 0.092, P = 0.22, N = 859)
rs1968433(T)/5:155628282	SGCD	(0.66, 0.0076, P = 2.2e-05, N = 7824)	(0.93, -0.11, P = 0.27, N = 859)
rs10043015(T)/5:168658371	SLIT3	(0.71, 0.0082, P = 5.6e-06, N = 7824)	(0.61, -0.13, P = 0.011, N = 859)
rs9313504(A)/5:169830698*	CTD-2270F17.1	(0.99, -0.074, P = 3.4e-05, N = 7824)	(0.8, 0.072, P = 0.23, N = 859)
rs2731709(T)/5:171788634*	SH3PXD2B	(0.67, -0.0078, P = 1.6e-05, N = 7824)	(0.85, -0.065, P = 0.33, N = 859)
rs12654113(C)/5:20326490	CDH18	(0.47, -0.0077, P = 1.7e-05, N = 7824)	(0.83, -0.042, P = 0.51, N = 859)
rs7710027(T)/5:55901945*	AC022431.2	(0.29, 0.0081, P = 9.2e-06, N = 7824)	(0.65, 0.075, P = 0.13, N = 859)
rs2534835(T)/5:56948443	intergenic	(0.24, -0.0083, P = 6.2e-06, N = 7824)	(0.081, 0.018, P = 0.83, N = 859)
rs113693608(TAA)/5:7660900	ADCY2	(0.18, 0.23, P = 9.9e-06, N = 1958)	(0.2, 0.027, P = 0.66, N = 859)
rs10074809(T)/5:95818902	CTD-2337A12.1	(0.29, 0.0079, P = 1.3e-05, N = 7824)	(0.047, 0.06, P = 0.6, N = 859)
rs7734922(T)/5:96745629	RP11-155G15.2	(0.92, 0.029, P = 3.2e-05, N = 7824)	(0.79, 0.083, P = 0.16, N = 859)
rs9387010(T)/6:111705944*	REV3L	(0.065, -0.015, P = 2.9e-05, N = 7824)	(0.053, 0.037, P = 0.73, N = 859)
rs9372398(T)/6:114833591	intergenic	(0.55, 0.0081, P = 6.7e-06, N = 7824)	(0.26, -0.058, P = 0.27, N = 859)
rs768581(T)/6:117277972	intergenic	(0.19, -0.011, P = 2.7e-05, N = 7824)	(0.26, 0.11, P = 0.046, N = 859)
rs2224382(A)/6:133611341	EYA4	(0.4, -0.01, P = 4.4e-05, N = 7824)	(0.43, 0.051, P = 0.3, N = 859)
rs9389071(A)/6:133674634*	EYA4	(0.16, -0.012, P = 5.6e-06, N = 7824)	(0.23, 0.056, P = 0.32, N = 859)
rs3777804(A)/6:133708746*	EYA4	(0.87, 0.011, P = 2.2e-05, N = 7824)	(0.71, 0.015, P = 0.78, N = 859)
rs2143327(T)/6:146616239	GRM1	(0.013, 0.039, P = 4.3e-06, N = 7824)	(0.28, -0.0049, P = 0.93, N = 859)
rs2294784(T)/6:148852391*	SASH1	(0.86, -0.011, P = 4.9e-05, N = 7824)	(0.76, 0.01, P = 0.85, N = 859)
rs2880072(A)/6:159825449*	intergenic	(0.39, 0.0072, P = 5e-05, N = 7824)	(0.69, -0.064, P = 0.23, N = 859)
rs9355391(G)/6:162689005	PARK2	(0.18, -0.2, P = 4.2e-06, N = 1958)	(0.62, -0.057, P = 0.24, N = 859)
rs12213498(T)/6:169753177	intergenic	(0.14, 0.26, P = 8.4e-06, N = 1958)	(0.016, 0.24, P = 0.21, N = 859)
rs910616(T)/6:44074976	intergenic	(0.5, -0.0093, P = 2e-07, N = 7824)	(0.18, -0.025, P = 0.69, N = 859)
rs4236146(T)/6:56960612	ZNF451	(0.19, 0.012, P = 4.7e-05, N = 7824)	(0.48, -0.061, P = 0.2, N = 859)
rs11243250(T)/6:8364262*	intergenic	(0.36, 0.0073, P = 4.6e-05, N = 7824)	(0.75, -0.0052, P = 0.93, N = 859)
rs1890954(T)/6:8386802	intergenic	(0.3, -0.008, P = 9.8e-06, N = 7824)	(0.094, -0.13, P = 0.11, N = 859)
rs422252(A)/6:89893578	GABRR1	(0.48, -0.16, P = 9.5e-06, N = 1958)	(0.54, 0.0024, P = 0.96, N = 859)
rs2190406(C)/7:108081246	NRCAM	(0.29, 0.0073, P = 4.6e-05, N = 7824)	(0.52, 0.067, P = 0.16, N = 859)
rs6467552(T)/7:134390473	intergenic	(0.5, 0.0078, P = 1.4e-05, N = 7824)	(0.69, -0.13, P = 0.011, N = 859)
rs2299893(A)/7:139618590*	TBXAS1	(0.73, -0.0077, P = 3e-05, N = 7824)	(0.35, 0.059, P = 0.24, N = 859)
rs940697(A)/7:143183203	EPHA1-AS1	(0.27, 0.0082, P = 5.7e-06, N = 7824)	(0.36, -0.076, P = 0.13, N = 859)
rs2717875(T)/7:25222184	C7orf31	(0.93, 0.015, P = 1.5e-05, N = 7824)	(0.77, 0.048, P = 0.39, N = 859)
rs17158507(A)/7:83642711	SEMA3A	(0.13, -0.011, P = 3.2e-05, N = 7824)	(0.077, -0.069, P = 0.45, N = 859)
rs2049649(G)/7:94949329	PON1	(0.31, -0.14, P = 8.7e-06, N = 1958)	(0.44, -0.014, P = 0.78, N = 859)
rs6965510(T)/7:95229848*	PDK4	(0.059, 0.015, P = 3.4e-05, N = 7824)	(0.24, -0.048, P = 0.39, N = 859)
rs3133577(T)/8:101805542*	intergenic	(0.68, -0.0076, P = 2.3e-05, N = 7824)	(0.53, 0.065, P = 0.18, N = 859)
rs7012644(T)/8:118736914*	intergenic	(0.25, 0.0077, P = 3.1e-05, N = 7824)	(0.18, 0.023, P = 0.72, N = 859)
rs7837201(T)/8:133319798	KCNQ3	(0.8, -0.011, P = 2.3e-05, N = 7824)	(0.56, 0.066, P = 0.17, N = 859)
rs2623859(T)/8:68677337	intergenic	(0.93, 0.29, P = 2.7e-06, N = 1958)	(0.87, 0.0081, P = 0.91, N = 859)
rs10093959(A)/8:78050644*	intergenic	(0.63, -0.0075, P = 2.7e-05, N = 7824)	(0.37, -0.04, P = 0.42, N = 859)
rs1380634(A)/8:80237893	intergenic	(0.74, -0.0083, P = 5.2e-06, N = 7824)	(0.49, 0.023, P = 0.63, N = 859)
rs7465310(T)/8:80266503	intergenic	(0.63, -0.008, P = 7.3e-06, N = 7824)	(0.24, -0.038, P = 0.51, N = 859)
rs17461032(T)/8:81083077	TPD52	(0.71, -0.0077, P = 2.6e-05, N = 7824)	(0.78, 0.017, P = 0.77, N = 859)
rs10818640(A)/9:100997156	TBC1D2	(0.27, 0.008, P = 1.3e-05, N = 7824)	(0.17, 0.19, P = 0.0039, N = 859)
rs10978481(C)/9:109195928	RP11-308N19.1	(0.41, 0.0077, P = 1.7e-05, N = 7824)	(0.076, 0.00082, P = 0.99, N = 859)
rs2093403(T)/9:117611913	RP11-78H18.2	(0.88, -0.011, P = 2.8e-05, N = 7824)	(0.88, 0.0035, P = 0.96, N = 859)
rs2041472(C)/9:125539968*	intergenic	(0.017, 0.031, P = 1e-05, N = 7824)	(0.27, 0.038, P = 0.49, N = 859)
rs11103845(A)/9:138252603*	intergenic	(0.05, 0.018, P = 2.7e-05, N = 7824)	(0.011, 0.059, P = 0.79, N = 859)
rs868395(T)/9:85175793*	RP11-15B24.5	(0.67, 0.01, P = 2e-08, N = 7824)	(0.92, 0.18, P = 0.047, N = 859)
rs10992722(A)/9:96163761	intergenic	(0.016, 0.033, P = 2.4e-06, N = 7824)	(0.14, 0.061, P = 0.38, N = 859)
rs6479486(A)/9:96226164	FAM120A	(0.98, -0.032, P = 2.7e-06, N = 7824)	(0.94, 0.018, P = 0.86, N = 859)

Results from Univariable Mendelian Randomization of Citric acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	172	0.059 (-0.051- 0.17) P=0.29	3.3	27	1.74e-05 (0- 93)	NA	NA	-0.0018 P=0.72
MR-Egger	172	0.068 (-0.053- 0.19) P=0.27	3.3	27	1.74e-05 (0- 93)	177	0.35	-0.0018 P=0.72
Weighted median	172	0.097 (-0.054- 0.25) P=0.21	3.3	27	1.74e-05 (0- 93)	NA	NA	-0.0018 P=0.72

Results from Univariable MRPRESSO of Citric acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.06	0.06	1.05	0.3
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Citric acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	101	0.078 (-0.039- 0.2) P=0.19	5.1	25	0.0011 (0- 97.4)	NA	NA	-0.0061 P=0.38
MR-Egger	101	0.1 (-0.027- 0.23) P=0.12	5.1	25	0.0011 (0- 97.4)	109	0.24	-0.0061 P=0.38
Weighted median	101	0.097 (-0.057- 0.25) P=0.22	5.1	25	0.0011 (0- 97.4)	NA	NA	-0.0061 P=0.38

Results from Univariable MRPRESSO of Citric acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.08	0.06	1.3	0.2
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Citrulline

Instruments Associations with Citrulline & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Citrulline (Shin et al/Long et al)	eGFR (CSSCD)
rs6678521(T)/1:107387839	intergenic	(0.37, -0.007, P = 4.9e-05, N = 7824)	(0.32, -0.062, P = 0.24, N = 859)
rs10858075(T)/1:115877522*	NGF	(0.41, -0.0091, P = 1.1e-07, N = 7824)	(0.52, -0.04, P = 0.41, N = 859)
rs2486079(C)/1:116527617	SLC22A15	(0.7, -0.0071, P = 4.1e-05, N = 7824)	(0.53, -0.067, P = 0.17, N = 859)
rs310101(A)/1:153040570*	SPRR2B	(0.96, 0.037, P = 3.9e-06, N = 7824)	(0.65, 0.1, P = 0.046, N = 859)
rs72725073(T)/1:182552466	RNASEL	(0.2, -0.18, P = 4.2e-06, N = 1955)	(0.041, 0.0086, P = 0.94, N = 859)
rs7542381(A)/1:184635055	intergenic	(0.01, 0.068, P = 2.6e-05, N = 7824)	(0.1, 0.013, P = 0.87, N = 859)
rs1060060(T)/1:200143281*	NR5A2	(0.3, -0.0073, P = 2.9e-05, N = 7824)	(0.36, 0.073, P = 0.13, N = 859)
rs11119951(T)/1:212665790*	intergenic	(0.12, 0.012, P = 4.4e-06, N = 7824)	(0.02, 0.15, P = 0.39, N = 859)
rs2799085(A)/1:218552455	TGFB2	(0.32, -0.012, P = 2.3e-05, N = 7824)	(0.38, 0.049, P = 0.33, N = 859)
rs2247175(T)/1:97001894	intergenic	(0.84, 0.24, P = 2.8e-06, N = 1955)	(0.96, -0.082, P = 0.51, N = 859)
rs7099144(A)/10:101350970	intergenic	(0.61, -0.0075, P = 1.2e-05, N = 7824)	(0.59, -0.015, P = 0.76, N = 859)
rs430152(A)/10:119331597*	CTA-109P11.1	(0.32, -0.007, P = 4.9e-05, N = 7824)	(0.69, -0.0088, P = 0.87, N = 859)
rs7910118(A)/10:129958947	intergenic	(0.12, -0.011, P = 1.3e-05, N = 7824)	(0.15, -0.05, P = 0.44, N = 859)
rs3814664(C)/10:13740456	FRMD4A	(0.69, -0.0071, P = 4.7e-05, N = 7824)	(0.51, 0.0095, P = 0.85, N = 859)
rs10906682(T)/10:14500774	FRMD4A	(0.87, 0.011, P = 4.1e-05, N = 7824)	(0.66, 0.0041, P = 0.94, N = 859)
rs224768(A)/10:34281908	intergenic	(0.29, 0.11, P = 4.6e-06, N = 1955)	(0.53, -0.055, P = 0.26, N = 859)
rs4881230(G)/10:3939916	intergenic	(0.74, -0.19, P = 3.1e-06, N = 1955)	(0.53, 0.02, P = 0.69, N = 859)
rs12266210(T)/10:55188322*	intergenic	(0.3, -0.0074, P = 3.3e-05, N = 7824)	(0.33, 0.0024, P = 0.96, N = 859)
rs2704467(A)/10:71530680*	intergenic	(0.28, -0.0074, P = 4.2e-05, N = 7824)	(0.28, -0.022, P = 0.69, N = 859)
rs4244950(T)/10:86020700	RGR	(0.64, -0.0072, P = 3.3e-05, N = 7824)	(0.27, 0.059, P = 0.3, N = 859)
rs957646(T)/10:92064322	intergenic	(0.97, 0.025, P = 3.6e-05, N = 7824)	(0.78, -0.12, P = 0.036, N = 859)
rs4075311(T)/10:97574655	ENTPD1	(0.56, -0.0099, P = 5.5e-09, N = 7824)	(0.66, -0.034, P = 0.51, N = 859)
rs1935815(A)/10:97631492	ENTPD1	(0.35, 0.011, P = 1.5e-10, N = 7824)	(0.14, -0.0081, P = 0.91, N = 859)
rs10509698(A)/10:97792352	CC2D2B	(0.076, 0.014, P = 2.4e-05, N = 7824)	(0.046, 0.3, P = 0.0091, N = 859)
rs17030423(A)/12:101072465*	intergenic	(0.34, 0.0076, P = 1.2e-05, N = 7824)	(0.41, 0.02, P = 0.67, N = 859)
rs323846(T)/12:125879853*	TMEM132B	(0.4, 0.007, P = 4.1e-05, N = 7824)	(0.2, 0.024, P = 0.69, N = 859)
rs137938435(GA)/12:26377718	SSPN	(0.24, 0.18, P = 7e-06, N = 1955)	(0.031, 0.042, P = 0.76, N = 859)
rs7953233(A)/12:47223717*	SLC38A4	(0.54, -0.007, P = 3.9e-05, N = 7824)	(0.32, 0.058, P = 0.29, N = 859)
rs2711706(A)/12:47414993*	intergenic	(0.29, 0.19, P = 7e-07, N = 1955)	(0.59, 0.0033, P = 0.94, N = 859)
rs1466383(T)/12:57231497	RP11-74M13.4	(0.27, 0.0075, P = 2.8e-05, N = 7824)	(0.084, -0.083, P = 0.34, N = 859)
rs1546410(A)/12:61582882*	intergenic	(0.64, -0.0072, P = 3.8e-05, N = 7824)	(0.42, -0.038, P = 0.43, N = 859)
rs6581892(A)/12:69817077	RP11-159A18.1	(0.68, 0.0075, P = 1.5e-05, N = 7824)	(0.53, -0.014, P = 0.76, N = 859)
rs1868798(A)/12:7284081*	CLSTN3	(0.14, -0.011, P = 3.5e-05, N = 7824)	(0.2, 0.071, P = 0.24, N = 859)
rs1511589(A)/12:84061431*	intergenic	(0.46, 0.0077, P = 7.6e-06, N = 7824)	(0.27, 0.013, P = 0.81, N = 859)
rs7305379(T)/12:86431706	MGAT4C	(0.38, -0.15, P = 7.3e-07, N = 1955)	(0.52, 0.079, P = 0.091, N = 859)
rs9514083(A)/13:103680517	intergenic	(0.52, -0.0071, P = 3.7e-05, N = 7824)	(0.32, 0.013, P = 0.81, N = 859)
rs12874443(T)/13:38304884	TRPC4	(0.43, -0.0075, P = 1.2e-05, N = 7824)	(0.084, 0.084, P = 0.34, N = 859)
rs9566810(T)/13:42199332	VWA8	(0.28, 0.0076, P = 1.8e-05, N = 7824)	(0.45, -0.013, P = 0.79, N = 859)
rs7331220(T)/13:43294055	intergenic	(0.32, -0.0074, P = 2.4e-05, N = 7824)	(0.32, 0.089, P = 0.086, N = 859)
rs35543760(C)/14:100221612	EML1	(0.29, 0.18, P = 6.8e-06, N = 1955)	(0.12, 0.0014, P = 0.98, N = 859)
rs12147171(C)/14:20529449	OR4L1	(0.12, -0.012, P = 4.8e-06, N = 7824)	(0.027, -0.083, P = 0.57, N = 859)
rs11848535(T)/14:20777431*	TTC5	(0.44, 0.16, P = 3e-06, N = 1955)	(0.26, -0.091, P = 0.1, N = 859)
rs8021336(A)/14:32733465	intergenic	(0.31, -0.0086, P = 9.9e-07, N = 7824)	(0.31, 0.0079, P = 0.88, N = 859)
rs7157943(A)/14:32754446*	intergenic	(0.93, 0.015, P = 8.1e-06, N = 7824)	(0.81, 0.024, P = 0.7, N = 859)
rs17105196(T)/14:37208917*	SLC25A21	(0.28, -0.0074, P = 2.1e-05, N = 7824)	(0.16, -0.081, P = 0.22, N = 859)
rs996326(A)/14:40687518*	intergenic	(0.88, 0.011, P = 1.2e-05, N = 7824)	(0.92, -0.098, P = 0.28, N = 859)
rs3916613(T)/14:59552553	intergenic	(0.12, 0.011, P = 3.4e-05, N = 7824)	(0.1, -0.066, P = 0.4, N = 859)
rs2842322(A)/14:68915416	RAD51B	(0.31, -0.0076, P = 1e-05, N = 7824)	(0.21, -0.086, P = 0.15, N = 859)
rs11626446(A)/14:78710044	NRXN3	(0.27, -0.0097, P = 2.7e-05, N = 7824)	(0.12, -0.1, P = 0.17, N = 859)
rs2057311(C)/14:86086438	FLRT2	(0.58, 0.0074, P = 1.9e-05, N = 7824)	(0.58, 0.00029, P = 1, N = 859)
rs2959197(A)/15:101606890	LRRK1	(0.3, -0.0072, P = 4.1e-05, N = 7824)	(0.096, 0.21, P = 0.0083, N = 859)
rs892775(A)/15:33824530	RYR3	(0.74, 0.2, P = 2.6e-06, N = 1955)	(0.31, -0.053, P = 0.3, N = 859)
rs28631731(C)/15:36829334	intergenic	(0.39, 0.16, P = 3.2e-06, N = 1955)	(0.45, -0.15, P = 0.0023, N = 859)
rs17718330(T)/15:40123349*	GPR176	(0.7, 0.0072, P = 4.2e-05, N = 7824)	(0.86, 0.017, P = 0.81, N = 859)
rs10518834(A)/15:56345066*	intergenic	(0.64, -0.0071, P = 3.9e-05, N = 7824)	(0.76, -0.034, P = 0.55, N = 859)
rs8033140(T)/15:68198741*	intergenic	(0.35, 0.008, P = 4.3e-06, N = 7824)	(0.094, -0.086, P = 0.3, N = 859)
rs11634207(A)/15:93526003*	CHD2	(0.72, 0.0074, P = 2.8e-05, N = 7824)	(0.8, 0.026, P = 0.67, N = 859)
rs1437588(A)/15:96809782	NR2F2-AS1	(0.48, 0.0078, P = 7.7e-06, N = 7824)	(0.12, 0.15, P = 0.037, N = 859)
rs3112726(T)/16:2748699*	KCTD5	(0.46, 0.0073, P = 3.2e-05, N = 7824)	(0.68, -0.035, P = 0.49, N = 859)
rs9806843(A)/16:58704861*	SLC38A7	(0.6, -0.0073, P = 2.4e-05, N = 7824)	(0.5, -0.059, P = 0.22, N = 859)
rs7194755(T)/16:7064036*	RBFOX1	(0.26, -0.0099, P = 1.9e-05, N = 7824)	(0.16, -0.061, P = 0.36, N = 859)
rs10781983(A)/16:77441179*	ADAMTS18	(0.63, -0.0071, P = 5e-05, N = 7824)	(0.35, 0.0079, P = 0.88, N = 859)
rs8054103(A)/16:87420182	FBXO31	(0.55, 0.0071, P = 2.7e-05, N = 7824)	(0.11, -0.0028, P = 0.97, N = 859)
rs758186(T)/17:12500658	LINC00670	(0.65, -0.0077, P = 8.7e-06, N = 7824)	(0.53, -0.03, P = 0.53, N = 859)
rs733099(A)/17:4658971*	intergenic	(0.27, 0.0076, P = 1.4e-05, N = 7824)	(0.22, -0.023, P = 0.69, N = 859)
rs12600861(C)/17:7355621	CHRNB1	(0.33, -0.14, P = 2.5e-06, N = 1955)	(0.37, -0.042, P = 0.39, N = 859)
rs4791811(A)/17:9066853	NTN1	(0.71, 0.0077, P = 1.2e-05, N = 7824)	(0.63, -0.029, P = 0.56, N = 859)
rs17681684(A)/17:9792768*	GLP2R	(0.32, 0.0085, P = 1e-06, N = 7824)	(0.054, -0.07, P = 0.5, N = 859)
rs539904(A)/18:22085351	intergenic	(0.71, -0.0086, P = 1.5e-06, N = 7824)	(0.95, 0.17, P = 0.15, N = 859)
rs544049(A)/18:44204713*	LOXHD1	(0.12, -0.011, P = 2.3e-05, N = 7824)	(0.23, 0.039, P = 0.49, N = 859)
rs8097717(A)/18:69913058*	intergenic	(0.44, 0.0069, P = 4.5e-05, N = 7824)	(0.43, 0.045, P = 0.36, N = 859)
rs6510448(T)/19:35240154	intergenic	(0.67, 0.0077, P = 8.1e-06, N = 7824)	(0.59, -0.12, P = 0.017, N = 859)
rs7597477(A)/2:104826331*	intergenic	(0.93, -0.015, P = 6.8e-06, N = 7824)	(0.87, 0.11, P = 0.12, N = 859)
rs2723163(T)/2:113694339	AC079753.5	(0.45, -0.0069, P = 4.5e-05, N = 7824)	(0.2, -0.0053, P = 0.93, N = 859)
rs11123366(T)/2:117209104	intergenic	(0.86, -0.011, P = 1.6e-05, N = 7824)	(0.85, 0.075, P = 0.27, N = 859)
rs7594831(T)/2:204439701	intergenic	(0.28, 0.0074, P = 2.2e-05, N = 7824)	(0.3, 0.047, P = 0.36, N = 859)
rs1374708(T)/2:205316761	intergenic	(0.87, 0.011, P = 2.9e-05, N = 7824)	(0.75, 0.031, P = 0.58, N = 859)
rs10190763(T)/2:20573168	intergenic	(0.31, 0.0074, P = 1.9e-05, N = 7824)	(0.28, -0.059, P = 0.27, N = 859)
rs879126(T)/2:207922006*	intergenic	(0.33, -0.0086, P = 7.5e-07, N = 7824)	(0.37, 0.074, P = 0.12, N = 859)
rs759663(A)/2:208080975*	AC007879.1	(0.68, -0.0072, P = 3.8e-05, N = 7824)	(0.85, 0.04, P = 0.55, N = 859)
rs2007748(T)/2:211357642	CPS1	(0.53, 0.0095, P = 2.1e-08, N = 7824)	(0.2, 0.00063, P = 0.99, N = 859)
rs1509820(A)/2:211386484*	CPS1	(0.53, 0.0096, P = 1.7e-08, N = 7824)	(0.2, -0.0065, P = 0.91, N = 859)
rs2544307(A)/2:211403117*	CPS1	(0.39, -0.0078, P = 5.3e-06, N = 7824)	(0.43, -0.056, P = 0.26, N = 859)
rs13010668(T)/2:211470493*	CPS1	(0.85, 0.013, P = 3.6e-07, N = 7824)	(0.7, -0.016, P = 0.77, N = 859)
rs12470865(A)/2:211557762*	intergenic	(0.27, 0.009, P = 3.2e-07, N = 7824)	(0.3, -0.11, P = 0.041, N = 859)
rs10164524(A)/2:211664333*	intergenic	(0.68, -0.01, P = 1.1e-08, N = 7824)	(0.83, 0.044, P = 0.5, N = 859)
rs895663(C)/2:30874360	intergenic	(0.28, -0.2, P = 7e-06, N = 1955)	(0.48, -0.029, P = 0.54, N = 859)
rs6740771(T)/2:39789288	AC007246.3	(0.55, -0.14, P = 8.8e-06, N = 1955)	(0.24, 0.023, P = 0.69, N = 859)
rs6040877(A)/20:11756767*	intergenic	(0.27, -0.0081, P = 4e-06, N = 7824)	(0.63, 0.039, P = 0.43, N = 859)
rs2809591(A)/20:11763357	intergenic	(0.34, -0.0074, P = 1.8e-05, N = 7824)	(0.39, -0.015, P = 0.76, N = 859)
rs6136859(T)/20:19833437*	intergenic	(0.46, 0.0071, P = 3.8e-05, N = 7824)	(0.19, 0.067, P = 0.28, N = 859)
rs11086175(T)/20:45137362	ZNF334	(0.51, -0.014, P = 1.9e-05, N = 7824)	(0.35, -0.023, P = 0.65, N = 859)
rs163781(A)/20:57563765	NELFCD	(0.53, -0.0074, P = 1.6e-05, N = 7824)	(0.69, -0.036, P = 0.5, N = 859)
rs229084(A)/21:28251329	intergenic	(0.47, -0.0077, P = 6.6e-06, N = 7824)	(0.21, -0.12, P = 0.034, N = 859)
rs8140086(A)/22:36610386	intergenic	(0.59, -0.0069, P = 4.9e-05, N = 7824)	(0.33, -0.0068, P = 0.9, N = 859)
rs1920325(T)/3:103866190*	intergenic	(0.64, -0.0081, P = 3.7e-06, N = 7824)	(0.81, 0.049, P = 0.42, N = 859)
rs11128648(C)/3:13643640	FBLN2	(0.49, -0.007, P = 4.2e-05, N = 7824)	(0.4, -0.08, P = 0.11, N = 859)
rs7615965(T)/3:171041464*	TNIK	(0.71, 0.0086, P = 4.1e-06, N = 7824)	(0.61, 0.0089, P = 0.86, N = 859)
rs9824791(A)/3:171061886	TNIK	(0.48, 0.0079, P = 6e-06, N = 7824)	(0.26, -0.019, P = 0.73, N = 859)
rs11129411(A)/3:30535423	intergenic	(0.38, -0.0075, P = 2.3e-05, N = 7824)	(0.64, 0.051, P = 0.3, N = 859)
rs73067534(G)/3:32283278*	CMTM8	(0.2, -0.21, P = 9.9e-06, N = 1955)	(0.038, -0.14, P = 0.29, N = 859)
rs12636544(T)/3:82449136	RP11-260O18.1	(0.2, 0.17, P = 4.2e-06, N = 1955)	(0.19, 0.053, P = 0.38, N = 859)
rs1380162(A)/4:119970203*	SYNPO2	(0.33, 0.0076, P = 1.4e-05, N = 7824)	(0.22, 0.03, P = 0.61, N = 859)
rs12499180(A)/4:130953329	intergenic	(0.98, 0.058, P = 2e-05, N = 7824)	(0.38, -0.0048, P = 0.92, N = 859)
rs13105113(A)/4:136527846	intergenic	(0.88, 0.011, P = 9.2e-06, N = 7824)	(0.9, 0.11, P = 0.18, N = 859)
rs706333(T)/4:140517700*	SETD7	(0.46, 0.015, P = 1e-05, N = 7824)	(0.35, -0.044, P = 0.38, N = 859)
rs1921568(T)/4:185080276*	ENPP6	(0.29, 0.0073, P = 3.2e-05, N = 7824)	(0.32, -0.12, P = 0.03, N = 859)
rs7696056(C)/4:22549862	intergenic	(0.39, -0.014, P = 4.5e-05, N = 7824)	(0.21, -0.0053, P = 0.93, N = 859)
rs1089073(G)/4:24788474	SOD3	(0.98, -0.34, P = 1.1e-06, N = 1955)	(0.93, 0.036, P = 0.71, N = 859)
rs4692169(A)/4:27124674*	intergenic	(0.58, -0.0074, P = 1.7e-05, N = 7824)	(0.31, 0.041, P = 0.44, N = 859)
rs10489008(A)/4:31718284*	intergenic	(0.49, -0.0076, P = 7.4e-06, N = 7824)	(0.87, -0.047, P = 0.52, N = 859)
rs13122712(A)/4:39801668	intergenic	(0.65, -0.14, P = 1e-06, N = 1955)	(0.32, 0.011, P = 0.83, N = 859)
rs11721409(T)/4:7753417*	AFAP1-AS1	(0.32, 0.0074, P = 1.9e-05, N = 7824)	(0.1, 0.021, P = 0.8, N = 859)
rs11940899(T)/4:78352372	RP11-625I7.1	(0.34, -0.0075, P = 1.8e-05, N = 7824)	(0.52, 0.089, P = 0.074, N = 859)
rs16841570(T)/4:8016164*	ABLIM2	(0.97, 0.025, P = 8.6e-06, N = 7824)	(0.96, 0.031, P = 0.8, N = 859)
rs10477454(T)/5:109636551	TMEM232	(0.017, -0.037, P = 4.6e-06, N = 7824)	(0.5, 0.023, P = 0.63, N = 859)
rs17142889(T)/5:117041009	intergenic	(0.13, 0.011, P = 9.9e-06, N = 7824)	(0.68, 0.15, P = 0.003, N = 859)
rs17450677(T)/5:143919043	RN7SKP246	(0.97, 0.021, P = 1.9e-05, N = 7824)	(0.98, -0.012, P = 0.95, N = 859)
rs2400156(A)/5:144052940	intergenic	(0.84, -0.019, P = 3.1e-05, N = 7824)	(0.81, -0.043, P = 0.48, N = 859)
rs6889120(T)/5:158093340	intergenic	(0.94, -0.034, P = 7.4e-06, N = 7824)	(0.73, -0.064, P = 0.23, N = 859)
rs76001528(C)/5:163839445	CTC-340A15.2	(0.097, -0.2, P = 4.2e-06, N = 1955)	(0.16, -0.059, P = 0.37, N = 859)
rs10866666(T)/5:173036786	BOD1	(0.22, -0.21, P = 2.1e-06, N = 1955)	(0.028, 0.15, P = 0.3, N = 859)
rs682103(T)/5:53394938*	ARL15	(0.71, -0.0097, P = 4.3e-08, N = 7824)	(0.93, -0.14, P = 0.15, N = 859)
rs4143655(A)/5:66824167*	RP11-434D9.1	(0.14, -0.011, P = 3.6e-05, N = 7824)	(0.52, 0.042, P = 0.38, N = 859)
rs224807(A)/5:81686624*	ATP6AP1L	(0.29, -0.0072, P = 4e-05, N = 7824)	(0.28, 0.016, P = 0.77, N = 859)
rs9400834(T)/6:115675458*	RP11-126M14.1	(0.7, 0.008, P = 5.6e-06, N = 7824)	(0.91, 0.16, P = 0.062, N = 859)
rs9401513(A)/6:122675030	intergenic	(0.86, -0.022, P = 3.4e-05, N = 7824)	(0.68, -0.093, P = 0.072, N = 859)
rs10456994(T)/6:132515568*	intergenic	(0.52, -0.007, P = 4.3e-05, N = 7824)	(0.79, -0.022, P = 0.71, N = 859)
rs2506864(T)/6:141041299*	intergenic	(0.41, -0.0076, P = 8.8e-06, N = 7824)	(0.37, -0.015, P = 0.77, N = 859)
rs619095(C)/6:169098800*	intergenic	(0.64, -0.0073, P = 2.7e-05, N = 7824)	(0.12, -0.047, P = 0.52, N = 859)
rs7747114(G)/6:29919774*	HLA-W	(0.53, 0.16, P = 9.9e-06, N = 1955)	(0.68, 0.046, P = 0.35, N = 859)
rs112100248(T)/6:30798476*	LINC00243	(0.02, 0.51, P = 2.4e-06, N = 1955)	(0.035, -0.093, P = 0.46, N = 859)
rs9267536(C)/6:31651194	LY6G5C	(0.039, 0.43, P = 3e-06, N = 1955)	(0.079, 0.05, P = 0.57, N = 859)
rs239787(A)/6:54798887	FAM83B	(0.17, -0.01, P = 4.4e-05, N = 7824)	(0.32, -0.13, P = 0.01, N = 859)
rs6899649(T)/6:54892267*	intergenic	(0.38, 0.0072, P = 2.4e-05, N = 7824)	(0.41, 0.059, P = 0.23, N = 859)
rs3846917(T)/6:55257798*	GFRAL	(0.12, -0.011, P = 4.5e-05, N = 7824)	(0.45, -0.022, P = 0.65, N = 859)
rs9354336(T)/6:66609594	intergenic	(0.87, 0.011, P = 8.6e-06, N = 7824)	(0.87, -0.11, P = 0.11, N = 859)
rs779463(T)/6:69942066	BAI3	(0.3, -0.0077, P = 9.5e-06, N = 7824)	(0.048, 0.086, P = 0.46, N = 859)
rs2487410(T)/6:70547652	intergenic	(0.47, -0.0081, P = 1.8e-06, N = 7824)	(0.54, -0.019, P = 0.69, N = 859)
rs6925293(T)/6:99054479	intergenic	(0.58, 0.0073, P = 2.3e-05, N = 7824)	(0.12, -0.067, P = 0.35, N = 859)
rs10234187(T)/7:11216782	AC004538.3	(0.32, 0.0085, P = 1.1e-06, N = 7824)	(0.31, 0.041, P = 0.42, N = 859)
rs3778842(T)/7:134474096*	CALD1	(0.68, 0.0077, P = 1.1e-05, N = 7824)	(0.73, 0.058, P = 0.28, N = 859)
rs6952398(T)/7:151396253	PRKAG2	(0.63, -0.0081, P = 1.5e-05, N = 7824)	(0.43, 0.0087, P = 0.86, N = 859)
rs12701265(A)/7:32971236*	RP9P	(0.39, 0.0086, P = 7.4e-07, N = 7824)	(0.068, -0.02, P = 0.84, N = 859)
rs17821771(T)/7:33973249	BMPER	(0.35, -0.0082, P = 1.9e-06, N = 7824)	(0.27, -0.00061, P = 0.99, N = 859)
rs17670957(T)/7:54412203	RP11-436F9.1	(0.39, 0.007, P = 4.4e-05, N = 7824)	(0.39, -0.02, P = 0.69, N = 859)
rs28662(T)/7:92775019	SAMD9L	(0.18, -0.011, P = 1.3e-05, N = 7824)	(0.077, -0.031, P = 0.74, N = 859)
rs17766353(T)/8:10254824	MSRA	(0.14, 0.011, P = 4.9e-05, N = 7824)	(0.034, 0.061, P = 0.65, N = 859)
rs10955258(T)/8:102593321	GRHL2	(0.23, -0.0097, P = 4.3e-05, N = 7824)	(0.25, -0.058, P = 0.3, N = 859)
rs13267180(A)/8:10466482*	RP1L1	(0.48, 0.0081, P = 3.8e-06, N = 7824)	(0.41, 0.012, P = 0.81, N = 859)
rs7001456(C)/8:10804865	XKR6	(0.61, -0.0078, P = 5.1e-06, N = 7824)	(0.64, -0.067, P = 0.17, N = 859)
rs6601541(T)/8:10830743*	XKR6	(0.63, -0.0074, P = 2.3e-05, N = 7824)	(0.27, -0.062, P = 0.25, N = 859)
rs2350885(A)/8:111233137	intergenic	(0.35, -0.0079, P = 8.7e-06, N = 7824)	(0.68, 0.019, P = 0.72, N = 859)
rs6994363(A)/8:11125062*	LINC00529	(0.87, -0.012, P = 2.5e-06, N = 7824)	(0.63, -0.11, P = 0.031, N = 859)
rs73367050(T)/8:134689892	intergenic	(0.048, 0.28, P = 6.3e-06, N = 1955)	(0.11, 0.05, P = 0.52, N = 859)
rs34161175(T)/8:23631530	RP11-175E9.1	(0.36, 0.19, P = 3.8e-06, N = 1955)	(0.065, 0.0084, P = 0.93, N = 859)
rs11993007(A)/8:28307911	FBXO16	(0.32, -0.013, P = 5.2e-06, N = 7824)	(0.62, 0.038, P = 0.44, N = 859)
rs6999701(A)/8:74678452	RP11-463D19.2	(0.89, -0.014, P = 1.4e-05, N = 7824)	(0.88, -0.021, P = 0.78, N = 859)
rs10504742(A)/8:82788367*	intergenic	(0.55, -0.0081, P = 2.6e-06, N = 7824)	(0.87, 0.003, P = 0.97, N = 859)
rs1610360(A)/9:12385710*	intergenic	(0.67, 0.008, P = 4.6e-06, N = 7824)	(0.76, -0.081, P = 0.14, N = 859)
rs76266684(G)/9:132755555	FNBP1	(0.081, 0.29, P = 1.3e-06, N = 1955)	(0.032, 0.073, P = 0.6, N = 859)
rs10901320(A)/9:133290721	HMCN2	(0.43, 0.0087, P = 4.3e-07, N = 7824)	(0.27, -0.098, P = 0.073, N = 859)
rs10901047(T)/9:133323675	ASS1	(0.59, -0.009, P = 3e-07, N = 7824)	(0.76, 0.024, P = 0.66, N = 859)
rs554710(T)/9:136181848*	LCN1P2	(0.71, -0.0084, P = 1.6e-06, N = 7824)	(0.46, -0.078, P = 0.11, N = 859)
rs4961685(A)/9:16249141*	C9orf92	(0.33, -0.0073, P = 2.4e-05, N = 7824)	(0.3, 0.039, P = 0.45, N = 859)
rs12348439(T)/9:89869968	intergenic	(0.055, -0.018, P = 1.3e-05, N = 7824)	(0.19, 0.1, P = 0.089, N = 859)

Results from Univariable Mendelian Randomization of Citrulline & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	166	-0.052 (-0.19- 0.081) P=0.44	3.8	31	1.01 (0- 91.6)	NA	NA	0.003 P=0.58
MR-Egger	166	-0.072 (-0.22- 0.079) P=0.35	3.8	31	1.01 (0- 91.6)	188	0.096	0.003 P=0.58
Weighted median	166	0.012 (-0.18- 0.2) P=0.9	3.8	31	1.01 (0- 91.6)	NA	NA	0.003 P=0.58

Results from Univariable MRPRESSO of Citrulline & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.07	-0.77	0.45
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Citrulline & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	96	-0.06 (-0.22- 0.1) P=0.46	5.1	24	2.6 (0- 96.7)	NA	NA	0.0022 P=0.78
MR-Egger	96	-0.074 (-0.26- 0.11) P=0.44	5.1	24	2.6 (0- 96.7)	121	0.033	0.0022 P=0.78
Weighted median	96	0.031 (-0.17- 0.23) P=0.77	5.1	24	2.6 (0- 96.7)	NA	NA	0.0022 P=0.78

Results from Univariable MRPRESSO of Citrulline & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.06	0.08	-0.73	0.46
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Creatinine

Instruments Associations with Creatinine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Creatinine (Shin et al/Long et al)	eGFR (CSSCD)
rs6537817(C)/1:114752168*	RP4-543J13.1	(0.82, -0.0078, P = 1.2e-05, N = 7824)	(0.58, 0.085, P = 0.078, N = 859)
rs4460629(T)/1:155135335	intergenic	(0.52, -0.0045, P = 2.2e-06, N = 7824)	(0.3, 0.043, P = 0.42, N = 859)
rs6424850(A)/1:182344926	intergenic	(0.48, 0.14, P = 8.5e-07, N = 1958)	(0.74, 0.045, P = 0.4, N = 859)
rs815759(A)/1:189907398	intergenic	(0.048, 0.014, P = 2.8e-05, N = 7824)	(0.012, -0.051, P = 0.82, N = 859)
rs10159366(A)/1:204975980	NFASC	(0.87, 0.008, P = 2.5e-05, N = 7824)	(0.96, 0.023, P = 0.86, N = 859)
rs6663614(A)/1:213097941*	intergenic	(0.21, -0.01, P = 3.1e-06, N = 7824)	(0.23, -0.1, P = 0.073, N = 859)
rs496018(T)/1:238079056*	RP11-193H5.1	(0.2, 0.16, P = 1.2e-06, N = 1958)	(0.66, 0.11, P = 0.037, N = 859)
rs12142891(C)/1:61652197*	NFIA	(0.098, 0.23, P = 6.6e-06, N = 1958)	(0.015, 0.19, P = 0.33, N = 859)
rs1498350(A)/1:67294143*	WDR78	(0.5, 0.0045, P = 1.9e-06, N = 7824)	(0.62, 0.047, P = 0.33, N = 859)
rs394282(A)/1:8284657	RP11-431K24.4	(0.11, -0.016, P = 1e-06, N = 7824)	(0.22, -0.013, P = 0.83, N = 859)
rs1116866(T)/1:96976835	intergenic	(0.1, 0.0094, P = 2.9e-07, N = 7824)	(0.027, 0.084, P = 0.58, N = 859)
rs2694773(A)/10:117844652*	GFRA1	(0.92, 0.023, P = 2.8e-05, N = 7824)	(0.75, 0.0027, P = 0.96, N = 859)
rs11599763(T)/10:11855599*	intergenic	(0.39, -0.0069, P = 3.2e-05, N = 7824)	(0.51, 0.035, P = 0.48, N = 859)
rs10749270(G)/10:120542167*	U3	(0.75, 0.21, P = 7.1e-06, N = 1958)	(0.69, 0.055, P = 0.3, N = 859)
rs7910801(A)/10:126037889	intergenic	(0.96, 0.015, P = 4.5e-05, N = 7824)	(0.81, -0.0066, P = 0.92, N = 859)
rs12269670(A)/10:132619537	intergenic	(0.97, -0.015, P = 4.3e-05, N = 7824)	(0.81, 0.003, P = 0.96, N = 859)
rs703067(T)/10:31909119*	intergenic	(0.48, 0.18, P = 5.2e-06, N = 1958)	(0.25, 0.026, P = 0.65, N = 859)
rs2289804(A)/10:69993032	ATOH7	(0.93, -0.014, P = 1.2e-07, N = 7824)	(0.56, -0.017, P = 0.72, N = 859)
rs10823168(T)/10:70019917	KRT19P4	(0.055, 0.013, P = 6.2e-07, N = 7824)	(0.16, 0.014, P = 0.82, N = 859)
rs10998157(A)/10:70188523*	DNA2	(0.051, 0.011, P = 4.7e-05, N = 7824)	(0.16, -0.041, P = 0.54, N = 859)
rs7073038(T)/10:70308535	TMEM14D	(0.038, 0.015, P = 1.9e-05, N = 7824)	(0.13, -0.053, P = 0.47, N = 859)
rs827334(A)/10:72676412*	intergenic	(0.12, 0.0076, P = 3.8e-05, N = 7824)	(0.025, 0.038, P = 0.8, N = 859)
rs75751082(A)/10:73205549	CDH23	(0.11, -0.19, P = 3.1e-06, N = 1958)	(0.077, -0.064, P = 0.48, N = 859)
rs7087345(A)/10:78651808	KCNMA1	(0.95, 0.011, P = 4.9e-05, N = 7824)	(0.85, -0.0042, P = 0.95, N = 859)
rs12218515(C)/10:91054291	LIPA	(0.86, 0.0075, P = 2.6e-05, N = 7824)	(0.88, -0.034, P = 0.64, N = 859)
rs12770938(A)/10:91606212	intergenic	(0.11, 0.0077, P = 2.9e-05, N = 7824)	(0.33, -0.032, P = 0.54, N = 859)
rs17094111(T)/10:92121337	intergenic	(0.92, 0.01, P = 4.8e-05, N = 7824)	(0.95, 0.022, P = 0.84, N = 859)
rs482007(T)/11:100228729*	CNTN5	(0.89, 0.0077, P = 2.5e-05, N = 7824)	(0.8, -0.16, P = 0.0074, N = 859)
rs4937771(A)/11:133307073	snoU13	(0.042, 0.014, P = 2.6e-05, N = 7824)	(0.53, 0.019, P = 0.68, N = 859)
rs12801550(T)/11:13993754	SPON1	(0.87, 0.0088, P = 9.6e-07, N = 7824)	(0.98, -0.24, P = 0.2, N = 859)
rs11037075(A)/11:42827511*	intergenic	(0.87, 0.0074, P = 4.8e-05, N = 7824)	(0.76, -0.017, P = 0.76, N = 859)
rs11038386(T)/11:45316625*	intergenic	(0.98, 0.022, P = 2.2e-05, N = 7824)	(0.74, -0.029, P = 0.6, N = 859)
rs6578854(A)/11:7385437	SYT9	(0.93, 0.011, P = 3e-05, N = 7824)	(0.76, 0.051, P = 0.35, N = 859)
rs11054328(T)/12:11663755	RP11-434C1.3	(0.11, 0.0088, P = 1.5e-06, N = 7824)	(0.16, -0.035, P = 0.59, N = 859)
rs2286044(A)/12:120571084	GCN1L1	(0.87, 0.0076, P = 2.3e-05, N = 7824)	(0.85, -0.056, P = 0.4, N = 859)
rs10745813(A)/12:98265464	intergenic	(0.81, 0.0077, P = 1.4e-05, N = 7824)	(0.9, -0.058, P = 0.48, N = 859)
rs9577511(G)/13:113991823	GRTP1	(0.13, 0.21, P = 1e-06, N = 1958)	(0.21, 0.1, P = 0.09, N = 859)
rs16943547(A)/13:90552861	intergenic	(0.97, 0.018, P = 3.5e-05, N = 7824)	(0.98, 0.17, P = 0.31, N = 859)
rs8181962(A)/14:26598213*	RP11-314P15.2	(0.14, -0.0077, P = 2.1e-05, N = 7824)	(0.2, -0.11, P = 0.081, N = 859)
rs2933188(G)/14:47382492*	MDGA2	(0.96, -0.4, P = 6.5e-06, N = 1958)	(0.53, -0.023, P = 0.63, N = 859)
rs1044538(A)/14:70833537	SYNJ2BP	(0.071, -0.011, P = 1.1e-05, N = 7824)	(0.1, -0.073, P = 0.34, N = 859)
rs2332376(T)/14:70889285	RP11-486O13.4	(0.074, -0.011, P = 2e-05, N = 7824)	(0.065, -0.017, P = 0.86, N = 859)
rs4904742(T)/14:91510838	RPS6KA5	(0.75, -0.0077, P = 1.2e-05, N = 7824)	(0.9, 0.0086, P = 0.92, N = 859)
rs10519445(A)/15:24106808	intergenic	(0.53, -0.0045, P = 1.8e-06, N = 7824)	(0.18, -0.038, P = 0.53, N = 859)
rs11638382(T)/15:29496888	FAM189A1	(0.19, -0.017, P = 5.1e-06, N = 7824)	(0.077, -0.13, P = 0.13, N = 859)
rs12914647(A)/15:56594033	TEX9	(0.46, 0.13, P = 3.6e-06, N = 1958)	(0.15, -0.088, P = 0.2, N = 859)
rs12324230(T)/15:75806911	PTPN9	(0.52, 0.0042, P = 8.7e-06, N = 7824)	(0.81, 0.018, P = 0.76, N = 859)
rs12916220(T)/15:97091511	CTD-2027G2.1	(0.15, -0.0077, P = 3.5e-05, N = 7824)	(0.34, -0.008, P = 0.87, N = 859)
rs11574941(A)/16:30493000	ITGAL	(0.13, 0.0078, P = 2.3e-05, N = 7824)	(0.028, -0.0073, P = 0.96, N = 859)
rs113479674(C)/16:82193037	MPHOSPH6	(0.11, -0.25, P = 7.1e-07, N = 1958)	(0.058, 0.066, P = 0.52, N = 859)
rs146693640(GT)/16:82193730	MPHOSPH6	(0.12, -0.23, P = 5.2e-06, N = 1958)	(0.074, 0.041, P = 0.65, N = 859)
rs6502247(A)/17:13203562	AC003664.1	(0.12, -0.009, P = 6.8e-06, N = 7824)	(0.58, 0.0089, P = 0.85, N = 859)
rs12103754(T)/17:70912339*	SLC39A11	(0.26, -0.21, P = 8.2e-06, N = 1958)	(0.19, -0.0023, P = 0.97, N = 859)
rs12961855(A)/18:11670845	RP11-677O4.2	(0.48, 0.0039, P = 4e-05, N = 7824)	(0.82, 0.081, P = 0.2, N = 859)
rs10421262(T)/19:14172951	PALM3	(0.69, -0.021, P = 2.7e-05, N = 7824)	(0.48, -0.041, P = 0.41, N = 859)
rs4803352(T)/19:41159193*	intergenic	(0.87, -0.0079, P = 1.4e-05, N = 7824)	(0.78, -0.083, P = 0.15, N = 859)
rs10426415(A)/19:41183590*	NUMBL	(0.88, -0.0086, P = 3.1e-06, N = 7824)	(0.8, -0.041, P = 0.49, N = 859)
rs12459641(G)/19:7560784	C19orf45	(0.19, 0.23, P = 9.6e-06, N = 1958)	(0.29, 0.052, P = 0.33, N = 859)
rs10202838(C)/2:12749003*	AC096559.2	(0.53, 0.014, P = 3.3e-06, N = 7824)	(0.12, -0.046, P = 0.52, N = 859)
rs355818(A)/2:165707855	AC019181.2	(0.89, 0.0078, P = 2.2e-05, N = 7824)	(0.6, 0.012, P = 0.81, N = 859)
rs1374355(A)/2:200156193	SATB2	(0.11, 0.0083, P = 8.6e-06, N = 7824)	(0.46, 0.011, P = 0.82, N = 859)
rs13414802(A)/2:210732686*	UNC80	(0.88, 0.0077, P = 2.9e-05, N = 7824)	(0.65, -0.021, P = 0.67, N = 859)
rs2048277(A)/2:211151774*	MYL1	(0.9, 0.0083, P = 8.8e-06, N = 7824)	(0.78, 0.00076, P = 0.99, N = 859)
rs62192370(G)/2:237254757	IQCA1	(0.38, 0.14, P = 6.8e-07, N = 1958)	(0.26, 0.0014, P = 0.98, N = 859)
rs35202902(T)/2:240734453	intergenic	(0.27, -0.16, P = 3.3e-06, N = 1958)	(0.079, -0.13, P = 0.14, N = 859)
rs10175998(C)/2:38559325	ATL2	(0.28, 0.15, P = 1.5e-06, N = 1958)	(0.32, -0.02, P = 0.69, N = 859)
rs917969(T)/2:40207338	SLC8A1-AS1	(0.24, 0.0071, P = 4.3e-05, N = 7824)	(0.87, -0.02, P = 0.77, N = 859)
rs7596081(A)/2:46464297	intergenic	(0.53, -0.14, P = 1.7e-06, N = 1958)	(0.46, -0.03, P = 0.53, N = 859)
rs13031396(T)/2:60717399*	BCL11A	(0.25, -0.0076, P = 9.2e-06, N = 7824)	(0.074, -0.19, P = 0.035, N = 859)
rs2219379(A)/2:6711467	intergenic	(0.2, 0.0072, P = 4.1e-05, N = 7824)	(0.31, -0.12, P = 0.017, N = 859)
rs11694230(T)/2:6839127	intergenic	(0.34, -0.0075, P = 9e-06, N = 7824)	(0.13, -0.019, P = 0.79, N = 859)
rs4853412(C)/2:79019736	intergenic	(0.46, -0.14, P = 8.1e-06, N = 1958)	(0.24, -0.014, P = 0.81, N = 859)
rs7263330(A)/20:31534701	intergenic	(0.035, -0.015, P = 1.6e-05, N = 7824)	(0.13, -0.13, P = 0.06, N = 859)
rs925300(C)/20:5624244	intergenic	(0.48, -0.19, P = 1.2e-06, N = 1958)	(0.71, 0.07, P = 0.18, N = 859)
rs2833854(A)/21:33869440*	EVA1C	(0.86, -0.0076, P = 2.1e-05, N = 7824)	(0.89, -0.14, P = 0.07, N = 859)
rs3895614(T)/21:43182633*	RIPK4	(0.11, -0.0081, P = 1.5e-05, N = 7824)	(0.12, -0.016, P = 0.83, N = 859)
rs17002948(T)/22:42688724	TCF20	(0.86, 0.0079, P = 1.9e-05, N = 7824)	(0.83, -0.071, P = 0.27, N = 859)
rs1955135(A)/3:105164872*	ALCAM	(0.87, 0.008, P = 1e-05, N = 7824)	(0.83, 0.016, P = 0.8, N = 859)
rs4684042(A)/3:10559202*	ATP2B2	(0.98, -0.023, P = 1.2e-05, N = 7824)	(0.84, -0.012, P = 0.86, N = 859)
rs2007634(A)/3:139678136*	CLSTN2	(0.59, 0.2, P = 5.1e-07, N = 1958)	(0.23, -0.018, P = 0.75, N = 859)
rs11715139(A)/3:171732927	intergenic	(0.82, 0.0072, P = 4.2e-05, N = 7824)	(0.78, 0.12, P = 0.042, N = 859)
rs11925770(T)/3:36339059*	intergenic	(0.015, -0.76, P = 3.3e-06, N = 1958)	(0.17, 0.063, P = 0.33, N = 859)
rs34667937(G)/3:46576351	LRRC2	(0.36, 0.16, P = 7e-06, N = 1958)	(0.14, 0.068, P = 0.34, N = 859)
rs35119986(C)/3:74280018	intergenic	(0.13, -0.25, P = 9.4e-06, N = 1958)	(0.19, -0.004, P = 0.95, N = 859)
rs1447833(C)/3:79039406*	ROBO1	(0.091, -0.29, P = 6.6e-07, N = 1958)	(0.015, -0.42, P = 0.037, N = 859)
rs17785887(T)/4:179536770	intergenic	(0.82, -0.017, P = 2.1e-05, N = 7824)	(0.84, -0.028, P = 0.67, N = 859)
rs17533525(T)/5:106779692*	EFNA5	(0.15, 0.0082, P = 5e-06, N = 7824)	(0.032, -0.18, P = 0.2, N = 859)
rs9312777(T)/5:11556754*	CTNND2	(0.48, 0.0043, P = 4.7e-06, N = 7824)	(0.64, 0.02, P = 0.67, N = 859)
rs10478509(A)/5:120529790*	CTD-2020P22.1	(0.48, -0.0041, P = 1.4e-05, N = 7824)	(0.65, -0.0036, P = 0.94, N = 859)
rs2695978(A)/5:165695551	intergenic	(0.5, 0.004, P = 2e-05, N = 7824)	(0.39, -0.084, P = 0.087, N = 859)
rs28362590(T)/5:176731452*	PRELID1	(0.75, -0.18, P = 8.2e-07, N = 1958)	(0.86, -0.15, P = 0.04, N = 859)
rs12517218(C)/5:2157589*	intergenic	(0.067, -0.26, P = 9.1e-06, N = 1958)	(0.054, -0.027, P = 0.8, N = 859)
rs1330649(C)/5:26038348	intergenic	(0.99, 0.59, P = 3.8e-06, N = 1958)	(0.87, 0.053, P = 0.47, N = 859)
rs6452345(T)/5:26568243*	intergenic	(0.17, -0.0076, P = 1.4e-05, N = 7824)	(0.054, 0.14, P = 0.19, N = 859)
rs12517707(A)/5:5131299*	CTD-2297D10.2	(0.81, 0.0072, P = 3.7e-05, N = 7824)	(0.87, 0.07, P = 0.34, N = 859)
rs2278241(A)/5:76326885*	AGGF1	(0.27, -0.19, P = 1.2e-06, N = 1958)	(0.078, -0.12, P = 0.2, N = 859)
rs17235037(T)/5:9013608*	CTD-2215L10.1	(0.12, 0.0078, P = 1.6e-05, N = 7824)	(0.035, 0.22, P = 0.1, N = 859)
rs12175103(A)/6:100706809*	intergenic	(0.42, 0.0048, P = 4.9e-07, N = 7824)	(0.28, 0.045, P = 0.41, N = 859)
rs12660850(C)/6:139903229	intergenic	(0.93, -0.011, P = 1.2e-05, N = 7824)	(0.93, -0.12, P = 0.19, N = 859)
rs9477021(C)/6:16061453	intergenic	(0.018, -0.024, P = 7.7e-06, N = 7824)	(0.15, -0.13, P = 0.056, N = 859)
rs9456538(A)/6:160853393*	SLC22A3	(0.15, -0.0082, P = 4.2e-06, N = 7824)	(0.37, -0.12, P = 0.011, N = 859)
rs4960121(G)/6:5649266*	FARS2	(0.75, 0.19, P = 3.6e-06, N = 1958)	(0.53, -0.059, P = 0.22, N = 859)
rs6459184(T)/6:57160035	intergenic	(0.52, -0.0039, P = 3.9e-05, N = 7824)	(0.79, -0.064, P = 0.28, N = 859)
rs849415(A)/7:106552538	PIK3CG	(0.9, -0.0078, P = 2.2e-05, N = 7824)	(0.81, -0.0093, P = 0.88, N = 859)
rs10216203(T)/7:140168158*	MKRN1	(0.88, 0.0078, P = 2e-05, N = 7824)	(0.32, 0.035, P = 0.49, N = 859)
rs1990178(T)/7:21300265*	intergenic	(0.19, -0.016, P = 6.3e-06, N = 7824)	(0.069, -0.048, P = 0.61, N = 859)
rs2042499(A)/7:24095366	intergenic	(0.48, 0.0052, P = 4.9e-08, N = 7824)	(0.2, 0.0026, P = 0.97, N = 859)
rs4720409(A)/7:41884913*	intergenic	(0.68, 0.0068, P = 4.9e-05, N = 7824)	(0.81, 0.08, P = 0.19, N = 859)
rs6955253(T)/7:54619356	VSTM2A	(0.84, -0.017, P = 2.8e-05, N = 7824)	(0.73, 0.025, P = 0.64, N = 859)
rs13225353(T)/7:68441909	intergenic	(0.12, 0.0077, P = 2.1e-05, N = 7824)	(0.11, -0.01, P = 0.9, N = 859)
rs2521310(T)/7:89352860	intergenic	(0.87, 0.009, P = 6.8e-06, N = 7824)	(0.68, -0.026, P = 0.6, N = 859)
rs17198100(T)/8:103928846	KB-1507C5.2	(0.11, 0.02, P = 1.1e-05, N = 7824)	(0.024, 0.18, P = 0.26, N = 859)
rs11985537(T)/8:129168086*	intergenic	(0.13, 0.0076, P = 3.6e-05, N = 7824)	(0.086, -0.059, P = 0.48, N = 859)
rs10088988(C)/8:14112859	SGCZ	(0.15, 0.0073, P = 4.5e-05, N = 7824)	(0.44, -0.02, P = 0.67, N = 859)
rs71217388(AC)/8:18452739	PSD3	(0.13, 0.14, P = 6.6e-06, N = 1958)	(0.16, -0.052, P = 0.43, N = 859)
rs17830054(T)/8:1892619*	ARHGEF10	(0.12, -0.008, P = 1.5e-05, N = 7824)	(0.041, -0.2, P = 0.099, N = 859)
rs4961420(C)/8:20731339*	intergenic	(0.64, 0.007, P = 3.2e-05, N = 7824)	(0.69, -0.05, P = 0.32, N = 859)
rs2979688(T)/8:24814205*	NEFL	(0.64, 0.24, P = 3.6e-06, N = 1958)	(0.3, 0.0069, P = 0.9, N = 859)
rs2543041(A)/8:39817470*	IDO2	(0.12, 0.0076, P = 2.7e-05, N = 7824)	(0.42, 0.014, P = 0.77, N = 859)
rs17070697(T)/8:4447662	CSMD1	(0.13, -0.0075, P = 2.9e-05, N = 7824)	(0.41, 0.038, P = 0.44, N = 859)
rs10968052(T)/9:27678482*	intergenic	(0.12, 0.0075, P = 3.9e-05, N = 7824)	(0.038, 0.065, P = 0.61, N = 859)
rs10970461(A)/9:31632171	intergenic	(0.91, 0.01, P = 4.1e-05, N = 7824)	(0.99, 0.11, P = 0.61, N = 859)
rs10975539(T)/9:6308729*	intergenic	(0.23, -0.014, P = 4e-05, N = 7824)	(0.034, 0.042, P = 0.75, N = 859)

Results from Univariable Mendelian Randomization of Creatinine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	123	0.056 (-0.031- 0.14) P=0.21	6.3	39	1.53 (0- 80.3)	NA	NA	0.011 P=0.1
MR-Egger	123	0.015 (-0.084- 0.11) P=0.77	6.3	39	1.53 (0- 80.3)	122	0.47	0.011 P=0.1
Weighted median	123	0.03 (-0.1- 0.16) P=0.66	6.3	39	1.53 (0- 80.3)	NA	NA	0.011 P=0.1

Results from Univariable MRPRESSO of Creatinine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.06	0.04	1.27	0.21
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Creatinine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	71	0.081 (-0.042- 0.2) P=0.2	5.1	18	0 (0- 17.1)	NA	NA	0.0026 P=0.77
MR-Egger	71	0.068 (-0.095- 0.23) P=0.42	5.1	18	0 (0- 17.1)	54	0.91	0.0026 P=0.77
Weighted median	71	0.086 (-0.14- 0.31) P=0.46	5.1	18	0 (0- 17.1)	NA	NA	0.0026 P=0.77

Results from Univariable MRPRESSO of Creatinine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.08	0.06	1.29	0.2
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Cystathionine

Instruments Associations with L-Cystathionine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Cystathionine (Shin et al/Long et al)	eGFR (CSSCD)
rs115109644(C)/1:224064269*	intergenic	(0.015, 0.32, P = 9e-06, N = 1943)	(0.49, -0.063, P = 0.21, N = 859)
rs4649409(G)/1:232971657	RNU1-74P	(0.89, -0.28, P = 7.6e-07, N = 1943)	(0.3, -0.055, P = 0.3, N = 859)
rs72756259(G)/1:232986317	intergenic	(0.053, -0.34, P = 3.6e-06, N = 1943)	(0.012, 0.00067, P = 1, N = 859)
rs6585049(T)/10:113043378	intergenic	(0.89, -0.16, P = 9.6e-06, N = 1943)	(0.48, 0.071, P = 0.14, N = 859)
rs7918657(T)/10:14395828	FRMD4A	(0.12, 0.24, P = 1.5e-06, N = 1943)	(0.091, -0.0053, P = 0.95, N = 859)
rs2660220(T)/10:52736099	intergenic	(0.86, 0.18, P = 6.3e-06, N = 1943)	(0.96, 0.067, P = 0.59, N = 859)
rs4121607(C)/11:60306301	MS4A13	(0.81, -0.14, P = 7.3e-06, N = 1943)	(0.63, -0.025, P = 0.61, N = 859)
rs75745817(C)/12:71938404	LGR5	(0.061, 0.36, P = 4.9e-06, N = 1943)	(0.027, -0.018, P = 0.9, N = 859)
rs10048020(T)/15:39651363*	RP11-624L4.1	(0.63, -0.17, P = 5.9e-07, N = 1943)	(0.72, -0.062, P = 0.25, N = 859)
rs205132(A)/16:25622453	intergenic	(0.14, 0.18, P = 4.7e-06, N = 1943)	(0.22, -0.048, P = 0.4, N = 859)
rs8051862(C)/16:83386261	CDH13	(0.78, -0.23, P = 9e-06, N = 1943)	(0.69, 0.0085, P = 0.87, N = 859)
rs517175(C)/18:11532945	intergenic	(0.43, -0.15, P = 6.5e-06, N = 1943)	(0.84, -0.016, P = 0.82, N = 859)
rs9964990(A)/18:62249459	intergenic	(0.64, 0.18, P = 3.1e-06, N = 1943)	(0.91, -0.039, P = 0.63, N = 859)
rs35170371(A)/19:33355081	SLC7A9	(0.2, 0.25, P = 2.2e-07, N = 1943)	(0.29, 0.036, P = 0.5, N = 859)
rs13007863(C)/2:1048650	SNTG2	(0.27, 0.19, P = 8.3e-06, N = 1943)	(0.35, -0.0045, P = 0.93, N = 859)
rs2365208(T)/2:31355071*	GALNT14	(0.78, 0.23, P = 5.9e-06, N = 1943)	(0.96, 0.024, P = 0.85, N = 859)
rs9984606(T)/21:47580684	SPATC1L	(0.096, 0.25, P = 1e-05, N = 1943)	(0.22, -0.042, P = 0.47, N = 859)
rs462790(C)/3:1610784*	intergenic	(0.98, 0.49, P = 7.3e-06, N = 1943)	(0.98, 0.27, P = 0.099, N = 859)
rs9810573(T)/3:5451601*	intergenic	(0.48, 0.17, P = 3.7e-07, N = 1943)	(0.14, -0.012, P = 0.86, N = 859)
rs1166047(T)/3:9898895	TTLL3	(0.74, -0.18, P = 2.7e-06, N = 1943)	(0.93, 0.13, P = 0.15, N = 859)
rs16870330(T)/5:2703426	intergenic	(0.013, 0.72, P = 6.5e-07, N = 1943)	(0.39, -0.0033, P = 0.95, N = 859)
rs16899567(C)/5:2708588	intergenic	(0.01, 0.87, P = 4.9e-06, N = 1943)	(0.12, 0.057, P = 0.45, N = 859)
rs35492822(A)/6:169020658	SMOC2	(0.22, -0.2, P = 7.5e-07, N = 1943)	(0.2, 0.027, P = 0.64, N = 859)
rs9774587(A)/8:107336888	OXR1	(0.23, -0.2, P = 3.1e-06, N = 1943)	(0.63, 0.038, P = 0.45, N = 859)
rs7824505(A)/8:97330691*	PTDSS1	(0.47, 0.15, P = 7.5e-06, N = 1943)	(0.45, 0.067, P = 0.16, N = 859)
rs7026228(G)/9:110191946	RP11-363D24.1	(0.5, 0.16, P = 7.1e-06, N = 1943)	(0.21, -0.023, P = 0.7, N = 859)

Results from Univariable Mendelian Randomization of L-Cystathionine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	26	0.0036 (-0.061- 0.068) P=0.91	24	32	0 (0- 31.3)	NA	NA	-0.014 P=0.54
MR-Egger	26	0.041 (-0.1- 0.18) P=0.57	24	32	0 (0- 31.3)	17	0.86	-0.014 P=0.54
Weighted median	26	-0.0038 (-0.13- 0.12) P=0.95	24	32	0 (0- 31.3)	NA	NA	-0.014 P=0.54

Results from Univariable MRPRESSO of L-Cystathionine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.03	0.11	0.91
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Cystathionine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	20	-0.0046 (-0.064- 0.055) P=0.88	25	25	0 (0- 6.84)	NA	NA	-0.029 P=0.24
MR-Egger	20	0.069 (-0.077- 0.22) P=0.37	25	25	0 (0- 6.84)	8	0.98	-0.029 P=0.24
Weighted median	20	-0.0038 (-0.13- 0.12) P=0.95	25	25	0 (0- 6.84)	NA	NA	-0.029 P=0.24

Results from Univariable MRPRESSO of L-Cystathionine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.03	-0.15	0.88
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Glycine

Instruments Associations with Glycine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Glycine (Shin et al/Long et al)	eGFR (CSSCD)
rs964905(T)/1:101087131	intergenic	(0.49, -0.01, P = 2.6e-05, N = 7824)	(0.59, -0.0049, P = 0.92, N = 859)
rs8453(T)/1:115259599	CSDE1	(0.16, 0.014, P = 8.1e-06, N = 7824)	(0.024, -0.091, P = 0.56, N = 859)
rs12736195(T)/1:173307901	intergenic	(0.72, -0.01, P = 4.3e-05, N = 7824)	(0.87, 0.085, P = 0.24, N = 859)
rs12089471(A)/1:201162411	IGFN1	(0.35, -0.011, P = 1.1e-05, N = 7824)	(0.12, -0.031, P = 0.68, N = 859)
rs782791(A)/1:202998819*	TMEM183A	(0.7, 0.011, P = 2e-05, N = 7824)	(0.64, -0.0051, P = 0.92, N = 859)
rs10754598(A)/1:237463089*	RYR2	(0.38, -0.01, P = 2.5e-05, N = 7824)	(0.36, 0.031, P = 0.54, N = 859)
rs12035460(T)/1:33198711	intergenic	(0.028, -0.2, P = 5.1e-06, N = 1959)	(0.039, -0.21, P = 0.097, N = 859)
rs12562983(T)/1:3457311	MEGF6	(0.026, -0.065, P = 2.3e-05, N = 7824)	(0.015, 0.091, P = 0.65, N = 859)
rs6683669(A)/1:59041092*	TACSTD2	(0.068, -0.02, P = 2.8e-05, N = 7824)	(0.3, -0.14, P = 0.0063, N = 859)
rs7079730(A)/10:11392689*	intergenic	(0.81, -0.014, P = 1.4e-05, N = 7824)	(0.96, 0.28, P = 0.019, N = 859)
rs1907218(T)/10:122970216*	intergenic	(0.31, -0.01, P = 4.9e-05, N = 7824)	(0.43, 0.026, P = 0.6, N = 859)
rs2474711(C)/10:33441017*	intergenic	(0.72, -0.013, P = 9.4e-06, N = 7824)	(0.95, -0.044, P = 0.68, N = 859)
rs7908297(A)/10:5251702*	AKR1C4	(0.11, 0.016, P = 3.7e-05, N = 7824)	(0.033, -0.34, P = 0.013, N = 859)
rs16917276(A)/10:64230835*	ZNF365	(0.032, -0.031, P = 9e-06, N = 7824)	(0.027, 0.3, P = 0.049, N = 859)
rs619945(A)/11:58468173	GLYAT	(0.73, -0.011, P = 4.6e-05, N = 7824)	(0.92, 0.081, P = 0.36, N = 859)
rs10898864(T)/11:72405450*	ARAP1	(0.26, 0.013, P = 1.7e-05, N = 7824)	(0.22, -0.051, P = 0.38, N = 859)
rs491847(A)/12:101349040	ANO4	(0.35, -0.011, P = 5.3e-06, N = 7824)	(0.12, 0.014, P = 0.84, N = 859)
rs11111501(T)/12:103614448	intergenic	(0.076, -0.021, P = 5.9e-06, N = 7824)	(0.03, 0.037, P = 0.79, N = 859)
rs4761007(T)/12:127924890*	intergenic	(0.74, 0.016, P = 4.1e-07, N = 7824)	(0.62, -0.016, P = 0.75, N = 859)
rs7980864(A)/12:133168665	intergenic	(0.14, -0.25, P = 7.9e-06, N = 1959)	(0.059, 0.087, P = 0.4, N = 859)
rs2189669(A)/12:1586846*	ERC1	(0.68, -0.01, P = 4.3e-05, N = 7824)	(0.6, -0.089, P = 0.073, N = 859)
rs274987(G)/12:20388368	intergenic	(0.43, -0.18, P = 8.7e-06, N = 1959)	(0.61, -0.024, P = 0.62, N = 859)
rs739706(C)/12:47482666	PCED1B	(0.36, -0.33, P = 9.6e-06, N = 1959)	(0.44, -0.12, P = 0.017, N = 859)
rs17120574(T)/12:65988722	RP11-230G5.2	(0.92, 0.019, P = 2.6e-05, N = 7824)	(0.61, -0.072, P = 0.13, N = 859)
rs201421(T)/12:99218243*	ANKS1B	(0.72, 0.011, P = 1.3e-05, N = 7824)	(0.63, -0.11, P = 0.029, N = 859)
rs2209634(T)/13:48142372*	intergenic	(0.012, -0.083, P = 4.4e-05, N = 7824)	(0.38, -0.05, P = 0.34, N = 859)
rs1350361(A)/13:60250843*	DIAPH3	(0.49, 0.0097, P = 4.7e-05, N = 7824)	(0.19, -0.1, P = 0.11, N = 859)
rs9572629(A)/13:71622842*	LINC00348	(0.37, -0.01, P = 3.7e-05, N = 7824)	(0.28, 0.087, P = 0.11, N = 859)
rs4884012(T)/13:76243575*	RP11-29G8.3	(0.64, -0.01, P = 4.1e-05, N = 7824)	(0.65, -0.01, P = 0.83, N = 859)
rs10129340(A)/14:100932706	WDR25	(0.6, -0.01, P = 2.4e-05, N = 7824)	(0.41, -0.031, P = 0.52, N = 859)
rs268817(A)/14:58029965*	SLC35F4	(0.27, 0.013, P = 2.1e-05, N = 7824)	(0.047, 0.2, P = 0.078, N = 859)
rs3890482(A)/15:65840645	PTPLAD1	(0.74, 0.59, P = 7.3e-06, N = 1959)	(0.31, -0.024, P = 0.65, N = 859)
rs718663(A)/15:67412596	SMAD3	(0.93, -0.022, P = 1.6e-05, N = 7824)	(0.91, 0.037, P = 0.67, N = 859)
rs11857350(A)/15:88201409*	RP11-648K4.2	(0.81, 0.015, P = 2e-05, N = 7824)	(0.96, -0.16, P = 0.16, N = 859)
rs1143115(T)/15:93452297*	CHD2	(0.53, -0.017, P = 3.5e-05, N = 7824)	(0.59, -0.054, P = 0.25, N = 859)
rs4786584(T)/16:5097593	C16orf89	(0.14, 0.59, P = 1.8e-06, N = 1959)	(0.24, -0.0023, P = 0.97, N = 859)
rs804895(T)/16:81099713*	C16orf46	(0.078, -0.024, P = 8.4e-07, N = 7824)	(0.47, 0.03, P = 0.52, N = 859)
rs8082170(T)/17:62395382	intergenic	(0.18, 0.015, P = 1.1e-06, N = 7824)	(0.3, 0.0066, P = 0.9, N = 859)
rs17800159(T)/18:28720147	DSC1	(0.13, 0.015, P = 3.6e-05, N = 7824)	(0.037, -0.15, P = 0.22, N = 859)
rs9948977(C)/18:38610959*	intergenic	(0.5, -0.01, P = 2.2e-05, N = 7824)	(0.61, -0.051, P = 0.32, N = 859)
rs7243793(G)/18:3862654	DLGAP1	(0.39, 0.32, P = 4.8e-06, N = 1959)	(0.78, 0.048, P = 0.41, N = 859)
rs80004741(T)/19:48299916	TPRX1	(0.11, 1.1, P = 6.5e-06, N = 1959)	(0.024, -0.076, P = 0.63, N = 859)
rs6738001(A)/2:10660417	intergenic	(0.3, 0.011, P = 1.8e-05, N = 7824)	(0.39, 0.022, P = 0.66, N = 859)
rs10186202(C)/2:127555929	intergenic	(0.56, -0.0099, P = 4.4e-05, N = 7824)	(0.43, -0.016, P = 0.75, N = 859)
rs7608258(A)/2:142850098*	LRP1B	(0.32, -0.011, P = 1e-05, N = 7824)	(0.37, 0.0021, P = 0.97, N = 859)
rs7582822(A)/2:172034918	TLK1	(0.39, 0.011, P = 3.8e-06, N = 7824)	(0.75, 0.015, P = 0.79, N = 859)
rs6433432(T)/2:174579886	intergenic	(0.021, 0.039, P = 1.1e-05, N = 7824)	(0.22, 0.017, P = 0.77, N = 859)
rs111251927(TTTTA)/2:211351706	CPS1	(0.22, -0.18, P = 1.5e-06, N = 1959)	(0.064, 0.083, P = 0.4, N = 859)
rs2007748(T)/2:211357642	CPS1	(0.53, 0.011, P = 1.9e-06, N = 7824)	(0.2, 0.00063, P = 0.99, N = 859)
rs6714124(T)/2:211436065*	CPS1	(0.5, -0.017, P = 3.6e-12, N = 7824)	(0.57, 0.024, P = 0.61, N = 859)
rs12468557(T)/2:211495587*	CPS1	(0.38, -0.02, P = 1.7e-16, N = 7824)	(0.19, 0.093, P = 0.13, N = 859)
rs715(T)/2:211543055*	CPS1	(0.71, -0.076, P = 1.6e-147, N = 7824)	(0.81, -0.061, P = 0.33, N = 859)
rs13386028(A)/2:211547400*	CPS1	(0.38, -0.038, P = 3.6e-56, N = 7824)	(0.36, -0.12, P = 0.02, N = 859)
rs10164524(A)/2:211664333*	intergenic	(0.68, 0.03, P = 1.1e-33, N = 7824)	(0.83, 0.044, P = 0.5, N = 859)
rs1016403(A)/2:211704356*	intergenic	(0.86, 0.029, P = 4.2e-14, N = 7824)	(0.93, -0.071, P = 0.46, N = 859)
rs13394054(A)/2:211742818*	intergenic	(0.39, -0.029, P = 1.7e-33, N = 7824)	(0.63, -0.064, P = 0.2, N = 859)
rs4310999(A)/2:211750298*	intergenic	(0.25, 0.035, P = 3e-31, N = 7824)	(0.083, 0.077, P = 0.37, N = 859)
rs6720902(T)/2:212094151	intergenic	(0.59, -0.0099, P = 4.6e-05, N = 7824)	(0.79, -0.012, P = 0.84, N = 859)
rs62141397(G)/2:80246161	CTNNA2	(0.19, 0.18, P = 2.7e-06, N = 1959)	(0.054, -0.15, P = 0.16, N = 859)
rs4619658(C)/2:98863523*	VWA3B	(0.79, 0.23, P = 9.1e-06, N = 1959)	(0.87, 0.093, P = 0.2, N = 859)
rs6136611(C)/20:19057513	intergenic	(0.036, 0.63, P = 7.4e-06, N = 1959)	(0.18, -0.038, P = 0.54, N = 859)
rs4810122(A)/20:56743597	intergenic	(0.45, 0.01, P = 3.5e-05, N = 7824)	(0.3, -0.013, P = 0.81, N = 859)
rs11578(T)/20:57253275*	STX16	(0.29, 0.014, P = 1.9e-07, N = 7824)	(0.18, -0.0015, P = 0.98, N = 859)
rs2825016(A)/21:20081605	AL109763.2	(0.32, 0.01, P = 3.1e-05, N = 7824)	(0.3, 4.4e-05, P = 1, N = 859)
rs1571724(A)/21:42148836*	DSCAM	(0.83, 0.014, P = 2.3e-05, N = 7824)	(0.85, -0.033, P = 0.63, N = 859)
rs12165565(A)/22:26226630	MYO18B	(0.016, 0.21, P = 3.1e-06, N = 1959)	(0.047, -0.071, P = 0.54, N = 859)
rs4494904(T)/3:101835064*	ZPLD1	(0.4, -0.011, P = 1.5e-05, N = 7824)	(0.17, -0.1, P = 0.11, N = 859)
rs1992854(T)/3:125909606*	ALDH1L1-AS2	(0.37, -0.011, P = 7e-06, N = 7824)	(0.36, -0.073, P = 0.14, N = 859)
rs12496373(A)/3:148497051*	intergenic	(0.73, -0.011, P = 2.3e-05, N = 7824)	(0.54, -0.037, P = 0.45, N = 859)
rs7613813(A)/3:149429485*	WWTR1	(0.33, -0.01, P = 2.7e-05, N = 7824)	(0.43, 0.0049, P = 0.92, N = 859)
rs9823316(A)/3:7999351	LMCD1-AS1	(0.09, 0.018, P = 1.1e-05, N = 7824)	(0.16, 0.06, P = 0.36, N = 859)
rs11942622(T)/4:12360318*	intergenic	(0.98, 0.071, P = 2.7e-06, N = 7824)	(0.78, -0.042, P = 0.47, N = 859)
rs6836137(A)/4:145250822	intergenic	(0.014, -0.079, P = 4.8e-06, N = 7824)	(0.016, -0.28, P = 0.15, N = 859)
rs4698310(T)/4:15083363	RP11-665G4.1	(0.42, -0.17, P = 2.7e-06, N = 1959)	(0.7, 0.058, P = 0.28, N = 859)
rs9998572(T)/4:170687567	intergenic	(0.033, -0.049, P = 2.7e-05, N = 7824)	(0.16, -0.08, P = 0.23, N = 859)
rs3904756(C)/4:19616531	RP11-608O21.1	(0.17, 0.16, P = 4.3e-06, N = 1959)	(0.079, 0.0018, P = 0.98, N = 859)
rs9992408(A)/4:76265330	RP11-542G1.1	(0.077, -0.019, P = 4e-05, N = 7824)	(0.066, -0.12, P = 0.23, N = 859)
rs12152753(A)/5:111443094*	intergenic	(0.32, 0.01, P = 2.9e-05, N = 7824)	(0.083, -0.12, P = 0.17, N = 859)
rs2560698(T)/5:115388091	ARL14EPL	(0.85, 0.016, P = 1.9e-05, N = 7824)	(0.65, -0.04, P = 0.44, N = 859)
rs7709785(T)/5:115406397	intergenic	(0.15, -0.018, P = 2e-06, N = 7824)	(0.26, -0.016, P = 0.76, N = 859)
rs329319(A)/5:133906609*	JADE2	(0.43, 0.013, P = 6.5e-07, N = 7824)	(0.52, -0.037, P = 0.44, N = 859)
rs13181561(A)/5:138850905*	TMEM173	(0.74, 0.012, P = 4.1e-05, N = 7824)	(0.41, -0.12, P = 0.012, N = 859)
rs1423029(A)/5:145930544*	intergenic	(0.53, -0.01, P = 2.6e-05, N = 7824)	(0.5, 0.051, P = 0.3, N = 859)
rs4437350(T)/5:34645265*	intergenic	(0.16, 0.39, P = 6.4e-06, N = 1959)	(0.037, -0.00099, P = 0.99, N = 859)
rs6897751(G)/5:79113505	CTC-431G16.2	(0.057, 0.26, P = 9.3e-06, N = 1959)	(0.26, 0.011, P = 0.84, N = 859)
rs268538(T)/5:9458650	SEMA5A	(0.021, -0.064, P = 1.5e-05, N = 7824)	(0.091, -0.018, P = 0.84, N = 859)
rs160508(A)/5:9588764	intergenic	(0.88, 0.017, P = 1.9e-05, N = 7824)	(0.96, -0.076, P = 0.55, N = 859)
rs583776(T)/6:10466171*	intergenic	(0.62, -0.019, P = 8.2e-06, N = 7824)	(0.64, 0.036, P = 0.47, N = 859)
rs11152896(C)/6:105997676	intergenic	(0.92, 0.022, P = 1.2e-05, N = 7824)	(0.73, 0.017, P = 0.75, N = 859)
rs9483617(T)/6:134129708	RP3-323P13.2	(0.032, -0.051, P = 4.6e-05, N = 7824)	(0.15, 0.021, P = 0.76, N = 859)
rs229914(A)/6:134323928	SLC2A12	(0.58, -0.011, P = 2.4e-06, N = 7824)	(0.49, -0.062, P = 0.2, N = 859)
rs13203202(T)/6:25582771	LRRC16A	(0.58, 0.011, P = 9.3e-06, N = 7824)	(0.48, -0.0018, P = 0.97, N = 859)
rs9328361(T)/6:6400475*	LY86-AS1	(0.14, -0.014, P = 3.5e-05, N = 7824)	(0.14, -0.021, P = 0.76, N = 859)
rs1125083(T)/6:73572090*	KCNQ5	(0.8, -0.013, P = 3.7e-05, N = 7824)	(0.84, 0.049, P = 0.46, N = 859)
rs12532734(A)/7:107472382*	intergenic	(0.2, -0.013, P = 3.5e-05, N = 7824)	(0.12, 0.048, P = 0.53, N = 859)
rs5009270(A)/7:112159178*	NPM1P14	(0.31, 0.011, P = 1.7e-05, N = 7824)	(0.5, 0.1, P = 0.036, N = 859)
rs7789056(A)/7:112908269	intergenic	(0.56, 0.01, P = 3.8e-05, N = 7824)	(0.52, -0.0018, P = 0.97, N = 859)
rs12534184(A)/7:123651077*	RP4-630C24.3	(0.11, -0.016, P = 4e-05, N = 7824)	(0.19, -0.075, P = 0.21, N = 859)
rs9655907(A)/7:137817625*	intergenic	(0.97, 0.05, P = 3.1e-05, N = 7824)	(0.79, -0.0076, P = 0.9, N = 859)
rs17557000(A)/7:151707893	GALNTL5	(0.63, -0.01, P = 3.3e-05, N = 7824)	(0.76, -0.092, P = 0.1, N = 859)
rs6464427(T)/7:154147779	DPP6	(0.19, 0.013, P = 4.3e-05, N = 7824)	(0.48, -0.1, P = 0.03, N = 859)
rs6951820(A)/7:154381783*	DPP6	(0.43, 0.011, P = 4.8e-06, N = 7824)	(0.23, 0.076, P = 0.18, N = 859)
rs117039120(T)/7:20607573	intergenic	(0.17, 0.15, P = 2.1e-07, N = 1959)	(0.038, -0.23, P = 0.056, N = 859)
rs6974377(C)/7:21397405	intergenic	(0.32, -0.37, P = 1.7e-06, N = 1959)	(0.24, 0.026, P = 0.66, N = 859)
rs10275982(A)/7:27953981	JAZF1	(0.35, -0.01, P = 2.2e-05, N = 7824)	(0.17, -0.14, P = 0.038, N = 859)
rs1123227(A)/7:42496495*	intergenic	(0.76, 0.017, P = 9.8e-06, N = 7824)	(0.84, 0.11, P = 0.12, N = 859)
rs983498(C)/7:53113752*	intergenic	(0.71, -0.02, P = 8e-06, N = 7824)	(0.78, -0.018, P = 0.75, N = 859)
rs3211913(G)/7:80294604	CD36	(0.022, -0.36, P = 5.1e-06, N = 1959)	(0.33, -0.027, P = 0.61, N = 859)
rs17635249(C)/8:49806968	intergenic	(0.36, 0.01, P = 3.9e-05, N = 7824)	(0.26, 0.035, P = 0.53, N = 859)
rs182914(T)/8:50060960*	intergenic	(0.47, -0.0098, P = 4.6e-05, N = 7824)	(0.32, -0.079, P = 0.13, N = 859)
rs17370395(A)/9:105976900	RP11-341A22.2	(0.93, 0.047, P = 2e-05, N = 7824)	(0.92, 0.018, P = 0.84, N = 859)
rs11573691(T)/9:110081653	RAD23B	(0.094, -0.28, P = 5.4e-06, N = 1959)	(0.015, -0.088, P = 0.65, N = 859)
rs12349613(T)/9:117607806*	RP11-78H18.2	(0.055, 0.034, P = 5.6e-06, N = 7824)	(0.18, -0.056, P = 0.36, N = 859)
rs3012739(A)/9:134654306*	EIF4A1P3	(0.48, 0.012, P = 2.1e-06, N = 7824)	(0.22, -0.0098, P = 0.86, N = 859)
rs4240706(A)/9:137669555	COL5A1	(0.015, -0.1, P = 1.9e-05, N = 7824)	(0.25, -0.024, P = 0.67, N = 859)
rs10964319(T)/9:1994871*	intergenic	(0.097, -0.017, P = 4.7e-05, N = 7824)	(0.21, -0.008, P = 0.9, N = 859)
rs10971687(T)/9:33761112*	PRSS3	(0.37, -0.01, P = 1.8e-05, N = 7824)	(0.13, 0.21, P = 0.0034, N = 859)
rs2297442(T)/9:6540540	GLDC	(0.7, 0.011, P = 2.9e-05, N = 7824)	(0.83, 0.041, P = 0.53, N = 859)
rs952045(T)/9:73161881	TRPM3	(0.95, 0.025, P = 7.3e-06, N = 7824)	(0.77, -0.046, P = 0.42, N = 859)

Results from Univariable Mendelian Randomization of Glycine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	119	0.014 (-0.072- 0.1) P=0.75	15	80	0.00117 (0- 97.3)	NA	NA	0.0028 P=0.69
MR-Egger	119	0.0051 (-0.091- 0.1) P=0.92	15	80	0.00117 (0- 97.3)	149	0.024	0.0028 P=0.69
Weighted median	119	-0.027 (-0.13- 0.077) P=0.61	15	80	0.00117 (0- 97.3)	NA	NA	0.0028 P=0.69

Results from Univariable MRPRESSO of Glycine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.01	0.04	0.32	0.75
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Glycine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	61	0.003 (-0.068- 0.074) P=0.93	27	73	0 (0- 45)	NA	NA	0.0054 P=0.57
MR-Egger	61	-0.011 (-0.1- 0.081) P=0.81	27	73	0 (0- 45)	49	0.82	0.0054 P=0.57
Weighted median	61	-0.03 (-0.13- 0.072) P=0.56	27	73	0 (0- 45)	NA	NA	0.0054 P=0.57

Results from Univariable MRPRESSO of Glycine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.04	0.08	0.93
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Hippuric acid

Instruments Associations with Hippuric acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Hippuric acid (Shin et al/Long et al)	eGFR (CSSCD)
rs520229(T)/1:78876209	PTGFR	(0.69, -0.15, P = 3.4e-06, N = 1956)	(0.58, -0.021, P = 0.67, N = 859)
rs12410147(T)/1:94289120	BCAR3	(0.071, 0.23, P = 8e-06, N = 1956)	(0.16, 0.083, P = 0.22, N = 859)
rs10786630(C)/10:103075639	RP11-107I14.2	(0.65, 0.19, P = 7.8e-07, N = 1956)	(0.28, 0.12, P = 0.023, N = 859)
rs282692(C)/10:60655066	intergenic	(0.78, -0.19, P = 9e-06, N = 1956)	(0.4, 0.017, P = 0.73, N = 859)
rs9518260(C)/13:101632306	NALCN-AS1	(0.27, -0.16, P = 9.9e-07, N = 1956)	(0.097, -0.019, P = 0.81, N = 859)
rs420176(C)/13:111216902	RAB20	(0.93, 0.34, P = 4.2e-06, N = 1956)	(0.75, -0.051, P = 0.37, N = 859)
rs2045930(G)/15:74100160	intergenic	(0.46, 0.15, P = 8e-07, N = 1956)	(0.098, -0.069, P = 0.39, N = 859)
rs4553581(C)/15:74194348	intergenic	(0.56, 0.17, P = 3e-08, N = 1956)	(0.33, 0.037, P = 0.45, N = 859)
rs12935540(T)/16:48586557	N4BP1	(0.29, -0.16, P = 3.4e-06, N = 1956)	(0.41, -0.013, P = 0.79, N = 859)
rs3095573(G)/16:53377003*	intergenic	(0.35, 0.15, P = 9.2e-06, N = 1956)	(0.11, -0.041, P = 0.59, N = 859)
rs10195231(G)/2:121152012	intergenic	(0.48, 0.14, P = 5.2e-06, N = 1956)	(0.88, 0.09, P = 0.21, N = 859)
rs6053232(G)/20:5241396	intergenic	(0.72, -0.19, P = 3.4e-06, N = 1956)	(0.88, 0.14, P = 0.062, N = 859)
rs77077232(A)/3:125463283	OR7E97P	(0.039, -0.37, P = 4e-06, N = 1956)	(0.38, 0.0089, P = 0.85, N = 859)
rs745168(A)/3:194325010	TMEM44	(0.32, 0.09, P = 8.9e-06, N = 1956)	(0.29, 0.0077, P = 0.89, N = 859)
rs1452177(T)/3:83496775*	intergenic	(0.5, -0.17, P = 1.9e-06, N = 1956)	(0.49, 0.074, P = 0.12, N = 859)
rs11730547(G)/4:117903947	intergenic	(0.1, -0.32, P = 1.8e-07, N = 1956)	(0.16, 0.11, P = 0.097, N = 859)
rs7682799(C)/4:118010613*	TRAM1L1	(0.11, -0.34, P = 2.6e-08, N = 1956)	(0.18, 0.011, P = 0.87, N = 859)
rs11791193(A)/9:117084020	ORM1	(0.14, 0.26, P = 6.6e-07, N = 1956)	(0.024, -0.046, P = 0.77, N = 859)
rs7029058(T)/9:84233764	TLE1	(0.36, -0.13, P = 4.1e-06, N = 1956)	(0.61, 0.063, P = 0.21, N = 859)

Results from Univariable Mendelian Randomization of Hippuric acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	19	-0.05 (-0.18- 0.079) P=0.45	25	24	6.24 (0- 66.7)	NA	NA	0.019 P=0.64
MR-Egger	19	-0.13 (-0.48- 0.22) P=0.48	25	24	6.24 (0- 66.7)	20	0.25	0.019 P=0.64
Weighted median	19	-0.03 (-0.21- 0.15) P=0.75	25	24	6.24 (0- 66.7)	NA	NA	0.019 P=0.64

Results from Univariable MRPRESSO of Hippuric acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.07	-0.76	0.46
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Hippuric acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	16	-0.027 (-0.17- 0.12) P=0.72	23	19	20 (0- 71.8)	NA	NA	0.037 P=0.41
MR-Egger	16	-0.18 (-0.58- 0.21) P=0.37	23	19	20 (0- 71.8)	18	0.22	0.037 P=0.41
Weighted median	16	-0.046 (-0.25- 0.16) P=0.66	23	19	20 (0- 71.8)	NA	NA	0.037 P=0.41

Results from Univariable MRPRESSO of Hippuric acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.08	-0.36	0.73
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Indoxyl sulfate

Instruments Associations with Indoxyl sulfate & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Indoxyl sulfate (Shin et al/Long et al)	eGFR (CSSCD)
rs6679229(G)/1:15914078*	AGMAT	(0.3, -0.18, P = 2.1e-06, N = 1954)	(0.27, -0.0022, P = 0.97, N = 859)
rs4587548(C)/1:195834979*	intergenic	(0.62, 0.015, P = 2.5e-05, N = 7339)	(0.16, 0.05, P = 0.46, N = 859)
rs4288539(A)/1:25282993*	RUNX3	(0.61, -0.015, P = 2.1e-05, N = 7339)	(0.89, 0.096, P = 0.23, N = 859)
rs1564485(A)/1:53621628*	intergenic	(0.48, 0.016, P = 7.8e-06, N = 7339)	(0.56, -0.0031, P = 0.95, N = 859)
rs7095620(A)/10:114448218*	VTI1A	(0.31, -0.016, P = 2.7e-05, N = 7339)	(0.68, 0.05, P = 0.35, N = 859)
rs12217409(A)/10:129707769	PTPRE	(0.14, -0.27, P = 3e-06, N = 1954)	(0.31, 0.085, P = 0.1, N = 859)
rs7100757(C)/10:73325757	CDH23	(0.46, 0.15, P = 4.6e-06, N = 1954)	(0.62, -0.027, P = 0.58, N = 859)
rs4937006(C)/11:125252738	PKNOX2	(0.075, 0.036, P = 3.2e-05, N = 7339)	(0.17, -0.071, P = 0.27, N = 859)
rs527140(A)/11:57500134*	TMX2	(0.75, -0.033, P = 6.8e-06, N = 1758)	(0.77, -0.055, P = 0.33, N = 859)
rs1283170(A)/12:52423179	NR4A1	(0.3, -0.03, P = 2.7e-05, N = 1758)	(0.32, -0.055, P = 0.3, N = 859)
rs7327909(A)/13:100505367*	CLYBL	(0.39, 0.016, P = 1.3e-05, N = 7339)	(0.27, -0.057, P = 0.31, N = 859)
rs9508849(A)/13:20261939*	PSPC1	(0.95, 0.076, P = 3.4e-05, N = 1758)	(0.71, 0.031, P = 0.57, N = 859)
rs4363758(T)/13:77386392*	intergenic	(0.23, 0.018, P = 2.3e-05, N = 7339)	(0.2, 0.0031, P = 0.96, N = 859)
rs7161167(A)/14:29740046	RP11-562L8.1	(0.051, -0.036, P = 1.6e-05, N = 7339)	(0.2, 0.096, P = 0.12, N = 859)
rs2765904(T)/14:85289193	intergenic	(0.51, -0.015, P = 4e-05, N = 7339)	(0.19, 0.012, P = 0.84, N = 859)
rs12599018(C)/16:6085186	RBFOX1	(0.19, -0.021, P = 2.6e-05, N = 7339)	(0.29, -0.038, P = 0.48, N = 859)
rs12597663(A)/16:66396875*	CDH5	(0.63, 0.015, P = 4.4e-05, N = 7339)	(0.42, -0.012, P = 0.81, N = 859)
rs3907371(T)/18:69684916	intergenic	(0.65, -0.03, P = 1.1e-05, N = 1758)	(0.62, -0.038, P = 0.46, N = 859)
rs7937(T)/19:41302706*	EGLN2	(0.56, -0.015, P = 1.9e-05, N = 7339)	(0.31, -0.028, P = 0.61, N = 859)
rs373996356(G)/19:429599	SHC2	(0.011, -0.56, P = 7.5e-06, N = 1954)	(0.061, -0.05, P = 0.63, N = 859)
rs17043547(A)/2:115539056	DPP10	(0.012, -0.079, P = 4.9e-06, N = 7339)	(0.036, -0.011, P = 0.93, N = 859)
rs1179644(A)/2:217796770*	AC007563.5	(0.93, 0.029, P = 2.6e-05, N = 7339)	(0.49, 0.012, P = 0.8, N = 859)
rs7261614(T)/20:17604260*	RRBP1	(0.24, 0.034, P = 1.3e-05, N = 1758)	(0.65, -0.029, P = 0.57, N = 859)
rs12480161(T)/20:40389664*	intergenic	(0.75, -0.032, P = 4.1e-05, N = 1758)	(0.83, -0.018, P = 0.79, N = 859)
rs7262150(C)/20:62354494	ZGPAT	(0.21, 0.24, P = 4.8e-06, N = 1954)	(0.078, 0.033, P = 0.72, N = 859)
rs9863394(T)/3:125456532*	OR7E53P	(0.059, 0.037, P = 2.5e-05, N = 7339)	(0.41, -0.0057, P = 0.91, N = 859)
rs7631707(A)/3:20300268*	intergenic	(0.56, 0.015, P = 2.9e-05, N = 7339)	(0.59, -0.089, P = 0.077, N = 859)
rs17024808(T)/4:134386587*	intergenic	(0.63, 0.015, P = 4.2e-05, N = 7339)	(0.4, 0.066, P = 0.18, N = 859)
rs10031835(T)/4:136087584*	intergenic	(0.7, -0.034, P = 5.8e-06, N = 1758)	(0.9, 0.068, P = 0.4, N = 859)
rs295224(T)/4:161227411*	intergenic	(0.41, -0.017, P = 2.4e-05, N = 7339)	(0.26, -0.015, P = 0.79, N = 859)
rs77431462(T)/4:174899979	RP11-161D15.3	(0.74, -0.12, P = 8.6e-06, N = 1954)	(0.55, 0.0067, P = 0.89, N = 859)
rs13145712(T)/4:62041029*	intergenic	(0.73, -0.034, P = 4.1e-05, N = 1758)	(0.89, -0.12, P = 0.14, N = 859)
rs2090189(T)/4:64337600*	RP11-12K22.1	(0.4, 0.015, P = 1.6e-05, N = 7339)	(0.36, 0.093, P = 0.058, N = 859)
rs698172(A)/5:127154927	CTC-228N24.1	(0.42, -0.015, P = 3.4e-05, N = 7339)	(0.15, 0.018, P = 0.79, N = 859)
rs1039438(A)/5:156476770*	HAVCR1	(0.28, -0.019, P = 1e-05, N = 7339)	(0.15, -0.011, P = 0.87, N = 859)
rs13361283(T)/5:169722546	LCP2	(0.92, 0.057, P = 1.8e-05, N = 1758)	(0.9, -0.091, P = 0.26, N = 859)
rs2927892(A)/6:120659453	intergenic	(0.27, -0.018, P = 3.8e-05, N = 7339)	(0.23, 0.012, P = 0.83, N = 859)
rs9489956(T)/6:120781346*	intergenic	(0.78, 0.04, P = 5.3e-07, N = 1758)	(0.75, -0.0097, P = 0.86, N = 859)
rs11758810(T)/6:155418671	TIAM2	(0.38, 0.16, P = 1.9e-06, N = 1954)	(0.26, 0.021, P = 0.72, N = 859)
rs9379897(T)/6:26601526*	ABT1	(0.87, -0.026, P = 2e-06, N = 7339)	(0.86, 0.021, P = 0.77, N = 859)
rs3847067(A)/7:100500615*	RN7SL549P	(0.29, -0.032, P = 6.7e-06, N = 1758)	(0.096, -0.05, P = 0.53, N = 859)
rs2273933(T)/9:14313712*	NFIB	(0.1, 0.026, P = 3.7e-05, N = 7339)	(0.56, 0.0099, P = 0.84, N = 859)
rs7855409(T)/9:24296518	intergenic	(0.01, -0.58, P = 8.5e-06, N = 1954)	(0.022, -0.23, P = 0.17, N = 859)
rs943628(T)/9:293360*	DOCK8	(0.26, 0.018, P = 4.2e-05, N = 7339)	(0.34, 0.039, P = 0.45, N = 859)
rs7858948(A)/9:89621759*	CDC20P1	(0.011, -0.13, P = 3.5e-05, N = 1758)	(0.3, -0.091, P = 0.082, N = 859)

Results from Univariable Mendelian Randomization of Indoxyl sulfate & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	45	0.032 (-0.12- 0.19) P=0.68	4.8	10	2.69 (0- 30.2)	NA	NA	0.0024 P=0.82
MR-Egger	45	0.018 (-0.2- 0.23) P=0.87	4.8	10	2.69 (0- 30.2)	34	0.83	0.0024 P=0.82
Weighted median	45	0.052 (-0.22- 0.33) P=0.71	4.8	10	2.69 (0- 30.2)	NA	NA	0.0024 P=0.82

Results from Univariable MRPRESSO of Indoxyl sulfate & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.03	0.08	0.41	0.68
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Indoxyl sulfate & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	17	-0.022 (-0.19- 0.15) P=0.81	9.8	8.2	5.28 (0- 69.7)	NA	NA	-0.013 P=0.53
MR-Egger	17	0.034 (-0.22- 0.29) P=0.8	9.8	8.2	5.28 (0- 69.7)	12	0.67	-0.013 P=0.53
Weighted median	17	0.027 (-0.27- 0.32) P=0.86	9.8	8.2	5.28 (0- 69.7)	NA	NA	-0.013 P=0.53

Results from Univariable MRPRESSO of Indoxyl sulfate & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.02	0.09	-0.25	0.81
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Methylmalonylcarnitine

Instruments Associations with Methylmalonyl carnitine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Methylmalonyl carnitine (Shin et al/Long et al)	eGFR (CSSCD)
rs10999344(A)/10:53525932*	PRKG1	(0.12, 0.22, P = 9.4e-06, N = 1818)	(0.12, 0.012, P = 0.87, N = 859)
rs1842830(T)/11:7863201*	RP11-35J10.5	(0.99, -0.6, P = 6.4e-07, N = 1818)	(0.88, -0.046, P = 0.52, N = 859)
rs578157537(ATTTTTTT)/12:104366864	TDG	(0.039, -0.39, P = 3.4e-06, N = 1818)	(0.76, 0.068, P = 0.24, N = 859)
rs880118(C)/13:112023039*	intergenic	(0.99, -0.47, P = 1.2e-06, N = 1818)	(0.7, 0.016, P = 0.77, N = 859)
rs1885076(G)/14:27043304	NOVA1	(0.62, -0.13, P = 1.4e-06, N = 1818)	(0.15, -0.17, P = 0.013, N = 859)
rs11890(A)/16:1820992*	NME3	(0.77, -0.18, P = 8.3e-07, N = 1818)	(0.84, -0.041, P = 0.54, N = 859)
rs2967147(C)/16:57849280*	CTD-2600O9.1	(0.079, -0.31, P = 3.6e-06, N = 1818)	(0.26, -0.088, P = 0.097, N = 859)
rs56720646(A)/18:49036947	RP11-267C16.1	(0.06, 0.29, P = 2.7e-06, N = 1818)	(0.12, -0.01, P = 0.89, N = 859)
rs200472465(C)/2:11956875*	LPIN1	(0.014, 0.49, P = 5.8e-06, N = 1818)	(0.074, -0.098, P = 0.29, N = 859)
rs140740345(CA)/2:198092325	ANKRD44	(0.22, -0.22, P = 4.9e-06, N = 1818)	(0.82, 0.073, P = 0.25, N = 859)
rs112638583(T)/2:23341246	AC016768.1	(0.016, 0.65, P = 7.4e-06, N = 1818)	(0.022, 0.0055, P = 0.97, N = 859)
rs1075726(C)/2:23412686*	AC016768.1	(0.067, 0.35, P = 4.7e-06, N = 1818)	(0.09, 0.12, P = 0.15, N = 859)
rs1569910(G)/20:54377395*	intergenic	(0.033, -0.37, P = 9.3e-06, N = 1818)	(0.063, -0.17, P = 0.083, N = 859)
rs4810141(T)/20:57209899	MGC4294	(0.58, 0.15, P = 6.2e-06, N = 1818)	(0.41, 0.021, P = 0.67, N = 859)
rs10077410(A)/5:122450771*	PRDM6	(0.14, 0.23, P = 6.7e-06, N = 1818)	(0.14, 0.019, P = 0.79, N = 859)
rs3095825(A)/5:31440389*	DROSHA	(0.82, -0.22, P = 4.4e-06, N = 1818)	(0.92, 0.092, P = 0.31, N = 859)
rs59448538(G)/6:150631830	intergenic	(0.26, -0.2, P = 2.9e-07, N = 1818)	(0.32, -0.072, P = 0.15, N = 859)
rs7810641(C)/7:146979044	CNTNAP2	(0.72, -0.17, P = 6.7e-06, N = 1818)	(0.96, -0.14, P = 0.25, N = 859)
rs4743171(T)/9:100908135	CORO2A	(0.27, -0.19, P = 6.5e-06, N = 1818)	(0.31, 0.018, P = 0.74, N = 859)
rs79410245(C)/9:7666483	intergenic	(0.015, 0.59, P = 7.9e-06, N = 1818)	(0.069, -0.17, P = 0.075, N = 859)

Results from Univariable Mendelian Randomization of Methylmalonyl carnitine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	20	0.02 (-0.09- 0.13) P=0.72	21	23	21.5 (0- 77.6)	NA	NA	0.07 P=0.095
MR-Egger	20	-0.18 (-0.42- 0.066) P=0.17	21	23	21.5 (0- 77.6)	23	0.21	0.07 P=0.095
Weighted median	20	-0.01 (-0.15- 0.13) P=0.89	21	23	21.5 (0- 77.6)	NA	NA	0.07 P=0.095

Results from Univariable MRPRESSO of Methylmalonyl carnitine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.02	0.06	0.35	0.73
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Methylmalonyl carnitine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	10	-0.065 (-0.26- 0.13) P=0.51	22	12	24.1 (0- 91.3)	NA	NA	0.12 P=0.04
MR-Egger	10	-0.45 (-0.8- -0.11) P=0.034	22	12	24.1 (0- 91.3)	8.6	0.38	0.12 P=0.04
Weighted median	10	-0.13 (-0.35- 0.093) P=0.26	22	12	24.1 (0- 91.3)	NA	NA	0.12 P=0.04

Results from Univariable MRPRESSO of Methylmalonyl carnitine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.07	0.1	-0.66	0.53
beta.exposure	Outlier-corrected	NA	NA	NA	NA

myo-Inositol

Instruments Associations with myo-Inositol & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	myo-Inositol (Shin et al/Long et al)	eGFR (CSSCD)
rs10875336(T)/1:101241384	intergenic	(0.61, -0.0073, P = 2.4e-05, N = 7824)	(0.55, -0.14, P = 0.0037, N = 859)
rs856084(T)/1:158915141*	PYHIN1	(0.72, 0.0078, P = 1e-05, N = 7824)	(0.92, 0.023, P = 0.8, N = 859)
rs7544659(A)/1:175647041*	TNR	(0.4, 0.0089, P = 3.1e-07, N = 7824)	(0.47, 0.031, P = 0.52, N = 859)
rs7556049(C)/1:200138774	NR5A2	(0.12, 0.22, P = 5.2e-06, N = 1951)	(0.39, -0.05, P = 0.3, N = 859)
rs10735491(A)/1:217113278*	ESRRG	(0.45, 0.0072, P = 3.9e-05, N = 7824)	(0.18, 0.037, P = 0.55, N = 859)
rs12744888(A)/1:229336778	intergenic	(0.93, -0.02, P = 1.4e-05, N = 7824)	(0.99, -0.055, P = 0.8, N = 859)
rs4659612(A)/1:236033290*	LYST	(0.74, 0.017, P = 5.9e-06, N = 7824)	(0.72, 0.11, P = 0.045, N = 859)
rs7541937(T)/1:35341982*	DLGAP3	(0.46, 0.0079, P = 2.2e-05, N = 7824)	(0.53, -0.05, P = 0.31, N = 859)
rs12146051(C)/1:46742952	RAD54L	(0.31, -0.0074, P = 2.8e-05, N = 7824)	(0.059, 0.062, P = 0.54, N = 859)
rs12077102(C)/1:60183404	FGGY	(0.012, 0.066, P = 1.9e-05, N = 7824)	(0.14, -0.015, P = 0.83, N = 859)
rs6584573(C)/10:105570406*	SH3PXD2A	(0.016, 0.032, P = 2.7e-05, N = 7824)	(0.13, -0.11, P = 0.14, N = 859)
rs11192466(A)/10:107278956*	intergenic	(0.013, 0.069, P = 8.3e-06, N = 7824)	(0.12, -0.084, P = 0.25, N = 859)
rs11010733(A)/10:19912562*	MALRD1	(0.025, 0.046, P = 4.1e-05, N = 7824)	(0.19, -0.02, P = 0.75, N = 859)
rs3004261(A)/10:43491592*	MIR5100	(0.42, 0.0082, P = 1.8e-06, N = 7824)	(0.33, -0.0069, P = 0.9, N = 859)
rs10996699(A)/10:53063382	PRKG1	(0.77, -0.013, P = 4.4e-05, N = 7824)	(0.94, 0.071, P = 0.47, N = 859)
rs7071294(G)/10:53396926	PRKG1	(0.23, -0.25, P = 2.9e-06, N = 1951)	(0.19, 0.027, P = 0.66, N = 859)
rs2642588(T)/10:71466578	intergenic	(0.31, -0.0079, P = 5.8e-06, N = 7824)	(0.52, -0.029, P = 0.55, N = 859)
rs12266321(T)/10:78777947*	KCNMA1	(0.99, -0.066, P = 6.1e-06, N = 7824)	(0.97, 0.24, P = 0.097, N = 859)
rs265455(A)/10:83075585*	intergenic	(0.29, 0.0072, P = 4.5e-05, N = 7824)	(0.39, -0.042, P = 0.39, N = 859)
rs265487(A)/10:83117262*	intergenic	(0.49, -0.0077, P = 7.6e-06, N = 7824)	(0.26, -0.052, P = 0.33, N = 859)
rs10502069(A)/11:106316611*	intergenic	(0.73, -0.0078, P = 8.4e-06, N = 7824)	(0.77, 0.12, P = 0.03, N = 859)
rs1944518(T)/11:120843742*	GRIK4	(0.31, -0.0086, P = 1.3e-06, N = 7824)	(0.051, -0.18, P = 0.11, N = 859)
rs2922048(T)/11:41389942	LRRC4C	(0.66, 0.0071, P = 4.9e-05, N = 7824)	(0.45, -0.0089, P = 0.86, N = 859)
rs2510500(C)/11:79194246	intergenic	(0.43, -0.0076, P = 1e-05, N = 7824)	(0.48, 0.034, P = 0.48, N = 859)
rs12277739(C)/11:87624457*	RP11-665E10.3	(0.97, -0.046, P = 2.2e-05, N = 7824)	(0.85, 0.046, P = 0.51, N = 859)
rs7312321(A)/12:120036235*	TMEM233	(0.35, -0.0072, P = 3.4e-05, N = 7824)	(0.4, -0.067, P = 0.17, N = 859)
rs9651790(T)/12:129389777	GLT1D1	(0.47, -0.0073, P = 2.5e-05, N = 7824)	(0.22, 0.056, P = 0.35, N = 859)
rs4759824(T)/12:131486985*	GPR133	(0.68, 0.0083, P = 1.9e-06, N = 7824)	(0.67, -0.038, P = 0.46, N = 859)
rs10505911(A)/12:24022160*	SOX5	(0.23, 0.01, P = 3e-05, N = 7824)	(0.33, 0.053, P = 0.31, N = 859)
rs58671007(ATT)/13:37491536	SMAD9	(0.012, 0.44, P = 7.5e-06, N = 1951)	(0.16, -0.042, P = 0.52, N = 859)
rs12552(A)/13:53625781*	OLFM4	(0.44, 0.0074, P = 1.5e-05, N = 7824)	(0.4, 0.13, P = 0.0062, N = 859)
rs9317855(T)/13:70543601*	KLHL1	(0.35, -0.008, P = 4.3e-06, N = 7824)	(0.42, 0.016, P = 0.74, N = 859)
rs9529872(T)/13:71875477*	RABEPKP1	(0.024, 0.048, P = 4.8e-05, N = 7824)	(0.16, -0.012, P = 0.86, N = 859)
rs1764963(T)/13:86259295	intergenic	(0.65, -0.008, P = 4.4e-06, N = 7824)	(0.48, -0.054, P = 0.27, N = 859)
rs1956194(G)/14:59477771*	RP11-112J1.2	(0.86, -0.21, P = 5.8e-06, N = 1951)	(0.86, 0.059, P = 0.37, N = 859)
rs6573359(T)/14:61582316	intergenic	(0.98, 0.048, P = 3.3e-05, N = 7824)	(0.64, 0.0012, P = 0.98, N = 859)
rs12589229(T)/14:91820675*	CCDC88C	(0.33, 0.0083, P = 2.4e-06, N = 7824)	(0.22, 0.034, P = 0.56, N = 859)
rs2107582(A)/15:25753469	AC124997.1	(0.32, -0.0075, P = 2.2e-05, N = 7824)	(0.42, 7e-05, P = 1, N = 859)
rs11070699(T)/15:49800789*	FAM227B	(0.65, -0.0075, P = 2e-05, N = 7824)	(0.49, 0.031, P = 0.53, N = 859)
rs11631036(T)/15:51298925	AP4E1	(0.11, -0.24, P = 9.4e-06, N = 1951)	(0.017, -0.2, P = 0.28, N = 859)
rs72734509(G)/15:76093382	intergenic	(0.023, 0.55, P = 9.6e-06, N = 1951)	(0.013, -0.092, P = 0.67, N = 859)
rs1896864(A)/15:85382193	ALPK3	(0.65, 0.0075, P = 1.6e-05, N = 7824)	(0.69, -0.078, P = 0.14, N = 859)
rs7200640(C)/16:12774993	CPPED1	(0.88, -0.014, P = 1.6e-05, N = 7824)	(0.93, 0.16, P = 0.078, N = 859)
rs4788439(T)/16:24931798*	ARHGAP17	(0.077, -0.027, P = 6.6e-13, N = 7824)	(0.67, -0.1, P = 0.051, N = 859)
rs16974319(A)/16:25054644*	RP11-266L9.4	(0.42, -0.0072, P = 3.4e-05, N = 7824)	(0.45, -0.0011, P = 0.98, N = 859)
rs6500418(T)/16:48876104	intergenic	(0.37, -0.0079, P = 5.9e-06, N = 7824)	(0.77, -0.039, P = 0.51, N = 859)
rs17711511(C)/16:80066149	intergenic	(0.92, -0.015, P = 1.1e-05, N = 7824)	(0.98, 0.083, P = 0.65, N = 859)
rs4243227(T)/16:82028082	SDR42E1	(0.8, 0.011, P = 4e-05, N = 7824)	(0.95, 0.02, P = 0.85, N = 859)
rs16957235(T)/16:82424223*	intergenic	(0.99, -0.071, P = 4.3e-06, N = 7824)	(0.88, -4.5e-06, P = 1, N = 859)
rs77193496(T)/17:13106988	intergenic	(0.035, 0.45, P = 8.7e-06, N = 1951)	(0.097, -0.036, P = 0.66, N = 859)
rs12942795(A)/17:34995473	CTB-75G16.3	(0.64, 0.0099, P = 3.6e-05, N = 7824)	(0.92, 0.0081, P = 0.93, N = 859)
rs3760124(T)/17:73597919	MYO15B	(0.31, 0.0074, P = 2.6e-05, N = 7824)	(0.11, -0.2, P = 0.0085, N = 859)
rs2678795(T)/18:28290604*	RP11-675P14.1	(0.64, -0.0071, P = 4e-05, N = 7824)	(0.57, 0.0099, P = 0.84, N = 859)
rs4940346(C)/18:45105566	CTD-2130O13.1	(0.13, 0.19, P = 4.7e-06, N = 1951)	(0.31, 0.0093, P = 0.86, N = 859)
rs9947181(C)/18:45580229	ZBTB7C	(0.03, -0.028, P = 9.2e-07, N = 7824)	(0.22, -0.1, P = 0.07, N = 859)
rs411805(T)/18:55298886*	RP11-35G9.3	(0.47, -0.0071, P = 3.1e-05, N = 7824)	(0.59, -0.11, P = 0.027, N = 859)
rs9959796(C)/18:64647334*	intergenic	(0.98, 0.029, P = 2.6e-05, N = 7824)	(0.98, -0.025, P = 0.9, N = 859)
rs722419(A)/19:13360233	CACNA1A	(0.45, 0.008, P = 4e-06, N = 7824)	(0.31, -0.098, P = 0.062, N = 859)
rs7251640(T)/19:18614935	ELL	(0.84, -0.012, P = 1.5e-06, N = 7824)	(0.54, -0.03, P = 0.53, N = 859)
rs4808136(A)/19:18618867*	ELL	(0.34, 0.013, P = 5.4e-14, N = 7824)	(0.75, -0.089, P = 0.11, N = 859)
rs34143665(G)/19:18766030	KLHL26	(0.21, 0.18, P = 7.1e-06, N = 1951)	(0.034, 0.039, P = 0.77, N = 859)
rs2160717(T)/19:29822729	CTC-525D6.1	(0.4, -0.0087, P = 4.6e-07, N = 7824)	(0.38, 0.028, P = 0.58, N = 859)
rs8113823(A)/19:46959053	intergenic	(0.15, -0.028, P = 2.5e-05, N = 7824)	(0.042, 0.035, P = 0.76, N = 859)
rs1844852(T)/2:117262186	intergenic	(0.88, -0.17, P = 3.8e-06, N = 1951)	(0.45, -0.07, P = 0.15, N = 859)
rs1492394(A)/2:141032676	LRP1B	(0.037, 0.04, P = 2.6e-05, N = 7824)	(0.18, 0.023, P = 0.71, N = 859)
rs1965407(A)/2:1429277	TPO	(0.23, -0.017, P = 2.7e-05, N = 7824)	(0.28, 0.11, P = 0.031, N = 859)
rs4664918(C)/2:158874088	UPP2	(0.59, 0.0071, P = 4.7e-05, N = 7824)	(0.27, -0.05, P = 0.36, N = 859)
rs2060198(A)/2:166245230	SCN2A	(0.26, -0.017, P = 2.2e-05, N = 7824)	(0.16, 0.095, P = 0.14, N = 859)
rs62188095(A)/2:184130538	LIN28AP1	(0.098, -0.24, P = 4.5e-06, N = 1951)	(0.015, -0.16, P = 0.44, N = 859)
rs4399682(A)/2:184891621*	intergenic	(0.72, 0.018, P = 2.1e-06, N = 7824)	(0.87, -0.017, P = 0.81, N = 859)
rs4665191(A)/2:23249712*	AC016768.1	(0.3, -0.0076, P = 1.7e-05, N = 7824)	(0.75, -0.00067, P = 0.99, N = 859)
rs4811076(A)/20:49109845*	intergenic	(0.49, -0.0074, P = 1.8e-05, N = 7824)	(0.39, -0.0048, P = 0.92, N = 859)
rs16996393(A)/20:9753835	PAK7	(0.69, -0.0083, P = 3.2e-06, N = 7824)	(0.48, 0.055, P = 0.27, N = 859)
rs2223728(A)/21:22233992	intergenic	(0.34, 0.0073, P = 2.5e-05, N = 7824)	(0.26, 0.033, P = 0.54, N = 859)
rs2832576(T)/21:31431705*	intergenic	(0.86, 0.011, P = 1.5e-05, N = 7824)	(0.68, -0.036, P = 0.48, N = 859)
rs2834059(A)/21:34375461	AP000282.2	(0.48, -0.0091, P = 1e-06, N = 7824)	(0.25, 0.084, P = 0.13, N = 859)
rs5994710(A)/22:33682273	LARGE	(0.077, -0.017, P = 1.2e-06, N = 7824)	(0.58, -0.0095, P = 0.85, N = 859)
rs4431081(T)/3:111482048	PLCXD2	(0.45, 0.016, P = 2.2e-06, N = 7824)	(0.83, -0.023, P = 0.73, N = 859)
rs12491897(A)/3:116356191	LSAMP	(0.18, -0.01, P = 2.8e-05, N = 7824)	(0.26, 0.00051, P = 0.99, N = 859)
rs10636873(GGA)/3:158701141	IQCJ	(0.64, 0.18, P = 8.3e-06, N = 1951)	(0.48, 0.017, P = 0.73, N = 859)
rs6786880(T)/3:165855100	intergenic	(0.59, 0.0074, P = 1.9e-05, N = 7824)	(0.39, 0.013, P = 0.79, N = 859)
rs13092031(A)/3:1719076	intergenic	(0.64, -0.0073, P = 3e-05, N = 7824)	(0.33, -0.032, P = 0.53, N = 859)
rs572746052(TAAA)/3:172786606	SPATA16	(0.021, -0.12, P = 4.3e-06, N = 1951)	(0.43, -0.019, P = 0.69, N = 859)
rs12635393(T)/3:187091583*	RTP4	(0.35, 0.015, P = 3.7e-05, N = 7824)	(0.19, 0.087, P = 0.15, N = 859)
rs4687367(T)/3:192631798*	MB21D2	(0.46, 0.0073, P = 3.5e-05, N = 7824)	(0.62, -0.016, P = 0.75, N = 859)
rs937107(T)/3:22331495*	ZNF385D	(0.019, 0.051, P = 4e-05, N = 7824)	(0.13, 0.12, P = 0.094, N = 859)
rs3872668(C)/3:314429*	CHL1	(0.37, -0.018, P = 7.3e-07, N = 7824)	(0.4, -0.0091, P = 0.85, N = 859)
rs2887159(A)/3:64128189	PRICKLE2	(0.085, 0.24, P = 8.7e-06, N = 1951)	(0.15, 0.15, P = 0.026, N = 859)
rs1899372(A)/3:77385745	ROBO2	(0.083, -0.26, P = 7.3e-06, N = 1951)	(0.14, -0.055, P = 0.41, N = 859)
rs11934095(A)/4:11884262	intergenic	(0.72, -0.0082, P = 3.1e-06, N = 7824)	(0.49, 0.011, P = 0.83, N = 859)
rs7678369(A)/4:124525133	intergenic	(0.74, 0.18, P = 2.7e-06, N = 1951)	(0.41, -0.00038, P = 0.99, N = 859)
rs200970756(T)/4:19170429	RP11-3J1.1	(0.16, 0.23, P = 2.1e-06, N = 1951)	(0.091, 0.082, P = 0.32, N = 859)
rs11942812(A)/4:26273531	RBPJ	(0.58, 0.0073, P = 2.9e-05, N = 7824)	(0.46, -0.017, P = 0.72, N = 859)
rs16879155(T)/4:27304493*	intergenic	(0.017, 0.056, P = 1.9e-05, N = 7824)	(0.15, -0.11, P = 0.1, N = 859)
rs62294538(T)/4:38989940*	TMEM156	(0.59, -0.13, P = 8.3e-06, N = 1951)	(0.41, -0.0091, P = 0.86, N = 859)
rs77437403(A)/4:57725538	intergenic	(0.035, -0.55, P = 1.2e-06, N = 1951)	(0.019, 0.42, P = 0.014, N = 859)
rs4690290(C)/4:689502	intergenic	(0.46, 0.034, P = 2.1e-05, N = 7824)	(0.59, -0.029, P = 0.55, N = 859)
rs4541491(A)/4:82604912*	RP11-689K5.3	(0.62, -0.0078, P = 6.6e-06, N = 7824)	(0.63, -0.032, P = 0.53, N = 859)
rs6893586(T)/5:163508338*	intergenic	(0.43, 0.0072, P = 4e-05, N = 7824)	(0.7, 0.023, P = 0.65, N = 859)
rs17063000(T)/5:163645278	CTC-207P7.1	(0.24, -0.01, P = 1.5e-05, N = 7824)	(0.081, -0.035, P = 0.68, N = 859)
rs12652381(A)/5:170023542*	KCNIP1	(0.61, 0.0091, P = 1.6e-07, N = 7824)	(0.91, 0.059, P = 0.47, N = 859)
rs4131290(A)/5:176780682*	RGS14	(0.7, -0.013, P = 7.5e-08, N = 7824)	(0.91, -0.16, P = 0.055, N = 859)
rs13181802(A)/5:55959493	intergenic	(0.68, 0.0077, P = 1.1e-05, N = 7824)	(0.61, 0.057, P = 0.28, N = 859)
rs386161(T)/5:57916579*	RAB3C	(0.58, -0.0075, P = 2.3e-05, N = 7824)	(0.82, 0.036, P = 0.56, N = 859)
rs588527(C)/5:9992296	intergenic	(0.95, 0.14, P = 7.5e-06, N = 1951)	(0.86, -0.14, P = 0.058, N = 859)
rs2400108(T)/6:105810450*	PREP	(0.85, 0.01, P = 4.6e-05, N = 7824)	(0.33, -0.042, P = 0.41, N = 859)
rs12210249(T)/6:110996079	CDK19	(0.032, -0.5, P = 5.9e-06, N = 1951)	(0.048, 0.19, P = 0.087, N = 859)
rs17052573(A)/6:125306814*	RNF217	(0.63, 0.0072, P = 3.7e-05, N = 7824)	(0.93, 0.045, P = 0.64, N = 859)
rs9369768(A)/6:13035947*	PHACTR1	(0.55, -0.007, P = 4.9e-05, N = 7824)	(0.16, 0.035, P = 0.59, N = 859)
rs2496162(G)/6:13361088	GFOD1	(0.55, 0.14, P = 4.2e-06, N = 1951)	(0.62, 0.006, P = 0.91, N = 859)
rs7758383(A)/6:143169723*	HIVEP2	(0.51, -0.0074, P = 1.5e-05, N = 7824)	(0.69, 0.084, P = 0.11, N = 859)
rs2504067(A)/6:152095987*	ESR1	(0.49, 0.0079, P = 8.3e-06, N = 7824)	(0.43, -0.11, P = 0.026, N = 859)
rs17083966(T)/6:153698951*	intergenic	(0.02, 0.056, P = 5e-06, N = 7824)	(0.066, 0.12, P = 0.19, N = 859)
rs11751128(T)/6:155561796*	TIAM2	(0.29, 0.0072, P = 4e-05, N = 7824)	(0.043, -0.027, P = 0.81, N = 859)
rs12191236(C)/6:157304918*	ARID1B	(0.69, 0.0083, P = 2.3e-06, N = 7824)	(0.84, -0.051, P = 0.43, N = 859)
rs7760342(A)/6:45195424	SUPT3H	(0.5, 0.016, P = 3.9e-06, N = 7824)	(0.22, -0.044, P = 0.45, N = 859)
rs1265213(A)/6:4521298*	intergenic	(0.8, 0.011, P = 1.1e-05, N = 7824)	(0.77, -0.0085, P = 0.88, N = 859)
rs6938321(C)/6:88836054	intergenic	(0.11, 0.19, P = 8.3e-06, N = 1951)	(0.12, 0.057, P = 0.45, N = 859)
rs57240465(G)/7:125463191	intergenic	(0.45, -0.16, P = 9.5e-06, N = 1951)	(0.12, 0.03, P = 0.67, N = 859)
rs7805995(A)/7:146516466	CNTNAP2	(0.99, 0.068, P = 2e-05, N = 7824)	(0.37, 0.02, P = 0.68, N = 859)
rs10480299(T)/7:151405818*	PRKAG2	(0.72, -0.0077, P = 1.3e-05, N = 7824)	(0.71, -0.024, P = 0.65, N = 859)
rs12718636(A)/7:52500628*	intergenic	(0.7, -0.0073, P = 2.8e-05, N = 7824)	(0.91, 0.046, P = 0.58, N = 859)
rs41608(T)/7:82651558	PCLO	(0.69, 0.0073, P = 2.5e-05, N = 7824)	(0.9, -0.014, P = 0.86, N = 859)
rs10086673(T)/8:10305317*	intergenic	(0.29, 0.0089, P = 5.3e-07, N = 7824)	(0.32, -0.025, P = 0.63, N = 859)
rs7837995(T)/8:11485820	intergenic	(0.45, 0.0089, P = 4.3e-07, N = 7824)	(0.76, 0.0034, P = 0.95, N = 859)
rs10112981(A)/8:114965243*	Y_RNA	(0.29, -0.008, P = 6.1e-06, N = 7824)	(0.48, 0.011, P = 0.82, N = 859)
rs2466216(G)/8:22775716*	PEBP4	(0.22, 0.21, P = 2.4e-06, N = 1951)	(0.034, -0.094, P = 0.48, N = 859)
rs2726955(T)/8:27797374*	SCARA5	(0.65, 0.0071, P = 4.9e-05, N = 7824)	(0.59, -0.089, P = 0.071, N = 859)
rs6997739(C)/8:51365291	SNTG1	(0.2, -0.01, P = 1.9e-05, N = 7824)	(0.78, 0.052, P = 0.36, N = 859)
rs1483643(A)/8:51459757*	SNTG1	(0.13, -0.011, P = 3.6e-05, N = 7824)	(0.42, -0.028, P = 0.56, N = 859)
rs6995644(A)/8:63635874	NKAIN3	(0.87, -0.011, P = 4e-05, N = 7824)	(0.36, 0.14, P = 0.0071, N = 859)
rs3885979(T)/8:70767051*	RP11-159H10.1	(0.093, -0.013, P = 4.9e-05, N = 7824)	(0.26, -0.046, P = 0.4, N = 859)
rs3104992(A)/8:96572791	KB-1047C11.2	(0.34, 0.0074, P = 2.2e-05, N = 7824)	(0.49, 0.073, P = 0.12, N = 859)
rs2807592(T)/9:126893436	intergenic	(0.7, -0.0081, P = 4.5e-06, N = 7824)	(0.94, -0.11, P = 0.29, N = 859)
rs16936951(A)/9:18657061	ADAMTSL1	(0.94, -0.015, P = 4.4e-05, N = 7824)	(0.95, 0.035, P = 0.76, N = 859)
rs10491883(C)/9:28562256	LINGO2	(0.16, -0.21, P = 8.8e-06, N = 1951)	(0.27, -0.0081, P = 0.88, N = 859)
rs744093(A)/9:32700942	intergenic	(0.89, -0.024, P = 8.5e-06, N = 7824)	(0.99, -0.25, P = 0.21, N = 859)
rs11144033(A)/9:77258265	RORB	(0.57, 0.0072, P = 2.8e-05, N = 7824)	(0.74, -0.055, P = 0.32, N = 859)
rs10867301(A)/9:81528270	intergenic	(0.34, -0.0077, P = 1.2e-05, N = 7824)	(0.35, 0.036, P = 0.47, N = 859)

Results from Univariable Mendelian Randomization of myo-Inositol & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	139	-0.041 (-0.16- 0.079) P=0.51	4.4	29	0.000591 (0- 92.3)	NA	NA	-0.0032 P=0.62
MR-Egger	139	-0.024 (-0.16- 0.11) P=0.74	4.4	29	0.000591 (0- 92.3)	164	0.06	-0.0032 P=0.62
Weighted median	139	-0.081 (-0.25- 0.09) P=0.35	4.4	29	0.000591 (0- 92.3)	NA	NA	-0.0032 P=0.62

Results from Univariable MRPRESSO of myo-Inositol & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.04	0.06	-0.67	0.51
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of myo-Inositol & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	76	-0.029 (-0.15- 0.095) P=0.65	6.8	25	2.05 (0- 94.8)	NA	NA	-0.0081 P=0.37
MR-Egger	76	0.0087 (-0.14- 0.16) P=0.91	6.8	25	2.05 (0- 94.8)	88	0.13	-0.0081 P=0.37
Weighted median	76	-0.076 (-0.25- 0.096) P=0.39	6.8	25	2.05 (0- 94.8)	NA	NA	-0.0081 P=0.37

Results from Univariable MRPRESSO of myo-Inositol & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.06	-0.46	0.65
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Kynurenic acid

Instruments Associations with Kynurenic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Kynurenic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs61825638(T)/1:241713402	KMO	(0.24, 0.31, P = 2.3e-16, N = 1958)	(0.055, 0.021, P = 0.83, N = 859)
rs1499662(C)/1:56057849*	RP11-466L17.1	(0.86, -0.22, P = 9e-06, N = 1958)	(0.62, 0.017, P = 0.73, N = 859)
rs2114406(G)/10:90033593*	RNLS	(0.34, -0.19, P = 3.8e-08, N = 1958)	(0.17, 0.037, P = 0.56, N = 859)
rs112927155(TAATGGATGTC)/11:58668376	AP001652.1	(0.77, 0.1, P = 9.5e-06, N = 1958)	(0.6, -0.046, P = 0.35, N = 859)
rs11531036(A)/12:21241016	SLCO1B7	(0.017, 0.6, P = 5.1e-06, N = 1958)	(0.058, -0.21, P = 0.039, N = 859)
rs10784757(A)/12:69508022*	AC139931.1	(0.74, 0.19, P = 6.4e-06, N = 1958)	(0.6, 0.029, P = 0.55, N = 859)
rs2391396(T)/13:107626059	AL354741.1	(0.51, -0.16, P = 5.9e-07, N = 1958)	(0.33, 0.013, P = 0.81, N = 859)
rs1333184(T)/13:107643612	intergenic	(0.5, -0.15, P = 7.7e-06, N = 1958)	(0.3, 0.057, P = 0.28, N = 859)
rs9597397(C)/13:56963440*	intergenic	(0.19, 0.19, P = 6.7e-06, N = 1958)	(0.068, 0.14, P = 0.16, N = 859)
rs9517419(C)/13:99373101	SLC15A1	(0.11, -0.28, P = 5.5e-06, N = 1958)	(0.21, 0.039, P = 0.51, N = 859)
rs8054775(T)/16:58793570*	RP11-410D17.2	(0.11, 0.22, P = 4.1e-21, N = 1958)	(0.4, -0.11, P = 0.024, N = 859)
rs11864685(T)/16:58805130*	RP11-410D17.2	(0.12, 0.42, P = 5.1e-22, N = 1958)	(0.39, -0.092, P = 0.055, N = 859)
rs200341493(AT)/17:2808176	RAP1GAP2	(0.071, 0.25, P = 6.2e-06, N = 1958)	(0.056, -0.057, P = 0.58, N = 859)
rs57861026(G)/3:76996620	ROBO2	(0.059, 0.41, P = 2e-06, N = 1958)	(0.04, 0.081, P = 0.51, N = 859)
rs113677552(G)/4:56843171*	CEP135	(0.011, 0.85, P = 6.1e-06, N = 1958)	(0.014, 0.12, P = 0.55, N = 859)
rs17208191(G)/5:13846802*	DNAH5	(0.15, 0.18, P = 9.7e-06, N = 1958)	(0.14, 0.032, P = 0.63, N = 859)
rs546403634(CCCG)/6:151186857	MTHFD1L	(0.082, 0.25, P = 2.5e-06, N = 1958)	(0.98, 0.31, P = 0.076, N = 859)
rs2342637(T)/6:169020665*	SMOC2	(0.69, -0.2, P = 6e-06, N = 1958)	(0.54, -0.011, P = 0.81, N = 859)
rs862427(C)/6:38843970	DNAH8	(0.88, 0.22, P = 4e-06, N = 1958)	(0.88, -0.071, P = 0.33, N = 859)
rs12533147(G)/7:4200552	SDK1	(0.51, -0.13, P = 4.3e-06, N = 1958)	(0.21, 0.075, P = 0.21, N = 859)
rs112860567(C)/8:11273641	C8orf12	(0.13, 0.25, P = 5.8e-06, N = 1958)	(0.19, 0.005, P = 0.94, N = 859)
rs7014584(A)/8:59886072	TOX	(0.92, -0.3, P = 5.3e-07, N = 1958)	(0.98, 0.041, P = 0.83, N = 859)
rs140664372(T)/8:99851438	STK3	(0.016, 0.83, P = 8.6e-07, N = 1958)	(0.037, -0.058, P = 0.65, N = 859)
rs12350923(T)/9:8189408	intergenic	(0.093, 0.27, P = 7.3e-06, N = 1958)	(0.11, 0.15, P = 0.052, N = 859)

Results from Univariable Mendelian Randomization of Kynurenic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	24	-0.1 (-0.21- 0.0038) P=0.059	29	35	6.51 (0- 63.7)	NA	NA	-0.0028 P=0.93
MR-Egger	24	-0.093 (-0.33- 0.14) P=0.45	29	35	6.51 (0- 63.7)	25	0.27	-0.0028 P=0.93
Weighted median	24	-0.079 (-0.23- 0.071) P=0.3	29	35	6.51 (0- 63.7)	NA	NA	-0.0028 P=0.93

Results from Univariable MRPRESSO of Kynurenic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.1	0.05	-1.89	0.07
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Kynurenic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	15	-0.095 (-0.24- 0.053) P=0.21	28	21	5.73 (0- 74)	NA	NA	-0.02 P=0.63
MR-Egger	15	-0.032 (-0.33- 0.26) P=0.83	28	21	5.73 (0- 74)	15	0.3	-0.02 P=0.63
Weighted median	15	-0.078 (-0.29- 0.13) P=0.47	28	21	5.73 (0- 74)	NA	NA	-0.02 P=0.63

Results from Univariable MRPRESSO of Kynurenic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.1	0.08	-1.26	0.23
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Kynurenine

Instruments Associations with L-Kynurenine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Kynurenine (Shin et al/Long et al)	eGFR (CSSCD)
rs1530683(G)/1:104990673*	intergenic	(0.87, -0.2, P = 7.5e-06, N = 1955)	(0.78, -0.059, P = 0.32, N = 859)
rs6702848(T)/1:11453577*	intergenic	(0.6, 0.0077, P = 1.1e-05, N = 7824)	(0.5, 0.013, P = 0.79, N = 859)
rs21327(A)/1:146528521*	NBPF13P	(0.29, 0.0095, P = 1.2e-07, N = 7824)	(0.15, -0.0038, P = 0.95, N = 859)
rs7549498(A)/1:182363623*	GLUL	(0.44, 0.16, P = 3.8e-06, N = 1955)	(0.75, 0.022, P = 0.68, N = 859)
rs1687113(T)/1:238082623*	RP11-193H5.1	(0.23, 0.19, P = 5.9e-06, N = 1955)	(0.66, 0.11, P = 0.037, N = 859)
rs12082398(T)/1:25234781	RUNX3	(0.59, 0.012, P = 9.3e-07, N = 7824)	(0.11, 0.058, P = 0.44, N = 859)
rs7548008(A)/1:43202095*	CLDN19	(0.5, 0.016, P = 3.6e-06, N = 7824)	(0.59, 0.12, P = 0.016, N = 859)
rs9436977(G)/1:56122967	RP11-466L17.1	(0.035, -0.39, P = 6.4e-06, N = 1955)	(0.4, -0.03, P = 0.53, N = 859)
rs2375475(T)/1:65211843	RAVER2	(0.32, -0.0084, P = 1.4e-06, N = 7824)	(0.78, -0.022, P = 0.71, N = 859)
rs274588(G)/1:74942672	FPGT-TNNI3K	(0.58, 0.14, P = 4.5e-06, N = 1955)	(0.46, 0.0035, P = 0.94, N = 859)
rs669764(T)/1:78691660*	RP11-183M13.1	(0.32, -0.0078, P = 7.7e-06, N = 7824)	(0.63, -0.018, P = 0.71, N = 859)
rs11162752(A)/1:80060337*	intergenic	(0.6, -0.0077, P = 8.1e-06, N = 7824)	(0.37, -0.033, P = 0.51, N = 859)
rs2491294(A)/1:88302604*	intergenic	(0.31, -0.01, P = 5.7e-07, N = 7824)	(0.26, 0.02, P = 0.71, N = 859)
rs7906282(T)/10:19083596*	intergenic	(0.31, 0.0094, P = 8.1e-08, N = 7824)	(0.25, 0.00041, P = 0.99, N = 859)
rs16924894(A)/10:24845525*	intergenic	(0.024, 0.081, P = 2.3e-08, N = 7824)	(0.083, -0.14, P = 0.12, N = 859)
rs11593042(A)/10:6933467*	RP11-799O21.2	(0.092, 0.015, P = 4.5e-06, N = 7824)	(0.016, -0.28, P = 0.16, N = 859)
rs12802337(A)/11:55531892*	intergenic	(0.078, -0.016, P = 6e-06, N = 7824)	(0.16, -0.086, P = 0.17, N = 859)
rs511797(A)/11:95895139	MAML2	(0.13, 0.012, P = 3.8e-06, N = 7824)	(0.024, -0.073, P = 0.64, N = 859)
rs3184504(T)/12:111884608*	SH2B3	(0.49, 0.015, P = 6e-18, N = 7824)	(0.073, -0.03, P = 0.74, N = 859)
rs10744774(A)/12:112090022*	BRAP	(0.83, 0.012, P = 2.4e-06, N = 7824)	(0.98, -0.14, P = 0.37, N = 859)
rs739744(T)/12:113185462	RPH3A	(0.55, -0.0082, P = 1.9e-06, N = 7824)	(0.46, -0.052, P = 0.3, N = 859)
rs11057695(T)/12:125083336*	intergenic	(0.057, 0.021, P = 8e-06, N = 7824)	(0.016, -0.25, P = 0.19, N = 859)
rs3789978(A)/12:32947193*	PKP2	(0.85, 0.012, P = 1.3e-06, N = 7824)	(0.67, 0.088, P = 0.083, N = 859)
rs28815546(T)/12:622231	B4GALNT3	(0.026, 0.48, P = 1.2e-06, N = 1955)	(0.3, 0.12, P = 0.022, N = 859)
rs3809198(A)/12:96883306*	C12orf55	(0.02, 0.055, P = 4.3e-06, N = 7824)	(0.078, -0.15, P = 0.082, N = 859)
rs9533582(A)/13:44250866*	ENOX1	(0.035, -0.022, P = 1e-05, N = 7824)	(0.13, 0.0072, P = 0.92, N = 859)
rs2324935(A)/13:66985241	PCDH9	(0.53, 0.0075, P = 1.5e-05, N = 7824)	(0.73, -0.02, P = 0.71, N = 859)
rs1952337(A)/14:67608948	GPHN	(0.64, -0.0076, P = 1.2e-05, N = 7824)	(0.15, 0.025, P = 0.71, N = 859)
rs434943(A)/14:69314059*	RN7SL224P	(0.32, -0.0077, P = 1.5e-05, N = 7824)	(0.14, -0.086, P = 0.23, N = 859)
rs6575634(T)/14:98248954*	RP11-204N11.2	(0.62, -0.016, P = 4.8e-06, N = 7824)	(0.38, -0.039, P = 0.42, N = 859)
rs2651516(T)/15:53302309*	intergenic	(0.66, 0.008, P = 4.3e-06, N = 7824)	(0.19, -0.063, P = 0.29, N = 859)
rs11646849(A)/16:82817251*	CDH13	(0.5, -0.0086, P = 6.4e-07, N = 7824)	(0.29, -0.073, P = 0.16, N = 859)
rs8063871(A)/16:87863500*	SLC7A5	(0.71, 0.017, P = 4.7e-12, N = 7824)	(0.69, -0.065, P = 0.21, N = 859)
rs8051149(A)/16:87878822*	SLC7A5	(0.21, 0.026, P = 9.1e-26, N = 7824)	(0.6, 0.045, P = 0.36, N = 859)
rs2434860(T)/16:89696217	DPEP1	(0.41, 0.26, P = 1.1e-07, N = 1955)	(0.16, 0.058, P = 0.39, N = 859)
rs164746(A)/16:89709019*	DPEP1	(0.41, 0.19, P = 7.8e-08, N = 1955)	(0.19, 0.022, P = 0.73, N = 859)
rs12937634(T)/17:47444442*	ZNF652	(0.54, -0.0082, P = 2.3e-06, N = 7824)	(0.58, -0.0042, P = 0.93, N = 859)
rs180050(T)/17:67977529	AC004562.1	(0.58, 0.008, P = 7.6e-06, N = 7824)	(0.097, -0.028, P = 0.74, N = 859)
rs16974854(T)/17:68029032*	AC002539.1	(0.038, -0.023, P = 1.2e-06, N = 7824)	(0.019, 0.019, P = 0.92, N = 859)
rs7240271(A)/18:56909115*	intergenic	(0.51, 0.0074, P = 1.4e-05, N = 7824)	(0.24, -0.076, P = 0.18, N = 859)
rs4891267(A)/18:73076464*	intergenic	(0.78, -0.18, P = 2e-06, N = 1955)	(0.59, -0.0073, P = 0.88, N = 859)
rs8090890(C)/18:75305345	intergenic	(0.64, -0.0075, P = 1.5e-05, N = 7824)	(0.57, 0.052, P = 0.3, N = 859)
rs2270623(T)/19:18245512*	MAST3	(0.54, -0.0076, P = 1.2e-05, N = 7824)	(0.33, 0.012, P = 0.81, N = 859)
rs1496635(A)/19:31692461*	CTC-439O9.3	(0.34, -0.0091, P = 2.1e-07, N = 7824)	(0.24, 0.014, P = 0.81, N = 859)
rs113916293(GGT)/19:45966650	FOSB	(0.28, -0.22, P = 9.4e-06, N = 1955)	(0.68, -0.11, P = 0.042, N = 859)
rs260621(T)/2:109628974*	intergenic	(0.53, 0.026, P = 1.5e-05, N = 7824)	(0.91, 0.13, P = 0.11, N = 859)
rs13415349(C)/2:223924792	KCNE4	(0.088, 0.22, P = 4e-06, N = 1955)	(0.25, -0.12, P = 0.028, N = 859)
rs2161901(A)/2:36465942	intergenic	(0.45, 0.16, P = 8.6e-06, N = 1955)	(0.81, 0.027, P = 0.66, N = 859)
rs759507(T)/2:50754813*	NRXN1	(0.37, 0.008, P = 5.2e-06, N = 7824)	(0.088, -0.055, P = 0.53, N = 859)
rs1239074(T)/2:78842192*	intergenic	(0.74, 0.011, P = 1.2e-05, N = 7824)	(0.58, -0.0094, P = 0.85, N = 859)
rs145129891(A)/20:4798828	RASSF2	(0.058, 0.34, P = 1.8e-06, N = 1955)	(0.011, -0.14, P = 0.54, N = 859)
rs756577(T)/21:44118323*	PDE9A	(0.38, 0.0078, P = 1e-05, N = 7824)	(0.06, -0.07, P = 0.48, N = 859)
rs6518219(T)/21:46654717*	LINC00334	(0.051, 0.32, P = 1.5e-06, N = 1955)	(0.32, 0.091, P = 0.072, N = 859)
rs5756751(C)/22:22423139	IGLVIV-65	(0.36, -0.18, P = 7.9e-06, N = 1955)	(0.71, 0.084, P = 0.11, N = 859)
rs3859880(C)/22:26232110*	MYO18B	(0.34, -0.17, P = 3.5e-06, N = 1955)	(0.51, 0.024, P = 0.63, N = 859)
rs4820242(A)/22:36982675*	CACNG2	(0.62, -0.0085, P = 9e-07, N = 7824)	(0.76, -0.041, P = 0.47, N = 859)
rs3788706(A)/22:46869170*	CELSR1	(0.13, -0.012, P = 6.1e-06, N = 7824)	(0.16, 0.081, P = 0.21, N = 859)
rs6770323(T)/3:161850410*	intergenic	(0.43, -0.008, P = 3.3e-06, N = 7824)	(0.14, 0.13, P = 0.069, N = 859)
rs7619568(A)/3:191433799*	intergenic	(0.94, 0.018, P = 9.5e-06, N = 7824)	(0.79, 0.021, P = 0.71, N = 859)
rs12490394(T)/3:5496096*	intergenic	(0.5, 0.0084, P = 8e-06, N = 7824)	(0.42, 0.031, P = 0.53, N = 859)
rs9857268(A)/3:83398721*	intergenic	(0.41, 0.008, P = 3.1e-06, N = 7824)	(0.18, -0.045, P = 0.47, N = 859)
rs7619096(A)/3:84199075*	intergenic	(0.69, 0.008, P = 4.9e-06, N = 7824)	(0.59, 0.051, P = 0.29, N = 859)
rs2320536(T)/4:140801676*	MAML3	(0.41, 0.0081, P = 3.3e-06, N = 7824)	(0.31, 0.024, P = 0.63, N = 859)
rs1426134(C)/4:14179729	RP11-669M16.1	(0.37, -0.0081, P = 3.8e-06, N = 7824)	(0.18, -0.058, P = 0.35, N = 859)
rs10857319(T)/4:159729794*	FNIP2	(0.35, -0.0086, P = 9.5e-07, N = 7824)	(0.061, -0.071, P = 0.49, N = 859)
rs10937762(A)/4:6918679*	TBC1D14	(0.57, 0.0078, P = 8.2e-06, N = 7824)	(0.68, 0.072, P = 0.16, N = 859)
rs13110221(T)/4:9517737	OR7E83P	(0.82, 0.18, P = 8.1e-06, N = 1955)	(0.48, -0.0038, P = 0.94, N = 859)
rs6815057(A)/4:97782257	intergenic	(0.58, 0.0085, P = 1.1e-06, N = 7824)	(0.88, 0.015, P = 0.84, N = 859)
rs10072101(A)/5:105182600	intergenic	(0.38, -0.0077, P = 1.4e-05, N = 7824)	(0.49, 0.045, P = 0.35, N = 859)
rs3131010(T)/6:31105147	PSORS1C1	(0.15, 0.24, P = 1.5e-06, N = 1955)	(0.056, -0.11, P = 0.31, N = 859)
rs112790520(C)/6:33024031	intergenic	(0.049, 0.43, P = 3.2e-06, N = 1955)	(0.17, 0.093, P = 0.15, N = 859)
rs75219340(C)/7:113576177	PPP1R3A	(0.015, -0.74, P = 2.3e-06, N = 1955)	(0.16, -0.0023, P = 0.97, N = 859)
rs13224451(T)/7:128155486*	intergenic	(0.16, -0.18, P = 9.7e-06, N = 1955)	(0.22, 0.086, P = 0.14, N = 859)
rs6946693(T)/7:70153068*	AUTS2	(0.71, 0.01, P = 9.2e-06, N = 7824)	(0.91, -0.14, P = 0.087, N = 859)
rs6978674(T)/7:77859611*	MAGI2	(0.59, 0.0076, P = 1.3e-05, N = 7824)	(0.88, 0.05, P = 0.49, N = 859)
rs11563854(C)/7:90142005*	CTB-13L3.1	(0.067, 0.28, P = 5.1e-06, N = 1955)	(0.15, -0.076, P = 0.26, N = 859)
rs10263361(G)/7:93678234	AC003092.1	(0.59, -0.12, P = 9.2e-06, N = 1955)	(0.93, -0.17, P = 0.074, N = 859)
rs35534138(A)/8:38894334	ADAM9	(0.29, -0.16, P = 9.3e-07, N = 1955)	(0.13, 0.12, P = 0.096, N = 859)
rs10085935(T)/8:39806267*	IDO2	(0.38, -0.01, P = 3.3e-09, N = 7824)	(0.35, -0.0088, P = 0.86, N = 859)
rs7843776(T)/8:75008787*	RP11-6I2.3	(0.4, -0.0084, P = 7.4e-06, N = 7824)	(0.31, -0.09, P = 0.084, N = 859)
rs542062(G)/9:134191501	intergenic	(0.83, 0.18, P = 5.2e-06, N = 1955)	(0.53, 0.016, P = 0.75, N = 859)
rs7851112(T)/9:7029050	KDM4C	(0.62, -0.0077, P = 1.2e-05, N = 7824)	(0.8, -0.028, P = 0.65, N = 859)

Results from Univariable Mendelian Randomization of L-Kynurenine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	82	0.079 (-0.0076- 0.17) P=0.074	8.1	32	11.1 (0- 82.9)	NA	NA	0.006 P=0.48
MR-Egger	82	0.059 (-0.046- 0.16) P=0.28	8.1	32	11.1 (0- 82.9)	93	0.16	0.006 P=0.48
Weighted median	82	0.072 (-0.053- 0.2) P=0.26	8.1	32	11.1 (0- 82.9)	NA	NA	0.006 P=0.48

Results from Univariable MRPRESSO of L-Kynurenine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.08	0.04	1.79	0.08
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Kynurenine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	28	0.072 (-0.027- 0.17) P=0.16	15	22	21.9 (0- 69.7)	NA	NA	-0.0066 P=0.7
MR-Egger	28	0.091 (-0.047- 0.23) P=0.21	15	22	21.9 (0- 69.7)	31	0.24	-0.0066 P=0.7
Weighted median	28	0.054 (-0.09- 0.2) P=0.46	15	22	21.9 (0- 69.7)	NA	NA	-0.0066 P=0.7

Results from Univariable MRPRESSO of L-Kynurenine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.07	0.05	1.42	0.17
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Lactic acid

Instruments Associations with L-Lactic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Lactic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs4631734(T)/1:171220236*	RP1-45C12.1	(0.069, 0.017, P = 2.1e-05, N = 7365)	(0.12, -0.052, P = 0.47, N = 859)
rs1193345(A)/1:17913714*	ARHGEF10L	(0.94, -0.022, P = 1.4e-06, N = 7365)	(0.79, 0.029, P = 0.62, N = 859)
rs1775466(A)/1:197754967*	intergenic	(0.2, -0.011, P = 1.8e-05, N = 7365)	(0.083, -0.082, P = 0.35, N = 859)
rs2906458(A)/1:44336389*	ST3GAL3	(0.75, 0.0096, P = 4.5e-05, N = 7365)	(0.2, 0.035, P = 0.56, N = 859)
rs10788232(T)/10:123803584*	TACC2	(0.68, -0.011, P = 2.5e-06, N = 7365)	(0.31, -0.076, P = 0.15, N = 859)
rs11253881(A)/10:16321532*	RP11-461K13.1	(0.067, -0.018, P = 2.1e-05, N = 7365)	(0.064, 0.095, P = 0.34, N = 859)
rs16937124(A)/10:36885746*	intergenic	(0.95, -0.021, P = 5.6e-06, N = 7365)	(0.94, -0.014, P = 0.89, N = 859)
rs1930151(A)/10:56331387*	PCDH15	(0.025, -0.029, P = 3.3e-05, N = 7365)	(0.15, 0.012, P = 0.86, N = 859)
rs5785130(AT)/10:57194371	RP11-168O22.1	(0.4, 0.08, P = 6.9e-06, N = 1957)	(0.91, 0.12, P = 0.14, N = 859)
rs7090753(A)/10:67201788*	intergenic	(0.99, 0.068, P = 3.3e-05, N = 1761)	(0.79, -0.2, P = 0.00074, N = 859)
rs10887850(C)/10:90490627*	LIPK	(0.33, 0.19, P = 3e-06, N = 1957)	(0.44, 0.00078, P = 0.99, N = 859)
rs10734178(A)/11:11244511	intergenic	(0.82, 0.17, P = 2.9e-06, N = 1957)	(0.74, -0.00071, P = 0.99, N = 859)
rs948094(C)/11:121092679	intergenic	(0.51, -0.19, P = 8.6e-06, N = 1957)	(0.25, -0.17, P = 0.0026, N = 859)
rs939522(C)/11:126691069	KIRREL3	(0.78, 0.21, P = 6.5e-07, N = 1957)	(0.95, -0.064, P = 0.57, N = 859)
rs1499511(C)/11:36087853	LDLRAD3	(0.58, 0.18, P = 9.8e-06, N = 1957)	(0.86, -0.053, P = 0.44, N = 859)
rs79469454(T)/11:4173635	intergenic	(0.24, 0.23, P = 8.7e-06, N = 1957)	(0.23, -0.06, P = 0.3, N = 859)
rs72931768(C)/11:69829717	RP11-626H12.1	(0.11, -0.24, P = 4.8e-06, N = 1957)	(0.037, 0.11, P = 0.39, N = 859)
rs4763349(G)/12:13623999	intergenic	(0.91, 0.3, P = 3.9e-06, N = 1957)	(0.86, 0.15, P = 0.027, N = 859)
rs2242578(C)/12:57853153*	GLI1	(0.67, -0.011, P = 5.1e-06, N = 7365)	(0.49, -0.051, P = 0.29, N = 859)
rs6581752(A)/12:67777751	intergenic	(0.22, -0.01, P = 1.9e-05, N = 7365)	(0.8, 0.0048, P = 0.94, N = 859)
rs1330523(A)/13:104925616*	intergenic	(0.23, -0.012, P = 1.6e-06, N = 7365)	(0.26, -0.014, P = 0.79, N = 859)
rs278050(A)/13:30436968*	TIMM8BP1	(0.8, 0.01, P = 4.2e-05, N = 7365)	(0.65, 0.064, P = 0.21, N = 859)
rs1751857(T)/13:40969438*	intergenic	(0.93, 0.016, P = 2.6e-05, N = 7365)	(0.87, 0.083, P = 0.25, N = 859)
rs7995949(T)/13:63339902	intergenic	(0.98, 0.031, P = 2.8e-05, N = 7365)	(0.89, 0.023, P = 0.77, N = 859)
rs6571843(C)/14:21940701*	RAB2B	(0.063, 0.018, P = 1.4e-05, N = 7365)	(0.016, -0.45, P = 0.019, N = 859)
rs12897027(T)/14:73190091	DPF3	(0.33, -0.14, P = 4.6e-06, N = 1957)	(0.15, -0.027, P = 0.68, N = 859)
rs7155689(G)/14:98585327	RP11-61O1.1	(0.39, -0.16, P = 1.1e-06, N = 1957)	(0.25, 0.015, P = 0.78, N = 859)
rs17392679(T)/15:49310954*	SECISBP2L	(0.075, 0.016, P = 4.4e-05, N = 7365)	(0.014, 0.19, P = 0.35, N = 859)
rs10851537(C)/15:53555661*	intergenic	(0.97, 0.49, P = 3.2e-06, N = 1957)	(0.96, 0.15, P = 0.25, N = 859)
rs7172532(G)/15:54369796	UNC13C	(0.57, 0.17, P = 7.7e-06, N = 1957)	(0.22, -0.094, P = 0.12, N = 859)
rs10851750(A)/15:66121590*	RAB11A	(0.13, -0.013, P = 2.9e-05, N = 7365)	(0.3, 0.031, P = 0.58, N = 859)
rs2911125(T)/16:65557406	LINC00922	(0.15, 0.013, P = 3.7e-05, N = 7365)	(0.047, -0.16, P = 0.18, N = 859)
rs3096276(T)/16:65577365*	LINC00922	(0.16, 0.012, P = 4.5e-05, N = 7365)	(0.063, -0.093, P = 0.35, N = 859)
rs17687360(C)/16:7708034*	RBFOX1	(0.12, -0.28, P = 6.8e-06, N = 1957)	(0.022, -0.005, P = 0.98, N = 859)
rs3785024(A)/16:84136233	MBTPS1	(0.95, -0.022, P = 5.6e-06, N = 7365)	(0.98, 0.023, P = 0.88, N = 859)
rs234608(T)/17:15583555	TRIM16	(0.15, -0.021, P = 3.2e-05, N = 1761)	(0.28, -0.077, P = 0.15, N = 859)
rs112207538(G)/18:18684507	ROCK1	(0.047, -0.39, P = 4.2e-06, N = 1957)	(0.12, -0.09, P = 0.21, N = 859)
rs2000812(T)/18:47093790*	LIPG	(0.82, 0.011, P = 9.7e-06, N = 7365)	(0.96, -0.13, P = 0.31, N = 859)
rs2305996(A)/18:693828	ENOSF1	(0.63, 0.015, P = 3.1e-05, N = 1761)	(0.7, -0.047, P = 0.36, N = 859)
rs10424746(A)/19:11839659*	ZNF823	(0.98, -0.052, P = 1e-05, N = 1761)	(0.75, 0.073, P = 0.18, N = 859)
rs35054599(A)/2:123156656	intergenic	(0.47, -0.19, P = 6e-06, N = 1957)	(0.39, 0.019, P = 0.69, N = 859)
rs4316948(T)/2:162834595*	SLC4A10	(0.8, 0.01, P = 4.3e-05, N = 7365)	(0.86, 0.053, P = 0.45, N = 859)
rs780093(T)/2:27742603*	GCKR	(0.4, 0.012, P = 1.9e-07, N = 7365)	(0.14, -0.071, P = 0.3, N = 859)
rs4635489(A)/2:30126856	ALK	(0.018, 0.036, P = 5.7e-06, N = 7365)	(0.14, -0.15, P = 0.036, N = 859)
rs4425121(C)/2:41341481	intergenic	(0.47, -0.13, P = 4.5e-06, N = 1957)	(0.28, 0.0067, P = 0.9, N = 859)
rs10202912(G)/2:66786405	MEIS1	(0.54, 0.13, P = 9.5e-06, N = 1957)	(0.55, 0.061, P = 0.22, N = 859)
rs13403441(A)/2:83225802*	intergenic	(0.86, -0.024, P = 1e-06, N = 1761)	(0.65, -0.039, P = 0.44, N = 859)
rs6736348(A)/2:85506104*	TCF7L1	(0.79, 0.0099, P = 4.2e-05, N = 7365)	(0.49, -0.024, P = 0.61, N = 859)
rs6105651(A)/20:16740242	OTOR	(0.74, 0.0097, P = 4.8e-05, N = 7365)	(0.85, -0.037, P = 0.58, N = 859)
rs13038639(A)/20:24893918*	intergenic	(0.22, 0.01, P = 1.9e-05, N = 7365)	(0.04, 0.054, P = 0.66, N = 859)
rs6139395(A)/20:4309611*	intergenic	(0.2, -0.011, P = 1.7e-05, N = 7365)	(0.069, 0.11, P = 0.23, N = 859)
rs2826779(T)/21:22669952*	NCAM2	(0.27, 0.016, P = 4.3e-05, N = 1761)	(0.46, -0.093, P = 0.048, N = 859)
rs9607371(T)/22:37083494*	CACNG2	(0.79, -0.01, P = 3.9e-05, N = 7365)	(0.95, -0.0057, P = 0.96, N = 859)
rs4688540(A)/3:61408148*	intergenic	(0.041, -0.025, P = 3.1e-05, N = 5604)	(0.45, -0.053, P = 0.27, N = 859)
rs3112842(C)/4:112386094	intergenic	(0.88, -0.3, P = 9.5e-07, N = 1957)	(0.94, 0.021, P = 0.83, N = 859)
rs12648879(T)/4:177900078*	intergenic	(0.7, -0.0098, P = 3.3e-05, N = 7365)	(0.95, 0.036, P = 0.74, N = 859)
rs13101859(T)/4:189247182*	intergenic	(0.22, -0.01, P = 3.6e-05, N = 7365)	(0.35, 0.048, P = 0.35, N = 859)
rs61261762(A)/4:23845240*	PPARGC1A	(0.014, 0.69, P = 5.8e-06, N = 1957)	(0.065, -0.18, P = 0.064, N = 859)
rs7682064(T)/4:25087708*	intergenic	(0.71, 0.01, P = 2.2e-05, N = 7365)	(0.65, 0.033, P = 0.5, N = 859)
rs6820352(C)/4:83644113	SCD5	(0.32, -0.16, P = 4.9e-07, N = 1957)	(0.68, 0.0028, P = 0.96, N = 859)
rs327838(T)/5:125159259*	intergenic	(0.53, 0.0096, P = 3.3e-05, N = 7365)	(0.48, 0.019, P = 0.69, N = 859)
rs58808503(A)/5:31913006	PDZD2	(0.14, -0.29, P = 8.7e-08, N = 1957)	(0.02, 0.024, P = 0.89, N = 859)
rs10941232(A)/5:35054639*	PRLR	(0.71, -0.14, P = 9.7e-06, N = 1957)	(0.57, 0.0024, P = 0.96, N = 859)
rs10051776(T)/5:39207781*	FYB	(0.046, -0.39, P = 7.5e-06, N = 1957)	(0.088, 0.019, P = 0.83, N = 859)
rs2042342(T)/5:55969146	intergenic	(0.97, 0.033, P = 2.3e-05, N = 1761)	(0.88, -0.069, P = 0.35, N = 859)
rs10475426(T)/5:8362200*	RP11-480D4.1	(0.99, -0.078, P = 2.9e-05, N = 1761)	(0.82, -0.02, P = 0.75, N = 859)
rs827867(A)/6:158714489*	RP11-732M18.3	(0.9, 0.014, P = 2.5e-05, N = 7365)	(0.75, 0.016, P = 0.78, N = 859)
rs4706063(G)/6:79449874	intergenic	(0.4, -0.16, P = 3.3e-06, N = 1957)	(0.25, -0.041, P = 0.44, N = 859)
rs6976221(T)/7:127833995*	intergenic	(0.76, 0.01, P = 2.5e-05, N = 7365)	(0.69, -0.025, P = 0.64, N = 859)
rs759167(T)/7:55127784	EGFR	(0.2, -0.011, P = 1.5e-05, N = 7365)	(0.27, 0.012, P = 0.83, N = 859)
rs723526(A)/7:55134819*	EGFR	(0.2, -0.011, P = 6.6e-06, N = 7365)	(0.045, 0.029, P = 0.8, N = 859)
rs4718532(T)/7:66805000	RP11-166O4.5	(0.51, -0.016, P = 6.6e-06, N = 1761)	(0.33, 0.065, P = 0.2, N = 859)
rs4841405(A)/8:10506235	RP1L1	(0.28, -0.011, P = 1.3e-05, N = 7365)	(0.69, 0.0072, P = 0.89, N = 859)
rs13282889(G)/8:105847029*	RP11-127H5.1	(0.34, 0.17, P = 8.6e-06, N = 1957)	(0.2, -0.029, P = 0.64, N = 859)
rs1385495(T)/8:120077018*	COLEC10	(0.81, 0.0099, P = 4.4e-05, N = 7365)	(0.78, 0.028, P = 0.62, N = 859)
rs1551903(A)/8:54462119*	intergenic	(0.74, 0.01, P = 2.8e-05, N = 7365)	(0.94, -0.021, P = 0.84, N = 859)
rs10435634(A)/8:54863001*	RGS20	(0.56, -0.0095, P = 4.3e-05, N = 7365)	(0.61, -0.073, P = 0.14, N = 859)
rs9298249(A)/8:76037728*	intergenic	(0.014, 0.04, P = 2.2e-05, N = 7365)	(0.046, -0.15, P = 0.19, N = 859)
rs146976936(G)/9:77959488	intergenic	(0.011, -0.73, P = 3.4e-06, N = 1957)	(0.16, -0.13, P = 0.055, N = 859)
rs1876100(A)/9:81189702	intergenic	(0.26, -0.011, P = 9.2e-06, N = 7365)	(0.077, 0.019, P = 0.83, N = 859)

Results from Univariable Mendelian Randomization of L-Lactic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	80	0.05 (-0.052- 0.15) P=0.34	9.1	36	13 (0- 72)	NA	NA	-0.0085 P=0.37
MR-Egger	80	0.083 (-0.042- 0.21) P=0.2	9.1	36	13 (0- 72)	91	0.15	-0.0085 P=0.37
Weighted median	80	0.0072 (-0.15- 0.16) P=0.93	9.1	36	13 (0- 72)	NA	NA	-0.0085 P=0.37

Results from Univariable MRPRESSO of L-Lactic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.05	0.05	0.96	0.34
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Lactic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	33	0.12 (0.00058- 0.24) P=0.049	16	27	17.5 (0- 71.2)	NA	NA	-0.027 P=0.11
MR-Egger	33	0.22 (0.053- 0.38) P=0.014	16	27	17.5 (0- 71.2)	34	0.33	-0.027 P=0.11
Weighted median	33	0.13 (-0.057- 0.31) P=0.18	16	27	17.5 (0- 71.2)	NA	NA	-0.027 P=0.11

Results from Univariable MRPRESSO of L-Lactic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.12	0.06	1.97	0.06
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Oxalic acid

Instruments Associations with Oxalic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Oxalic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs1938451(G)/1:68364218*	GNG12-AS1	(0.69, -0.19, P = 1e-06, N = 1957)	(0.81, -0.052, P = 0.4, N = 859)
rs12279359(A)/11:130730544	RP11-890B15.2	(0.4, -0.16, P = 2.1e-06, N = 1957)	(0.35, -0.063, P = 0.22, N = 859)
rs12419619(T)/11:5952146	TRIM5	(0.46, 0.17, P = 1.3e-06, N = 1957)	(0.18, 0.065, P = 0.3, N = 859)
rs113046166(T)/11:62222568*	AHNAK	(0.14, -0.21, P = 7e-06, N = 1957)	(0.07, 0.023, P = 0.81, N = 859)
rs7119319(T)/11:90384749*	DISC1FP1	(0.18, 0.22, P = 2.2e-06, N = 1957)	(0.49, 0.012, P = 0.8, N = 859)
rs527373600(CAAAAA)/13:111174762	RAB20	(0.024, -0.22, P = 8.8e-06, N = 1957)	(0.34, -0.0022, P = 0.97, N = 859)
rs796188220(CT)/13:72333063	DACH1	(0.028, -0.37, P = 2.6e-06, N = 1957)	(0.84, -0.083, P = 0.21, N = 859)
rs753041(T)/13:99000485*	FARP1	(0.33, -0.17, P = 8.1e-06, N = 1957)	(0.11, 0.012, P = 0.87, N = 859)
rs35432338(C)/15:60595448	intergenic	(0.4, 0.12, P = 8.3e-06, N = 1957)	(0.4, -0.015, P = 0.76, N = 859)
rs72803825(T)/16:77506227	intergenic	(0.13, -0.28, P = 4.4e-06, N = 1957)	(0.026, 0.032, P = 0.83, N = 859)
rs2289470(A)/2:135214259*	TMEM163	(0.16, -0.18, P = 5.8e-06, N = 1957)	(0.28, 0.032, P = 0.56, N = 859)
rs4814550(T)/20:16733848	OTOR	(0.17, -0.16, P = 3.5e-06, N = 1957)	(0.039, 0.026, P = 0.84, N = 859)
rs34230332(G)/3:14725878	C3orf20	(0.076, 0.24, P = 3.7e-06, N = 1957)	(0.02, -0.44, P = 0.011, N = 859)
rs6444594(T)/3:191661608	intergenic	(0.43, -0.18, P = 4.1e-07, N = 1957)	(0.51, -0.016, P = 0.73, N = 859)
rs11132006(C)/4:181512510	intergenic	(0.31, -0.18, P = 1.7e-06, N = 1957)	(0.28, 0.026, P = 0.64, N = 859)
rs73793418(C)/6:169685826	XXyac-YX65C7_A.3	(0.06, -0.29, P = 1.9e-06, N = 1957)	(0.14, 0.052, P = 0.44, N = 859)
rs9477739(T)/6:18422473*	RNF144B	(0.044, 0.36, P = 7.6e-07, N = 1957)	(0.14, 0.082, P = 0.24, N = 859)
rs199549415(A)/6:24291915	DCDC2	(0.1, -0.29, P = 5.2e-06, N = 1957)	(0.02, -0.15, P = 0.39, N = 859)
rs116315297(A)/6:24414380	MRS2	(0.011, 0.97, P = 5.4e-07, N = 1957)	(0.031, -0.053, P = 0.71, N = 859)
rs77760991(G)/6:72039148	RP3-331H24.5	(0.075, -0.26, P = 1.2e-06, N = 1957)	(0.056, 0.0069, P = 0.95, N = 859)
rs58349860(A)/7:143024197*	CLCN1	(0.34, -0.18, P = 6.3e-06, N = 1957)	(0.45, -0.021, P = 0.67, N = 859)
rs567931256(CT)/8:1177501	CTD-2281E23.2	(0.013, -0.69, P = 8.5e-06, N = 1957)	(0.098, 0.078, P = 0.32, N = 859)
rs6992200(C)/8:1835183	ARHGEF10	(0.022, 0.45, P = 9.3e-06, N = 1957)	(0.08, 0.084, P = 0.35, N = 859)

Results from Univariable Mendelian Randomization of Oxalic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	23	0.023 (-0.067- 0.11) P=0.62	23	27	1.82e-05 (0- 48.6)	NA	NA	0.019 P=0.51
MR-Egger	23	-0.039 (-0.25- 0.17) P=0.72	23	27	1.82e-05 (0- 48.6)	17	0.74	0.019 P=0.51
Weighted median	23	-0.032 (-0.18- 0.11) P=0.66	23	27	1.82e-05 (0- 48.6)	NA	NA	0.019 P=0.51

Results from Univariable MRPRESSO of Oxalic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.02	0.05	0.5	0.62
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Oxalic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	16	-2e-04 (-0.11- 0.11) P=1	22	18	0.000204 (0- 80.2)	NA	NA	0.024 P=0.48
MR-Egger	16	-0.068 (-0.28- 0.15) P=0.55	22	18	0.000204 (0- 80.2)	14	0.46	0.024 P=0.48
Weighted median	16	-0.06 (-0.23- 0.11) P=0.49	22	18	0.000204 (0- 80.2)	NA	NA	0.024 P=0.48

Results from Univariable MRPRESSO of Oxalic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.06	0	1
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Pantothenic acid

Instruments Associations with Pantothenic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Pantothenic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs10919047(A)/1:169033499	LINC00970	(0.14, 0.018, P = 6.8e-07, N = 7160)	(0.039, -0.17, P = 0.17, N = 859)
rs3949865(C)/1:183930806*	COLGALT2	(0.62, -0.011, P = 9.5e-06, N = 7160)	(0.34, 0.019, P = 0.7, N = 859)
rs553719(C)/1:37332937*	GRIK3	(0.93, 0.34, P = 2.7e-06, N = 1953)	(0.83, 0.017, P = 0.8, N = 859)
rs1998432(A)/10:10743956	intergenic	(0.52, -0.011, P = 3.7e-05, N = 7160)	(0.35, -0.059, P = 0.24, N = 859)
rs12242254(A)/10:19369100	intergenic	(0.69, 0.011, P = 1.6e-05, N = 7160)	(0.92, -0.17, P = 0.068, N = 859)
rs2457214(T)/10:50015097	WDFY4	(0.63, -0.011, P = 1.3e-05, N = 7160)	(0.35, 0.065, P = 0.19, N = 859)
rs79209616(T)/10:67616849	intergenic	(0.059, 0.41, P = 3.1e-06, N = 1953)	(0.41, -0.092, P = 0.061, N = 859)
rs4746017(A)/10:71774872*	intergenic	(0.71, -0.012, P = 5.1e-06, N = 7160)	(0.77, -0.056, P = 0.31, N = 859)
rs554027365(CT)/10:86169332	CCSER2	(0.11, 0.28, P = 1.4e-08, N = 1953)	(0.16, 0.03, P = 0.64, N = 859)
rs2636805(T)/10:98927016	SLIT1	(0.53, -0.011, P = 3.2e-05, N = 7160)	(0.27, -0.081, P = 0.14, N = 859)
rs3781966(A)/11:61956428	SCGB1D1	(0.31, -0.024, P = 2.4e-05, N = 1650)	(0.65, -0.036, P = 0.47, N = 859)
rs78668216(T)/11:75873779	intergenic	(0.055, -0.39, P = 9.1e-06, N = 1953)	(0.019, 0.2, P = 0.25, N = 859)
rs7296705(T)/12:3374675	TSPAN9	(0.83, 0.014, P = 4.2e-05, N = 7160)	(0.61, 0.0082, P = 0.87, N = 859)
rs11175024(A)/12:40463950	SLC2A13	(0.59, 0.011, P = 1.9e-05, N = 7160)	(0.65, -0.037, P = 0.48, N = 859)
rs9788090(C)/12:67889960*	intergenic	(0.73, 0.015, P = 1.2e-05, N = 7160)	(0.22, 0.075, P = 0.19, N = 859)
rs73133802(A)/12:68038605	DYRK2	(0.054, -0.28, P = 3.6e-06, N = 1953)	(0.07, -0.04, P = 0.68, N = 859)
rs1163004(T)/12:81079471	intergenic	(0.85, -0.014, P = 3.4e-05, N = 7160)	(0.25, 0.0081, P = 0.88, N = 859)
rs199931900(A)/13:107397379	intergenic	(0.28, -0.23, P = 2.6e-06, N = 1953)	(0.065, -0.0089, P = 0.93, N = 859)
rs9514571(T)/13:107405459	intergenic	(0.28, -0.23, P = 6.4e-06, N = 1953)	(0.049, -0.051, P = 0.65, N = 859)
rs2183242(C)/13:21271776*	IL17D	(0.041, 0.029, P = 2.3e-05, N = 7160)	(0.11, 0.024, P = 0.76, N = 859)
rs17082600(T)/13:26228314*	ATP8A2	(0.019, 0.048, P = 4.1e-07, N = 7160)	(0.068, 0.047, P = 0.63, N = 859)
rs9524526(T)/13:95150472	intergenic	(0.34, 0.011, P = 2.9e-05, N = 7160)	(0.3, 0.0025, P = 0.96, N = 859)
rs7997736(T)/13:98438292	intergenic	(0.76, 0.024, P = 3.9e-05, N = 1650)	(0.42, -0.049, P = 0.31, N = 859)
rs2346674(A)/14:57795057	intergenic	(0.16, 0.015, P = 2.4e-05, N = 7160)	(0.027, -0.069, P = 0.65, N = 859)
rs17751805(A)/14:65034363*	PPP1R36	(0.96, 0.063, P = 3.4e-06, N = 1650)	(0.93, -0.21, P = 0.026, N = 859)
rs2268984(C)/14:69408567	ACTN1	(0.91, 0.02, P = 2.4e-05, N = 7160)	(0.94, 0.088, P = 0.39, N = 859)
rs4904868(T)/14:92781001	intergenic	(0.44, -0.011, P = 1.4e-05, N = 7160)	(0.8, 0.037, P = 0.54, N = 859)
rs7166370(C)/15:60959089*	RORA	(0.43, 0.012, P = 5.2e-06, N = 7160)	(0.25, 0.014, P = 0.8, N = 859)
rs8039191(C)/15:66406574	MEGF11	(0.53, -0.15, P = 3.4e-06, N = 1953)	(0.64, 0.0024, P = 0.96, N = 859)
rs1561886(A)/15:71497130*	THSD4	(0.067, -0.041, P = 3.1e-05, N = 1650)	(0.14, 0.13, P = 0.065, N = 859)
rs8023317(A)/15:86541098	intergenic	(0.31, 0.011, P = 3.5e-05, N = 7160)	(0.54, 0.006, P = 0.9, N = 859)
rs1975271(T)/16:9497663*	RP11-243A14.1	(0.59, 0.012, P = 8.7e-06, N = 7160)	(0.89, -0.049, P = 0.51, N = 859)
rs432432(C)/17:15225813*	TEKT3	(0.61, -0.011, P = 3.2e-05, N = 7160)	(0.8, 0.013, P = 0.82, N = 859)
rs2526477(A)/17:20131193*	SPECC1	(0.61, -0.012, P = 3e-06, N = 7160)	(0.58, 0.082, P = 0.088, N = 859)
rs2671822(T)/17:33597682	SLFN5	(0.65, -0.011, P = 2.6e-05, N = 7160)	(0.86, -0.027, P = 0.69, N = 859)
rs8065435(A)/17:56157617*	DYNLL2	(0.33, -0.013, P = 5e-06, N = 7160)	(0.066, 0.02, P = 0.84, N = 859)
rs12951496(T)/17:6955671	intergenic	(0.87, -0.018, P = 1.7e-05, N = 7160)	(0.82, -0.018, P = 0.78, N = 859)
rs4789816(A)/17:80607830	WDR45B	(0.33, 0.011, P = 3.5e-05, N = 7160)	(0.11, 0.072, P = 0.36, N = 859)
rs74580079(G)/18:6776863	ARHGAP28	(0.048, 0.4, P = 8e-06, N = 1953)	(0.016, 0.072, P = 0.71, N = 859)
rs3865404(T)/18:755862	YES1	(0.49, -0.021, P = 3.7e-05, N = 1650)	(0.69, -0.015, P = 0.78, N = 859)
rs2967437(A)/19:37086645	AC092295.7	(0.69, -0.013, P = 1.9e-06, N = 7160)	(0.79, 0.017, P = 0.77, N = 859)
rs7574257(T)/2:105988447*	FHL2	(0.33, 0.012, P = 7.8e-06, N = 7160)	(0.2, 0.047, P = 0.45, N = 859)
rs12617095(A)/2:134762590	intergenic	(0.039, 0.054, P = 3.2e-05, N = 1650)	(0.12, 0.12, P = 0.11, N = 859)
rs1607363(T)/2:156670123*	intergenic	(0.72, 0.011, P = 3.5e-05, N = 7160)	(0.7, -0.052, P = 0.33, N = 859)
rs839524(T)/2:212815801	ERBB4	(0.12, 0.019, P = 8.5e-06, N = 7160)	(0.11, 0.13, P = 0.087, N = 859)
rs10185729(T)/2:212842777*	ERBB4	(0.86, -0.015, P = 2.1e-05, N = 7160)	(0.58, -0.026, P = 0.6, N = 859)
rs1395(A)/2:27424636*	SLC5A6	(0.7, 0.017, P = 8.1e-11, N = 7160)	(0.23, -0.14, P = 0.019, N = 859)
rs17049936(T)/2:59346812*	intergenic	(0.89, -0.019, P = 9.6e-06, N = 7160)	(0.98, 0.37, P = 0.052, N = 859)
rs12614153(A)/2:99502489	KIAA1211L	(0.02, -0.041, P = 1.1e-05, N = 7160)	(0.023, 0.092, P = 0.57, N = 859)
rs16996604(C)/20:15792861*	MACROD2	(0.97, -0.053, P = 7.2e-06, N = 1650)	(0.92, 0.062, P = 0.49, N = 859)
rs6034318(A)/20:15863999*	MACROD2	(0.013, 0.11, P = 4.5e-06, N = 1650)	(0.11, -0.042, P = 0.58, N = 859)
rs6078500(T)/20:182013*	intergenic	(0.51, -0.012, P = 4.5e-06, N = 7160)	(0.49, 0.12, P = 0.01, N = 859)
rs7280622(A)/21:39417006*	DSCR4	(0.7, -0.011, P = 4.3e-05, N = 7160)	(0.87, -0.0057, P = 0.94, N = 859)
rs760130(C)/21:41356039	intergenic	(0.69, -0.12, P = 4.9e-06, N = 1953)	(0.9, -0.14, P = 0.087, N = 859)
rs762407(A)/21:45181446	PDXK	(0.3, -0.011, P = 2e-05, N = 7160)	(0.38, -0.011, P = 0.83, N = 859)
rs2330959(T)/22:25343430	TMEM211	(0.14, -0.24, P = 7.3e-06, N = 1953)	(0.024, 0.12, P = 0.44, N = 859)
rs1350858(A)/3:109874627	intergenic	(0.18, 0.015, P = 8.2e-06, N = 7160)	(0.36, -0.056, P = 0.26, N = 859)
rs1282954(T)/3:111627743	PHLDB2	(0.98, -0.14, P = 7.1e-07, N = 1650)	(0.89, -0.013, P = 0.86, N = 859)
rs2173615(T)/3:191673577*	RP11-655G22.2	(0.32, 0.013, P = 1.7e-06, N = 7160)	(0.27, -0.048, P = 0.38, N = 859)
rs11719633(A)/3:20402881	intergenic	(0.095, -0.021, P = 3e-06, N = 7160)	(0.02, -0.22, P = 0.2, N = 859)
rs13091209(A)/3:24958459*	AC133680.1	(0.84, 0.014, P = 2.8e-05, N = 7160)	(0.93, -0.071, P = 0.46, N = 859)
rs6774965(A)/3:27548813*	intergenic	(0.86, -0.016, P = 3.2e-06, N = 7160)	(0.76, 0.019, P = 0.74, N = 859)
rs11374874(CT)/3:46776965	PRSS50	(0.045, 0.31, P = 6.2e-06, N = 1953)	(0.31, 0.032, P = 0.54, N = 859)
rs9813765(T)/3:4896746	AC018816.3	(0.92, 0.02, P = 3.3e-05, N = 7160)	(0.76, -0.063, P = 0.27, N = 859)
rs7634314(A)/3:61464280	intergenic	(0.31, 0.011, P = 2e-05, N = 7160)	(0.21, -0.076, P = 0.21, N = 859)
rs75342462(T)/3:61547164	PTPRG	(0.27, 0.17, P = 3.3e-06, N = 1953)	(0.13, 0.0054, P = 0.94, N = 859)
rs10510382(T)/3:7997953*	LMCD1-AS1	(0.79, -0.015, P = 1.1e-05, N = 7160)	(0.89, -0.043, P = 0.57, N = 859)
rs6848070(A)/4:127862814*	intergenic	(0.35, -0.012, P = 9.9e-06, N = 7160)	(0.1, 0.13, P = 0.12, N = 859)
rs795365(A)/4:140485914	SETD7	(0.73, -0.014, P = 2.5e-05, N = 7160)	(0.44, 0.047, P = 0.34, N = 859)
rs4692562(T)/4:169990660	intergenic	(0.66, -0.027, P = 1.9e-05, N = 1650)	(0.62, -0.033, P = 0.5, N = 859)
rs10012798(T)/4:169993004	intergenic	(0.67, -0.024, P = 1.4e-05, N = 1650)	(0.7, -0.00084, P = 0.99, N = 859)
rs10520541(C)/4:183680605*	TENM3	(0.83, 0.014, P = 3.4e-05, N = 7160)	(0.9, -0.058, P = 0.48, N = 859)
rs6837566(G)/4:186789501	SORBS2	(0.098, 0.26, P = 6.9e-06, N = 1953)	(0.094, 0.06, P = 0.46, N = 859)
rs10024571(C)/4:188772103*	intergenic	(0.98, -0.082, P = 1.6e-05, N = 1650)	(0.97, 0.068, P = 0.61, N = 859)
rs1895918(T)/4:37111619*	RP11-103J17.1	(0.56, 0.12, P = 8.4e-06, N = 1953)	(0.26, 0.11, P = 0.049, N = 859)
rs2457411(T)/4:48244026*	TEC	(0.3, 0.011, P = 1.9e-05, N = 7160)	(0.052, 0.14, P = 0.18, N = 859)
rs12522179(A)/5:101403134*	intergenic	(0.82, -0.028, P = 3.8e-05, N = 1650)	(0.58, -0.057, P = 0.23, N = 859)
rs4078252(T)/5:112455467*	MCC	(0.32, -0.011, P = 3.9e-05, N = 7160)	(0.13, 0.023, P = 0.75, N = 859)
rs2605200(T)/5:114751410	intergenic	(0.22, -0.016, P = 2.1e-05, N = 7160)	(0.31, -0.016, P = 0.75, N = 859)
rs248063(A)/5:126500208*	intergenic	(0.5, -0.024, P = 2.4e-06, N = 1650)	(0.68, 0.089, P = 0.082, N = 859)
rs271072(A)/5:144532826	intergenic	(0.38, -0.012, P = 5.9e-06, N = 7160)	(0.25, 0.0073, P = 0.9, N = 859)
rs726550(T)/5:144668820*	intergenic	(0.33, 0.011, P = 3.7e-05, N = 7160)	(0.58, -0.069, P = 0.15, N = 859)
rs6873171(A)/5:145305766*	intergenic	(0.065, 0.041, P = 4.5e-05, N = 1650)	(0.24, -0.065, P = 0.25, N = 859)
rs1994860(G)/5:152989323	GRIA1	(0.28, 0.19, P = 6.1e-06, N = 1953)	(0.1, 0.079, P = 0.31, N = 859)
rs2255493(T)/5:153432970	MFAP3	(0.63, -0.011, P = 3.8e-05, N = 7160)	(0.65, 0.04, P = 0.44, N = 859)
rs31705(C)/5:154683887*	intergenic	(0.33, 0.012, P = 1e-05, N = 7160)	(0.39, -0.046, P = 0.36, N = 859)
rs10051445(G)/5:82356099	TMEM167A	(0.45, 0.16, P = 5.2e-07, N = 1953)	(0.59, 0.0014, P = 0.98, N = 859)
rs1674726(A)/6:153858614*	intergenic	(0.35, -0.011, P = 4e-05, N = 7160)	(0.29, -0.034, P = 0.53, N = 859)
rs6557395(A)/6:155369261	TIAM2	(0.83, -0.015, P = 2.9e-05, N = 7160)	(0.88, 0.032, P = 0.67, N = 859)
rs9365106(A)/6:160282834*	intergenic	(0.68, -0.012, P = 8.1e-06, N = 7160)	(0.54, -0.059, P = 0.24, N = 859)
rs960295(T)/6:1726623	GMDS	(0.25, -0.025, P = 1.3e-05, N = 1650)	(0.084, 0.0017, P = 0.98, N = 859)
rs7774567(A)/6:25425526*	LRRC16A	(0.083, 0.02, P = 1.8e-05, N = 7160)	(0.11, -0.015, P = 0.84, N = 859)
rs13212846(A)/6:50301100	intergenic	(0.93, -0.024, P = 2.9e-06, N = 7160)	(0.99, 0.21, P = 0.3, N = 859)
rs17141663(T)/6:6063348*	intergenic	(0.074, -0.021, P = 4.4e-05, N = 7160)	(0.072, 0.16, P = 0.091, N = 859)
rs9649040(T)/7:131859395	PLXNA4	(0.12, -0.017, P = 4.3e-05, N = 7160)	(0.082, -0.00026, P = 1, N = 859)
rs192735620(T)/7:152543295	ACTR3B	(0.012, 0.63, P = 5.8e-06, N = 1953)	(0.02, -0.2, P = 0.25, N = 859)
rs754554(T)/7:24758818	DFNA5	(0.15, 0.015, P = 2e-05, N = 7160)	(0.21, 0.012, P = 0.84, N = 859)
rs7458704(T)/7:67422093	intergenic	(0.98, -0.054, P = 5.6e-07, N = 7160)	(0.84, -0.095, P = 0.15, N = 859)
rs17158882(T)/7:83963481*	SEMA3A	(0.91, -0.024, P = 3.9e-05, N = 7160)	(0.92, 0.11, P = 0.25, N = 859)
rs1034495(A)/8:111157151	intergenic	(0.7, 0.011, P = 4.2e-05, N = 7160)	(0.93, 0.022, P = 0.82, N = 859)
rs283734(G)/8:128270368	intergenic	(0.22, -0.15, P = 7.2e-06, N = 1953)	(0.5, -0.0055, P = 0.91, N = 859)
rs4269521(A)/8:132358549*	intergenic	(0.84, 0.017, P = 1e-06, N = 7160)	(0.95, 0.18, P = 0.13, N = 859)
rs12544560(A)/8:21368451	intergenic	(0.15, 0.016, P = 3.3e-06, N = 7160)	(0.065, -0.015, P = 0.88, N = 859)
rs2979166(A)/8:8228245	SGK223	(0.47, 0.011, P = 1.5e-05, N = 7160)	(0.74, 0.094, P = 0.092, N = 859)
rs7009776(T)/8:90373191	intergenic	(0.33, -0.027, P = 7.1e-06, N = 1650)	(0.23, 0.0098, P = 0.87, N = 859)
rs17771752(T)/9:28195226*	LINGO2	(0.049, 0.025, P = 2e-05, N = 7160)	(0.023, -0.0049, P = 0.98, N = 859)
rs700978(A)/9:98496807*	intergenic	(0.31, -0.014, P = 1.9e-05, N = 7160)	(0.5, 0.069, P = 0.15, N = 859)

Results from Univariable Mendelian Randomization of Pantothenic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	107	-0.027 (-0.15- 0.096) P=0.67	4.9	25	1.06 (0- 81.2)	NA	NA	-0.01 P=0.16
MR-Egger	107	0.024 (-0.12- 0.17) P=0.74	4.9	25	1.06 (0- 81.2)	109	0.38	-0.01 P=0.16
Weighted median	107	0.04 (-0.14- 0.22) P=0.67	4.9	25	1.06 (0- 81.2)	NA	NA	-0.01 P=0.16

Results from Univariable MRPRESSO of Pantothenic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.06	-0.43	0.67
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Pantothenic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	62	-0.021 (-0.14- 0.093) P=0.72	7.4	23	2.08 (0- 20.7)	NA	NA	0.005 P=0.6
MR-Egger	62	-0.044 (-0.2- 0.11) P=0.58	7.4	23	2.08 (0- 20.7)	47	0.88	0.005 P=0.6
Weighted median	62	0.035 (-0.16- 0.23) P=0.72	7.4	23	2.08 (0- 20.7)	NA	NA	0.005 P=0.6

Results from Univariable MRPRESSO of Pantothenic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.02	0.06	-0.36	0.72
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Phenylalanine

Instruments Associations with L-Phenylalanine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Phenylalanine (Shin et al/Long et al)	eGFR (CSSCD)
rs10913071(A)/1:175712239	TNR	(0.22, -0.0051, P = 2.8e-05, N = 7824)	(0.1, 0.2, P = 0.014, N = 859)
rs149766(T)/1:57642394*	DAB1	(0.071, -0.0099, P = 2.6e-05, N = 7824)	(0.012, -0.33, P = 0.14, N = 859)
rs1865020(A)/10:78688976	KCNMA1	(0.33, 0.0049, P = 3.2e-05, N = 7824)	(0.52, -0.037, P = 0.45, N = 859)
rs628223(A)/11:82968164*	CCDC90B	(0.69, 0.0048, P = 4.3e-05, N = 7824)	(0.86, 0.016, P = 0.82, N = 859)
rs1498694(A)/12:103257876*	PAH	(0.4, 0.0075, P = 7.3e-11, N = 7824)	(0.32, 0.08, P = 0.12, N = 859)
rs11066801(T)/12:114319498*	RBM19	(0.2, -0.0092, P = 4.8e-05, N = 7824)	(0.18, -0.0018, P = 0.98, N = 859)
rs1163900(A)/12:17612617*	intergenic	(0.26, -0.0054, P = 1e-05, N = 7824)	(0.44, -0.018, P = 0.72, N = 859)
rs12370281(C)/12:98249633*	intergenic	(0.7, -0.0048, P = 4.9e-05, N = 7824)	(0.59, -0.088, P = 0.072, N = 859)
rs17300024(A)/13:93913236*	GPC6	(0.99, -0.037, P = 2.9e-05, N = 7824)	(0.95, -0.069, P = 0.54, N = 859)
rs10145453(T)/14:63735954*	RHOJ	(0.81, -0.0051, P = 4.7e-05, N = 7824)	(0.47, 0.11, P = 0.021, N = 859)
rs16975959(T)/15:96564721*	intergenic	(0.99, -0.035, P = 2e-05, N = 7824)	(0.93, -0.034, P = 0.71, N = 859)
rs12598787(A)/16:77403469*	ADAMTS18	(0.88, -0.0089, P = 1.6e-05, N = 7824)	(0.98, 0.14, P = 0.39, N = 859)
rs10445272(A)/17:12621782*	MYOCD	(0.21, 0.0051, P = 3.7e-05, N = 7824)	(0.43, -0.0084, P = 0.86, N = 859)
rs2905873(A)/17:29532356*	NF1	(0.69, 0.0055, P = 3e-06, N = 7824)	(0.94, -0.0093, P = 0.93, N = 859)
rs1468260(A)/17:39052931*	intergenic	(0.49, -0.0053, P = 3.5e-05, N = 7824)	(0.82, -0.012, P = 0.85, N = 859)
rs6736106(C)/2:217328446*	SMARCAL1	(0.2, 0.0053, P = 2.1e-05, N = 7824)	(0.5, 0.051, P = 0.31, N = 859)
rs10050054(T)/4:178647306*	LINC01098	(0.98, -0.033, P = 2.6e-06, N = 7824)	(0.67, 0.11, P = 0.029, N = 859)
rs1872445(T)/4:186504058*	SORBS2	(0.55, -0.0049, P = 1.9e-05, N = 7824)	(0.87, 0.068, P = 0.34, N = 859)
rs4863027(T)/4:190729688*	AF146191.4	(0.96, -0.019, P = 4.3e-05, N = 7824)	(0.82, 0.086, P = 0.17, N = 859)
rs6831907(T)/4:190761715	AF146191.4	(0.04, 0.021, P = 7.1e-06, N = 7824)	(0.04, 0.13, P = 0.27, N = 859)
rs17732494(T)/5:56301267	intergenic	(0.46, 0.0076, P = 4.7e-05, N = 7824)	(0.63, 0.034, P = 0.51, N = 859)
rs899855(A)/6:130094673*	intergenic	(0.93, -0.0097, P = 1.4e-05, N = 7824)	(0.93, -0.032, P = 0.73, N = 859)
rs7764865(T)/6:42835487	GLTSCR1L	(0.059, 0.012, P = 3.9e-05, N = 7824)	(0.51, -0.05, P = 0.31, N = 859)
rs2613565(A)/6:95894399	intergenic	(0.64, 0.0084, P = 4.5e-05, N = 7824)	(0.59, -0.091, P = 0.068, N = 859)
rs2456946(C)/7:113200934*	intergenic	(0.023, 0.033, P = 4.7e-05, N = 7824)	(0.047, -0.077, P = 0.5, N = 859)
rs12706142(A)/7:116775046*	ST7	(0.77, -0.0052, P = 2.9e-05, N = 7824)	(0.97, 0.029, P = 0.83, N = 859)
rs6965127(A)/7:42866718	AC010132.10	(0.34, -0.005, P = 2.4e-05, N = 7824)	(0.051, -0.064, P = 0.54, N = 859)
rs1565225(A)/8:85687107*	RALYL	(0.24, 0.007, P = 2.3e-06, N = 7824)	(0.58, -0.055, P = 0.27, N = 859)
rs12001237(C)/9:115854670	intergenic	(0.91, 0.0082, P = 3.5e-05, N = 7824)	(0.98, 0.3, P = 0.081, N = 859)
rs944982(T)/9:119847448*	ASTN2	(0.11, 0.013, P = 1.1e-05, N = 7824)	(0.063, 0.1, P = 0.3, N = 859)

Results from Univariable Mendelian Randomization of L-Phenylalanine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	30	-1.5 (-3.6- 0.62) P=0.16	0.15	0.057	9.11 (0- 77.2)	NA	NA	0.0016 P=0.94
MR-Egger	30	-1.6 (-4.9- 1.7) P=0.35	0.15	0.057	9.11 (0- 77.2)	40	0.072	0.0016 P=0.94
Weighted median	30	-2.6 (-5.3- 0.16) P=0.065	0.15	0.057	9.11 (0- 77.2)	NA	NA	0.0016 P=0.94

Results from Univariable MRPRESSO of L-Phenylalanine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-1.5	1.08	-1.39	0.18
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Phenylalanine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	8	-2.4 (-9.7- 4.8) P=0.51	0.15	0.015	41.8 (0- 87.8)	NA	NA	-0.087 P=0.35
MR-Egger	8	6.6 (-12- 26) P=0.52	0.15	0.015	41.8 (0- 87.8)	13	0.044	-0.087 P=0.35
Weighted median	8	-2.3 (-9.5- 4.9) P=0.53	0.15	0.015	41.8 (0- 87.8)	NA	NA	-0.087 P=0.35

Results from Univariable MRPRESSO of L-Phenylalanine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-2.44	3.72	-0.66	0.53
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Proline

Instruments Associations with L-Proline & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Proline (Shin et al/Long et al)	eGFR (CSSCD)
rs773585(T)/1:113841023*	intergenic	(0.65, 0.0076, P = 1.9e-05, N = 7824)	(0.91, 0.08, P = 0.34, N = 859)
rs11802885(A)/1:113896872	intergenic	(0.36, 0.0098, P = 2.3e-08, N = 7824)	(0.25, 0.029, P = 0.6, N = 859)
rs17492329(T)/1:202461103	PPP1R12B	(0.78, -0.011, P = 2.4e-05, N = 7824)	(0.97, 0.27, P = 0.044, N = 859)
rs2993536(A)/1:212154930	INTS7	(0.97, 0.021, P = 3.5e-05, N = 7824)	(0.91, -0.12, P = 0.18, N = 859)
rs587043(T)/1:226797522*	C1orf95	(0.33, -0.0077, P = 1.3e-05, N = 7824)	(0.23, 0.023, P = 0.7, N = 859)
rs10495434(T)/1:239473965*	intergenic	(0.079, -0.015, P = 3.2e-05, N = 7824)	(0.16, -0.0096, P = 0.88, N = 859)
rs1888182(T)/1:54967890	AC099796.1	(0.42, 0.0079, P = 7.9e-06, N = 7824)	(0.14, 0.032, P = 0.65, N = 859)
rs852767(G)/1:58287224	DAB1	(0.36, 0.18, P = 9.2e-06, N = 1957)	(0.12, 0.045, P = 0.55, N = 859)
rs34821139(T)/1:61645881*	NFIA	(0.098, 0.23, P = 4.1e-06, N = 1957)	(0.02, 0.14, P = 0.43, N = 859)
rs7546702(T)/1:93948403*	FNBP1L	(0.56, -0.15, P = 4.2e-06, N = 1957)	(0.12, -0.096, P = 0.19, N = 859)
rs11192397(G)/10:107070578*	intergenic	(0.15, -0.27, P = 9.1e-06, N = 1957)	(0.026, 0.041, P = 0.79, N = 859)
rs532728(C)/10:129652583*	intergenic	(0.61, 0.0074, P = 3e-05, N = 7824)	(0.71, -0.033, P = 0.54, N = 859)
rs112873694(AT)/10:18655806	CACNB2	(0.056, 0.47, P = 3.6e-06, N = 1957)	(0.08, -0.044, P = 0.63, N = 859)
rs12243290(A)/10:66938581*	intergenic	(0.9, -0.016, P = 4e-06, N = 7824)	(0.76, -0.012, P = 0.83, N = 859)
rs10887554(A)/10:87824238	GRID1	(0.53, 0.0072, P = 3.9e-05, N = 7824)	(0.25, 0.11, P = 0.042, N = 859)
rs10905627(G)/10:9905850	intergenic	(0.74, 0.19, P = 2.8e-06, N = 1957)	(0.45, -0.062, P = 0.2, N = 859)
rs4755121(A)/11:105804856	GRIA4	(0.084, 0.015, P = 2.3e-05, N = 7824)	(0.025, 0.019, P = 0.9, N = 859)
rs1371674(T)/11:40531941	LRRC4C	(0.59, -0.0076, P = 1.9e-05, N = 7824)	(0.52, 0.013, P = 0.8, N = 859)
rs10501294(T)/11:43086410	RP11-111A24.2	(0.87, -0.012, P = 3.1e-06, N = 7824)	(0.97, -0.13, P = 0.35, N = 859)
rs535633(A)/11:92825738*	intergenic	(0.58, -0.0086, P = 1e-06, N = 7824)	(0.65, 0.023, P = 0.66, N = 859)
rs562808(T)/11:95961049*	MAML2	(0.61, -0.0076, P = 1.8e-05, N = 7824)	(0.37, 0.0017, P = 0.97, N = 859)
rs7296105(A)/12:117842549	NOS1	(0.88, 0.026, P = 2.3e-06, N = 7824)	(0.45, 0.046, P = 0.36, N = 859)
rs11183620(A)/12:47212370*	SLC38A4	(0.47, 0.0082, P = 2.3e-06, N = 7824)	(0.8, -0.00048, P = 0.99, N = 859)
rs7958568(T)/12:47431496*	intergenic	(0.47, 0.0078, P = 8.9e-06, N = 7824)	(0.62, -0.027, P = 0.59, N = 859)
rs4082475(A)/12:52907240	KRT5	(0.13, 0.011, P = 2e-05, N = 7824)	(0.2, -0.032, P = 0.6, N = 859)
rs10783990(A)/12:59976616	RNU4-20P	(0.64, 0.0072, P = 4.2e-05, N = 7824)	(0.75, 0.0032, P = 0.95, N = 859)
rs10747856(A)/12:60262116	intergenic	(0.52, -0.0079, P = 6e-06, N = 7824)	(0.44, 0.11, P = 0.022, N = 859)
rs950755(T)/12:61227957*	intergenic	(0.86, -0.012, P = 8.5e-06, N = 7824)	(0.7, 0.036, P = 0.49, N = 859)
rs2278823(A)/12:7288734*	CLSTN3	(0.14, -0.011, P = 4.8e-05, N = 7824)	(0.2, 0.032, P = 0.59, N = 859)
rs3132360(A)/13:26297093	ATP8A2	(0.21, -0.011, P = 2.1e-05, N = 7824)	(0.2, -0.071, P = 0.23, N = 859)
rs17245120(A)/13:31319133	ALOX5AP	(0.072, 0.027, P = 4.8e-05, N = 7824)	(0.044, 0.029, P = 0.81, N = 859)
rs993158(T)/13:62992697	intergenic	(0.86, 0.011, P = 1.5e-05, N = 7824)	(0.48, -0.012, P = 0.81, N = 859)
rs2449697(T)/13:64025289	intergenic	(0.66, 0.0072, P = 4.9e-05, N = 7824)	(0.5, 0.072, P = 0.14, N = 859)
rs9540462(T)/13:66100680	intergenic	(0.88, -0.012, P = 4.8e-06, N = 7824)	(0.89, -0.0067, P = 0.93, N = 859)
rs9523512(T)/13:92775592*	GPC5	(0.47, 0.0077, P = 1.3e-05, N = 7824)	(0.8, -0.042, P = 0.49, N = 859)
rs10431644(T)/14:103694331	intergenic	(0.028, 0.45, P = 1.9e-06, N = 1957)	(0.077, -0.1, P = 0.27, N = 859)
rs62008719(C)/14:103698656	intergenic	(0.028, 0.45, P = 1.5e-06, N = 1957)	(0.11, -0.16, P = 0.047, N = 859)
rs2101244(A)/14:42848284	CTD-2307P3.1	(0.024, 0.66, P = 4.8e-06, N = 1957)	(0.14, 0.045, P = 0.51, N = 859)
rs12889337(T)/14:46784593*	LINC00871	(0.36, 0.0077, P = 1.5e-05, N = 7824)	(0.82, 0.0092, P = 0.89, N = 859)
rs11848063(A)/14:47235445*	intergenic	(0.59, 0.0087, P = 7.1e-07, N = 7824)	(0.44, -0.028, P = 0.57, N = 859)
rs12901694(A)/15:87326551	AGBL1	(0.4, 0.0076, P = 1.2e-05, N = 7824)	(0.84, -0.1, P = 0.12, N = 859)
rs7162266(T)/15:94673885	intergenic	(0.6, 0.0072, P = 3.9e-05, N = 7824)	(0.69, -0.0069, P = 0.89, N = 859)
rs11638366(T)/15:98810226*	CTD-2544M6.1	(0.43, -0.0076, P = 1.6e-05, N = 7824)	(0.4, 0.00042, P = 0.99, N = 859)
rs869289(T)/16:12385806*	SNX29	(0.38, -0.0077, P = 1.5e-05, N = 7824)	(0.27, -0.041, P = 0.45, N = 859)
rs74016008(C)/16:27150916	EEF1A1P38	(0.11, 0.25, P = 2.1e-06, N = 1957)	(0.14, 0.027, P = 0.69, N = 859)
rs893175(A)/16:49303818	intergenic	(0.59, -0.0086, P = 1.5e-06, N = 7824)	(0.33, -0.099, P = 0.05, N = 859)
rs11075967(T)/16:73154049	intergenic	(0.67, -0.0087, P = 8.7e-07, N = 7824)	(0.3, -0.061, P = 0.22, N = 859)
rs17144033(G)/16:7590752*	RBFOX1	(0.089, -0.27, P = 2.7e-06, N = 1957)	(0.18, -0.08, P = 0.22, N = 859)
rs1080941(A)/16:77890685	VAT1L	(0.63, 0.0078, P = 1.1e-05, N = 7824)	(0.41, -0.0023, P = 0.96, N = 859)
rs17750740(T)/16:80651109*	CDYL2	(0.83, 0.01, P = 2.2e-05, N = 7824)	(0.96, -0.029, P = 0.81, N = 859)
rs7208186(T)/17:10680890*	CTC-297N7.5	(0.86, 0.014, P = 6.3e-08, N = 7824)	(0.57, 0.038, P = 0.44, N = 859)
rs8077659(A)/17:13042271	intergenic	(0.36, 0.0073, P = 3.7e-05, N = 7824)	(0.19, 0.035, P = 0.59, N = 859)
rs8080958(A)/17:27508704	MYO18A	(0.55, -0.0073, P = 2.7e-05, N = 7824)	(0.83, 0.096, P = 0.13, N = 859)
rs1984518(T)/17:41521666	MIR2117	(0.58, -0.0074, P = 2.9e-05, N = 7824)	(0.55, 0.023, P = 0.64, N = 859)
rs7209219(A)/17:66300683	ARSG	(0.87, -0.013, P = 4.2e-05, N = 7824)	(0.88, -0.038, P = 0.61, N = 859)
rs1859930(T)/17:70334561	RP11-1124B17.1	(0.59, 0.0077, P = 1.2e-05, N = 7824)	(0.57, -0.077, P = 0.11, N = 859)
rs12955313(T)/18:11952865*	intergenic	(0.069, -0.29, P = 8.3e-06, N = 1957)	(0.061, 0.038, P = 0.71, N = 859)
rs55928301(A)/18:25277047	intergenic	(0.055, 0.35, P = 2.1e-06, N = 1957)	(0.19, 0.068, P = 0.26, N = 859)
rs2612561(T)/18:42982959*	SLC14A2	(0.45, 0.0074, P = 2.7e-05, N = 7824)	(0.48, -0.03, P = 0.54, N = 859)
rs34467380(T)/18:6472786	intergenic	(0.2, -0.19, P = 4.2e-06, N = 1957)	(0.26, 0.13, P = 0.017, N = 859)
rs7241461(T)/18:74778515*	MBP	(0.47, 0.0074, P = 2.1e-05, N = 7824)	(0.42, 0.036, P = 0.48, N = 859)
rs12984032(T)/19:19809147	CTC-412M14.6	(0.76, 0.011, P = 2.5e-05, N = 7824)	(0.73, -0.064, P = 0.23, N = 859)
rs4801654(A)/19:56483863	NLRP8	(0.086, 0.014, P = 2.6e-05, N = 7824)	(0.18, -0.0035, P = 0.95, N = 859)
rs56375520(T)/19:58434877	ZNF418	(0.24, 0.19, P = 8.6e-06, N = 1957)	(0.25, 0.14, P = 0.0081, N = 859)
rs10404819(A)/19:9227673*	OR7G1	(0.17, -0.011, P = 1.9e-05, N = 7824)	(0.61, 0.036, P = 0.48, N = 859)
rs10183099(A)/2:152245087	intergenic	(0.64, -0.0084, P = 2.4e-06, N = 7824)	(0.9, 0.0098, P = 0.9, N = 859)
rs2290368(T)/2:152266473	RIF1	(0.57, -0.0075, P = 2.2e-05, N = 7824)	(0.62, -0.046, P = 0.36, N = 859)
rs1564080(A)/2:157529960	intergenic	(0.32, 0.0079, P = 7.5e-06, N = 7824)	(0.45, 0.059, P = 0.23, N = 859)
rs1615586(T)/2:161743385*	intergenic	(0.77, -0.02, P = 4.2e-06, N = 7824)	(0.8, 0.048, P = 0.42, N = 859)
rs11684292(T)/2:172117094	intergenic	(0.052, -0.02, P = 1e-05, N = 7824)	(0.037, 0.19, P = 0.12, N = 859)
rs17476649(A)/2:17262830*	intergenic	(0.35, 0.0073, P = 3.5e-05, N = 7824)	(0.079, -0.028, P = 0.76, N = 859)
rs1486239(A)/2:180631925	ZNF385B	(0.41, -0.0075, P = 2.1e-05, N = 7824)	(0.6, -0.043, P = 0.37, N = 859)
rs1534208(C)/2:185009665	intergenic	(0.55, -0.16, P = 6.1e-06, N = 1957)	(0.15, -0.04, P = 0.55, N = 859)
rs7573642(T)/2:213010332	ERBB4	(0.98, -0.048, P = 4.9e-05, N = 7824)	(0.75, -0.0041, P = 0.94, N = 859)
rs7592552(C)/2:214563795	SPAG16	(0.4, 0.16, P = 4.8e-06, N = 1957)	(0.6, -0.044, P = 0.38, N = 859)
rs142363454(TCA)/2:215286688*	VWC2L	(0.12, 0.23, P = 5.2e-06, N = 1957)	(0.41, -0.018, P = 0.71, N = 859)
rs7601275(A)/2:239060766	KLHL30	(0.35, 0.15, P = 9e-06, N = 1957)	(0.68, 0.01, P = 0.84, N = 859)
rs7560860(A)/2:42497679	EML4	(0.43, 0.0079, P = 6.4e-06, N = 7824)	(0.13, -0.04, P = 0.59, N = 859)
rs4564826(A)/2:43058278*	AC098824.6	(0.23, -0.19, P = 9.4e-06, N = 1957)	(0.22, 0.08, P = 0.17, N = 859)
rs55684321(A)/2:4978939	intergenic	(0.38, -0.15, P = 1e-06, N = 1957)	(0.17, -0.16, P = 0.015, N = 859)
rs13388859(T)/2:81051251	AC084193.1	(0.011, 0.082, P = 1.3e-05, N = 7824)	(0.066, 0.13, P = 0.18, N = 859)
rs408961(C)/20:15045215*	MACROD2	(0.64, -0.0073, P = 3.1e-05, N = 7824)	(0.29, -0.067, P = 0.21, N = 859)
rs6085052(T)/20:5239399	intergenic	(0.98, -0.026, P = 3.3e-05, N = 7824)	(0.96, -0.11, P = 0.38, N = 859)
rs6085132(T)/20:5344064	intergenic	(0.97, -0.027, P = 4e-06, N = 7824)	(0.77, -0.014, P = 0.8, N = 859)
rs6011169(C)/20:62456818	ZBTB46	(0.13, -0.011, P = 2.7e-05, N = 7824)	(0.29, -0.048, P = 0.36, N = 859)
rs1009576(T)/21:16542572	intergenic	(0.14, -0.28, P = 1.9e-06, N = 1957)	(0.75, 0.13, P = 0.016, N = 859)
rs2823289(T)/21:16841195*	intergenic	(0.58, -0.0073, P = 4.4e-05, N = 7824)	(0.49, 0.047, P = 0.33, N = 859)
rs17693038(T)/21:18820372	C21orf37	(0.06, 0.032, P = 1.3e-05, N = 7824)	(0.01, 0.12, P = 0.61, N = 859)
rs228029(A)/21:44068362	AP001626.2	(0.38, 0.0072, P = 4.9e-05, N = 7824)	(0.24, -0.053, P = 0.34, N = 859)
rs17742907(A)/22:18890615	DGCR6	(0.076, 0.017, P = 9.6e-06, N = 7824)	(0.036, 0.098, P = 0.45, N = 859)
rs5747934(T)/22:18915282	PRODH	(0.047, 0.071, P = 2e-44, N = 7824)	(0.2, -0.025, P = 0.68, N = 859)
rs35059460(C)/22:18964791	DGCR5	(0.66, 0.21, P = 6.4e-09, N = 1957)	(0.5, 0.081, P = 0.08, N = 859)
rs2518802(A)/22:18975345*	DGCR5	(0.9, -0.053, P = 4.2e-59, N = 7824)	(0.86, 0.096, P = 0.18, N = 859)
rs4819778(T)/22:19134083	DGCR14	(0.33, -0.0097, P = 5.5e-08, N = 7824)	(0.65, 0.087, P = 0.088, N = 859)
rs9827536(T)/3:191846778	intergenic	(0.63, 0.0075, P = 1.9e-05, N = 7824)	(0.28, -0.031, P = 0.56, N = 859)
rs1394836(T)/3:192454733*	FGF12	(0.6, 0.0083, P = 2.2e-06, N = 7824)	(0.84, -0.031, P = 0.64, N = 859)
rs11129161(T)/3:24738868	AC133680.1	(0.59, 0.0078, P = 1.4e-05, N = 7824)	(0.73, -0.065, P = 0.23, N = 859)
rs11716669(T)/3:60801815	FHIT	(0.4, 0.18, P = 7.8e-06, N = 1957)	(0.24, -0.039, P = 0.48, N = 859)
rs6798346(A)/3:73078044*	PPP4R2	(0.63, -0.017, P = 8.8e-06, N = 7824)	(0.54, 0.0018, P = 0.97, N = 859)
rs6769362(C)/3:99296437*	intergenic	(0.64, -0.0079, P = 7.8e-06, N = 7824)	(0.18, -0.093, P = 0.14, N = 859)
rs10494317(T)/4:130094338*	RP11-378N18.1	(0.69, -0.0075, P = 2.5e-05, N = 7824)	(0.71, -0.032, P = 0.55, N = 859)
rs17314804(T)/4:140946828*	MAML3	(0.35, -0.0074, P = 2.9e-05, N = 7824)	(0.082, 0.052, P = 0.54, N = 859)
rs4580644(T)/4:15785201	CD38	(0.49, 0.016, P = 8.2e-06, N = 7824)	(0.66, -0.12, P = 0.023, N = 859)
rs2286460(A)/4:15964040*	FGFBP2	(0.54, -0.0075, P = 2e-05, N = 7824)	(0.43, 0.012, P = 0.8, N = 859)
rs732224(T)/4:162783324	FSTL5	(0.51, 0.0072, P = 3.8e-05, N = 7824)	(0.53, 0.042, P = 0.39, N = 859)
rs12503744(A)/4:172203928*	intergenic	(0.02, -0.055, P = 1.6e-05, N = 7824)	(0.32, -0.014, P = 0.78, N = 859)
rs6853509(T)/4:188999227	intergenic	(0.44, -0.0076, P = 2.2e-05, N = 7824)	(0.82, 0.044, P = 0.48, N = 859)
rs10517422(T)/4:37405256*	KIAA1239	(0.2, 0.21, P = 4.8e-06, N = 1957)	(0.02, 0.16, P = 0.35, N = 859)
rs4860172(C)/4:60389483*	intergenic	(0.37, 0.0077, P = 1.5e-05, N = 7824)	(0.065, -0.026, P = 0.79, N = 859)
rs6446553(T)/4:6942857	TBC1D14	(0.59, -0.0077, P = 1.8e-05, N = 7824)	(0.41, -0.027, P = 0.58, N = 859)
rs10007509(A)/4:71171720	intergenic	(0.07, -0.31, P = 1e-05, N = 1957)	(0.14, 0.056, P = 0.42, N = 859)
rs10155062(A)/4:7133905*	intergenic	(0.33, 0.0073, P = 4.3e-05, N = 7824)	(0.59, 0.08, P = 0.1, N = 859)
rs1363786(T)/5:102225196	PAM	(0.07, 0.016, P = 1.1e-05, N = 7824)	(0.24, -0.0028, P = 0.96, N = 859)
rs10073414(C)/5:108436526	FER	(0.89, 0.025, P = 3.8e-05, N = 7824)	(0.87, -0.013, P = 0.85, N = 859)
rs7702811(G)/5:125923056	ALDH7A1	(0.55, 0.15, P = 2.7e-07, N = 1957)	(0.92, 0.0087, P = 0.92, N = 859)
rs4868254(T)/5:172732331	intergenic	(0.43, -0.0076, P = 2.7e-05, N = 7824)	(0.54, 0.013, P = 0.78, N = 859)
rs147198383(G)/5:17395773	intergenic	(0.037, 0.4, P = 9.7e-07, N = 1957)	(0.011, 0.26, P = 0.27, N = 859)
rs2935623(A)/5:2767556	intergenic	(0.62, -0.0079, P = 8.7e-06, N = 7824)	(0.58, -0.043, P = 0.37, N = 859)
rs10512634(A)/5:35987551	UGT3A1	(0.14, 0.012, P = 8.6e-06, N = 7824)	(0.023, -0.11, P = 0.49, N = 859)
rs10941406(A)/5:38756294*	CTD-2127H9.1	(0.34, 0.0074, P = 3.3e-05, N = 7824)	(0.41, -0.081, P = 0.097, N = 859)
rs31242(T)/5:53368869*	ARL15	(0.86, 0.011, P = 2.2e-05, N = 7824)	(0.92, -0.082, P = 0.35, N = 859)
rs4395600(A)/5:53989831	intergenic	(0.083, -0.014, P = 3.7e-05, N = 7824)	(0.15, -0.041, P = 0.53, N = 859)
rs16900163(A)/5:71915010	CTC-347C20.2	(0.81, -0.018, P = 4.9e-05, N = 7824)	(0.74, -0.077, P = 0.17, N = 859)
rs1650723(T)/5:79922030	DHFR	(0.17, 0.011, P = 3e-05, N = 7824)	(0.065, 0.086, P = 0.38, N = 859)
rs11963846(A)/6:112489446	LAMA4	(0.45, 0.008, P = 8.6e-06, N = 7824)	(0.8, -0.0083, P = 0.89, N = 859)
rs9385646(T)/6:133725127	EYA4	(0.84, -0.23, P = 5.1e-06, N = 1957)	(0.42, -0.022, P = 0.66, N = 859)
rs175866(T)/6:151225521*	MTHFD1L	(0.58, -0.0086, P = 1.1e-06, N = 7824)	(0.87, 0.13, P = 0.068, N = 859)
rs4869824(C)/6:154758528*	CNKSR3	(0.52, 0.0074, P = 1.8e-05, N = 7824)	(0.39, -0.05, P = 0.29, N = 859)
rs7755193(A)/6:158644859*	intergenic	(0.15, -0.011, P = 2.9e-05, N = 7824)	(0.37, -0.026, P = 0.61, N = 859)
rs9396897(A)/6:18668391	intergenic	(0.63, 0.0072, P = 3.6e-05, N = 7824)	(0.69, -0.015, P = 0.78, N = 859)
rs2185865(A)/6:18828241	intergenic	(0.92, 0.018, P = 1.7e-07, N = 7824)	(0.85, -0.056, P = 0.4, N = 859)
rs612262(T)/6:35891608*	SRPK1	(0.36, -0.0073, P = 3.3e-05, N = 7824)	(0.73, -0.0042, P = 0.94, N = 859)
rs12202955(A)/6:53299090	intergenic	(0.51, -0.0074, P = 2.5e-05, N = 7824)	(0.37, -0.1, P = 0.039, N = 859)
rs2145543(C)/6:66874550	intergenic	(0.096, 0.36, P = 3.7e-06, N = 1957)	(0.16, 0.014, P = 0.83, N = 859)
rs9360494(T)/6:72485205*	intergenic	(0.6, -0.0083, P = 2.7e-06, N = 7824)	(0.83, -0.0092, P = 0.88, N = 859)
rs60933810(C)/7:120981502	WNT16	(0.1, 0.23, P = 8.3e-06, N = 1957)	(0.034, 0.13, P = 0.32, N = 859)
rs10954090(T)/7:125529994	intergenic	(0.15, 0.013, P = 4e-07, N = 7824)	(0.16, 0.0062, P = 0.92, N = 859)
rs17167391(C)/7:133704633	EXOC4	(0.2, 0.17, P = 3.2e-06, N = 1957)	(0.039, -0.075, P = 0.54, N = 859)
rs12540186(T)/7:141728622	MGAM	(0.19, -0.011, P = 2.4e-05, N = 7824)	(0.18, -0.057, P = 0.38, N = 859)
rs12333473(A)/7:144729497*	intergenic	(0.66, 0.0072, P = 4.6e-05, N = 7824)	(0.7, -0.039, P = 0.45, N = 859)
rs4726811(C)/7:146540777*	CNTNAP2	(0.22, 0.19, P = 2.9e-06, N = 1957)	(0.16, -0.0031, P = 0.96, N = 859)
rs4509197(A)/7:26594653*	AC004947.2	(0.36, -0.0075, P = 2.1e-05, N = 7824)	(0.27, -0.0094, P = 0.86, N = 859)
rs1524385(T)/7:54084188	intergenic	(0.17, 0.021, P = 3.8e-05, N = 7824)	(0.38, 0.097, P = 0.056, N = 859)
rs6465597(C)/7:97180908*	intergenic	(0.069, 0.2, P = 9.2e-07, N = 1957)	(0.21, -0.042, P = 0.47, N = 859)
rs13258818(T)/8:121639595*	SNTB1	(0.63, 0.0073, P = 3.5e-05, N = 7824)	(0.13, -0.11, P = 0.14, N = 859)
rs7819776(A)/8:135465833*	intergenic	(0.42, -0.0073, P = 2.9e-05, N = 7824)	(0.31, -0.014, P = 0.78, N = 859)
rs11784679(T)/8:22831150*	RN7SL303P	(0.78, -0.012, P = 3.6e-06, N = 7824)	(0.95, 0.075, P = 0.49, N = 859)
rs13258708(C)/8:3938103	CSMD1	(0.1, -0.014, P = 3.1e-05, N = 7824)	(0.023, 0.18, P = 0.27, N = 859)
rs2445717(T)/8:95245949	intergenic	(0.64, -0.0075, P = 2.1e-05, N = 7824)	(0.77, 0.02, P = 0.72, N = 859)
rs2680218(T)/9:109998648*	intergenic	(0.46, -0.0077, P = 1.1e-05, N = 7824)	(0.29, -0.012, P = 0.82, N = 859)
rs4978836(A)/9:112338981*	intergenic	(0.39, 0.009, P = 6.8e-06, N = 7824)	(0.31, 0.059, P = 0.25, N = 859)
rs13285974(A)/9:119579217	ASTN2	(0.42, 0.0076, P = 1.7e-05, N = 7824)	(0.64, 0.12, P = 0.022, N = 859)
rs10121207(T)/9:119990164*	ASTN2	(0.48, 0.0075, P = 3e-05, N = 7824)	(0.56, 0.026, P = 0.59, N = 859)
rs6478330(T)/9:120619093	RP11-281A20.1	(0.9, 0.014, P = 3.4e-05, N = 7824)	(0.95, 0.034, P = 0.76, N = 859)
rs1928871(C)/9:12350794*	intergenic	(0.4, 0.0083, P = 2.8e-06, N = 7824)	(0.084, -0.12, P = 0.14, N = 859)
rs1929425(T)/9:12367988*	intergenic	(0.4, 0.0072, P = 3.9e-05, N = 7824)	(0.71, -0.066, P = 0.21, N = 859)
rs7029664(T)/9:132048953*	RP11-344B5.2	(0.51, 0.0077, P = 9.7e-06, N = 7824)	(0.62, 0.034, P = 0.51, N = 859)
rs776783(A)/9:18653316*	ADAMTSL1	(0.97, -0.049, P = 1.7e-05, N = 7824)	(0.74, -0.061, P = 0.27, N = 859)
rs12550887(G)/9:32344871	intergenic	(0.18, -0.14, P = 2.3e-06, N = 1957)	(0.19, 0.013, P = 0.83, N = 859)
rs11143935(T)/9:76966194	intergenic	(0.33, 0.18, P = 7e-06, N = 1957)	(0.18, 0.014, P = 0.83, N = 859)
rs7858706(T)/9:77966690	intergenic	(0.5, -0.0077, P = 9.7e-06, N = 7824)	(0.14, 0.011, P = 0.87, N = 859)

Results from Univariable Mendelian Randomization of L-Proline & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	161	-0.01 (-0.096- 0.075) P=0.81	6.1	48	9.06 (0- 45.8)	NA	NA	0.0011 P=0.84
MR-Egger	161	-0.015 (-0.11- 0.082) P=0.76	6.1	48	9.06 (0- 45.8)	165	0.35	0.0011 P=0.84
Weighted median	161	0.051 (-0.087- 0.19) P=0.47	6.1	48	9.06 (0- 45.8)	NA	NA	0.0011 P=0.84

Results from Univariable MRPRESSO of L-Proline & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.04	-0.24	0.81
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Proline & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	97	-0.01 (-0.11- 0.093) P=0.85	7.5	36	16.2 (0- 93.7)	NA	NA	0.0077 P=0.35
MR-Egger	97	-0.04 (-0.16- 0.08) P=0.51	7.5	36	16.2 (0- 93.7)	121	0.04	0.0077 P=0.35
Weighted median	97	0.068 (-0.084- 0.22) P=0.38	7.5	36	16.2 (0- 93.7)	NA	NA	0.0077 P=0.35

Results from Univariable MRPRESSO of L-Proline & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.05	-0.19	0.85
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Pyruvic acid

Instruments Associations with Pyruvic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Pyruvic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs12124783(T)/1:176891453*	ASTN1	(0.25, 0.018, P = 3.5e-05, N = 7824)	(0.3, -0.022, P = 0.68, N = 859)
rs764151(A)/1:20746568*	LINC01141	(0.083, 0.029, P = 3.7e-05, N = 7824)	(0.17, -0.02, P = 0.76, N = 859)
rs4648464(A)/1:3171929	PRDM16	(0.55, -0.016, P = 9.4e-06, N = 7824)	(0.13, -0.024, P = 0.74, N = 859)
rs7085088(A)/10:112799928	intergenic	(0.2, -0.018, P = 2.7e-05, N = 7824)	(0.29, 0.013, P = 0.8, N = 859)
rs1327690(A)/10:6763749	intergenic	(0.095, -0.026, P = 2.8e-05, N = 7824)	(0.016, -0.34, P = 0.064, N = 859)
rs2488068(T)/10:94506628*	intergenic	(0.33, 0.018, P = 3.7e-05, N = 7824)	(0.38, -0.15, P = 0.0022, N = 859)
rs11216267(T)/11:116952392*	SIK3	(0.64, 0.017, P = 1.6e-06, N = 7824)	(0.15, -0.0017, P = 0.98, N = 859)
rs7941871(T)/11:13228006	intergenic	(0.84, -0.024, P = 1.6e-06, N = 7824)	(0.54, -0.042, P = 0.38, N = 859)
rs922762(A)/11:13228375*	intergenic	(0.34, 0.017, P = 4e-05, N = 7824)	(0.34, -0.072, P = 0.16, N = 859)
rs1983255(T)/11:1836032*	intergenic	(0.4, -0.015, P = 2e-05, N = 7824)	(0.6, -0.093, P = 0.056, N = 859)
rs10835174(T)/11:3853473*	RHOG	(0.65, -0.015, P = 2.1e-05, N = 7824)	(0.77, 0.00046, P = 0.99, N = 859)
rs11038739(A)/11:46017895*	PHF21A	(0.79, -0.02, P = 3e-06, N = 7824)	(0.9, 0.064, P = 0.44, N = 859)
rs505621(A)/11:83277927*	DLG2	(0.63, -0.014, P = 4.3e-05, N = 7824)	(0.87, -0.0015, P = 0.98, N = 859)
rs16946212(T)/12:116200202	RP11-110L15.1	(0.79, -0.018, P = 1.9e-05, N = 7824)	(0.8, 0.016, P = 0.79, N = 859)
rs3925033(T)/12:18456713	PIK3C2G	(0.46, -0.016, P = 2.6e-06, N = 7824)	(0.58, 0.018, P = 0.73, N = 859)
rs10505896(T)/12:23770330*	SOX5	(0.88, 0.025, P = 2.3e-05, N = 7824)	(0.91, -0.002, P = 0.98, N = 859)
rs12368229(A)/12:40747462*	LRRK2	(0.15, 0.02, P = 4.7e-05, N = 7824)	(0.08, 0.068, P = 0.44, N = 859)
rs11063657(A)/12:5517590	RP11-1038A11.1	(0.92, -0.028, P = 4.7e-05, N = 7824)	(0.98, -0.15, P = 0.35, N = 859)
rs1305261(A)/12:81141819*	intergenic	(0.98, 0.16, P = 5.9e-06, N = 7824)	(0.82, -0.065, P = 0.29, N = 859)
rs9558110(A)/13:104217164*	intergenic	(0.73, -0.02, P = 4.2e-05, N = 7824)	(0.96, -0.054, P = 0.65, N = 859)
rs924483(A)/13:27061003*	intergenic	(0.092, -0.029, P = 3.3e-06, N = 7824)	(0.19, 0.053, P = 0.39, N = 859)
rs868116(T)/13:70512698*	KLHL1	(0.37, -0.015, P = 1.4e-05, N = 7824)	(0.51, -0.013, P = 0.78, N = 859)
rs912857(T)/14:33657980*	NPAS3	(0.54, 0.014, P = 4.7e-05, N = 7824)	(0.58, -0.055, P = 0.27, N = 859)
rs8009583(T)/14:84765763	intergenic	(0.77, 0.018, P = 1.5e-05, N = 7824)	(0.72, 0.044, P = 0.4, N = 859)
rs1437543(A)/15:61468467*	RP11-39M21.1	(0.25, 0.018, P = 2.2e-05, N = 7824)	(0.42, 0.035, P = 0.49, N = 859)
rs8028830(A)/15:77508046*	PEAK1	(0.85, -0.021, P = 2.9e-05, N = 7824)	(0.97, 0.1, P = 0.43, N = 859)
rs11259923(A)/15:84535704	ADAMTSL3	(0.81, 0.042, P = 3.9e-06, N = 7824)	(0.72, 0.045, P = 0.4, N = 859)
rs2198307(T)/15:87237609*	AGBL1	(0.47, -0.014, P = 4.7e-05, N = 7824)	(0.87, -0.019, P = 0.79, N = 859)
rs7206138(T)/16:26504692	intergenic	(0.64, -0.017, P = 4.5e-05, N = 7824)	(0.77, -0.017, P = 0.76, N = 859)
rs2880608(A)/16:6028451*	RP11-420N3.2	(0.5, 0.014, P = 4.3e-05, N = 7824)	(0.77, -0.074, P = 0.21, N = 859)
rs6503455(T)/17:44140748*	KANSL1	(0.4, -0.014, P = 4.4e-05, N = 7824)	(0.25, -0.098, P = 0.074, N = 859)
rs4794245(T)/17:49461290*	intergenic	(0.26, -0.019, P = 1.1e-05, N = 7824)	(0.38, -0.048, P = 0.34, N = 859)
rs4790946(T)/17:63366847*	intergenic	(0.23, 0.036, P = 3.6e-05, N = 7824)	(0.16, 0.068, P = 0.3, N = 859)
rs334384(T)/18:7137068*	SLC25A51P2	(0.79, -0.018, P = 3.7e-05, N = 7824)	(0.85, 0.09, P = 0.18, N = 859)
rs2115100(C)/19:48522894*	ELSPBP1	(0.5, 0.015, P = 3.9e-05, N = 7824)	(0.69, -0.0079, P = 0.88, N = 859)
rs2445857(T)/19:58708507*	ZNF274	(0.089, -0.028, P = 1.5e-05, N = 7824)	(0.28, -0.042, P = 0.43, N = 859)
rs10500204(A)/19:7182963*	INSR	(0.72, 0.017, P = 4.7e-05, N = 7824)	(0.8, -0.079, P = 0.18, N = 859)
rs6743415(A)/2:15826092*	AC008271.1	(0.49, 0.015, P = 3.9e-05, N = 7824)	(0.68, 0.091, P = 0.081, N = 859)
rs780094(T)/2:27741237*	GCKR	(0.39, 0.015, P = 1.6e-05, N = 7824)	(0.17, -0.11, P = 0.083, N = 859)
rs6432031(A)/2:9831131	RP11-521D12.2	(0.11, 0.029, P = 2.9e-05, N = 7824)	(0.19, -0.071, P = 0.25, N = 859)
rs6055991(A)/20:8655834*	PLCB1	(0.81, -0.021, P = 3.3e-05, N = 7824)	(0.94, 0.014, P = 0.9, N = 859)
rs4816172(T)/20:9742096*	PAK7	(0.85, -0.026, P = 2.3e-05, N = 7824)	(0.92, 0.025, P = 0.78, N = 859)
rs2833657(A)/21:33478113*	LINC00159	(0.83, 0.024, P = 3e-06, N = 7824)	(0.72, 0.0038, P = 0.94, N = 859)
rs2252264(A)/22:18640203	USP18	(0.94, 0.07, P = 4.4e-05, N = 7824)	(0.76, 0.11, P = 0.056, N = 859)
rs7631540(T)/3:113830519*	intergenic	(0.48, -0.015, P = 2.5e-05, N = 7824)	(0.16, -0.021, P = 0.74, N = 859)
rs1133034(T)/3:182640615*	ATP11B	(0.076, 0.032, P = 3.9e-06, N = 7824)	(0.22, 0.069, P = 0.25, N = 859)
rs2880322(T)/4:108991375*	LEF1	(0.088, -0.026, P = 3.6e-05, N = 7824)	(0.35, 0.03, P = 0.55, N = 859)
rs11131981(T)/4:181186334*	intergenic	(0.38, -0.02, P = 3.4e-05, N = 7824)	(0.2, -0.027, P = 0.65, N = 859)
rs12515830(T)/5:101178314*	intergenic	(0.87, 0.024, P = 5.8e-06, N = 7824)	(0.98, -0.16, P = 0.33, N = 859)
rs6895278(T)/5:147122020*	JAKMIP2	(0.34, 0.017, P = 4.1e-06, N = 7824)	(0.21, 0.1, P = 0.083, N = 859)
rs2964063(T)/5:173859251*	RP11-267A15.1	(0.99, -0.073, P = 2.2e-06, N = 7824)	(0.93, 0.027, P = 0.77, N = 859)
rs2925703(A)/5:6286005*	HMGB3P3	(0.81, -0.018, P = 3.6e-05, N = 7824)	(0.66, 0.075, P = 0.14, N = 859)
rs7715701(C)/5:92717972	intergenic	(0.013, -0.15, P = 1.3e-05, N = 7824)	(0.48, 0.031, P = 0.53, N = 859)
rs13195863(A)/6:100393761*	MCHR2	(0.2, 0.022, P = 4.1e-07, N = 7824)	(0.36, 0.05, P = 0.33, N = 859)
rs11753541(A)/6:154126010	intergenic	(0.82, 0.039, P = 2.8e-05, N = 7824)	(0.97, -0.029, P = 0.83, N = 859)
rs9505008(T)/6:7033860*	intergenic	(0.59, 0.014, P = 4.2e-05, N = 7824)	(0.25, 0.074, P = 0.18, N = 859)
rs1316976(A)/6:73572196*	KCNQ5	(0.49, 0.015, P = 3e-05, N = 7824)	(0.67, -0.02, P = 0.69, N = 859)
rs2207444(A)/6:99513061	intergenic	(0.7, 0.018, P = 2.4e-05, N = 7824)	(0.6, 0.032, P = 0.52, N = 859)
rs848853(A)/7:108993043	intergenic	(0.07, -0.03, P = 4.8e-05, N = 7824)	(0.34, 0.026, P = 0.62, N = 859)
rs6979475(A)/7:24917974	OSBPL3	(0.25, 0.017, P = 4.7e-05, N = 7824)	(0.21, -0.06, P = 0.31, N = 859)
rs10237319(T)/7:4073601*	SDK1	(0.15, 0.023, P = 9.8e-06, N = 7824)	(0.51, -0.094, P = 0.05, N = 859)
rs13247447(A)/7:5698964	RNF216	(0.44, 0.015, P = 2.3e-05, N = 7824)	(0.16, 0.015, P = 0.82, N = 859)
rs7813799(C)/8:135396144*	intergenic	(0.43, -0.015, P = 2.5e-05, N = 7824)	(0.38, -0.047, P = 0.34, N = 859)
rs2748410(A)/8:142503676*	MROH5	(0.68, -0.032, P = 3.2e-05, N = 7824)	(0.62, 0.094, P = 0.062, N = 859)
rs937970(T)/8:22770139	PEBP4	(0.47, 0.017, P = 3.7e-05, N = 7824)	(0.6, -0.011, P = 0.82, N = 859)
rs2350463(A)/8:39640851	ADAM2	(0.82, -0.041, P = 2.9e-05, N = 7824)	(0.96, -0.33, P = 0.012, N = 859)
rs13283334(A)/9:117531782*	intergenic	(0.3, -0.018, P = 2.7e-05, N = 7824)	(0.088, 0.062, P = 0.45, N = 859)
rs1948080(T)/9:11852043*	intergenic	(0.62, -0.015, P = 3.3e-05, N = 7824)	(0.87, -0.088, P = 0.21, N = 859)
rs2809428(A)/9:129001029*	intergenic	(0.67, -0.018, P = 1.5e-05, N = 7824)	(0.89, -0.037, P = 0.63, N = 859)
rs9406589(T)/9:16222313	C9orf92	(0.88, -0.024, P = 2.6e-05, N = 7824)	(0.75, 0.091, P = 0.1, N = 859)

Results from Univariable Mendelian Randomization of Pyruvic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	70	-0.12 (-0.55- 0.3) P=0.56	1.3	1.2	5.87 (0- 64)	NA	NA	0.0024 P=0.83
MR-Egger	70	-0.17 (-0.77- 0.43) P=0.58	1.3	1.2	5.87 (0- 64)	83	0.11	0.0024 P=0.83
Weighted median	70	-0.3 (-0.87- 0.27) P=0.31	1.3	1.2	5.87 (0- 64)	NA	NA	0.0024 P=0.83

Results from Univariable MRPRESSO of Pyruvic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.12	0.22	-0.58	0.56
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Pyruvic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	21	0.095 (-0.48- 0.67) P=0.75	1.7	0.47	12.7 (0- 78.5)	NA	NA	0.0054 P=0.79
MR-Egger	21	0.015 (-0.82- 0.85) P=0.97	1.7	0.47	12.7 (0- 78.5)	23	0.24	0.0054 P=0.79
Weighted median	21	-0.03 (-0.73- 0.67) P=0.93	1.7	0.47	12.7 (0- 78.5)	NA	NA	0.0054 P=0.79

Results from Univariable MRPRESSO of Pyruvic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.09	0.29	0.32	0.75
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Quinolinic acid

Instruments Associations with Quinolinic acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Quinolinic acid (Shin et al/Long et al)	eGFR (CSSCD)
rs76358452(G)/1:11052159	CFL1P6	(0.027, 0.6, P = 1.1e-06, N = 1925)	(0.46, -0.017, P = 0.73, N = 859)
rs557549(C)/10:115138169*	intergenic	(0.99, 0.21, P = 1.7e-06, N = 1925)	(0.64, -0.062, P = 0.23, N = 859)
rs16921251(T)/10:21201598	NEBL	(0.012, -0.78, P = 1.8e-07, N = 1925)	(0.1, -0.15, P = 0.063, N = 859)
rs35350651(AC)/12:111907431*	ATXN2	(0.5, -0.11, P = 2.6e-06, N = 1925)	(0.93, 0.026, P = 0.77, N = 859)
rs76795319(C)/12:24821381*	intergenic	(0.022, -0.62, P = 4e-06, N = 1925)	(0.07, 0.12, P = 0.2, N = 859)
rs373374952(CGT)/12:76934267	OSBPL8	(0.023, -0.57, P = 4.9e-06, N = 1925)	(0.46, 0.077, P = 0.11, N = 859)
rs12100998(A)/14:74050925	intergenic	(0.018, -0.45, P = 7.3e-06, N = 1925)	(0.36, 0.058, P = 0.23, N = 859)
rs576870357(CA)/16:9032196	USP7	(0.032, 0.37, P = 3e-06, N = 1925)	(0.13, 0.039, P = 0.58, N = 859)
rs62123404(A)/19:23738581	ZNF675	(0.099, -0.31, P = 5.2e-07, N = 1925)	(0.013, 0.34, P = 0.11, N = 859)
rs113615666(CT)/2:29375775*	CLIP4	(0.34, 0.19, P = 4.2e-06, N = 1925)	(0.2, 0.0023, P = 0.97, N = 859)
rs55849091(G)/2:60600972	AC007381.2	(0.14, 0.3, P = 9.7e-08, N = 1925)	(0.16, 0.13, P = 0.053, N = 859)
rs13039318(C)/20:3737232	C20orf27	(0.26, -0.22, P = 7.8e-06, N = 1925)	(0.49, 0.067, P = 0.15, N = 859)
rs137076(C)/22:42976456	POLDIP3	(0.11, -0.2, P = 8e-06, N = 1925)	(0.31, 0.075, P = 0.16, N = 859)
rs5852001(CT)/3:115957699	LSAMP	(0.44, -0.1, P = 3.6e-07, N = 1925)	(0.49, -0.016, P = 0.74, N = 859)
rs78044678(G)/3:166732391	intergenic	(0.023, -0.46, P = 5.2e-06, N = 1925)	(0.042, 0.067, P = 0.58, N = 859)
rs6444180(C)/3:186607448*	intergenic	(0.96, 0.27, P = 6.6e-06, N = 1925)	(0.94, -0.19, P = 0.05, N = 859)
rs529207629(AT)/3:189833176	LEPREL1	(0.098, -0.23, P = 5e-06, N = 1925)	(0.11, -0.071, P = 0.35, N = 859)
rs140021783(T)/4:158544831	intergenic	(0.032, 0.33, P = 7.3e-06, N = 1925)	(0.011, -0.45, P = 0.053, N = 859)
rs143827831(G)/4:69556127	intergenic	(0.17, -0.22, P = 3.7e-06, N = 1925)	(0.04, 0.085, P = 0.49, N = 859)
rs2306447(G)/4:9499419	UNC93B7	(0.88, 0.25, P = 5e-06, N = 1925)	(0.57, -0.0013, P = 0.98, N = 859)
rs35391681(C)/5:117845902	CTD-2281M20.1	(0.091, -0.28, P = 4.7e-06, N = 1925)	(0.089, -0.082, P = 0.34, N = 859)
rs60689100(T)/5:159718987	CCNJL	(0.097, -0.27, P = 2.5e-06, N = 1925)	(0.21, 0.12, P = 0.05, N = 859)
rs10940993(G)/5:32020001*	PDZD2	(0.63, 0.17, P = 8.2e-06, N = 1925)	(0.2, 0.012, P = 0.85, N = 859)
rs34922076(C)/5:40897141	intergenic	(0.24, -0.2, P = 2.5e-06, N = 1925)	(0.037, 0.17, P = 0.18, N = 859)
rs62427973(A)/6:121904036	RNU2-8P	(0.2, -0.17, P = 1.1e-06, N = 1925)	(0.03, -0.047, P = 0.74, N = 859)
rs662138(G)/6:160564476*	SLC22A1	(0.17, -0.29, P = 5.9e-08, N = 1925)	(0.054, -0.099, P = 0.35, N = 859)
rs7761574(C)/6:33843039*	LINC01016	(0.26, 0.19, P = 7.5e-06, N = 1925)	(0.45, 0.0096, P = 0.84, N = 859)
rs35559950(G)/7:148162915	intergenic	(0.24, 0.17, P = 9.7e-06, N = 1925)	(0.095, 0.04, P = 0.63, N = 859)
rs35716920(A)/7:89574638	STEAP2-AS1	(0.07, 0.29, P = 5.6e-06, N = 1925)	(0.15, -0.11, P = 0.11, N = 859)
rs4472563(C)/8:1893021	ARHGEF10	(0.034, -0.4, P = 9.1e-06, N = 1925)	(0.17, -0.015, P = 0.82, N = 859)
rs149173925(G)/8:55718870	RP11-56A10.1	(0.011, -0.69, P = 8.5e-06, N = 1925)	(0.07, 0.17, P = 0.076, N = 859)
rs1121220(G)/8:96592156*	KB-1047C11.2	(0.41, -0.19, P = 7.3e-08, N = 1925)	(0.28, 0.027, P = 0.61, N = 859)
rs2197049(T)/9:10143304	PTPRD	(0.14, -0.21, P = 7.6e-06, N = 1925)	(0.11, 0.058, P = 0.45, N = 859)

Results from Univariable Mendelian Randomization of Quinolinic acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	33	-0.074 (-0.15- -4.6e-05) P=0.05	24	40	19.9 (0- 67.1)	NA	NA	-0.017 P=0.54
MR-Egger	33	-0.03 (-0.19- 0.13) P=0.71	24	40	19.9 (0- 67.1)	40	0.13	-0.017 P=0.54
Weighted median	33	-0.094 (-0.2- 0.0089) P=0.073	24	40	19.9 (0- 67.1)	NA	NA	-0.017 P=0.54

Results from Univariable MRPRESSO of Quinolinic acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.07	0.04	-1.96	0.06
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Quinolinic acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	24	-0.063 (-0.15- 0.022) P=0.15	23	29	28.9 (0- 80.5)	NA	NA	-0.026 P=0.49
MR-Egger	24	-0.002 (-0.19- 0.19) P=0.98	23	29	28.9 (0- 80.5)	33	0.06	-0.026 P=0.49
Weighted median	24	-0.082 (-0.19- 0.027) P=0.14	23	29	28.9 (0- 80.5)	NA	NA	-0.026 P=0.49

Results from Univariable MRPRESSO of Quinolinic acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.06	0.04	-1.45	0.16
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Salicyluric acid

Instruments Associations with Salicyluric acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Salicyluric acid (Shin et al/Long et al)	eGFR (CSSCD)
rs2138800(A)/1:102981095*	intergenic	(0.98, -0.94, P = 1.5e-05, N = 7824)	(0.8, 0.03, P = 0.63, N = 859)
rs10886877(T)/10:85425691	intergenic	(0.91, -0.17, P = 1.7e-06, N = 7824)	(0.97, -0.32, P = 0.034, N = 859)
rs11824477(T)/11:111103318	intergenic	(0.58, 0.095, P = 9.6e-06, N = 7824)	(0.65, 0.002, P = 0.97, N = 859)
rs2283208(A)/11:2743859*	KCNQ1	(0.49, -0.081, P = 4.2e-05, N = 7824)	(0.24, 0.034, P = 0.53, N = 859)
rs2126432(A)/11:38205040*	intergenic	(0.99, -0.46, P = 3.6e-05, N = 7824)	(0.77, -0.05, P = 0.38, N = 859)
rs11105725(T)/12:91045724	intergenic	(0.3, -0.11, P = 1.7e-05, N = 7824)	(0.041, -0.094, P = 0.44, N = 859)
rs9599763(A)/13:35440514	intergenic	(0.036, 0.24, P = 1.7e-05, N = 7824)	(0.3, -0.047, P = 0.38, N = 859)
rs9534848(T)/13:48431473	intergenic	(0.51, -0.23, P = 1.7e-05, N = 7824)	(0.15, 0.039, P = 0.56, N = 859)
rs9599057(A)/13:66611146*	intergenic	(0.91, -0.14, P = 3.8e-05, N = 7824)	(0.99, -0.23, P = 0.33, N = 859)
rs1713440(A)/14:20875269*	TEP1	(0.34, -0.089, P = 4e-05, N = 7824)	(0.76, 0.077, P = 0.15, N = 859)
rs1951656(T)/14:54530629*	intergenic	(0.99, -0.42, P = 2.2e-06, N = 7824)	(0.68, 0.1, P = 0.052, N = 859)
rs6574873(C)/14:86611700	intergenic	(0.02, 1.1, P = 1.1e-05, N = 7824)	(0.11, 0.016, P = 0.84, N = 859)
rs17114742(C)/15:25058590*	intergenic	(0.13, 0.12, P = 3.6e-05, N = 7824)	(0.26, 0.024, P = 0.66, N = 859)
rs1484976(T)/15:25839363*	intergenic	(0.98, -0.34, P = 9.5e-06, N = 7824)	(0.98, -0.14, P = 0.39, N = 859)
rs7178993(A)/15:25844529*	intergenic	(0.98, -0.32, P = 1.2e-05, N = 7824)	(0.92, 0.011, P = 0.9, N = 859)
rs3093322(C)/16:27445360	IL21R	(0.18, -0.14, P = 2e-05, N = 7824)	(0.045, -0.1, P = 0.38, N = 859)
rs37058(A)/16:58563199*	CNOT1	(0.069, 0.19, P = 5.3e-06, N = 7824)	(0.023, 0.011, P = 0.94, N = 859)
rs10420258(T)/19:33602757	GPATCH1	(0.14, 0.11, P = 4.3e-05, N = 7824)	(0.1, 0.019, P = 0.81, N = 859)
rs735507(A)/19:58720360*	ZNF274	(0.81, -0.11, P = 4.6e-06, N = 7824)	(0.82, -0.054, P = 0.39, N = 859)
rs12461352(A)/19:58869180	ZNF497	(0.47, 0.087, P = 2.6e-05, N = 7824)	(0.19, -0.018, P = 0.77, N = 859)
rs12982977(A)/19:9043021*	MUC16	(0.95, -0.38, P = 1.5e-05, N = 7824)	(0.84, -0.027, P = 0.68, N = 859)
rs2293220(T)/2:152728509*	CACNB4	(0.014, 0.41, P = 1.5e-05, N = 7824)	(0.17, -0.13, P = 0.04, N = 859)
rs219633(A)/21:27868059	CYYR1	(0.12, 0.15, P = 6e-07, N = 7824)	(0.47, -0.033, P = 0.5, N = 859)
rs9977045(T)/21:43363686*	C2CD2	(0.6, 0.086, P = 3.4e-05, N = 7824)	(0.51, 0.037, P = 0.45, N = 859)
rs4858919(T)/3:162362878	intergenic	(0.89, -0.13, P = 2.1e-05, N = 7824)	(0.97, -0.099, P = 0.5, N = 859)
rs9848396(A)/3:164977695*	RP11-85M11.2	(0.23, 0.095, P = 2.8e-05, N = 7824)	(0.13, -0.061, P = 0.39, N = 859)
rs3964616(A)/3:181691234	RP11-416O18.1	(0.7, -0.25, P = 3.6e-05, N = 7824)	(0.75, -0.012, P = 0.83, N = 859)
rs7663798(A)/4:141715430*	intergenic	(0.049, 0.2, P = 7.2e-06, N = 7824)	(0.068, 0.057, P = 0.55, N = 859)
rs530424(T)/4:176124914*	intergenic	(0.97, -0.8, P = 2.6e-05, N = 7824)	(0.85, -0.13, P = 0.042, N = 859)
rs919028(A)/4:99208331	RAP1GDS1	(0.95, -0.55, P = 8.7e-06, N = 7824)	(0.93, -0.052, P = 0.59, N = 859)
rs6895553(T)/5:114821667	CTB-161J7.1	(0.95, -0.2, P = 1.3e-05, N = 7824)	(0.62, -0.021, P = 0.67, N = 859)
rs2961632(A)/5:136640875	SPOCK1	(0.39, -0.081, P = 4.3e-05, N = 7824)	(0.43, -0.033, P = 0.5, N = 859)
rs17317833(A)/5:67533624*	PIK3R1	(0.14, -0.12, P = 1.4e-05, N = 7824)	(0.046, -0.048, P = 0.68, N = 859)
rs3800052(T)/6:1773297*	GMDS	(0.085, 0.17, P = 5.5e-06, N = 7824)	(0.019, -0.096, P = 0.59, N = 859)
rs17537088(T)/7:128027749	IMPDH1	(0.85, -0.12, P = 2.2e-05, N = 7824)	(0.96, -0.17, P = 0.18, N = 859)
rs10258070(T)/7:15318473*	AGMO	(0.72, -0.09, P = 1.7e-05, N = 7824)	(0.18, -0.072, P = 0.25, N = 859)
rs2470997(A)/7:47432942	TNS3	(0.72, -0.09, P = 1.8e-05, N = 7824)	(0.96, 0.06, P = 0.62, N = 859)
rs6944358(T)/7:5814178*	RNF216	(0.47, -0.084, P = 1.1e-05, N = 7824)	(0.3, 0.023, P = 0.66, N = 859)
rs1179620(T)/7:75252714*	HIP1	(0.55, 0.083, P = 1.2e-05, N = 7824)	(0.47, 0.045, P = 0.37, N = 859)
rs17682068(A)/8:119398255*	SAMD12	(0.92, -0.18, P = 1.5e-07, N = 7824)	(0.99, -0.12, P = 0.56, N = 859)
rs7839700(A)/8:127096690	intergenic	(0.96, -0.21, P = 2e-05, N = 7824)	(0.93, 0.048, P = 0.62, N = 859)
rs2244320(A)/8:18670908	PSD3	(0.95, -0.22, P = 4.6e-05, N = 7824)	(0.95, -0.24, P = 0.026, N = 859)
rs7003385(T)/8:41586750	ANK1	(0.66, -0.086, P = 1.5e-05, N = 7824)	(0.89, -0.026, P = 0.74, N = 859)
rs7016707(T)/8:41586822	ANK1	(0.099, 0.14, P = 5.8e-06, N = 7824)	(0.36, -0.052, P = 0.3, N = 859)
rs7049159(T)/9:91266181	RP13-60M5.2	(0.17, 0.3, P = 4.3e-05, N = 7824)	(0.49, 0.016, P = 0.74, N = 859)
rs10993714(A)/9:93613106*	SYK	(0.98, -0.29, P = 4.3e-05, N = 7824)	(0.88, 0.0054, P = 0.94, N = 859)

Results from Univariable Mendelian Randomization of Salicyluric acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	46	0.013 (-0.044- 0.071) P=0.65	66	38	7.84 (0- 40.6)	NA	NA	0.0037 P=0.8
MR-Egger	46	0.005 (-0.084- 0.094) P=0.91	66	38	7.84 (0- 40.6)	41	0.62	0.0037 P=0.8
Weighted median	46	0.0079 (-0.084- 0.1) P=0.87	66	38	7.84 (0- 40.6)	NA	NA	0.0037 P=0.8

Results from Univariable MRPRESSO of Salicyluric acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.01	0.03	0.45	0.65
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Salicyluric acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	22	0.027 (-0.063- 0.12) P=0.55	82	22	0 (0- 72.4)	NA	NA	0.006 P=0.78
MR-Egger	22	0.012 (-0.14- 0.16) P=0.88	82	22	0 (0- 72.4)	17	0.64	0.006 P=0.78
Weighted median	22	0.017 (-0.13- 0.16) P=0.82	82	22	0 (0- 72.4)	NA	NA	0.006 P=0.78

Results from Univariable MRPRESSO of Salicyluric acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.03	0.05	0.59	0.56
beta.exposure	Outlier-corrected	NA	NA	NA	NA

L-Serine

Instruments Associations with L-Serine & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Serine (Shin et al/Long et al)	eGFR (CSSCD)
rs1163251(T)/1:120209755*	PHGDH	(0.6, 0.019, P = 7.1e-27, N = 7824)	(0.86, 0.026, P = 0.71, N = 859)
rs3790707(T)/1:120264573*	PHGDH	(0.027, 0.27, P = 6.1e-09, N = 1957)	(0.069, -0.048, P = 0.62, N = 859)
rs12144094(C)/1:120264823	PHGDH	(0.85, -0.016, P = 1.8e-07, N = 7824)	(0.97, 0.046, P = 0.76, N = 859)
rs921516(A)/1:195854637*	intergenic	(0.51, 0.0079, P = 8.4e-06, N = 7824)	(0.32, -0.027, P = 0.61, N = 859)
rs10863629(A)/1:221682419*	RP11-103C3.1	(0.74, 0.01, P = 1.8e-05, N = 7824)	(0.92, -0.07, P = 0.43, N = 859)
rs454774(T)/1:30923203*	intergenic	(0.025, -0.047, P = 2.4e-05, N = 7824)	(0.28, -0.046, P = 0.41, N = 859)
rs841845(T)/1:43404713*	SLC2A1	(0.78, 0.011, P = 9.2e-06, N = 7824)	(0.65, -0.018, P = 0.71, N = 859)
rs6576936(A)/1:84191562	RP11-475O6.1	(0.3, 0.016, P = 1.6e-05, N = 7824)	(0.3, 0.0092, P = 0.86, N = 859)
rs12784903(A)/10:124956180*	intergenic	(0.19, 0.011, P = 1.2e-05, N = 7824)	(0.03, -0.22, P = 0.12, N = 859)
rs11248451(T)/10:124973893	AC012391.1	(0.2, 0.0099, P = 4.6e-05, N = 7824)	(0.036, -0.14, P = 0.3, N = 859)
rs943097(A)/10:13723773	FRMD4A	(0.19, 0.01, P = 4.1e-05, N = 7824)	(0.028, -0.011, P = 0.94, N = 859)
rs2277251(T)/10:31996242	RP11-472N13.3	(0.46, 0.0079, P = 9.7e-06, N = 7824)	(0.5, 0.035, P = 0.47, N = 859)
rs7908297(A)/10:5251702*	AKR1C4	(0.11, 0.016, P = 1.6e-06, N = 7824)	(0.033, -0.34, P = 0.013, N = 859)
rs11000319(C)/10:53726843	PRKG1	(0.19, -0.23, P = 4.1e-06, N = 1957)	(0.11, 0.1, P = 0.17, N = 859)
rs4747042(A)/10:72263690	PALD1	(0.48, -0.0076, P = 1.3e-05, N = 7824)	(0.39, 0.037, P = 0.44, N = 859)
rs580333(A)/10:84643651*	NRG3	(0.49, 0.0082, P = 1.8e-06, N = 7824)	(0.8, 0.084, P = 0.16, N = 859)
rs2632003(A)/11:11338853*	GALNT18	(0.95, -0.02, P = 2.7e-05, N = 7824)	(0.8, -0.07, P = 0.24, N = 859)
rs450208(T)/11:2931981	SLC22A18	(0.79, 0.01, P = 2.8e-05, N = 7824)	(0.85, 0.0037, P = 0.96, N = 859)
rs1874795(A)/11:80729659	intergenic	(0.43, -0.0083, P = 2.3e-06, N = 7824)	(0.15, 0.024, P = 0.73, N = 859)
rs7114828(T)/11:95717607	MAML2	(0.041, -0.022, P = 4.2e-05, N = 7824)	(0.4, -0.06, P = 0.22, N = 859)
rs12369136(A)/12:20576874	PDE3A	(0.99, 0.092, P = 2.1e-05, N = 7824)	(0.99, -0.18, P = 0.38, N = 859)
rs1042725(T)/12:66358347*	HMGA2	(0.5, -0.0085, P = 8e-07, N = 7824)	(0.38, -0.038, P = 0.44, N = 859)
rs7305455(C)/12:73599986*	RP11-314D7.2	(0.07, 0.018, P = 1.1e-05, N = 7824)	(0.26, 0.02, P = 0.71, N = 859)
rs142170634(TATA)/12:94701019	PLXNC1	(0.19, -0.22, P = 3.2e-06, N = 1957)	(0.019, 0.016, P = 0.93, N = 859)
rs10478(T)/13:30777202*	KATNAL1	(0.54, -0.0071, P = 3.8e-05, N = 7824)	(0.88, -0.037, P = 0.62, N = 859)
rs540497(T)/13:80905334	SPRY2	(0.033, -0.041, P = 1.9e-05, N = 7824)	(0.35, 0.013, P = 0.8, N = 859)
rs440371(C)/13:89058784	intergenic	(0.99, 0.038, P = 2.5e-05, N = 7824)	(0.93, -0.049, P = 0.61, N = 859)
rs4773797(T)/13:95136420*	DCT	(0.55, 0.0072, P = 3.5e-05, N = 7824)	(0.29, 0.013, P = 0.81, N = 859)
rs10483419(T)/14:33168063*	AKAP6	(0.44, -0.0074, P = 2.1e-05, N = 7824)	(0.23, -0.087, P = 0.14, N = 859)
rs12433855(A)/14:49051094	intergenic	(0.51, -0.0073, P = 3.3e-05, N = 7824)	(0.54, -0.052, P = 0.29, N = 859)
rs268817(A)/14:58029965*	SLC35F4	(0.27, 0.01, P = 2e-05, N = 7824)	(0.047, 0.2, P = 0.078, N = 859)
rs59356185(A)/15:30985526	ARHGAP11B	(0.17, 0.76, P = 3.6e-06, N = 1957)	(0.3, -0.042, P = 0.42, N = 859)
rs1457244(A)/15:37783906*	RP11-720L8.1	(0.46, 0.0073, P = 2.9e-05, N = 7824)	(0.33, -0.0099, P = 0.84, N = 859)
rs1143115(T)/15:93452297*	CHD2	(0.53, -0.014, P = 3.5e-05, N = 7824)	(0.59, -0.054, P = 0.25, N = 859)
rs1420235(T)/16:49691859	ZNF423	(0.16, -0.013, P = 2.5e-05, N = 7824)	(0.051, -0.11, P = 0.29, N = 859)
rs6564181(A)/16:74905905*	WDR59	(0.45, 0.0078, P = 8.2e-06, N = 7824)	(0.52, 0.0044, P = 0.93, N = 859)
rs10514413(C)/16:77342569	ADAMTS18	(0.024, -0.27, P = 9.9e-06, N = 1957)	(0.029, 0.073, P = 0.62, N = 859)
rs2959520(A)/18:19362376	MIB1	(0.98, -0.054, P = 3.7e-05, N = 7824)	(0.81, -0.072, P = 0.24, N = 859)
rs4800190(T)/18:22453101*	RP11-449D8.5	(0.85, 0.01, P = 4.4e-05, N = 7824)	(0.95, -0.036, P = 0.75, N = 859)
rs11659824(T)/18:36729428	intergenic	(0.5, 0.0071, P = 3.4e-05, N = 7824)	(0.23, 0.0068, P = 0.9, N = 859)
rs1442089(A)/18:51107079*	RP11-202D1.2	(0.91, -0.014, P = 1.9e-05, N = 7824)	(0.64, 0.028, P = 0.58, N = 859)
rs34734297(A)/18:67283673	DOK6	(0.6, -0.26, P = 2e-06, N = 1957)	(0.55, -0.047, P = 0.33, N = 859)
rs10426856(A)/19:33096406*	ANKRD27	(0.9, -0.015, P = 4.2e-06, N = 7824)	(0.66, 0.058, P = 0.26, N = 859)
rs12621772(T)/2:114913436	intergenic	(0.23, 0.012, P = 1.2e-06, N = 7824)	(0.55, 0.044, P = 0.36, N = 859)
rs6740983(T)/2:114913608	intergenic	(0.78, -0.012, P = 1.2e-06, N = 7824)	(0.45, -0.043, P = 0.37, N = 859)
rs6431176(T)/2:127533079	intergenic	(0.36, -0.01, P = 8.3e-06, N = 7824)	(0.41, -0.011, P = 0.81, N = 859)
rs7573748(T)/2:160701198*	LY75-CD302	(0.83, -0.019, P = 2.4e-05, N = 7824)	(0.56, -0.074, P = 0.13, N = 859)
rs12992925(A)/2:179860406	CCDC141	(0.58, 0.0084, P = 1.3e-06, N = 7824)	(0.21, 0.11, P = 0.052, N = 859)
rs3900115(A)/2:202050677*	CASP10	(0.48, 0.0074, P = 1.8e-05, N = 7824)	(0.5, 0.023, P = 0.62, N = 859)
rs7579488(T)/2:207995116*	KLF7	(0.9, 0.016, P = 3.7e-05, N = 7824)	(0.61, -0.035, P = 0.48, N = 859)
rs715(T)/2:211543055*	CPS1	(0.71, -0.022, P = 2.7e-21, N = 7824)	(0.81, -0.061, P = 0.33, N = 859)
rs1990797(C)/2:211641068*	intergenic	(0.17, -0.011, P = 3.7e-05, N = 7824)	(0.024, -0.12, P = 0.45, N = 859)
rs986294(A)/2:211671984*	intergenic	(0.24, 0.015, P = 1.7e-09, N = 7824)	(0.12, -0.13, P = 0.079, N = 859)
rs4130275(T)/2:211730557*	intergenic	(0.83, 0.013, P = 8e-07, N = 7824)	(0.73, 0.011, P = 0.84, N = 859)
rs13394054(A)/2:211742818*	intergenic	(0.39, -0.01, P = 1e-05, N = 7824)	(0.63, -0.064, P = 0.2, N = 859)
rs4663379(A)/2:235209795	intergenic	(0.89, 0.014, P = 7.8e-06, N = 7824)	(0.98, -0.12, P = 0.45, N = 859)
rs1111967(T)/2:45443480	LINC01121	(0.77, 0.011, P = 1.6e-05, N = 7824)	(0.93, 0.18, P = 0.057, N = 859)
rs11563112(T)/2:52038675*	AC007682.1	(0.39, 0.0094, P = 3.7e-05, N = 7824)	(0.66, -0.099, P = 0.051, N = 859)
rs1541543(T)/2:59799996	RP11-444A22.1	(0.62, 0.01, P = 1.9e-05, N = 7824)	(0.61, -0.089, P = 0.073, N = 859)
rs13033420(T)/2:98758323	VWA3B	(0.44, 0.0082, P = 1.9e-06, N = 7824)	(0.46, 0.033, P = 0.5, N = 859)
rs390836(A)/20:15057002*	MACROD2	(0.42, -0.0074, P = 2.1e-05, N = 7824)	(0.25, -0.03, P = 0.58, N = 859)
rs6069057(C)/20:36806809*	intergenic	(0.87, 0.013, P = 4.3e-05, N = 7824)	(0.91, -0.087, P = 0.31, N = 859)
rs4925188(A)/20:60195570*	CDH4	(0.74, -0.0099, P = 2.2e-05, N = 7824)	(0.24, 0.033, P = 0.55, N = 859)
rs1001972(C)/21:42147762*	DSCAM	(0.82, 0.011, P = 8.4e-06, N = 7824)	(0.88, -0.017, P = 0.82, N = 859)
rs9981086(T)/21:45446328*	TRAPPC10	(0.061, -0.22, P = 6.3e-06, N = 1957)	(0.24, 0.17, P = 0.0031, N = 859)
rs17760136(A)/22:22380667*	PRAMENP	(0.18, -0.022, P = 1.5e-05, N = 7824)	(0.022, -0.33, P = 0.048, N = 859)
rs5751770(T)/22:24252842*	AP000350.5	(0.37, 0.014, P = 4.9e-05, N = 7824)	(0.46, -0.04, P = 0.41, N = 859)
rs131460(A)/22:24931490*	GUCD1	(0.17, -0.02, P = 1.8e-05, N = 7824)	(0.51, -0.0086, P = 0.86, N = 859)
rs3184121(A)/3:124686733	HEG1	(0.21, -0.01, P = 2e-05, N = 7824)	(0.2, -0.068, P = 0.26, N = 859)
rs9874508(A)/3:125902417*	ALDH1L1	(0.46, -0.0084, P = 1.4e-06, N = 7824)	(0.67, 0.048, P = 0.34, N = 859)
rs67138915(C)/3:13907483	WNT7A	(0.17, -0.2, P = 1e-05, N = 1957)	(0.24, 0.022, P = 0.7, N = 859)
rs11718229(A)/3:148487600*	intergenic	(0.15, 0.013, P = 2.1e-05, N = 7824)	(0.13, 0.16, P = 0.028, N = 859)
rs701120(C)/3:154102004*	GPR149	(0.85, 0.01, P = 4.2e-05, N = 7824)	(0.81, -0.086, P = 0.16, N = 859)
rs9882567(T)/3:188988930	TPRG1	(0.05, -0.02, P = 1.1e-05, N = 7824)	(0.16, 0.032, P = 0.62, N = 859)
rs941348(T)/3:22113690*	ZNF385D	(0.2, -0.011, P = 7.1e-06, N = 7824)	(0.19, -0.086, P = 0.16, N = 859)
rs12715076(A)/3:26002178*	intergenic	(0.78, -0.01, P = 1.6e-05, N = 7824)	(0.85, 0.029, P = 0.67, N = 859)
rs1388509(C)/3:68354402	FAM19A1	(0.075, -0.24, P = 5.7e-07, N = 1957)	(0.024, -0.045, P = 0.78, N = 859)
rs11942744(T)/4:12360579*	intergenic	(0.98, 0.055, P = 4.5e-05, N = 7824)	(0.83, -0.051, P = 0.42, N = 859)
rs2320467(A)/4:18179501	intergenic	(0.26, 0.01, P = 1.2e-05, N = 7824)	(0.08, -0.0073, P = 0.93, N = 859)
rs4241779(A)/4:184600601*	TRAPPC11	(0.58, 0.0082, P = 2.8e-06, N = 7824)	(0.37, 0.035, P = 0.49, N = 859)
rs16844542(A)/4:3524909	LRPAP1	(0.97, -0.03, P = 2.4e-05, N = 7824)	(0.96, -0.012, P = 0.92, N = 859)
rs4865070(A)/4:57093826	KIAA1211	(0.11, -0.21, P = 8.5e-06, N = 1957)	(0.24, -0.053, P = 0.35, N = 859)
rs36790(T)/5:109331459	intergenic	(0.74, -0.25, P = 1.5e-06, N = 1957)	(0.44, 0.036, P = 0.45, N = 859)
rs197442(A)/5:116861349	LINC00992	(0.6, 0.01, P = 7.6e-06, N = 7824)	(0.19, -0.093, P = 0.13, N = 859)
rs403636(A)/5:1438354*	SLC6A3	(0.15, -0.012, P = 5.9e-06, N = 7824)	(0.28, -0.064, P = 0.23, N = 859)
rs10040689(A)/5:149097211	RN7SL868P	(0.53, 0.0082, P = 1.8e-06, N = 7824)	(0.65, -0.02, P = 0.69, N = 859)
rs342563(A)/5:16187424	RP11-19O2.2	(0.47, -0.01, P = 7.9e-06, N = 7824)	(0.56, -0.0027, P = 0.96, N = 859)
rs17658389(T)/5:172205155*	RP11-779O18.3	(0.36, -0.015, P = 3.3e-05, N = 7824)	(0.18, -2.8e-05, P = 1, N = 859)
rs11953664(T)/5:23696111	intergenic	(0.41, -0.007, P = 4.7e-05, N = 7824)	(0.44, -0.0018, P = 0.97, N = 859)
rs710998(T)/5:3591916*	IRX1	(0.92, 0.014, P = 5e-05, N = 7824)	(0.75, 0.033, P = 0.55, N = 859)
rs1645273(T)/5:53383314	ARL15	(0.78, -0.01, P = 2.1e-05, N = 7824)	(0.55, 0.089, P = 0.071, N = 859)
rs35107028(A)/5:93051362	FAM172A	(0.1, -0.17, P = 5.4e-07, N = 1957)	(0.024, 0.14, P = 0.38, N = 859)
rs9373846(A)/6:106778384	ATG5	(0.81, 0.011, P = 8.9e-06, N = 7824)	(0.88, 0.15, P = 0.051, N = 859)
rs6933154(T)/6:129141684	intergenic	(0.58, 0.0096, P = 2.4e-05, N = 7824)	(0.48, 0.1, P = 0.036, N = 859)
rs12663563(C)/6:25339003	LRRC16A	(0.047, -0.021, P = 8.2e-06, N = 7824)	(0.099, 0.039, P = 0.63, N = 859)
rs2269713(A)/6:31141127*	POU5F1	(0.98, 0.032, P = 1.1e-06, N = 7824)	(0.82, -0.013, P = 0.84, N = 859)
rs2762343(A)/6:35066091*	intergenic	(0.51, 0.0083, P = 1.2e-06, N = 7824)	(0.78, -0.039, P = 0.5, N = 859)
rs74394751(A)/6:76964078	intergenic	(0.079, -0.97, P = 8.4e-06, N = 1957)	(0.015, 0.29, P = 0.15, N = 859)
rs9450325(T)/6:86475814*	intergenic	(0.56, 0.007, P = 4.8e-05, N = 7824)	(0.53, -0.044, P = 0.37, N = 859)
rs17154498(A)/7:107468125	intergenic	(0.2, -0.011, P = 6.3e-06, N = 7824)	(0.12, 0.1, P = 0.18, N = 859)
rs2189725(A)/7:15041873*	intergenic	(0.46, 0.0073, P = 4e-05, N = 7824)	(0.42, -0.12, P = 0.011, N = 859)
rs4726207(T)/7:152496656	ACTR3B	(0.63, 0.01, P = 1.5e-05, N = 7824)	(0.34, 0.015, P = 0.77, N = 859)
rs6946890(T)/7:154384796*	DPP6	(0.53, -0.0075, P = 1.6e-05, N = 7824)	(0.71, -0.057, P = 0.28, N = 859)
rs4338001(A)/7:33701080	intergenic	(0.042, 0.023, P = 4.9e-05, N = 7824)	(0.051, -0.04, P = 0.72, N = 859)
rs4947534(T)/7:56079094*	PSPH	(0.25, -0.018, P = 2e-14, N = 7824)	(0.37, -0.046, P = 0.35, N = 859)
rs4717437(A)/7:67633440*	RP5-945F2.3	(0.31, -0.01, P = 3.8e-05, N = 7824)	(0.52, -0.036, P = 0.45, N = 859)
rs7779884(A)/7:76949393*	GSAP	(0.51, 0.0072, P = 3.5e-05, N = 7824)	(0.78, 0.034, P = 0.56, N = 859)
rs38971(A)/7:88956699*	ZNF804B	(0.83, 0.011, P = 1.9e-05, N = 7824)	(0.81, 0.013, P = 0.83, N = 859)
rs11982782(A)/7:94063700*	COL1A2	(0.082, -0.017, P = 7.9e-06, N = 7824)	(0.5, -0.03, P = 0.53, N = 859)
rs17166293(A)/7:94081432	intergenic	(0.081, -0.017, P = 1.3e-05, N = 7824)	(0.013, -0.19, P = 0.38, N = 859)
rs12334472(G)/8:55452455	intergenic	(0.52, 0.38, P = 5.4e-06, N = 1957)	(0.35, -0.019, P = 0.7, N = 859)
rs2979710(A)/8:80652442	intergenic	(0.88, -0.013, P = 3.4e-05, N = 7824)	(0.8, 0.087, P = 0.13, N = 859)
rs10978424(A)/9:108877072	intergenic	(0.047, 0.02, P = 2.9e-05, N = 7824)	(0.03, -0.016, P = 0.91, N = 859)
rs315711(A)/9:114548451	C9orf84	(0.54, 0.0073, P = 2.7e-05, N = 7824)	(0.49, 0.024, P = 0.61, N = 859)
rs7022371(T)/9:114601074*	RNU6-1013P	(0.5, 0.0086, P = 6.5e-07, N = 7824)	(0.71, -0.0059, P = 0.91, N = 859)
rs28465292(T)/9:115708237	intergenic	(0.21, -0.27, P = 9e-06, N = 1957)	(0.31, -0.045, P = 0.39, N = 859)
rs10283912(T)/9:12285170	RP11-71E22.1	(0.51, -0.0076, P = 1.3e-05, N = 7824)	(0.76, 0.11, P = 0.056, N = 859)
rs10812054(A)/9:24495241*	intergenic	(0.51, -0.0083, P = 2.6e-06, N = 7824)	(0.68, -0.021, P = 0.68, N = 859)
rs10972101(T)/9:34417750*	FAM219A	(0.11, -0.014, P = 6.9e-06, N = 7824)	(0.013, 0.44, P = 0.03, N = 859)
rs572099418(GTT)/9:34608298	RPP25L	(0.042, -0.19, P = 3.7e-06, N = 1957)	(0.038, -0.14, P = 0.26, N = 859)
rs144362640(A)/9:71839441	TJP2	(0.091, 0.25, P = 8.7e-06, N = 1957)	(0.04, 0.22, P = 0.073, N = 859)

Results from Univariable Mendelian Randomization of L-Serine & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	121	-0.053 (-0.15- 0.046) P=0.29	10	55	0.00115 (0- 96.1)	NA	NA	0.0065 P=0.31
MR-Egger	121	-0.074 (-0.18- 0.033) P=0.18	10	55	0.00115 (0- 96.1)	138	0.11	0.0065 P=0.31
Weighted median	121	-0.055 (-0.19- 0.078) P=0.42	10	55	0.00115 (0- 96.1)	NA	NA	0.0065 P=0.31

Results from Univariable MRPRESSO of L-Serine & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.05	-1.05	0.3
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Serine & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	59	-0.03 (-0.13- 0.066) P=0.54	20	54	0 (0- 96.7)	NA	NA	0.0085 P=0.37
MR-Egger	59	-0.053 (-0.16- 0.056) P=0.34	20	54	0 (0- 96.7)	59	0.4	0.0085 P=0.37
Weighted median	59	-0.054 (-0.18- 0.076) P=0.41	20	54	0 (0- 96.7)	NA	NA	0.0085 P=0.37

Results from Univariable MRPRESSO of L-Serine & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.05	-0.61	0.54
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Sorbitol

Instruments Associations with Sorbitol & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Sorbitol (Shin et al/Long et al)	eGFR (CSSCD)
rs1343274(T)/1:112875033*	RP5-965F6.2	(0.95, 0.088, P = 1.6e-05, N = 7824)	(0.79, -0.0031, P = 0.96, N = 859)
rs12720497(T)/1:186830420*	PLA2G4A	(0.29, -0.056, P = 1.7e-05, N = 7824)	(0.11, -0.21, P = 0.0088, N = 859)
rs6687118(A)/1:86551785	COL24A1	(0.96, -0.17, P = 2e-05, N = 7824)	(0.68, -0.041, P = 0.42, N = 859)
rs6657899(T)/1:86703902*	intergenic	(0.032, 0.19, P = 8e-06, N = 7824)	(0.038, 0.1, P = 0.41, N = 859)
rs6658767(T)/1:94529895*	ABCA4	(0.042, 0.095, P = 2.8e-05, N = 7824)	(0.014, 0.14, P = 0.49, N = 859)
rs4917405(T)/10:105638232	OBFC1	(0.044, 0.097, P = 6.3e-06, N = 7824)	(0.087, 0.15, P = 0.083, N = 859)
rs12269274(A)/10:2724048*	intergenic	(0.11, -0.059, P = 4.3e-05, N = 7824)	(0.059, 0.062, P = 0.56, N = 859)
rs656587(A)/11:128624028*	FLI1	(0.3, -0.078, P = 2.9e-05, N = 7824)	(0.094, -0.11, P = 0.2, N = 859)
rs1516988(T)/11:35479735	PAMR1	(0.46, -0.037, P = 4.7e-05, N = 7824)	(0.31, 0.041, P = 0.45, N = 859)
rs7303378(A)/12:22258068	ST8SIA1	(0.88, 0.062, P = 1.1e-05, N = 7824)	(0.98, -0.17, P = 0.33, N = 859)
rs2900501(T)/12:22387507*	ST8SIA1	(0.5, -0.04, P = 1.9e-05, N = 7824)	(0.51, 0.049, P = 0.31, N = 859)
rs488225(A)/12:3229827	TSPAN9	(0.39, -0.041, P = 4.9e-06, N = 7824)	(0.37, -0.041, P = 0.42, N = 859)
rs1570553(A)/13:76281653*	RP11-29G8.3	(0.97, -0.19, P = 2.2e-05, N = 7824)	(0.79, 0.076, P = 0.21, N = 859)
rs1998053(A)/14:101320034*	MEG3	(0.086, 0.072, P = 5.6e-06, N = 7824)	(0.011, -0.04, P = 0.86, N = 859)
rs17488344(T)/14:32909977*	AKAP6	(0.9, -0.065, P = 1.8e-05, N = 7824)	(0.96, 0.12, P = 0.33, N = 859)
rs7178693(A)/15:51394298	TNFAIP8L3	(0.038, 0.096, P = 3.7e-05, N = 7824)	(0.037, -0.1, P = 0.42, N = 859)
rs4489954(T)/15:68072075*	MAP2K5	(0.3, -0.041, P = 2.3e-05, N = 7824)	(0.35, 0.038, P = 0.46, N = 859)
rs1053730(A)/16:1560886	IFT140	(0.74, -0.073, P = 3.1e-05, N = 7824)	(0.42, -0.08, P = 0.1, N = 859)
rs7184992(T)/16:27432010*	IL21R	(0.3, 0.081, P = 1.3e-06, N = 7824)	(0.4, -0.035, P = 0.47, N = 859)
rs1862858(A)/16:55320317	RP11-26L20.3	(0.024, 0.12, P = 4.8e-05, N = 7824)	(0.15, 0.041, P = 0.54, N = 859)
rs1020065(T)/16:55369954*	RP11-26L20.3	(0.021, 0.14, P = 1.2e-05, N = 7824)	(0.11, 0.057, P = 0.45, N = 859)
rs2926133(C)/16:64282835*	AC012322.1	(0.41, -0.038, P = 1.5e-05, N = 7824)	(0.35, 0.047, P = 0.36, N = 859)
rs16967757(T)/16:64636513*	RP11-467L24.1	(0.3, 0.05, P = 1.4e-06, N = 7824)	(0.27, 0.025, P = 0.64, N = 859)
rs12934440(A)/16:82458443*	intergenic	(0.17, -0.059, P = 1.2e-05, N = 7824)	(0.29, -0.066, P = 0.23, N = 859)
rs7240261(T)/18:5428938*	EPB41L3	(0.56, 0.057, P = 7.5e-06, N = 7824)	(0.57, -0.053, P = 0.27, N = 859)
rs317914(T)/19:11476599*	DKFZP761J1410	(0.01, 0.35, P = 1.2e-05, N = 7824)	(0.11, -0.052, P = 0.5, N = 859)
rs6434811(T)/2:196866420*	DNAH7	(0.93, -0.079, P = 3.5e-06, N = 7824)	(0.28, 0.067, P = 0.2, N = 859)
rs4831124(T)/3:115945873	LSAMP	(0.68, 0.041, P = 4.2e-05, N = 7824)	(0.48, 0.018, P = 0.72, N = 859)
rs6786557(A)/3:16766989*	intergenic	(0.02, 0.14, P = 1.9e-05, N = 7824)	(0.2, -0.039, P = 0.5, N = 859)
rs1384953(T)/3:176178846	intergenic	(0.63, -0.039, P = 4.1e-05, N = 7824)	(0.48, 0.007, P = 0.88, N = 859)
rs10017961(A)/4:141000337	MAML3	(0.27, 0.049, P = 5.6e-06, N = 7824)	(0.15, 0.038, P = 0.58, N = 859)
rs2365522(A)/4:72776163	intergenic	(0.71, 0.044, P = 6.7e-06, N = 7824)	(0.75, 0.056, P = 0.32, N = 859)
rs4859463(T)/4:77760785*	intergenic	(0.15, -0.053, P = 4.5e-05, N = 7824)	(0.19, -0.065, P = 0.28, N = 859)
rs2306337(A)/5:141044472*	ARAP3	(0.85, -0.056, P = 1.3e-05, N = 7824)	(0.88, 0.0035, P = 0.96, N = 859)
rs4867710(T)/5:172845597*	CTB-32H22.1	(0.3, 0.04, P = 4.6e-05, N = 7824)	(0.1, -0.034, P = 0.67, N = 859)
rs1532331(T)/5:43116830	ZNF131	(0.7, -0.044, P = 1.9e-05, N = 7824)	(0.69, 0.058, P = 0.26, N = 859)
rs1864037(A)/5:65590269	RP11-305P14.1	(0.85, 0.056, P = 1e-05, N = 7824)	(0.89, 0.053, P = 0.5, N = 859)
rs9344148(T)/6:82018723*	intergenic	(0.75, 0.043, P = 4.9e-05, N = 7824)	(0.95, -0.0069, P = 0.95, N = 859)
rs11487092(A)/7:107693740*	LAMB4	(0.012, 0.25, P = 2.9e-06, N = 7824)	(0.58, -0.0046, P = 0.92, N = 859)
rs7809511(A)/7:4240975*	SDK1	(0.68, -0.041, P = 2.8e-05, N = 7824)	(0.5, 0.014, P = 0.78, N = 859)
rs898931(A)/7:46390643*	intergenic	(0.15, 0.087, P = 2.1e-05, N = 7824)	(0.36, -0.053, P = 0.28, N = 859)
rs1529225(T)/7:9322476*	intergenic	(0.08, -0.11, P = 4.8e-05, N = 7824)	(0.22, -0.053, P = 0.37, N = 859)
rs4404993(T)/9:19367826*	DENND4C	(0.18, 0.096, P = 3.2e-06, N = 7824)	(0.038, 0.01, P = 0.93, N = 859)
rs10811658(A)/9:22128600*	intergenic	(0.26, -0.061, P = 6.2e-06, N = 7824)	(0.45, -0.025, P = 0.6, N = 859)

Results from Univariable Mendelian Randomization of Sorbitol & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	44	0.0037 (-0.16- 0.17) P=0.97	9.3	5.2	0 (0- 43.9)	NA	NA	0.0046 P=0.77
MR-Egger	44	-0.032 (-0.33- 0.27) P=0.83	9.3	5.2	0 (0- 43.9)	38	0.65	0.0046 P=0.77
Weighted median	44	-0.029 (-0.29- 0.23) P=0.83	9.3	5.2	0 (0- 43.9)	NA	NA	0.0046 P=0.77

Results from Univariable MRPRESSO of Sorbitol & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0	0.09	0.04	0.97
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Sorbitol & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	14	0.35 (-2.3e-06- 0.7) P=0.05	7.6	1.4	0 (0- 64.2)	NA	NA	-0.0049 P=0.87
MR-Egger	14	0.4 (-0.36- 1.2) P=0.32	7.6	1.4	0 (0- 64.2)	9.8	0.63	-0.0049 P=0.87
Weighted median	14	0.29 (-0.28- 0.85) P=0.32	7.6	1.4	0 (0- 64.2)	NA	NA	-0.0049 P=0.87

Results from Univariable MRPRESSO of Sorbitol & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.35	0.18	1.96	0.07
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Sucrose

Instruments Associations with Sucrose & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Sucrose (Shin et al/Long et al)	eGFR (CSSCD)
rs72860869(G)/1:9404367*	SPSB1	(0.073, 1.4, P = 5.1e-07, N = 1439)	(0.31, 0.018, P = 0.73, N = 859)
rs72731803(A)/1:96314983*	intergenic	(0.15, 1.7, P = 7.5e-06, N = 1439)	(0.43, 0.03, P = 0.54, N = 859)
rs845088(C)/10:125208693*	RP11-282I1.1	(0.79, 0.6, P = 9e-06, N = 1439)	(0.97, 0.34, P = 0.018, N = 859)
rs1893360(C)/11:74399526*	RN7SKP297	(0.75, 0.72, P = 7.3e-06, N = 1439)	(0.94, -0.08, P = 0.44, N = 859)
rs840225(T)/13:107566858*	intergenic	(0.41, 0.63, P = 8.6e-06, N = 1439)	(0.63, -0.099, P = 0.044, N = 859)
rs2765151(A)/13:24497442*	intergenic	(0.6, 1.4, P = 6.9e-06, N = 1439)	(0.18, -0.12, P = 0.058, N = 859)
rs7151852(A)/14:67945022*	TMEM229B	(0.026, 1.3, P = 2e-06, N = 1439)	(0.036, 0.19, P = 0.14, N = 859)
rs472591(G)/18:40483622*	RIT2	(0.76, 1.7, P = 6.4e-06, N = 1439)	(0.32, 0.056, P = 0.27, N = 859)
rs60172187(T)/18:9734084*	RAB31	(0.05, 1.7, P = 1.9e-06, N = 1439)	(0.15, 0.039, P = 0.56, N = 859)
rs34700006(G)/2:175149309*	intergenic	(0.41, 1.7, P = 5.9e-06, N = 1439)	(0.23, 0.1, P = 0.085, N = 859)
rs1413421(A)/20:56580881*	intergenic	(0.37, 1.7, P = 5.2e-06, N = 1439)	(0.36, -0.11, P = 0.04, N = 859)
rs4693441(C)/4:83386179*	ENOPH1	(0.45, 0.22, P = 4.3e-06, N = 1439)	(0.74, 0.064, P = 0.25, N = 859)
rs17085250(A)/6:149610639*	RN7SL234P	(0.11, -0.19, P = 7.5e-06, N = 1439)	(0.14, 0.025, P = 0.71, N = 859)
rs7767685(A)/6:20276539*	RP11-239H6.2	(0.27, 1.7, P = 9.9e-06, N = 1439)	(0.12, -0.041, P = 0.58, N = 859)
rs4721056(G)/7:12251262*	TMEM106B	(0.55, 1.7, P = 6.8e-06, N = 1439)	(0.71, -0.049, P = 0.36, N = 859)
rs6945187(C)/7:12509538*	AC013470.6	(0.49, 1.7, P = 9.9e-06, N = 1439)	(0.6, 0.059, P = 0.23, N = 859)
rs1593306(A)/7:131613963*	AC009518.4	(0.92, 0.74, P = 2.8e-06, N = 1439)	(0.59, 0.011, P = 0.82, N = 859)
rs6944685(T)/7:85356747*	intergenic	(0.31, 0.59, P = 3.4e-06, N = 1439)	(0.34, -0.028, P = 0.59, N = 859)
rs1457777(T)/8:133272817*	KCNQ3	(0.52, 1.7, P = 9.6e-06, N = 1439)	(0.17, -0.02, P = 0.76, N = 859)
rs4872085(C)/8:23075488*	TNFRSF10A	(0.43, 1.5, P = 9.9e-06, N = 1439)	(0.15, -0.026, P = 0.7, N = 859)

Results from Univariable Mendelian Randomization of Sucrose & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	20	-0.00022 (-0.024- 0.024) P=0.99	-1531	1323	24.2 (0- 89.6)	NA	NA	-0.013 P=0.77
MR-Egger	20	0.0086 (-0.054- 0.071) P=0.79	-1531	1323	24.2 (0- 89.6)	30	0.04	-0.013 P=0.77
Weighted median	20	0.014 (-0.014- 0.042) P=0.32	-1531	1323	24.2 (0- 89.6)	NA	NA	-0.013 P=0.77

Results from Univariable MRPRESSO of Sucrose & eGFR - model1

Results from Univariable Mendelian Randomization of Sucrose & eGFR - model2

Results from Univariable MRPRESSO of Sucrose & eGFR - model2

L-Tryptophan

Instruments Associations with L-Tryptophan & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	L-Tryptophan (Shin et al/Long et al)	eGFR (CSSCD)
rs2798184(T)/1:109096332	intergenic	(0.43, -0.0049, P = 6.4e-08, N = 7824)	(0.25, 0.0016, P = 0.98, N = 859)
rs2432(T)/1:114631980	SYT6	(0.47, 0.0046, P = 4.3e-07, N = 7824)	(0.19, -0.019, P = 0.75, N = 859)
rs148210(T)/1:114749024	RP4-543J13.1	(0.47, -0.0036, P = 4.9e-05, N = 7824)	(0.44, -0.024, P = 0.62, N = 859)
rs12021645(T)/1:146716517	CHD1L	(0.064, -0.35, P = 5.7e-06, N = 1959)	(0.26, -0.012, P = 0.83, N = 859)
rs6426929(A)/1:154750989	KCNN3	(0.46, 0.0039, P = 1.4e-05, N = 7824)	(0.52, -0.021, P = 0.65, N = 859)
rs11582932(T)/1:160369372	VANGL2	(0.64, 0.0039, P = 1.7e-05, N = 7824)	(0.68, -0.055, P = 0.3, N = 859)
rs2819322(T)/1:162281028*	NOS1AP	(0.46, -0.0038, P = 3.3e-05, N = 7824)	(0.44, -0.035, P = 0.48, N = 859)
rs2071921(T)/1:167825485	ADCY10	(0.59, 0.0037, P = 4.8e-05, N = 7824)	(0.54, 0.011, P = 0.82, N = 859)
rs6685230(T)/1:168368154	RP5-968D22.1	(0.4, -0.0042, P = 7.8e-06, N = 7824)	(0.083, 0.0072, P = 0.93, N = 859)
rs2977272(T)/1:17536952*	PADI1	(0.34, 0.005, P = 5.7e-07, N = 7824)	(0.079, -0.028, P = 0.75, N = 859)
rs12564117(T)/1:179625501	TDRD5	(0.6, 0.004, P = 1.1e-05, N = 7824)	(0.66, -0.028, P = 0.57, N = 859)
rs16823952(T)/1:185342562	intergenic	(0.91, -0.0083, P = 5.1e-06, N = 7824)	(0.91, 0.019, P = 0.82, N = 859)
rs1412972(T)/1:190245977	BRINP3	(0.5, 0.0097, P = 1.6e-06, N = 7824)	(0.76, 0.079, P = 0.15, N = 859)
rs17336405(T)/1:204875330	NFASC	(0.25, -0.16, P = 5.9e-06, N = 1959)	(0.1, -0.06, P = 0.46, N = 859)
rs12754274(T)/1:206670827	IKBKE	(0.48, -0.0038, P = 2.9e-05, N = 7824)	(0.37, 0.098, P = 0.05, N = 859)
rs6667202(A)/1:206957092	intergenic	(0.56, 0.0039, P = 2.3e-05, N = 7824)	(0.47, -0.03, P = 0.53, N = 859)
rs7552506(C)/1:209969902	IRF6	(0.35, 0.0037, P = 4.7e-05, N = 7824)	(0.25, -0.044, P = 0.43, N = 859)
rs3845524(T)/1:215886709	USH2A	(0.39, 0.0038, P = 2.3e-05, N = 7824)	(0.42, -0.001, P = 0.98, N = 859)
rs10495209(T)/1:223656537	intergenic	(0.49, 0.004, P = 8e-06, N = 7824)	(0.38, -0.081, P = 0.11, N = 859)
rs881979(C)/1:231435280	intergenic	(0.099, 0.0074, P = 2.5e-05, N = 7824)	(0.017, -0.29, P = 0.12, N = 859)
rs10927101(A)/1:244173872	RP11-278H7.1	(0.37, -0.0046, P = 2.7e-07, N = 7824)	(0.51, 0.017, P = 0.74, N = 859)
rs1704427(T)/1:245566986	KIF26B	(0.43, 0.0037, P = 3.9e-05, N = 7824)	(0.42, 0.11, P = 0.022, N = 859)
rs10802308(T)/1:246152478*	SMYD3	(0.9, 0.0072, P = 3e-05, N = 7824)	(0.63, -0.11, P = 0.034, N = 859)
rs502654(T)/1:31061501	intergenic	(0.56, -0.0046, P = 2.6e-07, N = 7824)	(0.19, -0.036, P = 0.54, N = 859)
rs4073324(T)/1:3797995	DFFB	(0.55, -0.004, P = 1.4e-05, N = 7824)	(0.47, 0.018, P = 0.71, N = 859)
rs688627(T)/1:44048283*	PTPRF	(0.59, 0.0042, P = 3.6e-06, N = 7824)	(0.29, -0.089, P = 0.093, N = 859)
rs9793263(A)/1:46722389*	RAD54L	(0.41, 0.0037, P = 4e-05, N = 7824)	(0.64, -0.013, P = 0.8, N = 859)
rs4926571(T)/1:53096614*	FAM159A	(0.52, -0.0048, P = 9e-08, N = 7824)	(0.14, 0.016, P = 0.81, N = 859)
rs699856(T)/1:75089136*	C1orf173	(0.37, 0.004, P = 8e-06, N = 7824)	(0.17, 0.065, P = 0.31, N = 859)
rs11804149(T)/1:77457748	ST6GALNAC5	(0.47, 0.0041, P = 4.6e-06, N = 7824)	(0.21, -0.014, P = 0.82, N = 859)
rs7545284(A)/1:8192898	intergenic	(0.43, -0.0038, P = 3.5e-05, N = 7824)	(0.19, 0.019, P = 0.76, N = 859)
rs2209695(A)/1:82974427	intergenic	(0.53, -0.0038, P = 2.2e-05, N = 7824)	(0.69, 0.052, P = 0.32, N = 859)
rs11802417(T)/1:84276046	RP11-475O6.1	(0.58, -0.0041, P = 4.5e-06, N = 7824)	(0.71, 0.012, P = 0.82, N = 859)
rs17130048(A)/1:88051115	intergenic	(0.99, -0.039, P = 4.3e-05, N = 7824)	(0.82, 0.033, P = 0.61, N = 859)
rs2813760(A)/1:90569361*	intergenic	(0.58, 0.0044, P = 1.2e-06, N = 7824)	(0.63, -0.0062, P = 0.9, N = 859)
rs284191(A)/1:92236048	TGFBR3	(0.61, -0.006, P = 2e-09, N = 7824)	(0.44, -0.074, P = 0.13, N = 859)
rs7909316(A)/10:108518774	SORCS1	(0.14, 0.007, P = 1.9e-05, N = 7824)	(0.3, -0.05, P = 0.34, N = 859)
rs11195297(A)/10:112498838	RBM20	(0.43, 0.0039, P = 1.8e-05, N = 7824)	(0.46, 0.044, P = 0.39, N = 859)
rs151598(A)/10:115697178	intergenic	(0.42, -0.0039, P = 1.1e-05, N = 7824)	(0.28, 0.039, P = 0.47, N = 859)
rs2769419(A)/10:117395006	ATRNL1	(0.48, 0.004, P = 6.2e-06, N = 7824)	(0.43, 0.043, P = 0.36, N = 859)
rs4611118(A)/10:122395120	intergenic	(0.61, -0.0044, P = 9.4e-07, N = 7824)	(0.48, 0.0037, P = 0.94, N = 859)
rs4751282(T)/10:129164681	DOCK1	(0.54, 0.0045, P = 7.4e-07, N = 7824)	(0.58, -0.042, P = 0.39, N = 859)
rs4880221(C)/10:134729792	TTC40	(0.29, 0.2, P = 9.1e-06, N = 1959)	(0.15, 0.058, P = 0.39, N = 859)
rs1879606(T)/10:14272502	FRMD4A	(0.38, 0.004, P = 1.7e-05, N = 7824)	(0.24, 0.041, P = 0.48, N = 859)
rs2688858(T)/10:14764993	FAM107B	(0.57, 0.0043, P = 2.8e-06, N = 7824)	(0.82, -0.011, P = 0.87, N = 859)
rs7072433(T)/10:15231980	intergenic	(0.43, 0.0039, P = 3.3e-05, N = 7824)	(0.39, -0.1, P = 0.043, N = 859)
rs4880888(A)/10:1661627	ADARB2	(0.48, -0.0046, P = 3.2e-07, N = 7824)	(0.58, 0.083, P = 0.09, N = 859)
rs17294277(T)/10:1919532	intergenic	(0.95, -0.011, P = 1.8e-05, N = 7824)	(0.92, 0.013, P = 0.88, N = 859)
rs1409344(A)/10:20290956	PLXDC2	(0.53, 0.0037, P = 4e-05, N = 7824)	(0.34, -0.022, P = 0.66, N = 859)
rs11012548(T)/10:21446033	NEBL	(0.12, -0.0071, P = 4.2e-05, N = 7824)	(0.081, 0.1, P = 0.25, N = 859)
rs2250411(T)/10:24833137	KIAA1217	(0.4, -0.004, P = 1.2e-05, N = 7824)	(0.28, 0.083, P = 0.12, N = 859)
rs2367059(A)/10:24864127	intergenic	(0.47, -0.0046, P = 4e-07, N = 7824)	(0.45, -0.079, P = 0.11, N = 859)
rs2484178(T)/10:27691799	PTCHD3	(0.61, 0.0043, P = 1.7e-06, N = 7824)	(0.56, 0.0022, P = 0.96, N = 859)
rs2388594(A)/10:3137445*	PFKP	(0.38, -0.0037, P = 3.5e-05, N = 7824)	(0.43, 0.042, P = 0.41, N = 859)
rs1332772(A)/10:36891028	intergenic	(0.39, 0.0037, P = 4.3e-05, N = 7824)	(0.29, -0.028, P = 0.62, N = 859)
rs2505644(T)/10:44175098*	ZNF32-AS3	(0.56, 0.005, P = 5.7e-07, N = 7824)	(0.58, -0.056, P = 0.25, N = 859)
rs6480970(A)/10:54568664	intergenic	(0.62, -0.0049, P = 4.3e-08, N = 7824)	(0.45, -0.072, P = 0.14, N = 859)
rs11593406(T)/10:58772842*	intergenic	(0.55, 0.0037, P = 3.6e-05, N = 7824)	(0.14, -0.068, P = 0.31, N = 859)
rs10822056(T)/10:64514111*	intergenic	(0.51, 0.0042, P = 2.7e-06, N = 7824)	(0.6, -0.077, P = 0.11, N = 859)
rs938040(T)/10:65738183	RP11-170M17.1	(0.11, 0.0074, P = 9.1e-06, N = 7824)	(0.4, 0.033, P = 0.5, N = 859)
rs10822442(A)/10:66844316	intergenic	(0.5, 0.0037, P = 3.5e-05, N = 7824)	(0.47, -0.036, P = 0.45, N = 859)
rs11201034(A)/10:81745367	RP11-479O17.7	(0.61, 0.0043, P = 1.9e-06, N = 7824)	(0.54, -0.048, P = 0.31, N = 859)
rs2488631(A)/10:86349294	intergenic	(0.37, 0.0038, P = 2.6e-05, N = 7824)	(0.26, -0.015, P = 0.79, N = 859)
rs11256264(C)/10:9621246	intergenic	(0.55, 0.0038, P = 1.9e-05, N = 7824)	(0.83, 0.077, P = 0.23, N = 859)
rs1145411(T)/11:100246959	intergenic	(0.56, -0.0037, P = 3.3e-05, N = 7824)	(0.2, -0.046, P = 0.44, N = 859)
rs7120953(T)/11:101452193	TRPC6	(0.46, 0.0038, P = 2.5e-05, N = 7824)	(0.3, 0.033, P = 0.53, N = 859)
rs6591150(A)/11:105941758	KBTBD3	(0.1, -0.0076, P = 1.1e-05, N = 7824)	(0.27, -0.053, P = 0.32, N = 859)
rs17393784(T)/11:105982171	RP11-677I18.4	(0.89, 0.0073, P = 1.5e-05, N = 7824)	(0.96, -0.15, P = 0.23, N = 859)
rs2510595(A)/11:106863491	GUCY1A2	(0.61, -0.0045, P = 5e-07, N = 7824)	(0.79, -0.027, P = 0.66, N = 859)
rs2091289(A)/11:112187392	RP11-356J5.12	(0.59, 0.0043, P = 1.5e-06, N = 7824)	(0.91, 0.0029, P = 0.97, N = 859)
rs603446(T)/11:116654435*	ZNF259	(0.44, 0.0051, P = 1.4e-08, N = 7824)	(0.18, -0.11, P = 0.067, N = 859)
rs7127212(T)/11:118953202*	HMBS	(0.4, 0.0038, P = 2.9e-05, N = 7824)	(0.65, 0.055, P = 0.27, N = 859)
rs1946084(A)/11:126626203*	KIRREL3	(0.39, -0.0037, P = 4.3e-05, N = 7824)	(0.53, 0.057, P = 0.24, N = 859)
rs2970335(A)/11:14325401*	RRAS2	(0.4, 0.0044, P = 1e-06, N = 7824)	(0.4, 0.0082, P = 0.86, N = 859)
rs7109477(A)/11:21413780*	NELL1	(0.46, -0.0047, P = 1.9e-07, N = 7824)	(0.81, 0.013, P = 0.83, N = 859)
rs179785(A)/11:2781519	KCNQ1	(0.47, 0.0038, P = 2e-05, N = 7824)	(0.66, 0.074, P = 0.16, N = 859)
rs10836364(T)/11:35306345*	SLC1A2	(0.61, 0.005, P = 5.7e-07, N = 7824)	(0.88, -0.041, P = 0.59, N = 859)
rs4755291(A)/11:44821921	TSPAN18	(0.46, -0.0041, P = 5.3e-06, N = 7824)	(0.58, -0.077, P = 0.11, N = 859)
rs7934096(T)/11:5748396	OR52P1P	(0.54, -0.0037, P = 4.1e-05, N = 7824)	(0.64, 0.067, P = 0.19, N = 859)
rs2178260(T)/11:62069365	SCGB1D4	(0.43, 0.0042, P = 3.6e-06, N = 7824)	(0.17, 0.0093, P = 0.88, N = 859)
rs590336(T)/11:73708521	UCP3	(0.51, -0.004, P = 6.5e-06, N = 7824)	(0.68, 0.049, P = 0.34, N = 859)
rs1790398(T)/11:73801265	C2CD3	(0.52, 0.0048, P = 5.8e-08, N = 7824)	(0.12, 0.069, P = 0.36, N = 859)
rs575257(A)/11:78869070	TENM4	(0.6, -0.0042, P = 3.5e-06, N = 7824)	(0.37, -0.04, P = 0.42, N = 859)
rs7946613(A)/11:83789540	DLG2	(0.89, -0.0072, P = 2.1e-05, N = 7824)	(0.9, 0.0014, P = 0.99, N = 859)
rs1871053(A)/11:88476191*	GRM5	(0.45, -0.0044, P = 7.7e-07, N = 7824)	(0.82, 0.074, P = 0.23, N = 859)
rs1349704(A)/11:96777666*	intergenic	(0.46, 0.0044, P = 8.3e-07, N = 7824)	(0.58, -0.022, P = 0.65, N = 859)
rs12278762(T)/11:98781993	intergenic	(0.52, 0.0043, P = 1.6e-06, N = 7824)	(0.49, -0.073, P = 0.13, N = 859)
rs10750415(T)/11:99750593*	CNTN5	(0.4, 0.0042, P = 2.8e-06, N = 7824)	(0.4, 0.0026, P = 0.96, N = 859)
rs1861809(A)/12:110245588	TRPV4	(0.49, -0.0039, P = 1.3e-05, N = 7824)	(0.23, 0.024, P = 0.68, N = 859)
rs10845331(C)/12:11474657	intergenic	(0.59, -0.0038, P = 2.1e-05, N = 7824)	(0.92, 0.051, P = 0.54, N = 859)
rs10846667(T)/12:124884424	NCOR2	(0.49, 0.0045, P = 1.7e-06, N = 7824)	(0.11, 0.087, P = 0.25, N = 859)
rs3751181(A)/12:125626535*	AACS	(0.61, 0.0041, P = 5.2e-06, N = 7824)	(0.51, 0.07, P = 0.13, N = 859)
rs871818(A)/12:130700729	RP11-143E21.1	(0.65, -0.0038, P = 3.5e-05, N = 7824)	(0.75, 0.031, P = 0.59, N = 859)
rs4418881(A)/12:133058066	intergenic	(0.65, 0.004, P = 2.5e-05, N = 7824)	(0.43, -0.039, P = 0.44, N = 859)
rs725124(T)/12:23853069*	SOX5	(0.64, -0.0038, P = 2.7e-05, N = 7824)	(0.44, -0.034, P = 0.48, N = 859)
rs7965657(A)/12:27786415	PPFIBP1	(0.63, 0.0037, P = 4.8e-05, N = 7824)	(0.76, -0.038, P = 0.52, N = 859)
rs11062520(T)/12:3241104	TSPAN9	(0.15, -0.0067, P = 3.8e-05, N = 7824)	(0.079, 0.016, P = 0.86, N = 859)
rs7137875(A)/12:3697839*	PRMT8	(0.62, 0.0038, P = 2.4e-05, N = 7824)	(0.62, -0.014, P = 0.78, N = 859)
rs10881004(T)/12:47236571*	intergenic	(0.48, 0.0041, P = 3.4e-06, N = 7824)	(0.89, -0.031, P = 0.69, N = 859)
rs17739600(T)/12:53210145	KRT4	(0.48, 0.0038, P = 2.6e-05, N = 7824)	(0.24, -0.065, P = 0.23, N = 859)
rs12818321(T)/12:62120103*	FAM19A2	(0.099, -0.0075, P = 1.4e-05, N = 7824)	(0.038, -0.2, P = 0.1, N = 859)
rs10784496(A)/12:66160971	RPSAP52	(0.54, 0.0045, P = 5.1e-07, N = 7824)	(0.23, -0.028, P = 0.63, N = 859)
rs17114354(A)/12:75291946*	intergenic	(0.99, 0.025, P = 3.5e-06, N = 7824)	(0.88, -0.074, P = 0.31, N = 859)
rs9517869(T)/13:100398242	CLYBL	(0.37, -0.0046, P = 3.5e-07, N = 7824)	(0.15, 0.078, P = 0.26, N = 859)
rs1015795(A)/13:103225700	intergenic	(0.51, 0.0043, P = 2.3e-06, N = 7824)	(0.18, 0.11, P = 0.09, N = 859)
rs2391128(T)/13:105219349	intergenic	(0.48, -0.0045, P = 4.7e-07, N = 7824)	(0.14, -0.021, P = 0.76, N = 859)
rs2181766(A)/13:109057109	intergenic	(0.35, 0.0037, P = 4e-05, N = 7824)	(0.36, 0.077, P = 0.12, N = 859)
rs9511152(A)/13:19596767	PHF2P2	(0.56, -0.005, P = 3e-08, N = 7824)	(0.71, -0.087, P = 0.11, N = 859)
rs8000457(T)/13:22871975*	intergenic	(0.97, 0.03, P = 4.7e-05, N = 7824)	(0.85, -0.023, P = 0.73, N = 859)
rs1330918(A)/13:23373129	RPL7AP73	(0.61, 0.0042, P = 2.2e-06, N = 7824)	(0.76, -0.012, P = 0.83, N = 859)
rs736081(T)/13:24659726	SPATA13	(0.45, 0.0039, P = 1.7e-05, N = 7824)	(0.66, -0.062, P = 0.23, N = 859)
rs1220605(A)/13:24789809	SPATA13	(0.63, -0.0046, P = 9.3e-07, N = 7824)	(0.68, 0.016, P = 0.76, N = 859)
rs9579653(T)/13:31344712	intergenic	(0.84, 0.0064, P = 3.9e-05, N = 7824)	(0.85, -0.028, P = 0.67, N = 859)
rs9541214(T)/13:35112824*	RP11-16D22.2	(0.65, -0.0042, P = 3.8e-06, N = 7824)	(0.83, 0.049, P = 0.44, N = 859)
rs9315440(A)/13:37293989	intergenic	(0.58, 0.0048, P = 6.7e-08, N = 7824)	(0.51, -0.016, P = 0.73, N = 859)
rs7318017(T)/13:52410120	intergenic	(0.73, -0.0065, P = 1.3e-05, N = 7824)	(0.46, 0.0046, P = 0.92, N = 859)
rs9543391(T)/13:74115140	LINC00393	(0.4, 0.0041, P = 6.4e-06, N = 7824)	(0.17, 0.035, P = 0.59, N = 859)
rs1948293(A)/13:82401892	intergenic	(0.4, -0.0039, P = 1.2e-05, N = 7824)	(0.41, 0.027, P = 0.59, N = 859)
rs982568(T)/13:83438876	intergenic	(0.43, 0.0037, P = 3.1e-05, N = 7824)	(0.37, 0.0052, P = 0.92, N = 859)
rs9556349(A)/13:87690351	intergenic	(0.095, 0.0075, P = 1.3e-05, N = 7824)	(0.029, 0.12, P = 0.39, N = 859)
rs1335494(A)/13:89060622*	intergenic	(0.62, -0.0038, P = 2.9e-05, N = 7824)	(0.37, -0.013, P = 0.8, N = 859)
rs9523030(T)/13:91262300	intergenic	(0.63, 0.0043, P = 5.6e-06, N = 7824)	(0.41, 0.0097, P = 0.84, N = 859)
rs885883(T)/14:107274052	IGHVII-78-1	(0.6, -0.0039, P = 1.3e-05, N = 7824)	(0.93, 0.0045, P = 0.96, N = 859)
rs12891553(T)/14:20692188	OR11H6	(0.52, -0.0043, P = 2.4e-06, N = 7824)	(0.48, -0.013, P = 0.78, N = 859)
rs718433(A)/14:22235890	TRAV6	(0.61, -0.0039, P = 1.5e-05, N = 7824)	(0.66, 0.038, P = 0.45, N = 859)
rs8021242(T)/14:22398968*	intergenic	(0.59, 0.0049, P = 5.2e-08, N = 7824)	(0.79, -0.038, P = 0.51, N = 859)
rs1241503(A)/14:25612502	intergenic	(0.43, 0.0039, P = 1.7e-05, N = 7824)	(0.62, -0.044, P = 0.35, N = 859)
rs3742929(T)/14:33165182	AKAP6	(0.51, -0.0044, P = 1e-06, N = 7824)	(0.8, 0.043, P = 0.47, N = 859)
rs10483460(T)/14:36525290*	RP11-116N8.1	(0.96, 0.014, P = 1.5e-05, N = 7824)	(0.8, -0.028, P = 0.64, N = 859)
rs428185(T)/14:48321936	intergenic	(0.59, -0.0045, P = 6.3e-07, N = 7824)	(0.32, -0.0099, P = 0.85, N = 859)
rs4479142(T)/14:51530897	TRIM9	(0.6, -0.0037, P = 4.8e-05, N = 7824)	(0.67, -0.053, P = 0.29, N = 859)
rs1254598(A)/14:52781195	PTGER2	(0.8, 0.15, P = 3.8e-06, N = 1959)	(0.39, -0.022, P = 0.66, N = 859)
rs1254336(T)/14:60918777	C14orf39	(0.065, -0.29, P = 6.6e-06, N = 1959)	(0.28, -0.023, P = 0.66, N = 859)
rs8006663(A)/14:69171003*	RAD51B	(0.46, -0.0046, P = 3e-07, N = 7824)	(0.36, 0.12, P = 0.016, N = 859)
rs4899797(T)/14:82360895*	RP11-666E17.1	(0.56, -0.0037, P = 3.1e-05, N = 7824)	(0.26, -0.02, P = 0.71, N = 859)
rs12893435(A)/14:83311362*	intergenic	(0.38, 0.0038, P = 2.7e-05, N = 7824)	(0.56, 0.025, P = 0.6, N = 859)
rs10151458(A)/14:89876847	FOXN3	(0.13, 0.007, P = 3.3e-05, N = 7824)	(0.45, 0.031, P = 0.53, N = 859)
rs2230532(T)/14:97321689*	VRK1	(0.35, 0.005, P = 5.7e-07, N = 7824)	(0.18, -0.0087, P = 0.89, N = 859)
rs17744500(T)/15:101599246*	LRRK1	(0.46, -0.0041, P = 4.2e-06, N = 7824)	(0.52, 0.14, P = 0.0069, N = 859)
rs2444964(A)/15:33433259	FMN1	(0.41, -0.0038, P = 1.9e-05, N = 7824)	(0.29, 0.0053, P = 0.92, N = 859)
rs837127(T)/15:37244186	MEIS2	(0.43, -0.0038, P = 2.3e-05, N = 7824)	(0.56, 0.1, P = 0.039, N = 859)
rs692155(A)/15:41407061*	INO80	(0.51, 0.0038, P = 2.6e-05, N = 7824)	(0.21, 0.027, P = 0.65, N = 859)
rs645953(A)/15:42394368	intergenic	(0.45, 0.0038, P = 2.6e-05, N = 7824)	(0.36, 0.037, P = 0.47, N = 859)
rs682359(T)/15:42426833*	intergenic	(0.58, 0.0044, P = 6.5e-07, N = 7824)	(0.86, 0.066, P = 0.34, N = 859)
rs8043246(C)/15:55330699*	intergenic	(0.16, -0.0071, P = 1.6e-05, N = 7824)	(0.13, 0.16, P = 0.025, N = 859)
rs12595508(T)/15:61870977	RP11-507B12.2	(0.45, 0.0038, P = 1.8e-05, N = 7824)	(0.86, 0.029, P = 0.69, N = 859)
rs6494862(A)/15:70671669	intergenic	(0.53, 0.0039, P = 1.5e-05, N = 7824)	(0.61, 0.048, P = 0.33, N = 859)
rs10519267(A)/15:79924714	intergenic	(0.029, 0.014, P = 2.5e-05, N = 7824)	(0.021, 0.21, P = 0.21, N = 859)
rs1347648(A)/15:80558947	LINC00927	(0.44, -0.0037, P = 2.9e-05, N = 7824)	(0.25, 0.11, P = 0.044, N = 859)
rs4843144(A)/15:83584065	HOMER2	(0.47, -0.0037, P = 4.8e-05, N = 7824)	(0.83, 0.058, P = 0.36, N = 859)
rs1455775(T)/15:93015278*	C15orf32	(0.44, -0.0039, P = 1.2e-05, N = 7824)	(0.37, 0.0075, P = 0.88, N = 859)
rs830727(A)/16:12309785*	SNX29	(0.43, -0.0038, P = 2.6e-05, N = 7824)	(0.84, -0.076, P = 0.25, N = 859)
rs928963(A)/16:13616231	U91319.1	(0.4, 0.0042, P = 3.6e-06, N = 7824)	(0.38, 0.15, P = 0.0027, N = 859)
rs7206838(A)/16:17356812*	XYLT1	(0.57, 0.0037, P = 4e-05, N = 7824)	(0.93, -0.1, P = 0.29, N = 859)
rs7189972(A)/16:19490008	TMC5	(0.043, -0.011, P = 3e-05, N = 7824)	(0.18, -0.098, P = 0.12, N = 859)
rs2520117(A)/16:26576299*	intergenic	(0.45, 0.0045, P = 5.1e-07, N = 7824)	(0.55, 0.016, P = 0.74, N = 859)
rs10521275(T)/16:52907039	intergenic	(0.47, -0.0042, P = 3.6e-06, N = 7824)	(0.49, 0.041, P = 0.39, N = 859)
rs8056052(C)/16:52912738	intergenic	(0.6, 0.0042, P = 3.3e-06, N = 7824)	(0.57, -0.04, P = 0.42, N = 859)
rs2111118(T)/16:54049153	FTO	(0.62, 0.0051, P = 1.2e-08, N = 7824)	(0.19, 0.064, P = 0.29, N = 859)
rs8046426(A)/16:7232302	RBFOX1	(0.37, 0.004, P = 8.1e-06, N = 7824)	(0.32, -0.018, P = 0.72, N = 859)
rs12919838(C)/16:7533330	RBFOX1	(0.51, 0.0039, P = 1.5e-05, N = 7824)	(0.89, -0.095, P = 0.23, N = 859)
rs62059845(G)/16:75430713	CFDP1	(0.34, 0.08, P = 9.4e-06, N = 1959)	(0.35, -0.013, P = 0.79, N = 859)
rs6500981(T)/16:7593575*	RBFOX1	(0.9, -0.25, P = 3.5e-06, N = 1959)	(0.81, 0.032, P = 0.61, N = 859)
rs881562(T)/16:7760884	RBFOX1	(0.5, 0.0044, P = 1.5e-06, N = 7824)	(0.74, 0.039, P = 0.5, N = 859)
rs2966079(T)/16:81511806	CMIP	(0.54, -0.0042, P = 2.5e-06, N = 7824)	(0.67, -0.042, P = 0.41, N = 859)
rs4783276(T)/16:82826944*	CDH13	(0.51, 0.0037, P = 4.6e-05, N = 7824)	(0.29, 0.019, P = 0.73, N = 859)
rs4783024(T)/16:84624525	COTL1	(0.49, -0.004, P = 2.8e-05, N = 7824)	(0.59, -0.026, P = 0.6, N = 859)
rs7198470(T)/16:87061782	intergenic	(0.61, 0.004, P = 9e-06, N = 7824)	(0.68, 0.046, P = 0.37, N = 859)
rs17698249(A)/16:87319938	RP11-178L8.5	(0.57, -0.0041, P = 5.5e-06, N = 7824)	(0.91, -0.071, P = 0.38, N = 859)
rs205021(T)/17:11320392	SHISA6	(0.89, 0.0074, P = 1.5e-05, N = 7824)	(0.73, -0.047, P = 0.39, N = 859)
rs11078180(A)/17:13622654*	intergenic	(0.52, -0.0037, P = 4.7e-05, N = 7824)	(0.4, 0.0079, P = 0.87, N = 859)
rs2078340(T)/17:13807276	COX10-AS1	(0.53, 0.0039, P = 2.7e-05, N = 7824)	(0.5, -0.029, P = 0.56, N = 859)
rs7217154(T)/17:14168109*	intergenic	(0.44, -0.0037, P = 4.1e-05, N = 7824)	(0.67, 0.033, P = 0.52, N = 859)
rs2386434(G)/17:20470679	COTL1P2	(0.43, 0.18, P = 4.4e-06, N = 1959)	(0.52, 0.11, P = 0.026, N = 859)
rs9635769(T)/17:33288363	CCT6B	(0.57, 0.0037, P = 4.9e-05, N = 7824)	(0.28, 0.081, P = 0.13, N = 859)
rs4790581(T)/17:4066657	ANKFY1	(0.4, -0.0037, P = 3.2e-05, N = 7824)	(0.69, 0.0013, P = 0.98, N = 859)
rs17842784(C)/17:41440236	intergenic	(0.95, 0.011, P = 1.7e-05, N = 7824)	(0.56, 0.012, P = 0.81, N = 859)
rs1825734(T)/17:50332557	intergenic	(0.85, 0.0069, P = 4.2e-05, N = 7824)	(0.76, -0.037, P = 0.52, N = 859)
rs11654913(A)/17:52369879	intergenic	(0.56, -0.004, P = 6.9e-06, N = 7824)	(0.5, 0.039, P = 0.43, N = 859)
rs8073123(A)/17:5773900*	WSCD1	(0.49, 0.0038, P = 3e-05, N = 7824)	(0.37, -0.11, P = 0.023, N = 859)
rs9947364(A)/18:25425442	intergenic	(0.64, -0.004, P = 1.2e-05, N = 7824)	(0.49, 0.0031, P = 0.95, N = 859)
rs11564346(T)/18:25826962	intergenic	(0.51, 0.0037, P = 2.9e-05, N = 7824)	(0.5, -0.083, P = 0.092, N = 859)
rs17801274(A)/18:28858921	intergenic	(0.044, 0.011, P = 1.5e-05, N = 7824)	(0.13, -0.069, P = 0.33, N = 859)
rs1037419(T)/18:31557113	NOL4	(0.58, -0.0039, P = 1.9e-05, N = 7824)	(0.73, -0.013, P = 0.81, N = 859)
rs9948912(A)/18:34853641*	CELF4	(0.36, 0.004, P = 9.6e-06, N = 7824)	(0.29, 0.15, P = 0.0035, N = 859)
rs7230740(A)/18:3636288*	DLGAP1	(0.67, 0.0044, P = 1.6e-06, N = 7824)	(0.72, 0.12, P = 0.028, N = 859)
rs540343(A)/18:41007699	intergenic	(0.62, -0.0037, P = 4.8e-05, N = 7824)	(0.83, -0.037, P = 0.56, N = 859)
rs9989564(A)/18:41305359	intergenic	(0.51, -0.0042, P = 3.1e-06, N = 7824)	(0.34, 0.019, P = 0.7, N = 859)
rs4890592(A)/18:43370963	RP11-618K16.4	(0.63, -0.0038, P = 3.2e-05, N = 7824)	(0.77, -0.057, P = 0.32, N = 859)
rs1623892(A)/18:47456441*	MYO5B	(0.44, 0.0038, P = 2.1e-05, N = 7824)	(0.58, -0.017, P = 0.73, N = 859)
rs993927(T)/18:50101294	DCC	(0.38, 0.0042, P = 2.6e-06, N = 7824)	(0.13, 0.027, P = 0.71, N = 859)
rs9959836(A)/18:50225499*	DCC	(0.098, -0.0069, P = 4.3e-05, N = 7824)	(0.26, 0.043, P = 0.44, N = 859)
rs9950125(A)/18:50548544	DCC	(0.45, -0.004, P = 7.7e-06, N = 7824)	(0.43, -0.06, P = 0.23, N = 859)
rs2658761(T)/18:54059039*	intergenic	(0.43, -0.0048, P = 6.7e-08, N = 7824)	(0.44, 0.028, P = 0.57, N = 859)
rs8088963(A)/18:59047314*	CDH20	(0.64, 0.0044, P = 8.3e-07, N = 7824)	(0.63, 0.0095, P = 0.85, N = 859)
rs11152350(A)/18:60240352	ZCCHC2	(0.47, -0.0038, P = 1.9e-05, N = 7824)	(0.47, 0.029, P = 0.54, N = 859)
rs860916(A)/18:60665539	intergenic	(0.42, -0.0047, P = 1.5e-07, N = 7824)	(0.9, 0.1, P = 0.2, N = 859)
rs7505177(T)/18:75220892	RP11-176N18.2	(0.41, -0.0043, P = 5.9e-06, N = 7824)	(0.75, -0.00022, P = 1, N = 859)
rs1249489(A)/18:8711942	RP11-674N23.1	(0.37, 0.0042, P = 3.7e-06, N = 7824)	(0.68, -0.024, P = 0.65, N = 859)
rs8110890(T)/19:19848485*	ZNF14	(0.47, 0.0045, P = 7.5e-07, N = 7824)	(0.64, -0.091, P = 0.06, N = 859)
rs7246393(A)/19:23388805	RP11-15H20.2	(0.52, 0.0043, P = 1.6e-06, N = 7824)	(0.81, -0.035, P = 0.56, N = 859)
rs1834970(A)/19:28615716	CTD-2043I16.1	(0.43, 0.0037, P = 4e-05, N = 7824)	(0.27, 0.055, P = 0.31, N = 859)
rs7251154(A)/19:42305941	CEACAM3	(0.37, -0.0037, P = 4.5e-05, N = 7824)	(0.63, 0.051, P = 0.31, N = 859)
rs6509523(T)/19:51767205	SIGLECL1	(0.5, 0.0043, P = 2.5e-06, N = 7824)	(0.79, -0.022, P = 0.71, N = 859)
rs875283(A)/19:51767485	SIGLECL1	(0.49, -0.0043, P = 2.3e-06, N = 7824)	(0.2, 0.0046, P = 0.94, N = 859)
rs10406056(T)/19:9536418*	ZNF266	(0.58, 0.0039, P = 1.6e-05, N = 7824)	(0.66, 0.048, P = 0.35, N = 859)
rs13001325(T)/2:102939036	IL1RL1	(0.38, -0.004, P = 7.4e-06, N = 7824)	(0.15, 0.033, P = 0.64, N = 859)
rs6729061(A)/2:106182953*	intergenic	(0.37, 0.004, P = 1.1e-05, N = 7824)	(0.6, 0.061, P = 0.22, N = 859)
rs4849291(C)/2:114594099*	AC104653.1	(0.61, 0.0041, P = 5.9e-06, N = 7824)	(0.12, -0.041, P = 0.58, N = 859)
rs7584842(T)/2:11756260*	GREB1	(0.54, -0.005, P = 4.2e-08, N = 7824)	(0.43, 0.0034, P = 0.94, N = 859)
rs2580344(T)/2:122047352*	TFCP2L1	(0.62, 0.0044, P = 8e-07, N = 7824)	(0.53, -0.042, P = 0.38, N = 859)
rs4063769(T)/2:132731387*	AJ239322.1	(0.53, -0.0043, P = 1.3e-06, N = 7824)	(0.83, 0.02, P = 0.76, N = 859)
rs1316293(A)/2:156659919*	intergenic	(0.6, -0.0039, P = 1.7e-05, N = 7824)	(0.62, 0.036, P = 0.47, N = 859)
rs1534259(T)/2:156911378*	intergenic	(0.5, 0.0038, P = 2.8e-05, N = 7824)	(0.64, 0.033, P = 0.51, N = 859)
rs16843561(T)/2:159875840	TANC1	(0.1, -0.0073, P = 1.7e-05, N = 7824)	(0.084, 0.21, P = 0.019, N = 859)
rs4972588(A)/2:174444590	AC013410.1	(0.51, -0.0046, P = 3.7e-07, N = 7824)	(0.27, 0.016, P = 0.78, N = 859)
rs577687(A)/2:174451691*	intergenic	(0.61, -0.0043, P = 2.3e-06, N = 7824)	(0.66, -0.013, P = 0.8, N = 859)
rs7570357(A)/2:181079460	intergenic	(0.45, -0.0037, P = 4.5e-05, N = 7824)	(0.25, 0.033, P = 0.55, N = 859)
rs288354(A)/2:183679421*	intergenic	(0.59, -0.004, P = 1.1e-05, N = 7824)	(0.74, -0.056, P = 0.32, N = 859)
rs10931041(T)/2:183685562	intergenic	(0.58, -0.0042, P = 3.4e-06, N = 7824)	(0.47, 0.009, P = 0.85, N = 859)
rs7421372(A)/2:1855717*	MYT1L	(0.48, 0.0037, P = 3.9e-05, N = 7824)	(0.7, -0.07, P = 0.19, N = 859)
rs7597815(A)/2:188436536*	intergenic	(0.58, -0.0038, P = 2.7e-05, N = 7824)	(0.8, -0.088, P = 0.13, N = 859)
rs992005(C)/2:199504765	AC019330.1	(0.58, -0.0039, P = 1.5e-05, N = 7824)	(0.81, -0.0098, P = 0.87, N = 859)
rs295142(A)/2:201211716	SPATS2L	(0.59, -0.0048, P = 1.5e-07, N = 7824)	(0.37, -0.03, P = 0.55, N = 859)
rs2349729(A)/2:202521624	MPP4	(0.51, -0.0041, P = 6.4e-06, N = 7824)	(0.71, -0.03, P = 0.58, N = 859)
rs6730726(A)/2:205154353	intergenic	(0.53, -0.004, P = 7.2e-06, N = 7824)	(0.23, 0.034, P = 0.55, N = 859)
rs1453165(A)/2:207813972	CPO	(0.46, 0.0038, P = 2.6e-05, N = 7824)	(0.63, 0.072, P = 0.16, N = 859)
rs2854717(A)/2:208996761	CRYGC	(0.65, -0.0037, P = 4.9e-05, N = 7824)	(0.74, 0.064, P = 0.24, N = 859)
rs2286963(T)/2:211060050*	ACADL	(0.65, 0.0039, P = 1.1e-05, N = 7824)	(0.87, 0.0011, P = 0.99, N = 859)
rs6435723(T)/2:213580723*	AC079610.1	(0.9, -0.008, P = 6.9e-06, N = 7824)	(0.91, 0.067, P = 0.42, N = 859)
rs207938(A)/2:217041881	XRCC5	(0.4, -0.0043, P = 1.3e-06, N = 7824)	(0.2, -0.094, P = 0.12, N = 859)
rs1835335(T)/2:218636444	intergenic	(0.48, -0.0038, P = 1.8e-05, N = 7824)	(0.59, 0.046, P = 0.34, N = 859)
rs6735596(A)/2:228093883*	COL4A3	(0.63, -0.0038, P = 3.4e-05, N = 7824)	(0.7, -0.001, P = 0.98, N = 859)
rs12468084(T)/2:230596352*	intergenic	(0.54, -0.0044, P = 1.2e-06, N = 7824)	(0.25, -0.034, P = 0.53, N = 859)
rs11678851(T)/2:233825947	NGEF	(0.41, 0.0041, P = 5.9e-06, N = 7824)	(0.27, -0.022, P = 0.69, N = 859)
rs4663553(A)/2:236100852	intergenic	(0.89, 0.0073, P = 1.5e-05, N = 7824)	(0.39, 0.012, P = 0.8, N = 859)
rs6736036(T)/2:239834334	intergenic	(0.1, -0.22, P = 2.6e-06, N = 1959)	(0.26, -0.02, P = 0.71, N = 859)
rs719564(A)/2:242101368	PPP1R7	(0.61, 0.0044, P = 1.3e-06, N = 7824)	(0.88, 0.077, P = 0.29, N = 859)
rs6746911(A)/2:2587538*	intergenic	(0.57, -0.0037, P = 3.7e-05, N = 7824)	(0.48, -0.0048, P = 0.92, N = 859)
rs2304681(A)/2:27315252*	KHK	(0.37, -0.0037, P = 3.7e-05, N = 7824)	(0.31, 0.042, P = 0.43, N = 859)
rs1260326(T)/2:27730940*	GCKR	(0.4, 0.0042, P = 2.7e-06, N = 7824)	(0.14, -0.019, P = 0.79, N = 859)
rs829590(T)/2:30623062	intergenic	(0.46, -0.0038, P = 1.8e-05, N = 7824)	(0.31, -0.021, P = 0.69, N = 859)
rs7594598(A)/2:31026603	CAPN13	(0.43, 0.004, P = 9.5e-06, N = 7824)	(0.21, -0.025, P = 0.67, N = 859)
rs7582140(T)/2:3326203	TSSC1	(0.64, 0.0038, P = 3e-05, N = 7824)	(0.39, -0.11, P = 0.022, N = 859)
rs1448561(A)/2:33854344	intergenic	(0.52, 0.0037, P = 4.1e-05, N = 7824)	(0.64, -0.0088, P = 0.87, N = 859)
rs6747650(A)/2:3451507	TRAPPC12	(0.58, -0.0041, P = 4.4e-06, N = 7824)	(0.78, 0.045, P = 0.43, N = 859)
rs6708411(T)/2:37718181*	intergenic	(0.52, -0.0038, P = 1.6e-05, N = 7824)	(0.54, 0.023, P = 0.64, N = 859)
rs1371404(A)/2:43040577	intergenic	(0.44, 0.0038, P = 2.5e-05, N = 7824)	(0.61, 0.062, P = 0.21, N = 859)
rs3936042(T)/2:43107039*	intergenic	(0.39, 0.0038, P = 2.5e-05, N = 7824)	(0.18, 0.045, P = 0.46, N = 859)
rs1530625(T)/2:46658067	TMEM247	(0.46, 0.0038, P = 2.3e-05, N = 7824)	(0.42, -0.031, P = 0.53, N = 859)
rs17038105(A)/2:49266747	FSHR	(0.98, -0.016, P = 2.2e-05, N = 7824)	(0.7, 0.087, P = 0.096, N = 859)
rs4971590(A)/2:52528277*	AC007682.1	(0.4, 0.0039, P = 1.6e-05, N = 7824)	(0.62, 0.00046, P = 0.99, N = 859)
rs12329050(A)/2:55894428	PNPT1	(0.4, -0.0037, P = 4.6e-05, N = 7824)	(0.62, 0.0072, P = 0.88, N = 859)
rs13008096(A)/2:62792689	RSL24D1P2	(0.4, -0.0042, P = 3.3e-06, N = 7824)	(0.81, 0.0011, P = 0.99, N = 859)
rs6759991(T)/2:75696816	AC007099.2	(0.86, 0.0076, P = 2.5e-06, N = 7824)	(0.59, -0.017, P = 0.72, N = 859)
rs11126537(T)/2:76744940*	intergenic	(0.55, 0.0036, P = 4.7e-05, N = 7824)	(0.33, 0.012, P = 0.82, N = 859)
rs2861078(A)/2:77697995*	LRRTM4	(0.54, 0.0038, P = 2.7e-05, N = 7824)	(0.63, 0.038, P = 0.45, N = 859)
rs10171387(A)/2:80261406	CTNNA2	(0.91, 0.008, P = 5.1e-06, N = 7824)	(0.98, 0.25, P = 0.16, N = 859)
rs3927971(T)/2:8776102	intergenic	(0.52, 0.0042, P = 9e-06, N = 7824)	(0.42, -0.018, P = 0.71, N = 859)
rs11691641(A)/2:98360443	ZAP70	(0.48, -0.0037, P = 4.1e-05, N = 7824)	(0.39, -0.041, P = 0.41, N = 859)
rs6079133(A)/20:1419294	NSFL1C	(0.43, 0.0038, P = 2.4e-05, N = 7824)	(0.28, -0.044, P = 0.42, N = 859)
rs6074798(A)/20:14761710	MACROD2	(0.5, -0.0037, P = 3.3e-05, N = 7824)	(0.22, 0.02, P = 0.73, N = 859)
rs6110544(T)/20:15166775	MACROD2	(0.44, 0.004, P = 7e-06, N = 7824)	(0.2, 0.047, P = 0.43, N = 859)
rs2208167(A)/20:20239744	C20orf26	(0.53, 0.0037, P = 3.1e-05, N = 7824)	(0.57, 0.0029, P = 0.95, N = 859)
rs6036180(A)/20:22679977	intergenic	(0.58, -0.0037, P = 5e-05, N = 7824)	(0.89, -0.1, P = 0.2, N = 859)
rs6075944(A)/20:22725941	intergenic	(0.21, -0.0062, P = 4.3e-05, N = 7824)	(0.22, -0.0025, P = 0.97, N = 859)
rs6130271(T)/20:41612425*	PTPRT	(0.54, -0.004, P = 7.4e-06, N = 7824)	(0.51, -0.038, P = 0.43, N = 859)
rs7262469(A)/20:4184858	intergenic	(0.53, 0.0039, P = 2.2e-05, N = 7824)	(0.091, 0.048, P = 0.57, N = 859)
rs112259693(A)/20:42794090	JPH2	(0.072, 0.24, P = 5.4e-06, N = 1959)	(0.016, -0.17, P = 0.37, N = 859)
rs2425672(A)/20:43526137	YWHAB	(0.43, -0.0038, P = 2.6e-05, N = 7824)	(0.3, 0.024, P = 0.65, N = 859)
rs459011(A)/20:44364020*	intergenic	(0.63, 0.0038, P = 3.7e-05, N = 7824)	(0.34, 0.019, P = 0.72, N = 859)
rs6104350(A)/20:44423843*	DNTTIP1	(0.65, 0.0037, P = 4.6e-05, N = 7824)	(0.36, 0.035, P = 0.47, N = 859)
rs8183309(A)/20:49076893	intergenic	(0.59, 0.0038, P = 2.7e-05, N = 7824)	(0.75, -0.055, P = 0.32, N = 859)
rs4811174(T)/20:50048133	NFATC2	(0.47, -0.0037, P = 4.6e-05, N = 7824)	(0.77, -0.045, P = 0.43, N = 859)
rs1276434(T)/20:55479307*	intergenic	(0.55, 0.0038, P = 2.3e-05, N = 7824)	(0.63, -0.016, P = 0.75, N = 859)
rs1418942(A)/20:58164306*	PHACTR3	(0.58, -0.004, P = 7.1e-06, N = 7824)	(0.85, 0.02, P = 0.76, N = 859)
rs6101058(T)/20:59336158	intergenic	(0.063, -0.0096, P = 3.4e-05, N = 7824)	(0.14, -0.024, P = 0.72, N = 859)
rs1884639(T)/20:719854*	intergenic	(0.39, 0.0039, P = 1.7e-05, N = 7824)	(0.5, -0.097, P = 0.047, N = 859)
rs6077611(T)/20:9893691	intergenic	(0.48, -0.0041, P = 5.3e-06, N = 7824)	(0.25, 0.024, P = 0.67, N = 859)
rs1663501(A)/21:28219307*	ADAMTS1	(0.46, -0.0047, P = 2.4e-07, N = 7824)	(0.57, 0.08, P = 0.098, N = 859)
rs1155158(C)/21:29039413	intergenic	(0.5, 0.0037, P = 4.4e-05, N = 7824)	(0.35, 0.047, P = 0.35, N = 859)
rs2834164(A)/21:34621948*	IFNAR2	(0.5, -0.0045, P = 4.8e-07, N = 7824)	(0.55, 0.068, P = 0.16, N = 859)
rs6517254(T)/21:36080290*	CLIC6	(0.4, -0.0042, P = 3.1e-06, N = 7824)	(0.63, 0.037, P = 0.46, N = 859)
rs460574(T)/21:39986245	ERG	(0.43, 0.0038, P = 2.4e-05, N = 7824)	(0.29, 0.12, P = 0.033, N = 859)
rs2836842(T)/21:40392537*	intergenic	(0.57, -0.0038, P = 2.2e-05, N = 7824)	(0.44, 0.02, P = 0.68, N = 859)
rs1015993(T)/21:42005288*	DSCAM	(0.47, 0.0041, P = 7.3e-06, N = 7824)	(0.59, 0.034, P = 0.49, N = 859)
rs6586235(A)/21:43174436	RIPK4	(0.46, 0.0043, P = 1.6e-06, N = 7824)	(0.42, 0.12, P = 0.012, N = 859)
rs150795(A)/21:43462379*	intergenic	(0.56, 0.0039, P = 1.5e-05, N = 7824)	(0.65, 0.0054, P = 0.91, N = 859)
rs234705(T)/21:44483772*	CBS	(0.35, 0.004, P = 1.2e-05, N = 7824)	(0.24, 0.013, P = 0.81, N = 859)
rs9941787(A)/21:45116042*	RRP1B	(0.39, -0.0039, P = 2.6e-05, N = 7824)	(0.23, 0.014, P = 0.81, N = 859)
rs2838569(C)/21:45898223*	MTND5P1	(0.5, -0.0038, P = 2.6e-05, N = 7824)	(0.79, -0.021, P = 0.73, N = 859)
rs4819811(A)/22:19609256	intergenic	(0.37, 0.0038, P = 3e-05, N = 7824)	(0.23, 0.06, P = 0.3, N = 859)
rs6001129(T)/22:22506340*	LL22NC03-30E12.10	(0.13, -0.009, P = 6.8e-06, N = 7824)	(0.41, -0.047, P = 0.34, N = 859)
rs5997110(T)/22:27036505	ISCA2P1	(0.52, -0.005, P = 5.7e-07, N = 7824)	(0.42, -0.021, P = 0.66, N = 859)
rs1884134(A)/22:27831650	intergenic	(0.63, 0.0039, P = 1.9e-05, N = 7824)	(0.66, -0.093, P = 0.064, N = 859)
rs9613768(T)/22:29402832	ZNRF3	(0.41, 0.0038, P = 1.9e-05, N = 7824)	(0.076, -0.15, P = 0.11, N = 859)
rs13056963(T)/22:33622667*	LARGE	(0.44, 0.0043, P = 5.6e-06, N = 7824)	(0.27, -0.12, P = 0.02, N = 859)
rs9610322(A)/22:35980173	intergenic	(0.52, -0.0043, P = 1.1e-06, N = 7824)	(0.41, 0.064, P = 0.19, N = 859)
rs2144411(A)/22:47478839	TBC1D22A	(0.38, -0.0037, P = 3.6e-05, N = 7824)	(0.46, 0.08, P = 0.099, N = 859)
rs4824056(A)/22:49928073	C22orf34	(0.82, 0.011, P = 1.8e-05, N = 7824)	(0.33, -0.02, P = 0.71, N = 859)
rs7621216(A)/3:112463310	RP11-572C15.5	(0.47, 0.0036, P = 4.8e-05, N = 7824)	(0.74, -0.19, P = 3e-04, N = 859)
rs3772343(A)/3:1273716	CNTN6	(0.99, 0.028, P = 3.1e-06, N = 7824)	(0.99, -0.25, P = 0.24, N = 859)
rs62284469(T)/3:151185595	intergenic	(0.28, 0.13, P = 3.1e-06, N = 1959)	(0.15, -0.056, P = 0.4, N = 859)
rs11719675(A)/3:168353685	EGFEM1P	(0.4, -0.0041, P = 5.1e-06, N = 7824)	(0.5, 0.074, P = 0.12, N = 859)
rs1798231(A)/3:169921441	intergenic	(0.42, -0.0038, P = 3.2e-05, N = 7824)	(0.35, -0.049, P = 0.32, N = 859)
rs16848052(A)/3:172247863*	intergenic	(0.016, -0.033, P = 2e-05, N = 7824)	(0.11, 0.00058, P = 0.99, N = 859)
rs4129414(T)/3:178385917	KCNMB2	(0.6, -0.0039, P = 1.2e-05, N = 7824)	(0.82, -0.016, P = 0.8, N = 859)
rs11720862(T)/3:1838974*	intergenic	(0.6, -0.0046, P = 3.6e-07, N = 7824)	(0.53, -0.015, P = 0.75, N = 859)
rs12497219(T)/3:1861001	intergenic	(0.55, -0.0045, P = 5.3e-07, N = 7824)	(0.72, -0.00026, P = 1, N = 859)
rs4686980(T)/3:188302851	LPP	(0.36, 0.005, P = 5.7e-07, N = 7824)	(0.41, 0.016, P = 0.74, N = 859)
rs1013667(A)/3:191089680	CCDC50	(0.61, -0.0041, P = 5.7e-06, N = 7824)	(0.31, -0.025, P = 0.63, N = 859)
rs972459(T)/3:191855497	FGF12	(0.58, 0.005, P = 2e-08, N = 7824)	(0.91, 0.022, P = 0.79, N = 859)
rs9877345(A)/3:197808975	ANKRD18DP	(0.56, -0.0039, P = 1.5e-05, N = 7824)	(0.59, 0.0041, P = 0.93, N = 859)
rs1356792(A)/3:20378153*	intergenic	(0.58, 0.0037, P = 3.8e-05, N = 7824)	(0.76, 0.017, P = 0.77, N = 859)
rs4306882(T)/3:21062584*	intergenic	(0.62, -0.0057, P = 2.5e-10, N = 7824)	(0.65, -0.025, P = 0.62, N = 859)
rs116683205(A)/3:22515451	intergenic	(0.2, 0.23, P = 6.7e-06, N = 1959)	(0.31, -0.033, P = 0.52, N = 859)
rs4356783(C)/3:25004834	AC133680.1	(0.59, -0.0041, P = 6.7e-06, N = 7824)	(0.54, -0.034, P = 0.49, N = 859)
rs9842801(C)/3:25047228*	AC133680.1	(0.51, 0.0044, P = 7.9e-07, N = 7824)	(0.29, 0.017, P = 0.74, N = 859)
rs6786397(A)/3:31721774	OSBPL10	(0.58, -0.0038, P = 2.5e-05, N = 7824)	(0.18, 0.011, P = 0.86, N = 859)
rs430727(T)/3:41128564	intergenic	(0.46, 0.0041, P = 5.1e-06, N = 7824)	(0.36, 0.055, P = 0.29, N = 859)
rs4973952(C)/3:41525357*	ULK4	(0.41, -0.0041, P = 6.5e-06, N = 7824)	(0.48, 0.019, P = 0.69, N = 859)
rs6807794(T)/3:446221	CHL1	(0.033, 0.39, P = 5.5e-06, N = 1959)	(0.32, 0.031, P = 0.55, N = 859)
rs7638383(A)/3:4994341	BHLHE40-AS1	(0.4, 0.0047, P = 1.6e-07, N = 7824)	(0.36, -0.083, P = 0.1, N = 859)
rs341973(T)/3:5268162	intergenic	(0.49, 0.005, P = 5.7e-07, N = 7824)	(0.66, 0.0074, P = 0.88, N = 859)
rs3773729(T)/3:53204845*	PRKCD	(0.63, 0.004, P = 8.6e-06, N = 7824)	(0.3, 0.025, P = 0.64, N = 859)
rs6793158(A)/3:55235233*	intergenic	(0.47, -0.0039, P = 1.1e-05, N = 7824)	(0.27, -0.021, P = 0.68, N = 859)
rs1403699(T)/3:63415109	SYNPR	(0.47, -0.0038, P = 1.7e-05, N = 7824)	(0.76, 0.073, P = 0.19, N = 859)
rs11706832(A)/3:66502981	LRIG1	(0.52, -0.0038, P = 2e-05, N = 7824)	(0.86, 0.021, P = 0.76, N = 859)
rs3864070(T)/3:7691250*	GRM7	(0.61, -0.0037, P = 4.1e-05, N = 7824)	(0.57, 0.043, P = 0.38, N = 859)
rs4684599(T)/3:8626572	AC034187.2	(0.63, -0.0042, P = 2.9e-06, N = 7824)	(0.73, 0.03, P = 0.57, N = 859)
rs7675057(T)/4:104007996	BDH2	(0.81, -0.0064, P = 4.8e-05, N = 7824)	(0.68, 0.027, P = 0.6, N = 859)
rs958962(A)/4:109974200	COL25A1	(0.64, 0.0038, P = 2.6e-05, N = 7824)	(0.3, 0.049, P = 0.35, N = 859)
rs4989308(A)/4:115289204	intergenic	(0.37, -0.0045, P = 8.4e-07, N = 7824)	(0.55, 0.039, P = 0.41, N = 859)
rs11729831(T)/4:11735115	RP11-281P23.2	(0.61, 0.004, P = 8.6e-06, N = 7824)	(0.39, 0.032, P = 0.51, N = 859)
rs7663985(T)/4:12105392	intergenic	(0.38, 0.0038, P = 3e-05, N = 7824)	(0.41, 0.032, P = 0.51, N = 859)
rs6858525(A)/4:127425634	intergenic	(0.15, 0.014, P = 1.4e-05, N = 7824)	(0.13, -0.0025, P = 0.97, N = 859)
rs6534667(C)/4:129066488	LARP1B	(0.42, -0.0043, P = 1.5e-06, N = 7824)	(0.16, 0.13, P = 0.046, N = 859)
rs4975249(A)/4:129676063	snoU13	(0.62, 0.0039, P = 1.6e-05, N = 7824)	(0.32, 0.028, P = 0.6, N = 859)
rs17034862(C)/4:135178352	RP11-400D2.2	(0.52, -0.004, P = 6.9e-06, N = 7824)	(0.45, 0.097, P = 0.052, N = 859)
rs6537156(T)/4:139067202*	SLC7A11-AS1	(0.45, 0.004, P = 8.1e-06, N = 7824)	(0.36, 0.09, P = 0.082, N = 859)
rs1995960(A)/4:142916958	intergenic	(0.59, -0.0047, P = 1.6e-07, N = 7824)	(0.14, 0.022, P = 0.75, N = 859)
rs1878284(A)/4:153919578	intergenic	(0.39, 0.0037, P = 4e-05, N = 7824)	(0.69, -0.00083, P = 0.99, N = 859)
rs4691944(T)/4:156753174*	ASIC5	(0.9, 0.011, P = 2e-10, N = 7824)	(0.97, -0.0081, P = 0.96, N = 859)
rs67803018(T)/4:156769319	ASIC5	(0.072, -0.33, P = 1.3e-06, N = 1959)	(0.024, 0.2, P = 0.21, N = 859)
rs13122250(T)/4:156808288*	TDO2	(0.55, 0.0062, P = 8.9e-12, N = 7824)	(0.2, 0.024, P = 0.69, N = 859)
rs6826247(T)/4:161635568	intergenic	(0.51, 0.0048, P = 8.8e-08, N = 7824)	(0.36, -0.11, P = 0.025, N = 859)
rs34686132(A)/4:169547663	PALLD	(0.54, 0.19, P = 2e-06, N = 1959)	(0.25, -0.023, P = 0.68, N = 859)
rs1508513(C)/4:172003439	intergenic	(0.64, 0.0042, P = 2.4e-06, N = 7824)	(0.36, 0.049, P = 0.34, N = 859)
rs9884164(A)/4:182662819	intergenic	(0.098, 0.0077, P = 1.1e-05, N = 7824)	(0.13, -0.066, P = 0.36, N = 859)
rs7687160(A)/4:183170004	TENM3	(0.44, 0.0039, P = 2.2e-05, N = 7824)	(0.65, 0.025, P = 0.62, N = 859)
rs6841061(A)/4:185999543*	RP11-386B13.3	(0.64, 0.0038, P = 2.3e-05, N = 7824)	(0.68, 0.073, P = 0.16, N = 859)
rs1519309(T)/4:187015089*	intergenic	(0.65, -0.0044, P = 1.2e-06, N = 7824)	(0.4, -0.00082, P = 0.99, N = 859)
rs12650762(A)/4:188071662	intergenic	(0.5, 0.0038, P = 2.1e-05, N = 7824)	(0.81, -0.056, P = 0.37, N = 859)
rs937382(T)/4:189971532	intergenic	(0.45, -0.0046, P = 2.3e-07, N = 7824)	(0.54, 0.053, P = 0.28, N = 859)
rs6819555(A)/4:27342170	intergenic	(0.59, -0.0043, P = 3.7e-06, N = 7824)	(0.92, -0.054, P = 0.53, N = 859)
rs4355437(A)/4:32728207	intergenic	(0.61, 0.0036, P = 4.6e-05, N = 7824)	(0.61, -0.047, P = 0.33, N = 859)
rs16990420(T)/4:34855432	intergenic	(0.63, 0.0039, P = 1.5e-05, N = 7824)	(0.21, -0.054, P = 0.38, N = 859)
rs10517336(T)/4:34920784*	intergenic	(0.36, 0.0039, P = 1.5e-05, N = 7824)	(0.41, -0.054, P = 0.28, N = 859)
rs4695289(A)/4:43965710	intergenic	(0.35, -0.0045, P = 7.9e-07, N = 7824)	(0.42, 0.082, P = 0.1, N = 859)
rs10007704(T)/4:44276751*	KCTD8	(0.64, -0.0044, P = 1.2e-06, N = 7824)	(0.59, 0.033, P = 0.5, N = 859)
rs4695138(A)/4:45956180	intergenic	(0.54, 0.0052, P = 8e-09, N = 7824)	(0.75, 0.003, P = 0.96, N = 859)
rs1512142(A)/4:47004305	GABRB1	(0.44, -0.0038, P = 2.6e-05, N = 7824)	(0.45, 0.024, P = 0.62, N = 859)
rs16836288(A)/4:4807203	intergenic	(0.044, 0.013, P = 5.6e-06, N = 7824)	(0.34, 0.04, P = 0.42, N = 859)
rs6554068(A)/4:54032319	SCFD2	(0.62, 0.0038, P = 2.2e-05, N = 7824)	(0.68, 0.052, P = 0.31, N = 859)
rs11729908(T)/4:55221410*	RP11-231C18.1	(0.5, 0.0039, P = 1.6e-05, N = 7824)	(0.71, -0.044, P = 0.41, N = 859)
rs6824858(A)/4:57439695	THEGL	(0.95, -0.013, P = 1e-05, N = 7824)	(0.85, -0.0045, P = 0.95, N = 859)
rs12649436(A)/4:59015876	intergenic	(0.51, 0.0038, P = 2.7e-05, N = 7824)	(0.75, 0.027, P = 0.63, N = 859)
rs13112589(A)/4:8525162	intergenic	(0.42, -0.0038, P = 2.7e-05, N = 7824)	(0.16, 0.027, P = 0.68, N = 859)
rs12109383(T)/5:105956344	intergenic	(0.64, -0.0039, P = 2.1e-05, N = 7824)	(0.75, 0.024, P = 0.66, N = 859)
rs1697901(A)/5:11019405*	CTNND2	(0.35, 0.0049, P = 6.3e-08, N = 7824)	(0.18, -0.026, P = 0.67, N = 859)
rs10900784(A)/5:125514918	RP11-114J13.1	(0.42, -0.0044, P = 9.7e-07, N = 7824)	(0.74, 0.017, P = 0.76, N = 859)
rs968355(A)/5:126140350*	LMNB1	(0.59, 0.0037, P = 4.1e-05, N = 7824)	(0.62, 0.067, P = 0.17, N = 859)
rs10071669(T)/5:126271596*	MARCH3	(0.47, -0.004, P = 1e-05, N = 7824)	(0.39, -0.04, P = 0.42, N = 859)
rs813165(A)/5:127144681	CTC-228N24.1	(0.61, -0.0039, P = 4e-05, N = 7824)	(0.82, -0.095, P = 0.13, N = 859)
rs1422444(C)/5:128114022	SLC27A6	(0.37, 0.0039, P = 1.3e-05, N = 7824)	(0.25, 0.022, P = 0.7, N = 859)
rs1434630(T)/5:136557055	SPOCK1	(0.15, 0.0071, P = 1.3e-05, N = 7824)	(0.33, 0.016, P = 0.75, N = 859)
rs16903000(T)/5:13995236	intergenic	(0.71, -0.0067, P = 7.9e-06, N = 7824)	(0.76, 0.011, P = 0.85, N = 859)
rs2569188(A)/5:140008419	CD14	(0.51, 0.0037, P = 3.3e-05, N = 7824)	(0.55, 0.016, P = 0.74, N = 859)
rs33980(C)/5:141941993	RPS12P10	(0.91, -0.0077, P = 9.1e-06, N = 7824)	(0.68, 0.0051, P = 0.92, N = 859)
rs258763(A)/5:142652361	intergenic	(0.56, -0.0042, P = 2.3e-06, N = 7824)	(0.34, 0.059, P = 0.24, N = 859)
rs1016522(A)/5:143193326	HMHB1	(0.58, 0.0058, P = 1.6e-10, N = 7824)	(0.86, -0.11, P = 0.12, N = 859)
rs161551(T)/5:143270815	intergenic	(0.4, 0.0042, P = 2.7e-06, N = 7824)	(0.3, 0.0049, P = 0.93, N = 859)
rs1042713(A)/5:148206440	ADRB2	(0.36, 0.0039, P = 1.5e-05, N = 7824)	(0.49, 0.044, P = 0.36, N = 859)
rs4958379(A)/5:154010041*	intergenic	(0.43, -0.005, P = 2.2e-08, N = 7824)	(0.32, -0.0063, P = 0.9, N = 859)
rs6873777(T)/5:156488903	HAVCR1	(0.38, -0.0039, P = 1.9e-05, N = 7824)	(0.38, 0.027, P = 0.6, N = 859)
rs154246(T)/5:16602451	FAM134B	(0.61, -0.0049, P = 6.7e-08, N = 7824)	(0.47, -0.0016, P = 0.97, N = 859)
rs1501803(T)/5:166430508	intergenic	(0.42, 0.0042, P = 4.6e-06, N = 7824)	(0.23, 0.043, P = 0.45, N = 859)
rs1875977(T)/5:168250429*	SLIT3	(0.57, 0.0038, P = 2.4e-05, N = 7824)	(0.74, 0.092, P = 0.092, N = 859)
rs875184(T)/5:170124362	KCNIP1	(0.4, -0.0041, P = 5.7e-06, N = 7824)	(0.18, -0.037, P = 0.54, N = 859)
rs4867633(A)/5:170258093	intergenic	(0.41, -0.0036, P = 4.9e-05, N = 7824)	(0.59, 0.046, P = 0.35, N = 859)
rs1559063(C)/5:172348594*	ERGIC1	(0.62, 0.0052, P = 7.8e-09, N = 7824)	(0.78, 0.087, P = 0.14, N = 859)
rs1549225(T)/5:174611949	intergenic	(0.61, 0.0045, P = 6.1e-07, N = 7824)	(0.36, 0.045, P = 0.38, N = 859)
rs5025649(A)/5:20358539	CDH18	(0.45, 0.0037, P = 4.2e-05, N = 7824)	(0.83, -0.054, P = 0.4, N = 859)
rs10942222(T)/5:26970581	CDH9	(0.57, -0.0039, P = 1.5e-05, N = 7824)	(0.9, 0.11, P = 0.16, N = 859)
rs2261659(C)/5:413594	AHRR	(0.44, -0.0043, P = 1.6e-06, N = 7824)	(0.53, 0.026, P = 0.6, N = 859)
rs7706787(T)/5:56336189	intergenic	(0.12, 0.017, P = 4.1e-05, N = 7824)	(0.34, -0.0039, P = 0.94, N = 859)
rs10805503(T)/5:57390158	intergenic	(0.63, 0.0043, P = 2e-06, N = 7824)	(0.4, 0.013, P = 0.78, N = 859)
rs347661(T)/5:62549141*	intergenic	(0.44, -0.0042, P = 6.8e-06, N = 7824)	(0.31, 0.019, P = 0.72, N = 859)
rs4615256(A)/5:62700867	intergenic	(0.53, 0.0049, P = 5e-08, N = 7824)	(0.74, -0.045, P = 0.42, N = 859)
rs7730404(T)/5:72242733*	intergenic	(0.86, -0.012, P = 3.7e-05, N = 7824)	(0.93, -0.2, P = 0.037, N = 859)
rs6862529(T)/5:75551209*	SV2C	(0.46, 0.0037, P = 4.4e-05, N = 7824)	(0.41, 0.051, P = 0.29, N = 859)
rs3797435(A)/5:75953678	IQGAP2	(0.47, 0.0037, P = 4.1e-05, N = 7824)	(0.58, -0.046, P = 0.35, N = 859)
rs353957(T)/5:77113027	TBCA	(0.44, -0.0036, P = 4.6e-05, N = 7824)	(0.39, 0.027, P = 0.59, N = 859)
rs1373962(T)/5:83527862	EDIL3	(0.6, 0.005, P = 2.7e-08, N = 7824)	(0.72, 0.041, P = 0.45, N = 859)
rs3822782(T)/5:9245629	SEMA5A	(0.43, 0.0039, P = 1.4e-05, N = 7824)	(0.24, 0.0031, P = 0.96, N = 859)
rs2662269(A)/5:98076517	intergenic	(0.42, 0.0045, P = 7.1e-07, N = 7824)	(0.38, 0.039, P = 0.44, N = 859)
rs970079(A)/5:98119864	RGMB	(0.49, -0.0041, P = 4.8e-06, N = 7824)	(0.14, 0.069, P = 0.32, N = 859)
rs1876564(T)/6:106292430	intergenic	(0.57, 0.0037, P = 4.6e-05, N = 7824)	(0.31, 0.053, P = 0.31, N = 859)
rs2126498(T)/6:110336225	intergenic	(0.62, -0.0042, P = 2.8e-06, N = 7824)	(0.48, 0.0085, P = 0.86, N = 859)
rs6901004(C)/6:111554822*	RP11-428F8.2	(0.57, -0.0061, P = 1.1e-11, N = 7824)	(0.44, -0.042, P = 0.38, N = 859)
rs12203093(T)/6:111585382*	KIAA1919	(0.86, -0.0075, P = 3.9e-06, N = 7824)	(0.98, 0.094, P = 0.56, N = 859)
rs1535353(T)/6:123925257*	TRDN	(0.85, 0.007, P = 1.4e-05, N = 7824)	(0.68, -0.086, P = 0.1, N = 859)
rs6935961(A)/6:125636350*	intergenic	(0.56, -0.0056, P = 3.8e-10, N = 7824)	(0.23, -0.031, P = 0.59, N = 859)
rs4374833(T)/6:129169353	intergenic	(0.45, 0.0037, P = 3.7e-05, N = 7824)	(0.62, -0.066, P = 0.2, N = 859)
rs9482945(A)/6:129170987	intergenic	(0.55, -0.0037, P = 3.7e-05, N = 7824)	(0.31, 0.02, P = 0.71, N = 859)
rs11154507(A)/6:130144867*	RP11-174C7.3	(0.51, 0.0039, P = 4e-05, N = 7824)	(0.79, 0.046, P = 0.43, N = 859)
rs9483215(G)/6:131415664	intergenic	(0.54, 0.11, P = 1.9e-06, N = 1959)	(0.78, 0.031, P = 0.59, N = 859)
rs9476538(A)/6:14349707	intergenic	(0.47, 0.0039, P = 2.8e-05, N = 7824)	(0.49, -0.012, P = 0.81, N = 859)
rs2473156(A)/6:144660881	UTRN	(0.6, -0.004, P = 1.1e-05, N = 7824)	(0.92, 0.1, P = 0.25, N = 859)
rs4870304(A)/6:154991843	intergenic	(0.58, 0.0041, P = 8.3e-06, N = 7824)	(0.39, 0.014, P = 0.77, N = 859)
rs13197644(A)/6:159122879	SYTL3	(0.47, -0.0037, P = 5e-05, N = 7824)	(0.54, 0.029, P = 0.56, N = 859)
rs17620480(T)/6:16035382	intergenic	(0.46, -0.0037, P = 3.9e-05, N = 7824)	(0.57, 0.042, P = 0.38, N = 859)
rs623897(A)/6:16769798	RP1-151F17.2	(0.36, -0.004, P = 1.5e-05, N = 7824)	(0.2, 0.02, P = 0.73, N = 859)
rs806971(G)/6:26144791*	intergenic	(0.013, -0.93, P = 1.8e-06, N = 1959)	(0.33, 0.011, P = 0.84, N = 859)
rs10807322(A)/6:45542617*	RP1-166H4.2	(0.59, 0.0043, P = 2e-06, N = 7824)	(0.39, 0.026, P = 0.61, N = 859)
rs9464137(A)/6:54669826	intergenic	(0.56, 0.0041, P = 4.4e-06, N = 7824)	(0.5, -0.0016, P = 0.97, N = 859)
rs508920(A)/6:69574261	BAI3	(0.52, -0.0038, P = 2e-05, N = 7824)	(0.23, 0.053, P = 0.34, N = 859)
rs9346328(T)/6:70382139*	LMBRD1	(0.41, -0.0038, P = 2.8e-05, N = 7824)	(0.23, 0.0093, P = 0.87, N = 859)
rs2063601(A)/6:78578306*	MEI4	(0.25, -0.011, P = 5.2e-06, N = 7824)	(0.063, -0.31, P = 0.0023, N = 859)
rs6454864(T)/6:92234894*	MIR4643	(0.37, 0.004, P = 8.9e-06, N = 7824)	(0.29, 0.086, P = 0.1, N = 859)
rs201262(T)/6:9987615*	OFCC1	(0.56, 0.0047, P = 1.4e-07, N = 7824)	(0.59, 0.085, P = 0.085, N = 859)
rs42162(T)/7:106475927	intergenic	(0.55, 0.004, P = 8.2e-06, N = 7824)	(0.76, 0.042, P = 0.46, N = 859)
rs40903(A)/7:108173891	PNPLA8	(0.62, -0.0039, P = 1.8e-05, N = 7824)	(0.79, 0.034, P = 0.56, N = 859)
rs13228748(T)/7:109785262	intergenic	(0.35, 0.004, P = 1.3e-05, N = 7824)	(0.098, -0.053, P = 0.52, N = 859)
rs2709480(T)/7:114694662*	intergenic	(0.63, 0.0037, P = 3.8e-05, N = 7824)	(0.46, -0.096, P = 0.046, N = 859)
rs10261671(T)/7:120783551*	CPED1	(0.38, -0.0037, P = 3.8e-05, N = 7824)	(0.35, 0.027, P = 0.59, N = 859)
rs10225863(T)/7:131910303*	PLXNA4	(0.39, -0.004, P = 9.8e-06, N = 7824)	(0.57, 0.043, P = 0.37, N = 859)
rs6946136(A)/7:135423424	FAM180A	(0.61, 0.0037, P = 4e-05, N = 7824)	(0.89, -0.032, P = 0.69, N = 859)
rs38271(A)/7:14307031	DGKB	(0.59, -0.0051, P = 1.2e-08, N = 7824)	(0.18, -0.013, P = 0.84, N = 859)
rs4725832(T)/7:149543751	ZNF862	(0.59, 0.0038, P = 3.1e-05, N = 7824)	(0.29, 0.087, P = 0.11, N = 859)
rs11760861(G)/7:155938607	intergenic	(0.19, 0.23, P = 6.4e-06, N = 1959)	(0.37, 0.032, P = 0.52, N = 859)
rs1000137(T)/7:157644152*	PTPRN2	(0.47, -0.005, P = 5.7e-07, N = 7824)	(0.59, 0.025, P = 0.61, N = 859)
rs12533939(A)/7:158450965	NCAPG2	(0.39, 0.0045, P = 6.5e-07, N = 7824)	(0.58, 0.033, P = 0.49, N = 859)
rs12531256(T)/7:17281820	intergenic	(0.5, 0.0037, P = 3.6e-05, N = 7824)	(0.26, -0.039, P = 0.48, N = 859)
rs3800908(T)/7:2159437	MAD1L1	(0.42, -0.0081, P = 4.2e-05, N = 7824)	(0.57, 0.033, P = 0.48, N = 859)
rs2722380(A)/7:24376142	intergenic	(0.59, 0.0042, P = 3.9e-06, N = 7824)	(0.45, -0.031, P = 0.53, N = 859)
rs4720151(A)/7:34160523*	BMPER	(0.6, 0.0039, P = 1.7e-05, N = 7824)	(0.75, -0.085, P = 0.12, N = 859)
rs2109365(C)/7:38303120	TRGC1	(0.33, 0.16, P = 6.4e-06, N = 1959)	(0.57, 9.9e-05, P = 1, N = 859)
rs11535192(C)/7:39324349*	POU6F2	(0.39, -0.0039, P = 1.4e-05, N = 7824)	(0.36, 0.048, P = 0.35, N = 859)
rs12702179(T)/7:45913913	intergenic	(0.5, 0.0038, P = 2.1e-05, N = 7824)	(0.41, 0.044, P = 0.39, N = 859)
rs1997238(A)/7:48538770	ABCA13	(0.51, 0.0045, P = 6.1e-07, N = 7824)	(0.91, 0.097, P = 0.23, N = 859)
rs10239854(A)/7:55714282*	TUBBP6	(0.46, -0.0039, P = 1.4e-05, N = 7824)	(0.3, -0.11, P = 0.033, N = 859)
rs6947698(C)/7:55954993*	MRPS17	(0.46, -0.004, P = 8.3e-06, N = 7824)	(0.4, 0.1, P = 0.037, N = 859)
rs3843530(T)/7:64732388	AC092685.1	(0.06, -0.0099, P = 5e-05, N = 7824)	(0.1, 0.076, P = 0.35, N = 859)
rs10256726(T)/7:70547132	intergenic	(0.5, -0.0039, P = 1.8e-05, N = 7824)	(0.48, -0.016, P = 0.74, N = 859)
rs2158735(C)/7:70601065	WBSCR17	(0.51, 0.0038, P = 2.8e-05, N = 7824)	(0.41, 0.038, P = 0.43, N = 859)
rs1179636(A)/7:75230392	HIP1	(0.54, -0.0045, P = 1.8e-06, N = 7824)	(0.89, 0.045, P = 0.55, N = 859)
rs10247586(T)/7:7980650	RPA3-AS1	(0.41, 0.0039, P = 1.5e-05, N = 7824)	(0.5, -0.039, P = 0.42, N = 859)
rs7810390(A)/7:82662097	PCLO	(0.59, -0.0045, P = 5.6e-07, N = 7824)	(0.45, 0.079, P = 0.11, N = 859)
rs1208853(A)/7:88904674	ZNF804B	(0.61, 0.0039, P = 1.8e-05, N = 7824)	(0.53, 0.011, P = 0.83, N = 859)
rs2051957(T)/7:89709883*	STEAP2-AS1	(0.75, 0.0066, P = 1.7e-05, N = 7824)	(0.33, 0.042, P = 0.41, N = 859)
rs651430(A)/7:99429843*	CYP3A43	(0.53, 0.004, P = 1.4e-05, N = 7824)	(0.16, -0.043, P = 0.49, N = 859)
rs1013482(A)/8:110505710	PKHD1L1	(0.38, 0.0047, P = 1.7e-07, N = 7824)	(0.54, -0.0066, P = 0.89, N = 859)
rs7463805(T)/8:110753672	intergenic	(0.52, -0.0053, P = 4.6e-09, N = 7824)	(0.36, 0.0033, P = 0.95, N = 859)
rs4076446(T)/8:130706301	intergenic	(0.47, -0.0038, P = 3.9e-05, N = 7824)	(0.48, -0.039, P = 0.42, N = 859)
rs4144737(A)/8:130761182*	GSDMC	(0.58, 0.004, P = 9.9e-06, N = 7824)	(0.24, 0.067, P = 0.24, N = 859)
rs9649963(T)/8:131697816*	intergenic	(0.63, 0.0041, P = 5.8e-06, N = 7824)	(0.81, -0.069, P = 0.26, N = 859)
rs7006068(T)/8:142656636*	intergenic	(0.63, 0.0045, P = 4.8e-07, N = 7824)	(0.36, 0.093, P = 0.068, N = 859)
rs2717586(A)/8:143897882	RP11-706C16.8	(0.4, 0.0043, P = 2.3e-06, N = 7824)	(0.27, -0.046, P = 0.38, N = 859)
rs1366671(T)/8:15488238*	TUSC3	(0.44, -0.0041, P = 4.9e-06, N = 7824)	(0.5, 0.013, P = 0.8, N = 859)
rs2604365(T)/8:15614315	TUSC3	(0.64, 0.0044, P = 1.5e-06, N = 7824)	(0.87, 0.06, P = 0.4, N = 859)
rs2055092(A)/8:16838292*	intergenic	(0.38, -0.004, P = 1.3e-05, N = 7824)	(0.41, -0.017, P = 0.72, N = 859)
rs10087419(T)/8:236656*	intergenic	(0.6, -0.0039, P = 1.9e-05, N = 7824)	(0.3, 0.014, P = 0.78, N = 859)
rs7012981(T)/8:29383034	RP11-486M23.1	(0.52, 0.17, P = 7.4e-06, N = 1959)	(0.1, -0.11, P = 0.15, N = 859)
rs4355794(A)/8:3154167	CSMD1	(0.35, -0.0038, P = 1.9e-05, N = 7824)	(0.56, 0.039, P = 0.42, N = 859)
rs2554639(T)/8:3939181	CSMD1	(0.54, 0.0039, P = 3.1e-05, N = 7824)	(0.23, -0.077, P = 0.19, N = 859)
rs4736967(A)/8:41182841	intergenic	(0.6, 0.0037, P = 4.9e-05, N = 7824)	(0.84, -0.019, P = 0.78, N = 859)
rs13281365(T)/8:55477437	RP11-53M11.3	(0.39, 0.0038, P = 3.4e-05, N = 7824)	(0.1, 0.014, P = 0.87, N = 859)
rs1849395(T)/8:5657312	intergenic	(0.5, -0.0039, P = 1.3e-05, N = 7824)	(0.57, -0.039, P = 0.43, N = 859)
rs6471830(A)/8:60713371	intergenic	(0.54, 0.0038, P = 2.2e-05, N = 7824)	(0.76, -0.029, P = 0.61, N = 859)
rs7009696(T)/8:72731717*	U8	(0.62, 0.0041, P = 6.2e-06, N = 7824)	(0.49, -0.057, P = 0.23, N = 859)
rs4588900(A)/8:73890425	intergenic	(0.52, 0.0038, P = 2.6e-05, N = 7824)	(0.32, -0.043, P = 0.4, N = 859)
rs10808793(T)/8:74060655	intergenic	(0.49, -0.0038, P = 1.9e-05, N = 7824)	(0.73, 0.024, P = 0.67, N = 859)
rs75534375(T)/8:76013726	intergenic	(0.07, -0.33, P = 1.7e-06, N = 1959)	(0.014, 0.21, P = 0.31, N = 859)
rs2941461(T)/8:76447309	HNF4G	(0.24, 0.2, P = 5.7e-06, N = 1959)	(0.37, -0.036, P = 0.47, N = 859)
rs7843149(T)/8:91474961	AF070718.1	(0.39, -0.0041, P = 6.6e-06, N = 7824)	(0.79, -0.011, P = 0.85, N = 859)
rs7027650(A)/9:101741969	COL15A1	(0.63, 0.0037, P = 4.6e-05, N = 7824)	(0.34, 0.031, P = 0.54, N = 859)
rs1929487(A)/9:104272503*	TMEM246	(0.42, -0.0041, P = 4.9e-06, N = 7824)	(0.23, 0.0096, P = 0.87, N = 859)
rs833413(T)/9:10555561	PTPRD	(0.48, 0.0037, P = 4.6e-05, N = 7824)	(0.6, -0.02, P = 0.68, N = 859)
rs893922(A)/9:112060144	EPB41L4B	(0.37, 0.0042, P = 3.9e-06, N = 7824)	(0.15, -0.033, P = 0.64, N = 859)
rs915281(T)/9:119967963*	ASTN2	(0.51, -0.0041, P = 4.4e-06, N = 7824)	(0.25, -0.072, P = 0.19, N = 859)
rs9299251(A)/9:120184143	intergenic	(0.37, -0.0037, P = 3.6e-05, N = 7824)	(0.18, 0.038, P = 0.54, N = 859)
rs10819114(T)/9:128846829	RP11-343J18.2	(0.26, 0.21, P = 1.7e-06, N = 1959)	(0.29, 0.022, P = 0.68, N = 859)
rs7028558(T)/9:128918482*	RP11-343J18.2	(0.48, 0.0039, P = 1.2e-05, N = 7824)	(0.25, -0.013, P = 0.81, N = 859)
rs625958(G)/9:136842109	VAV2	(0.6, -0.15, P = 2.4e-06, N = 1959)	(0.65, -0.075, P = 0.13, N = 859)
rs2224447(C)/9:17624700*	SH3GL2	(0.53, 0.0037, P = 3.5e-05, N = 7824)	(0.78, -0.062, P = 0.29, N = 859)
rs2383131(T)/9:19902822	intergenic	(0.44, -0.0043, P = 3.1e-06, N = 7824)	(0.69, 0.031, P = 0.54, N = 859)
rs12350168(T)/9:31257450	SLC25A6P2	(0.46, 0.0037, P = 4.1e-05, N = 7824)	(0.19, 0.012, P = 0.84, N = 859)
rs3780494(T)/9:33126224	B4GALT1	(0.99, -0.023, P = 7e-06, N = 7824)	(0.98, 0.071, P = 0.71, N = 859)
rs776008(C)/9:37921959*	SHB	(0.47, 0.004, P = 1e-05, N = 7824)	(0.4, 0.026, P = 0.59, N = 859)
rs458552(T)/9:4833437	RCL1	(0.59, -0.0037, P = 4.2e-05, N = 7824)	(0.18, 0.026, P = 0.68, N = 859)
rs1009282(A)/9:77752967	OSTF1	(0.43, 0.0037, P = 4.4e-05, N = 7824)	(0.75, 0.15, P = 0.0053, N = 859)
rs1502682(C)/9:85617668*	RASEF	(0.49, -0.0037, P = 3.4e-05, N = 7824)	(0.47, 0.044, P = 0.35, N = 859)
rs9330454(A)/9:92515514	RP5-1050E16.2	(0.4, -0.0066, P = 6e-06, N = 7824)	(0.54, 0.012, P = 0.8, N = 859)
rs6478302(T)/9:98392340	intergenic	(0.38, 0.004, P = 1.1e-05, N = 7824)	(0.34, 0.037, P = 0.47, N = 859)

Results from Univariable Mendelian Randomization of L-Tryptophan & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	505	0.0054 (-0.071- 0.082) P=0.89	1.2	30	0 (0- 89.1)	NA	NA	-0.0052 P=0.038
MR-Egger	505	0.026 (-0.054- 0.11) P=0.53	1.2	30	0 (0- 89.1)	488	0.67	-0.0052 P=0.038
Weighted median	505	-0.0063 (-0.12- 0.11) P=0.91	1.2	30	0 (0- 89.1)	NA	NA	-0.0052 P=0.038

Results from Univariable MRPRESSO of L-Tryptophan & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.01	0.04	0.14	0.89
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of L-Tryptophan & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	348	0.033 (-0.072- 0.14) P=0.54	1.6	27	0 (0- 27.3)	NA	NA	-0.0061 P=0.049
MR-Egger	348	0.069 (-0.047- 0.18) P=0.25	1.6	27	0 (0- 27.3)	308	0.93	-0.0061 P=0.049
Weighted median	348	0.076 (-0.083- 0.23) P=0.35	1.6	27	0 (0- 27.3)	NA	NA	-0.0061 P=0.049

Results from Univariable MRPRESSO of L-Tryptophan & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.03	0.05	0.61	0.54
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Uric acid

Instruments Associations with Uric acid & eGFR

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Uric acid (Shin et al/Long et al)	eGFR (CSSCD)
rs9725388(A)/1:104894190	intergenic	(0.19, 0.0072, P = 2.8e-05, N = 7824)	(0.25, -0.097, P = 0.077, N = 859)
rs2143295(C)/1:11669919	RP1-69M21.2	(0.058, -0.31, P = 9.2e-06, N = 1958)	(0.081, 0.019, P = 0.83, N = 859)
rs6427351(T)/1:157066950*	ETV3L	(0.94, 0.016, P = 2.7e-05, N = 7824)	(0.84, 0.063, P = 0.33, N = 859)
rs1316637(T)/1:18024794	ARHGEF10L	(0.58, 0.007, P = 4.3e-05, N = 7824)	(0.81, -0.022, P = 0.72, N = 859)
rs17352664(A)/1:20559927*	intergenic	(0.11, -0.0095, P = 4.6e-05, N = 7824)	(0.1, -0.012, P = 0.88, N = 859)
rs510032(T)/1:226724202	intergenic	(0.17, 0.009, P = 6.8e-06, N = 7824)	(0.062, 0.074, P = 0.46, N = 859)
rs12137216(A)/1:30632171	intergenic	(0.89, 0.01, P = 3.7e-05, N = 7824)	(0.95, -0.078, P = 0.49, N = 859)
rs13375139(T)/1:30691713*	intergenic	(0.17, -0.0075, P = 1.5e-05, N = 7824)	(0.42, 0.024, P = 0.63, N = 859)
rs1323821(T)/1:58225872*	AL137855.1	(0.43, 0.0067, P = 3.3e-05, N = 7824)	(0.66, 0.0075, P = 0.88, N = 859)
rs12027847(A)/1:81766037*	intergenic	(0.11, 0.01, P = 3.3e-05, N = 7824)	(0.028, -0.15, P = 0.3, N = 859)
rs12138486(T)/1:93865391*	intergenic	(0.79, 0.0074, P = 1.5e-05, N = 7824)	(0.25, -0.15, P = 0.011, N = 859)
rs7906282(T)/10:19083596*	intergenic	(0.31, 0.008, P = 1.1e-06, N = 7824)	(0.25, 0.00041, P = 0.99, N = 859)
rs35345503(AC)/10:28955618	RNU6-1067P	(0.17, -0.28, P = 1.6e-07, N = 1958)	(0.37, -0.013, P = 0.79, N = 859)
rs2659999(C)/10:68293030	CTNNA3	(0.81, -0.0073, P = 2.7e-05, N = 7824)	(0.43, -0.02, P = 0.7, N = 859)
rs10490946(A)/10:9143876*	intergenic	(0.033, 0.017, P = 2.7e-05, N = 7824)	(0.097, -0.071, P = 0.39, N = 859)
rs16924665(T)/11:11780607*	RP11-756D7.1	(0.84, -0.0071, P = 4.2e-05, N = 7824)	(0.91, -0.043, P = 0.6, N = 859)
rs353632(T)/11:35187348	CD44	(0.23, 0.013, P = 4.1e-05, N = 7824)	(0.3, 0.0015, P = 0.98, N = 859)
rs4378353(T)/11:98429388	intergenic	(0.49, 0.007, P = 1.3e-05, N = 7824)	(0.29, 0.061, P = 0.25, N = 859)
rs12817597(T)/12:114132363	RP11-438N16.1	(0.021, 0.023, P = 2.5e-05, N = 7824)	(0.013, 0.3, P = 0.17, N = 859)
rs12579148(T)/12:26803493	ITPR2	(0.19, -0.0077, P = 5.9e-06, N = 7824)	(0.031, 0.067, P = 0.63, N = 859)
rs10844317(T)/12:32874640	DNM1L	(0.16, -0.0086, P = 1.1e-06, N = 7824)	(0.22, -0.057, P = 0.32, N = 859)
rs17782050(T)/12:4340106*	intergenic	(0.31, -0.0068, P = 3.3e-05, N = 7824)	(0.12, -0.069, P = 0.36, N = 859)
rs7487146(A)/12:73794865	intergenic	(0.88, -0.017, P = 2.5e-05, N = 7824)	(0.95, 0.014, P = 0.9, N = 859)
rs35800043(C)/12:9029812	A2ML1	(0.26, -0.13, P = 9.3e-06, N = 1958)	(0.13, -0.085, P = 0.24, N = 859)
rs1901044(C)/12:98218675	intergenic	(0.17, 0.0071, P = 3.6e-05, N = 7824)	(0.47, 0.05, P = 0.29, N = 859)
rs9557545(A)/13:101578114	NALCN-AS1	(0.032, 0.018, P = 7.8e-06, N = 7824)	(0.029, -0.067, P = 0.64, N = 859)
rs4550321(A)/13:23823888*	SGCG	(0.36, 0.0065, P = 4.5e-05, N = 7824)	(0.23, 0.064, P = 0.26, N = 859)
rs9510740(C)/13:24017110	intergenic	(0.23, 0.0073, P = 1.4e-05, N = 7824)	(0.18, 0.04, P = 0.53, N = 859)
rs9549021(T)/13:40543493*	intergenic	(0.61, -0.013, P = 2.9e-06, N = 7824)	(0.59, 0.0068, P = 0.89, N = 859)
rs7327319(A)/13:40928617*	RP11-172E9.2	(0.19, -0.01, P = 1.7e-05, N = 7824)	(0.15, -0.009, P = 0.89, N = 859)
rs7329766(T)/13:54732465*	intergenic	(0.87, -0.017, P = 2e-05, N = 7824)	(0.8, -0.048, P = 0.42, N = 859)
rs1540639(T)/13:82344020*	intergenic	(0.15, 0.0072, P = 4.5e-05, N = 7824)	(0.22, 0.026, P = 0.65, N = 859)
rs10145908(C)/14:63753329*	RHOJ	(0.073, 0.28, P = 9.1e-06, N = 1958)	(0.73, -0.057, P = 0.29, N = 859)
rs2535896(T)/14:73434531	ZFYVE1	(0.25, 0.013, P = 4.3e-05, N = 7824)	(0.51, 0.012, P = 0.8, N = 859)
rs8011758(A)/14:89626459*	FOXN3	(0.34, -0.0067, P = 4.8e-05, N = 7824)	(0.39, 0.009, P = 0.86, N = 859)
rs1286087(T)/14:91437370	RPS6KA5	(0.84, 0.0077, P = 8.1e-06, N = 7824)	(0.84, -0.029, P = 0.66, N = 859)
rs4594244(A)/15:101340649*	RP11-66B24.5	(0.067, 0.014, P = 3e-05, N = 7824)	(0.17, -0.06, P = 0.34, N = 859)
rs35907301(G)/15:29139319	APBA2	(0.32, -0.13, P = 6.6e-06, N = 1958)	(0.77, 0.075, P = 0.19, N = 859)
rs1471226(T)/15:29888567	intergenic	(0.26, -0.0067, P = 4.9e-05, N = 7824)	(0.3, -0.0049, P = 0.93, N = 859)
rs12396(C)/15:52413316	GNB5	(0.54, 0.013, P = 4.5e-05, N = 7824)	(0.15, -0.073, P = 0.29, N = 859)
rs17184999(T)/15:63818369*	USP3	(0.85, -0.0076, P = 1.5e-05, N = 7824)	(0.98, 0.043, P = 0.81, N = 859)
rs374181299(GTCTA)/16:23622399	PALB2	(0.14, 0.2, P = 8e-06, N = 1958)	(0.19, 0.077, P = 0.19, N = 859)
rs12919486(A)/16:53093720*	CHD9	(0.25, 0.0072, P = 2.4e-05, N = 7824)	(0.17, -0.028, P = 0.66, N = 859)
rs16953268(A)/16:54286557	RP11-324D17.1	(0.069, -0.011, P = 7.7e-06, N = 7824)	(0.14, 0.14, P = 0.038, N = 859)
rs62065022(C)/16:59029432	RP11-410D17.2	(0.29, 0.2, P = 1.2e-06, N = 1958)	(0.082, 0.11, P = 0.21, N = 859)
rs7203578(A)/16:70758855*	VAC14	(0.83, 0.0072, P = 3.1e-05, N = 7824)	(0.64, 0.083, P = 0.11, N = 859)
rs17762472(A)/16:74860912*	intergenic	(0.71, -0.0067, P = 3.8e-05, N = 7824)	(0.91, 0.061, P = 0.48, N = 859)
rs9923451(A)/16:78952439*	WWOX	(0.011, 0.056, P = 4e-05, N = 7824)	(0.23, -0.062, P = 0.27, N = 859)
rs8080896(A)/17:14890929*	intergenic	(0.16, 0.0075, P = 1.7e-05, N = 7824)	(0.24, 0.0013, P = 0.98, N = 859)
rs4793781(A)/17:52962115	intergenic	(0.2, 0.0072, P = 2e-05, N = 7824)	(0.084, 0.064, P = 0.45, N = 859)
rs35401841(G)/17:66378322	ARSG	(0.086, 0.23, P = 5e-06, N = 1958)	(0.064, 0.074, P = 0.46, N = 859)
rs112095783(C)/2:111785895	ACOXL	(0.09, -0.29, P = 5.5e-07, N = 1958)	(0.016, 0.076, P = 0.7, N = 859)
rs35613251(A)/2:130166917	intergenic	(0.68, -0.13, P = 5.4e-06, N = 1958)	(0.12, 0.032, P = 0.66, N = 859)
rs10490734(A)/2:138012183*	THSD7B	(0.83, 0.0077, P = 7.9e-06, N = 7824)	(0.75, 0.063, P = 0.25, N = 859)
rs17642263(T)/2:138637196	AC020601.1	(0.47, -0.13, P = 5e-06, N = 1958)	(0.34, 0.037, P = 0.46, N = 859)
rs16853726(A)/2:168396030*	AC074363.1	(0.98, 0.047, P = 1.2e-05, N = 7824)	(0.87, 0.19, P = 0.0077, N = 859)
rs6731691(A)/2:173331754*	ITGA6	(0.17, -0.008, P = 5.3e-06, N = 7824)	(0.1, -0.035, P = 0.65, N = 859)
rs10165148(C)/2:208707326	PLEKHM3	(0.34, 0.17, P = 4.2e-06, N = 1958)	(0.32, -0.0011, P = 0.98, N = 859)
rs17010477(A)/2:31145844	GALNT14	(0.21, 0.0071, P = 4.7e-05, N = 7824)	(0.13, 0.0076, P = 0.92, N = 859)
rs3770872(T)/2:36685242	CRIM1	(0.02, -0.63, P = 5.3e-07, N = 1958)	(0.047, -0.0052, P = 0.96, N = 859)
rs7596989(G)/2:5421053*	intergenic	(0.61, -0.17, P = 1.4e-06, N = 1958)	(0.67, -0.043, P = 0.42, N = 859)
rs2422441(G)/2:65370766	intergenic	(0.72, -0.17, P = 7.4e-06, N = 1958)	(0.44, 0.038, P = 0.42, N = 859)
rs2223710(C)/20:11968878	intergenic	(0.17, 0.0072, P = 3e-05, N = 7824)	(0.45, -0.06, P = 0.21, N = 859)
rs1569683(A)/20:12068758*	intergenic	(0.16, 0.0073, P = 3.4e-05, N = 7824)	(0.25, 0.074, P = 0.19, N = 859)
rs742840(G)/20:2545527	TMC2	(0.11, -0.29, P = 7.6e-06, N = 1958)	(0.21, 0.013, P = 0.83, N = 859)
rs6051416(C)/20:2798425	C20orf141	(0.023, 0.45, P = 6.5e-06, N = 1958)	(0.28, -0.036, P = 0.49, N = 859)
rs16993414(T)/20:7308538*	intergenic	(0.98, 0.024, P = 4.6e-05, N = 7824)	(0.96, -0.067, P = 0.59, N = 859)
rs2838690(A)/21:46222486*	UBE2G2	(0.15, 0.0073, P = 3.1e-05, N = 7824)	(0.16, 0.097, P = 0.15, N = 859)
rs235320(A)/21:46277214*	PTTG1IP	(0.82, -0.0079, P = 3.7e-06, N = 7824)	(0.76, 0.05, P = 0.37, N = 859)
rs11913285(A)/22:19844492*	C22orf29	(0.81, -0.0072, P = 2.9e-05, N = 7824)	(0.95, 0.11, P = 0.31, N = 859)
rs2073079(A)/22:44385594	SAMM50	(0.82, 0.0072, P = 3.7e-05, N = 7824)	(0.79, -0.053, P = 0.37, N = 859)
rs13318012(T)/3:106674944	LINC00882	(0.84, -0.0078, P = 8.4e-06, N = 7824)	(0.86, -0.0023, P = 0.97, N = 859)
rs145484282(A)/3:159102816	IQCJ-SCHIP1	(0.062, 0.31, P = 2.7e-06, N = 1958)	(0.015, -0.38, P = 0.049, N = 859)
rs10936697(A)/3:171391416	PLD1	(0.21, -0.0075, P = 1e-05, N = 7824)	(0.23, 0.092, P = 0.098, N = 859)
rs73197782(G)/3:190853411	intergenic	(0.21, 0.19, P = 9.2e-06, N = 1958)	(0.1, -0.12, P = 0.13, N = 859)
rs1523125(A)/3:43115161	intergenic	(0.17, 0.007, P = 5e-05, N = 7824)	(0.041, -0.32, P = 0.0094, N = 859)
rs11130013(T)/3:43833177*	intergenic	(0.15, -0.0081, P = 5.1e-06, N = 7824)	(0.14, 0.026, P = 0.71, N = 859)
rs872114(A)/3:68603563*	intergenic	(0.97, -0.021, P = 2.3e-06, N = 7824)	(0.85, -0.078, P = 0.24, N = 859)
rs2133450(A)/3:7336452*	GRM7	(0.55, -0.007, P = 1.2e-05, N = 7824)	(0.75, 0.032, P = 0.56, N = 859)
rs6849273(T)/4:10021595	SLC2A9	(0.57, 0.017, P = 1.7e-26, N = 7824)	(0.37, 0.099, P = 0.049, N = 859)
rs9926(A)/4:10076860*	WDR1	(0.22, 0.015, P = 1.3e-19, N = 7824)	(0.076, -0.043, P = 0.62, N = 859)
rs1978274(T)/4:10245087*	intergenic	(0.79, 0.029, P = 1e-66, N = 7824)	(0.78, 0.071, P = 0.21, N = 859)
rs1558488(A)/4:10327414	intergenic	(0.29, 0.0069, P = 2.8e-05, N = 7824)	(0.49, 0.0072, P = 0.88, N = 859)
rs2868941(T)/4:10509699	CLNK	(0.28, -0.01, P = 1.2e-09, N = 7824)	(0.15, 0.049, P = 0.45, N = 859)
rs6835088(T)/4:114357856*	intergenic	(0.74, -0.0069, P = 3.5e-05, N = 7824)	(0.91, 0.094, P = 0.28, N = 859)
rs706344(A)/4:140549479*	intergenic	(0.77, -0.0074, P = 3.7e-05, N = 7824)	(0.79, -0.042, P = 0.47, N = 859)
rs62333080(G)/4:161389764	intergenic	(0.26, 0.22, P = 4.3e-06, N = 1958)	(0.11, -0.095, P = 0.22, N = 859)
rs17055114(A)/4:170658731*	C4orf27	(0.8, -0.0073, P = 3.4e-05, N = 7824)	(0.69, -0.023, P = 0.67, N = 859)
rs10866262(A)/4:184383036	intergenic	(0.65, -0.11, P = 3.9e-06, N = 1958)	(0.73, 0.041, P = 0.44, N = 859)
rs10517140(A)/4:28341254*	intergenic	(0.14, -0.0073, P = 3e-05, N = 7824)	(0.03, 0.0057, P = 0.97, N = 859)
rs10024206(A)/4:33782293	RNU7-131P	(0.94, 0.024, P = 1.8e-05, N = 7824)	(0.73, 0.051, P = 0.35, N = 859)
rs1158742(C)/4:58139506*	intergenic	(0.75, 0.0072, P = 1.4e-05, N = 7824)	(0.73, 0.014, P = 0.8, N = 859)
rs13110980(T)/4:63337758	intergenic	(0.29, -0.21, P = 6.3e-06, N = 1958)	(0.079, -0.19, P = 0.028, N = 859)
rs6857147(A)/4:71250769	SMR3B	(0.96, 0.014, P = 3.9e-05, N = 7824)	(0.92, 0.18, P = 0.035, N = 859)
rs2231142(T)/4:89052323*	ABCG2	(0.11, 0.012, P = 8.4e-07, N = 7824)	(0.027, -0.18, P = 0.23, N = 859)
rs1825043(A)/4:9573740*	intergenic	(0.96, 0.019, P = 5.3e-07, N = 7824)	(0.69, -0.046, P = 0.38, N = 859)
rs7678732(T)/4:9693253*	FAM86MP	(0.037, -0.019, P = 2.1e-06, N = 7824)	(0.042, -0.022, P = 0.85, N = 859)
rs938554(C)/4:9925692*	SLC2A9	(0.23, -0.035, P = 5.8e-93, N = 7824)	(0.46, -0.014, P = 0.77, N = 859)
rs233340(A)/5:13592425	intergenic	(0.071, -0.013, P = 2.5e-06, N = 7824)	(0.11, 0.18, P = 0.024, N = 859)
rs13159834(C)/5:141045281*	ARAP3	(0.84, -0.0072, P = 4.4e-05, N = 7824)	(0.88, 0.0085, P = 0.91, N = 859)
rs11749230(T)/5:149146535*	PPARGC1B	(0.054, -0.024, P = 3.4e-05, N = 7824)	(0.25, 0.033, P = 0.56, N = 859)
rs9313506(T)/5:169948896*	KCNIP1	(0.67, -0.0069, P = 2e-05, N = 7824)	(0.78, -0.011, P = 0.86, N = 859)
rs11741189(T)/5:179543546*	RASGEF1C	(0.18, -0.0087, P = 3.8e-07, N = 7824)	(0.14, 0.00046, P = 0.99, N = 859)
rs11750694(A)/5:29023304*	intergenic	(0.16, 0.0074, P = 2.7e-05, N = 7824)	(0.048, -0.014, P = 0.9, N = 859)
rs2956574(A)/5:36498183*	intergenic	(0.73, 0.0068, P = 4.7e-05, N = 7824)	(0.5, -0.0049, P = 0.92, N = 859)
rs10058947(T)/5:74227503	CTD-2503O16.1	(0.79, 0.22, P = 5.2e-07, N = 1958)	(0.41, -0.018, P = 0.71, N = 859)
rs6927639(A)/6:108009018	intergenic	(0.85, -0.0078, P = 9.3e-06, N = 7824)	(0.88, -0.15, P = 0.04, N = 859)
rs4712645(T)/6:21970303	CASC15	(0.97, -0.47, P = 9.9e-06, N = 1958)	(0.62, -0.054, P = 0.28, N = 859)
rs12614(T)/6:31914179*	CFB	(0.083, -0.26, P = 3.8e-06, N = 1958)	(0.33, 0.08, P = 0.12, N = 859)
rs1338715(C)/6:87243828	intergenic	(0.69, -0.14, P = 5e-06, N = 1958)	(0.37, -0.017, P = 0.74, N = 859)
rs6941452(T)/6:90678323	BACH2	(0.28, -0.0071, P = 4.5e-05, N = 7824)	(0.46, -0.0089, P = 0.85, N = 859)
rs10229191(T)/7:143796891*	OR2A12	(0.88, -0.022, P = 1.2e-05, N = 7824)	(0.64, 0.0064, P = 0.89, N = 859)
rs4724354(T)/7:45104623*	CCM2	(0.78, -0.0075, P = 1.3e-05, N = 7824)	(0.74, 0.0045, P = 0.94, N = 859)
rs9785033(T)/7:92537054	AC002454.1	(0.17, 0.0076, P = 1.6e-05, N = 7824)	(0.5, -0.016, P = 0.73, N = 859)
rs11786665(A)/8:144550160*	ZC3H3	(0.068, -0.011, P = 4.4e-05, N = 7824)	(0.019, -0.041, P = 0.81, N = 859)
rs6982652(T)/8:4977252*	intergenic	(0.73, 0.0071, P = 1.8e-05, N = 7824)	(0.38, -0.077, P = 0.12, N = 859)
rs10957085(T)/8:60217240	intergenic	(0.15, 0.17, P = 6.1e-06, N = 1958)	(0.52, -0.033, P = 0.49, N = 859)
rs6980733(T)/8:84738607	intergenic	(0.5, -0.007, P = 1.5e-05, N = 7824)	(0.86, -0.031, P = 0.66, N = 859)
rs11791985(A)/9:102507514	RP11-554F20.1	(0.15, -0.0075, P = 2.2e-05, N = 7824)	(0.034, -0.065, P = 0.61, N = 859)
rs10981877(C)/9:116431022	RP11-18B16.2	(0.68, 0.007, P = 2.4e-05, N = 7824)	(0.44, 0.05, P = 0.3, N = 859)
rs10982829(T)/9:118347052*	intergenic	(0.035, -0.64, P = 2.4e-08, N = 1958)	(0.11, 0.019, P = 0.81, N = 859)
rs10513281(C)/9:119812714	ASTN2	(0.83, -0.0075, P = 1.6e-05, N = 7824)	(0.83, -0.12, P = 0.067, N = 859)
rs13288611(C)/9:28501477*	LINGO2	(0.3, -0.0072, P = 1.4e-05, N = 7824)	(0.34, 0.028, P = 0.6, N = 859)
rs10973300(A)/9:37331037	ZCCHC7	(0.16, 0.0079, P = 3.9e-05, N = 7824)	(0.076, 0.16, P = 0.083, N = 859)

Results from Univariable Mendelian Randomization of Uric acid & eGFR - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	124	-0.026 (-0.11- 0.06) P=0.55	5.8	35	0 (0- 87.5)	NA	NA	0.0023 P=0.73
MR-Egger	124	-0.035 (-0.14- 0.065) P=0.49	5.8	35	0 (0- 87.5)	128	0.34	0.0023 P=0.73
Weighted median	124	-0.034 (-0.16- 0.094) P=0.61	5.8	35	0 (0- 87.5)	NA	NA	0.0023 P=0.73

Results from Univariable MRPRESSO of Uric acid & eGFR - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.03	0.04	-0.59	0.55
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Uric acid & eGFR - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	64	-0.0055 (-0.12- 0.11) P=0.92	9	29	0.000742 (0- 98.9)	NA	NA	0.0025 P=0.82
MR-Egger	64	-0.015 (-0.15- 0.12) P=0.83	9	29	0.000742 (0- 98.9)	80	0.063	0.0025 P=0.82
Weighted median	64	-0.012 (-0.15- 0.13) P=0.87	9	29	0.000742 (0- 98.9)	NA	NA	0.0025 P=0.82

Results from Univariable MRPRESSO of Uric acid & eGFR - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.01	0.06	-0.1	0.92
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Cholecystectomy

Deoxycholic acid glycine conjugate

Instruments Associations with Deoxycholic acid glycine conjugate & Cholecystectomy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Deoxycholic acid glycine conjugate (Shin et al/Long et al)	Cholecystectomy (CSSCD)
rs1776220(T)/1:10874522*	intergenic	(0.55, -0.066, P = 1e-05, N = 1457)	(0.28, -0.23, P = 0.13, N = 1084)
rs6585252(C)/10:115723678*	intergenic	(0.96, -0.15, P = 8.5e-07, N = 1457)	(0.76, -0.23, P = 0.14, N = 1084)
rs10741178(T)/10:130903004*	intergenic	(0.21, 0.092, P = 3.6e-05, N = 868)	(0.72, 0.13, P = 0.4, N = 1084)
rs2647530(A)/11:9105636*	SCUBE2	(0.88, -0.084, P = 3.9e-05, N = 1457)	(0.84, -0.16, P = 0.38, N = 1084)
rs963167(A)/11:9111558*	SCUBE2	(0.12, 0.093, P = 1.6e-05, N = 1457)	(0.16, 0.0033, P = 0.99, N = 1084)
rs833718(A)/12:103071086*	intergenic	(0.47, -0.056, P = 2.6e-05, N = 1457)	(0.37, -0.065, P = 0.63, N = 1084)
rs9669375(T)/12:15188765*	intergenic	(0.34, -0.089, P = 2.3e-05, N = 868)	(0.31, 0.24, P = 0.11, N = 1084)
rs806784(T)/12:32438189*	BICD1	(0.72, -0.095, P = 1.5e-06, N = 868)	(0.45, -0.055, P = 0.7, N = 1084)
rs10506675(T)/12:75481828*	KCNC2	(0.096, 0.088, P = 4e-05, N = 1457)	(0.12, -0.23, P = 0.27, N = 1084)
rs9301881(T)/13:94105286*	GPC6	(0.57, 0.059, P = 5.8e-06, N = 1457)	(0.74, 0.055, P = 0.71, N = 1084)
rs8016700(A)/14:100695157*	RP11-638I2.4	(0.045, 0.14, P = 4.7e-05, N = 1457)	(0.1, -0.026, P = 0.91, N = 1084)
rs17124276(T)/14:88685076*	KCNK10	(0.22, 0.07, P = 1.9e-05, N = 1457)	(0.14, 0.26, P = 0.19, N = 1084)
rs3825678(T)/14:88693676*	KCNK10	(0.26, 0.061, P = 4.9e-05, N = 1457)	(0.37, 0.22, P = 0.1, N = 1084)
rs11642055(A)/16:56644265*	MT2A	(0.15, -0.093, P = 1.9e-05, N = 1457)	(0.026, -0.58, P = 0.18, N = 1084)
rs16966727(A)/16:63943790*	intergenic	(0.033, 0.22, P = 1.8e-05, N = 868)	(0.081, 0.0045, P = 0.99, N = 1084)
rs7190849(A)/16:79472854*	intergenic	(0.92, -0.1, P = 4e-05, N = 1457)	(0.84, 0.15, P = 0.42, N = 1084)
rs4432315(T)/18:31293792*	ASXL3	(0.5, -0.054, P = 3.1e-05, N = 1457)	(0.58, -0.067, P = 0.63, N = 1084)
rs11660001(A)/18:55220229*	FECH	(0.21, 0.077, P = 2.8e-05, N = 1457)	(0.12, 0.085, P = 0.69, N = 1084)
rs4808544(T)/19:17083711*	CPAMD8	(0.22, 0.069, P = 2.2e-05, N = 1457)	(0.38, -0.036, P = 0.8, N = 1084)
rs7257166(T)/19:17788804*	UNC13A	(0.83, -0.075, P = 2.2e-05, N = 1457)	(0.44, 0.27, P = 0.048, N = 1084)
rs737094(A)/2:100089078*	REV1	(0.28, -0.062, P = 1.7e-05, N = 1457)	(0.095, -0.06, P = 0.8, N = 1084)
rs7561272(T)/2:121856858*	intergenic	(0.98, -0.27, P = 3.1e-05, N = 868)	(0.78, -0.095, P = 0.54, N = 1084)
rs10490230(A)/2:50538327*	NRXN1	(0.13, 0.084, P = 3.3e-05, N = 1457)	(0.29, -0.07, P = 0.64, N = 1084)
rs12477733(T)/2:72347041*	intergenic	(0.052, 0.13, P = 8.2e-06, N = 1457)	(0.21, 0.017, P = 0.91, N = 1084)
rs2420201(A)/2:72356370*	CYP26B1	(0.049, 0.15, P = 1.9e-06, N = 1457)	(0.14, -0.25, P = 0.18, N = 1084)
rs6081530(A)/20:19179535*	intergenic	(0.27, 0.086, P = 2.3e-05, N = 868)	(0.028, -0.62, P = 0.11, N = 1084)
rs1741315(A)/20:4155948*	SMOX	(0.42, -0.059, P = 2e-05, N = 1457)	(0.15, 0.14, P = 0.45, N = 1084)
rs133588(A)/22:48666450*	MIR3201	(0.84, -0.077, P = 2e-05, N = 1457)	(0.51, -0.17, P = 0.2, N = 1084)
rs2360865(A)/3:143407129*	SLC9A9	(0.35, -0.061, P = 1.1e-05, N = 1457)	(0.12, -0.3, P = 0.13, N = 1084)
rs6797793(T)/3:147087164*	RP11-649A16.1	(0.83, -0.1, P = 2.1e-05, N = 868)	(0.5, 0.038, P = 0.78, N = 1084)
rs7609993(A)/3:5858488*	intergenic	(0.83, 0.076, P = 1.8e-05, N = 1457)	(0.83, 0.033, P = 0.86, N = 1084)
rs6445500(T)/3:65712905*	MAGI1	(0.3, 0.059, P = 3.9e-05, N = 1457)	(0.5, 0.12, P = 0.38, N = 1084)
rs329044(A)/3:7748565*	GRM7	(0.97, -0.18, P = 4.5e-05, N = 1457)	(0.87, -0.23, P = 0.24, N = 1084)
rs230526(A)/4:103458825*	NFKB1	(0.4, 0.057, P = 2.3e-05, N = 1457)	(0.42, -0.044, P = 0.74, N = 1084)
rs13124866(A)/4:137834834*	RP11-138I17.1	(0.41, -0.066, P = 1.3e-05, N = 1457)	(0.3, 0.14, P = 0.34, N = 1084)
rs9312547(T)/4:174620399*	intergenic	(0.55, -0.06, P = 2.5e-05, N = 1457)	(0.71, 0.35, P = 0.022, N = 1084)
rs17746543(A)/4:55227440*	intergenic	(0.51, -0.088, P = 3.7e-06, N = 868)	(0.095, 0.25, P = 0.3, N = 1084)
rs420460(T)/5:150548930*	intergenic	(0.37, -0.061, P = 2.3e-05, N = 1457)	(0.44, 0.076, P = 0.58, N = 1084)
rs2591578(A)/5:165407709*	intergenic	(0.3, 0.06, P = 2.5e-05, N = 1457)	(0.18, -0.17, P = 0.34, N = 1084)
rs6881524(T)/5:174168668*	intergenic	(0.29, -0.12, P = 4.8e-05, N = 868)	(0.47, 0.2, P = 0.13, N = 1084)
rs11949031(A)/5:2370336*	intergenic	(0.16, 0.075, P = 3.5e-05, N = 1457)	(0.21, -0.0025, P = 0.99, N = 1084)
rs2524222(T)/6:30511170*	GNL1	(0.23, -0.07, P = 2.1e-05, N = 1457)	(0.058, 0.078, P = 0.79, N = 1084)
rs7746971(T)/6:52742295*	RP11-392A23.5	(0.96, -0.18, P = 4e-05, N = 868)	(0.74, 0.26, P = 0.093, N = 1084)
rs4338010(T)/7:152624870*	intergenic	(0.079, -0.11, P = 5.7e-06, N = 1457)	(0.32, 0.0034, P = 0.98, N = 1084)
rs3905501(T)/7:76542080*	UPK3B	(0.83, 0.11, P = 1.3e-05, N = 868)	(0.89, -0.42, P = 0.066, N = 1084)
rs10253564(T)/7:85262972*	AC092013.1	(0.27, -0.095, P = 2.6e-05, N = 868)	(0.83, 0.46, P = 0.013, N = 1084)
rs818555(A)/8:49999211*	intergenic	(0.5, -0.056, P = 3.3e-05, N = 1457)	(0.32, 0.019, P = 0.9, N = 1084)
rs4734519(T)/8:92358729*	SLC26A7	(0.67, 0.061, P = 1.6e-05, N = 1457)	(0.52, -0.02, P = 0.89, N = 1084)
rs12349595(T)/9:121310484*	intergenic	(0.86, 0.081, P = 3.1e-05, N = 1457)	(0.8, -0.097, P = 0.57, N = 1084)
rs7856830(T)/9:136457146*	intergenic	(0.15, -0.089, P = 2.3e-06, N = 1457)	(0.5, 0.16, P = 0.25, N = 1084)

Results from Univariable Mendelian Randomization of Deoxycholic acid glycine conjugate & Cholecystectomy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	50	0.76 (0.47- 1.2) P=0.28	2.6	11	11.1 (0- 52.3)	NA	NA	-0.018 P=0.77
MR-Egger	50	0.89 (0.28- 2.9) P=0.85	2.6	11	11.1 (0- 52.3)	57	0.18	-0.018 P=0.77
Weighted median	50	1 (0.48- 2.2) P=0.95	2.6	11	11.1 (0- 52.3)	NA	NA	-0.018 P=0.77

Results from Univariable MRPRESSO of Deoxycholic acid glycine conjugate & Cholecystectomy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.27	0.25	-1.08	0.29
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Deoxycholic acid glycine conjugate & Cholecystectomy - model2

Results from Univariable MRPRESSO of Deoxycholic acid glycine conjugate & Cholecystectomy - model2

Taurodeoxycholic acid

Instruments Associations with Taurodeoxycholic acid & Cholecystectomy

		Association of Variant with… (EAF, Beta, P Value, N)
SNP (hg19)	Gene Region	Taurodeoxycholic acid (Shin et al/Long et al)	Cholecystectomy (CSSCD)
rs1942235(C)/1:116083074*	intergenic	(0.9, 0.32, P = 3.7e-06, N = 1943)	(0.55, -0.034, P = 0.8, N = 1084)
rs1737349(T)/1:15124318	KAZN	(0.56, 0.054, P = 4.6e-05, N = 963)	(0.59, 0.34, P = 0.013, N = 1084)
rs2805468(G)/1:237721111*	RYR2	(0.7, -0.13, P = 7.7e-06, N = 1943)	(0.43, -0.16, P = 0.25, N = 1084)
rs4294448(T)/1:248847828*	OR14I1	(0.88, 0.081, P = 4.2e-05, N = 963)	(0.68, -0.093, P = 0.52, N = 1084)
rs16829526(T)/1:42907711	ZMYND12	(0.14, -0.062, P = 2.6e-05, N = 1543)	(0.045, -0.25, P = 0.44, N = 1084)
rs691135(A)/1:87266383*	intergenic	(0.037, -0.11, P = 1.9e-05, N = 1543)	(0.089, -0.16, P = 0.48, N = 1084)
rs1220398(A)/1:9994339*	LZIC	(0.13, -0.062, P = 4.2e-05, N = 1543)	(0.51, 0.11, P = 0.4, N = 1084)
rs10741178(T)/10:130903004*	intergenic	(0.21, 0.065, P = 4.3e-05, N = 963)	(0.72, 0.13, P = 0.4, N = 1084)
rs12781751(T)/10:31872826*	intergenic	(0.54, 0.13, P = 5.7e-06, N = 1943)	(0.48, 0.099, P = 0.46, N = 1084)
rs3004260(A)/10:43487986*	intergenic	(0.4, -0.046, P = 1.4e-05, N = 1543)	(0.32, 0.23, P = 0.12, N = 1084)
rs7067796(A)/10:86843226	intergenic	(0.78, 0.05, P = 2.7e-05, N = 1543)	(0.52, -0.095, P = 0.48, N = 1084)
rs17403795(A)/11:10581217*	LYVE1	(0.12, 0.073, P = 5.6e-06, N = 1543)	(0.022, -0.43, P = 0.37, N = 1084)
rs508479(A)/11:119775811*	intergenic	(0.19, 0.055, P = 2.1e-05, N = 1543)	(0.46, 0.13, P = 0.37, N = 1084)
rs11234448(A)/11:85568363	CCDC83	(0.046, -0.51, P = 3e-07, N = 1943)	(0.058, -0.31, P = 0.28, N = 1084)
rs10898422(T)/11:85582459	CCDC83	(0.047, -0.49, P = 4.9e-07, N = 1943)	(0.11, 0.36, P = 0.1, N = 1084)
rs11234461(T)/11:85596772	CCDC83	(0.047, -0.5, P = 1.3e-07, N = 1943)	(0.087, -0.2, P = 0.42, N = 1084)
rs2647873(A)/12:103081192*	intergenic	(0.49, 0.043, P = 2.6e-05, N = 1543)	(0.16, 0.23, P = 0.22, N = 1084)
rs7961079(A)/12:109123064*	CORO1C	(0.62, 0.053, P = 1.5e-06, N = 1543)	(0.92, 0.22, P = 0.38, N = 1084)
rs11170624(T)/12:54030238	RP11-972K6.1	(0.16, 0.057, P = 4.4e-05, N = 1543)	(0.51, -0.42, P = 0.0011, N = 1084)
rs7299605(G)/12:77285134	intergenic	(0.15, -0.27, P = 3.2e-06, N = 1943)	(0.15, 0.31, P = 0.11, N = 1084)
rs17022499(A)/12:94901589*	intergenic	(0.23, 0.054, P = 9.7e-06, N = 1543)	(0.082, 0.043, P = 0.86, N = 1084)
rs12428322(T)/13:83109538*	intergenic	(0.14, 0.063, P = 3.8e-05, N = 1543)	(0.13, -0.012, P = 0.95, N = 1084)
rs7984555(A)/13:90887749*	KRT18P27	(0.16, -0.061, P = 2e-05, N = 1543)	(0.089, -0.23, P = 0.32, N = 1084)
rs10146068(A)/14:51820214	RP11-255G12.2	(0.18, -0.23, P = 2.8e-06, N = 1943)	(0.32, -0.2, P = 0.17, N = 1084)
rs7140891(T)/14:97171176	intergenic	(0.98, -0.19, P = 2.2e-05, N = 963)	(0.88, -0.031, P = 0.88, N = 1084)
rs3803481(A)/15:61278958*	RORA	(0.81, -0.068, P = 3.4e-05, N = 963)	(0.71, -0.073, P = 0.62, N = 1084)
rs1532761(G)/15:97323639	SPATA8	(0.45, -0.15, P = 3.7e-06, N = 1943)	(0.51, 0.15, P = 0.25, N = 1084)
rs1362633(A)/16:50062572*	CNEP1R1	(0.73, -0.046, P = 3.3e-05, N = 1543)	(0.42, 0.043, P = 0.76, N = 1084)
rs7184864(A)/16:50188783	PAPD5	(0.8, -0.058, P = 9.1e-06, N = 1543)	(0.62, -0.03, P = 0.82, N = 1084)
rs732329(A)/16:83392422*	CDH13	(0.12, 0.066, P = 1.9e-05, N = 1543)	(0.25, 0.027, P = 0.86, N = 1084)
rs12452524(T)/17:36581020	ARHGAP23	(0.81, 0.068, P = 3.8e-05, N = 1543)	(0.56, -0.14, P = 0.3, N = 1084)
rs75587136(A)/18:65460203	RP11-638L3.1	(0.11, -0.23, P = 3.8e-06, N = 1943)	(0.03, -0.93, P = 0.018, N = 1084)
rs12968034(T)/18:7023548	LAMA1	(0.031, -0.13, P = 4.4e-05, N = 1543)	(0.049, -0.15, P = 0.63, N = 1084)
rs5022665(A)/19:15783162	CYP4F12	(0.89, 0.074, P = 3.3e-05, N = 1543)	(0.89, 0.034, P = 0.87, N = 1084)
rs7251585(T)/19:17800702	UNC13A	(0.058, 0.092, P = 3.3e-05, N = 1543)	(0.041, -0.41, P = 0.25, N = 1084)
rs10490431(T)/2:17108634*	intergenic	(0.052, -0.093, P = 3e-05, N = 1543)	(0.031, -0.49, P = 0.21, N = 1084)
rs1153699(T)/2:175922786*	intergenic	(0.24, 0.06, P = 3.9e-06, N = 1543)	(0.4, -0.088, P = 0.53, N = 1084)
rs371887376(TA)/2:183851142	NCKAP1	(0.02, -0.64, P = 6e-06, N = 1943)	(0.13, -0.13, P = 0.51, N = 1084)
rs1898906(A)/2:188892386*	LINC01090	(0.03, 0.14, P = 4.1e-06, N = 1543)	(0.1, -0.15, P = 0.5, N = 1084)
rs1377635(T)/2:5261555*	intergenic	(0.61, 0.14, P = 9.7e-06, N = 1943)	(0.52, 0.021, P = 0.87, N = 1084)
rs17588324(T)/2:68310748	C1D	(0.87, -0.063, P = 4.8e-05, N = 1543)	(0.95, 0.32, P = 0.33, N = 1084)
rs11906184(C)/20:58785070*	RP5-1043L13.1	(0.022, -0.55, P = 3.5e-06, N = 1943)	(0.081, -0.27, P = 0.29, N = 1084)
rs1297246(T)/21:16726906*	intergenic	(0.43, -0.045, P = 2.7e-05, N = 1543)	(0.14, 0.15, P = 0.45, N = 1084)
rs2032297(C)/21:22455320*	NCAM2	(0.79, 0.057, P = 3.9e-06, N = 1543)	(0.57, -0.019, P = 0.89, N = 1084)
rs2776341(A)/21:42490274*	intergenic	(0.48, -0.045, P = 2.2e-05, N = 1543)	(0.6, -0.1, P = 0.46, N = 1084)
rs8137495(A)/22:23972409	C22orf43	(0.74, 0.06, P = 7.8e-06, N = 1543)	(0.74, 0.0029, P = 0.98, N = 1084)
rs28453905(C)/3:135665019	intergenic	(0.31, 0.19, P = 8.7e-06, N = 1943)	(0.49, 0.094, P = 0.49, N = 1084)
rs1799598(A)/3:172409798	NCEH1	(0.79, 0.068, P = 1.3e-05, N = 963)	(0.75, 0.022, P = 0.89, N = 1084)
rs112391358(CA)/3:184673755	VPS8	(0.1, -0.3, P = 4.6e-07, N = 1943)	(0.94, 0.2, P = 0.48, N = 1084)
rs11131020(A)/3:65411716*	MAGI1	(0.53, 0.048, P = 4.6e-05, N = 1543)	(0.92, 0.055, P = 0.84, N = 1084)
rs11712688(A)/3:71379546*	FOXP1	(0.47, 0.043, P = 1.4e-05, N = 1543)	(0.13, -0.081, P = 0.69, N = 1084)
rs1445516(A)/4:137797233	RP11-138I17.1	(0.29, 0.047, P = 3.3e-05, N = 1543)	(0.15, -0.1, P = 0.57, N = 1084)
rs4076797(T)/4:159225610	intergenic	(0.051, 0.098, P = 2e-05, N = 1543)	(0.31, 0.17, P = 0.23, N = 1084)
rs4632709(T)/4:159246141	RXFP1	(0.95, -0.15, P = 4e-07, N = 963)	(0.68, -0.19, P = 0.17, N = 1084)
rs4692552(C)/4:169764631*	PALLD	(0.28, 0.2, P = 6.6e-06, N = 1943)	(0.096, -0.089, P = 0.7, N = 1084)
rs929617(A)/4:18240774*	intergenic	(0.17, 0.062, P = 1.6e-05, N = 1543)	(0.02, 0.42, P = 0.41, N = 1084)
rs11728685(A)/4:18465884*	intergenic	(0.35, -0.056, P = 3e-05, N = 963)	(0.21, 0.032, P = 0.85, N = 1084)
rs6553268(T)/4:189956524*	intergenic	(0.074, 0.098, P = 4.8e-05, N = 963)	(0.25, -0.17, P = 0.27, N = 1084)
rs2291530(A)/4:20756007	KCNIP4	(0.02, 0.16, P = 2.7e-05, N = 1543)	(0.042, 0.4, P = 0.22, N = 1084)
rs10464005(C)/5:103769981	RP11-6N13.1	(0.3, -0.23, P = 2e-06, N = 1943)	(0.23, 0.23, P = 0.16, N = 1084)
rs1820806(A)/5:108720463	PJA2	(0.94, 0.087, P = 4.4e-05, N = 1543)	(0.61, 0.015, P = 0.92, N = 1084)
rs289027(A)/5:114109101*	intergenic	(0.34, 0.045, P = 3.7e-05, N = 1543)	(0.14, -0.07, P = 0.73, N = 1084)
rs11241933(A)/5:126944341	intergenic	(0.27, -0.061, P = 1.1e-06, N = 1543)	(0.14, -0.054, P = 0.78, N = 1084)
rs3733672(A)/5:149439494*	CSF1R	(0.11, 0.068, P = 2.6e-05, N = 1543)	(0.1, -0.39, P = 0.092, N = 1084)
rs905177(T)/5:18833784	intergenic	(0.6, -0.068, P = 4.8e-05, N = 963)	(0.79, 0.17, P = 0.29, N = 1084)
rs11949031(A)/5:2370336*	intergenic	(0.16, 0.066, P = 1.5e-06, N = 1543)	(0.21, -0.0025, P = 0.99, N = 1084)
rs12654530(T)/5:77490596*	AP3B1	(0.052, 0.075, P = 4e-05, N = 1543)	(0.038, -0.16, P = 0.64, N = 1084)
rs7718530(A)/5:92485295	intergenic	(0.32, -0.14, P = 8e-06, N = 1943)	(0.53, 0.2, P = 0.15, N = 1084)
rs4896370(A)/6:138818837	NHSL1	(0.35, 0.056, P = 4.2e-06, N = 1543)	(0.39, -0.014, P = 0.92, N = 1084)
rs7763112(A)/6:159699814	intergenic	(0.82, 0.056, P = 2.6e-05, N = 1543)	(0.53, -0.15, P = 0.25, N = 1084)
rs9347691(A)/6:163249645*	PACRG	(0.95, 0.094, P = 2.3e-05, N = 1543)	(0.94, 0.016, P = 0.96, N = 1084)
rs10246722(A)/7:18965590	HDAC9	(0.77, 0.049, P = 3.1e-05, N = 1543)	(0.89, -0.28, P = 0.18, N = 1084)
rs17150615(T)/7:29219062	CPVL	(0.084, -0.079, P = 1.5e-05, N = 1543)	(0.015, 0.24, P = 0.68, N = 1084)
rs4719970(C)/7:29423773*	CHN2	(0.45, -0.18, P = 5.9e-06, N = 1943)	(0.5, -0.033, P = 0.81, N = 1084)
rs17374391(T)/7:3507092*	SDK1	(0.9, -0.067, P = 4.7e-05, N = 1543)	(0.78, -0.051, P = 0.76, N = 1084)
rs6959191(A)/7:52165673*	intergenic	(0.016, 0.23, P = 1.9e-05, N = 963)	(0.1, -0.25, P = 0.23, N = 1084)
rs2374374(A)/7:90579226	CDK14	(0.8, 0.16, P = 4e-07, N = 1943)	(0.88, 0.083, P = 0.69, N = 1084)
rs1207732(T)/7:96649668	DLX5	(0.76, 0.05, P = 3.5e-05, N = 1543)	(0.82, -0.069, P = 0.7, N = 1084)
rs7845099(T)/8:39316048	ADAM3A	(0.89, 0.086, P = 3.2e-05, N = 1543)	(0.67, 0.044, P = 0.77, N = 1084)
rs75543373(T)/8:70043220	GS1-44D20.1	(0.086, -0.28, P = 6.2e-06, N = 1943)	(0.027, 0.67, P = 0.13, N = 1084)
rs10820542(A)/9:106517270	intergenic	(0.15, -0.15, P = 4.2e-06, N = 1943)	(0.18, 0.077, P = 0.66, N = 1084)
rs925837(T)/9:108868577	intergenic	(0.59, -0.044, P = 2.9e-05, N = 1543)	(0.18, -0.03, P = 0.87, N = 1084)
rs1780158(C)/9:15133616*	RP11-54D18.3	(0.089, -0.073, P = 3.9e-05, N = 1543)	(0.31, -0.044, P = 0.76, N = 1084)
rs144820845(CGT)/9:16855132	BNC2	(0.047, -0.42, P = 5.9e-06, N = 1943)	(0.023, -0.42, P = 0.33, N = 1084)
rs3847229(A)/9:1801822	intergenic	(0.74, -0.052, P = 2e-05, N = 1543)	(0.25, 0.028, P = 0.86, N = 1084)
rs993233(G)/9:25890226	intergenic	(0.64, -0.1, P = 9e-06, N = 1943)	(0.39, 0.28, P = 0.039, N = 1084)
rs10975331(T)/9:5877594*	KIAA2026	(0.036, 0.12, P = 9.6e-06, N = 1543)	(0.12, 0.44, P = 0.029, N = 1084)

Results from Univariable Mendelian Randomization of Taurodeoxycholic acid & Cholecystectomy - model1

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
IVW(re)	87	1 (0.79- 1.3) P=0.95	8.8	41	4.13 (0- 43.2)	NA	NA	-0.033 P=0.26
MR-Egger	87	1.2 (0.82- 1.7) P=0.38	8.8	41	4.13 (0- 43.2)	88	0.39	-0.033 P=0.26
Weighted median	87	1.2 (0.82- 1.8) P=0.33	8.8	41	4.13 (0- 43.2)	NA	NA	-0.033 P=0.26

Results from Univariable MRPRESSO of Taurodeoxycholic acid & Cholecystectomy - model1

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	0.01	0.13	0.06	0.95
beta.exposure	Outlier-corrected	NA	NA	NA	NA

Results from Univariable Mendelian Randomization of Taurodeoxycholic acid & Cholecystectomy - model2

					Heterogeneity Statistics
Method	nSNP	Beta (95% CI) Pval	F	Var_ex	I2	Q	Q_pval	Egger intercept (Beta Pval)
taurodeoxycholate	cholecystectomy	IVW(re)	0.95 (0.67- 1.3) P=0.77	20.1 (0- 73.6)	45	12	28	NA
taurodeoxycholate	cholecystectomy	MR-Egger	1.2 (0.75- 2.1) P=0.4	20.1 (0- 73.6)	45	12	28	58
taurodeoxycholate	cholecystectomy	Weighted median	1.2 (0.76- 2) P=0.39	20.1 (0- 73.6)	45	12	28	NA

Results from Univariable MRPRESSO of Taurodeoxycholic acid & Cholecystectomy - model2

Exposure	MR.Analysis	Causal.Estimate	Sd	T.stat	P.value
beta.exposure	Raw	-0.05	0.18	-0.30	0.77
beta.exposure	Outlier-corrected	-0.02	0.16	-0.12	0.90